Label-free cancer cell separation from human whole blood using inertial microfluidics at low shear stress

Analytical Chemistry

Volumn 85, Issue 13, 2013, Pages 6213-6218

  Lee, Myung Gwon ^a   Shin, Joong Ho ^a   Bae, Chae Yun ^a   Choi, Sungyoung ^b   Park, Je Kyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FILTRATION PROCESS; HYDRODYNAMIC FIELD; INERTIAL MICROFLUIDICS; INERTIAL PARTICLES; LOW REYNOLDS NUMBER; MICRO-CHANNEL DEVICES; MICRO-FLUIDIC DEVICES; SEPARATION TECHNIQUES;

BLOOD; CELLS; FLUIDIC DEVICES; MICROCHANNELS; REYNOLDS NUMBER; SHEAR STRESS; SIZE SEPARATION;

MOLECULAR BIOLOGY;

ARTICLE; BLOOD CELL; CELL MOTION; CELL SEPARATION; CELL STRAIN MCF 7; CHEMISTRY; HUMAN; MECHANICAL STRESS; METHODOLOGY; MICROFLUIDICS; PHYSIOLOGY; SHEAR STRENGTH; TUMOR CELL LINE; TUMOR EMBOLISM;

BLOOD CELLS; CELL LINE, TUMOR; CELL MOVEMENT; CELL SEPARATION; HUMANS; MCF-7 CELLS; MICROFLUIDICS; NEOPLASTIC CELLS, CIRCULATING; SHEAR STRENGTH; STRESS, MECHANICAL;

EID: 84880003401     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac4006149     Document Type: Article

References (31)

1. Fehm, T.; Sagalowsky, A.; Clifford, E.; Beitsch, P.; Saboorian, H.; Euhus, D.; Meng, S.; Morrison, L.; Tucker, T.; Lane, N.; Ghadimi, B. M.; Heselmeyer-Haddad, K.; Ried, T.; Rao, C.; Uhr, J. Clin. Cancer Res. 2002, 8, 2073-2084
2. Crnic, I.; Christofori, G. Int. J. Dev. Biol. 2004, 48, 573-581
3. Pantel, K.; Brakenhoff, R. H.; Brandt, B. Nat. Rev. Cancer 2008, 8, 329-340
4. Cristofanilli, M.; Budd, G. T.; Ellis, M. J.; Stopeck, A.; Matera, J.; Miller, M. C.; Reuben, J. M.; Doyle, G. V.; Allard, W. J.; Terstappen, L. W. M. M.; Hayes, D. F. N. Engl. J. Med. 2004, 351, 781-791
5. Al-Mehdi, A.; Tozawa, K.; Fisher, A.; Shientag, L.; Lee, A.; Muschel, R. Nat. Med. 2000, 6, 100-102
6. Moreno, J. G.; O'Hara, S. M.; Gross, S.; Doyle, G.; Fritsche, H.; Gomella, L. G.; Terstappen, L. W. Urology 2001, 58, 386-392
7. Krivacic, R. T.; Ladanyi, A.; Curry, D. N.; Hsieh, H.; Kuhn, P.; Bergsrud, D. E.; Kepros, J. F.; Barbera, T.; Ho, M. Y.; Chen, L. B. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 10501-10504
8. Baker, M. K.; Mikhitarian, K.; Osta, W.; Callahan, K.; Hoda, R.; Brescia, F.; Kneuper-Hall, R.; Mitas, M.; Cole, D. J.; Gillanders, W. E. Clin. Cancer Res. 2003, 9, 4865-4871
9. Lara, O.; Tong, X.; Zborowski, M.; Chalmers, J. J. Exp. Hematol. 2004, 32, 891-904
10. Allard, W. J.; Matera, J.; Miller, M. C.; Repollet, M.; Connelly, M. C.; Rao, C.; Tibbe, A. G.; Uhr, J. W.; Terstappen, L. W. Clin. Cancer Res. 2004, 10, 6897-6904
11. Riethdorf, S.; Fritsche, H.; Müller, V.; Rau, T.; Schindlbeck, C.; Rack, B.; Janni, W.; Coith, C.; Beck, K.; Jänicke, F. Clin. Cancer Res. 2007, 13, 920-928
12. Nagrath, S.; Sequist, L. V.; Maheswaran, S.; Bell, D. W.; Irimia, D.; Ulkus, L.; Smith, M. R.; Kwak, E. L.; Digumarthy, S.; Muzikansky, A. Nature 2007, 450, 1235-1239
13. Stott, S. L.; Hsu, C.-H.; Tsukrov, D. I.; Yu, M.; Miyamoto, D. T.; Waltman, B. A.; Rothenberg, S. M.; Shah, A. M.; Smas, M. E.; Korir, G. K. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 18392-18397
14. den Toonder, J. Lab Chip 2011, 11, 375-377
15. Yu, M.; Stott, S.; Toner, M.; Maheswaran, S.; Haber, D. A. J. Cell Biol. 2011, 192, 373-382
16. Hoshino, K.; Huang, Y.-Y.; Lane, N.; Huebschman, M.; Uhr, J. W.; Frenkel, E. P.; Zhang, X. Lab Chip 2011, 11, 3449-3457
17. Meng, S.; Tripathy, D.; Frenkel, E. P.; Shete, S.; Naftalis, E. Z.; Huth, J. F.; Beitsch, P. D.; Leitch, M.; Hoover, S.; Euhus, D. Clin. Cancer Res. 2004, 10, 8152-8162
18. Hu, M.; Huang, M. C.; Cheong, W. C.; Gan, A. T. L.; Looi, X. L.; Leong, S. M.; Koay, E. S.-C.; Li, M.-H. Lab Chip 2011, 11, 912-920
19. Tan, S. J.; Yobas, L.; Lee, G. Y. H.; Ong, C. N.; Lim, C. T. Biomed. Microdevices 2009, 11, 883-892
20. Zheng, S.; Lin, H. K.; Lu, B.; Williams, A.; Datar, R.; Cote, R. J.; Tai, Y.-C. Biomed. Microdevices 2011, 13, 203-213
21. Zheng, S.; Liu, J.-Q.; Tai, Y.-C. J. Microelectromech. Syst. 2008, 17, 1029-1038
22. Di Carlo, D. Lab Chip 2009, 9, 3038-3046
23. Hur, S. C.; Henderson-MacLennan, N. K.; McCabe, E. R.; Di Carlo, D. Lab Chip 2011, 11, 912-920
24. Tanaka, T.; Ishikawa, T.; Numayama-Tsuruta, K.; Imai, Y.; Ueno, H.; Matsuki, N.; Yamaguchi, T. Lab Chip 2012, 12, 4336-4343
25. Sun, J.; Li, M.; Liu, C.; Zhang, Y.; Liu, D.; Liu, W.; Hu, G.; Jiang, X. Lab Chip 2012, 12, 3952-3960
26. Bhagat, A. A. S.; Hou, H. W.; Li, L. D.; Lim, C. T.; Han, J. Lab Chip 2011, 11, 1870-1878
27. Brooks, D. E. Biorheology 1984, 21, 85-91
28. Lee, M. G.; Choi, S.; Park, J.-K. J. Chromatogr., A 2011, 1218, 4138-4143
29. Lee, M. G.; Choi, S.; Park, J.-K. Appl. Phys. Lett. 2009, 95, 051902
30. Lee, M. G.; Choi, S.; Park, J.-K. Biomed. Microdevices 2010, 12, 1019-1026
31. Riethdorf, S.; Fritsche, H.; Müller, V.; Rau, T.; Schindlbeck, C.; Rack, B.; Janni, W.; Coith, C.; Beck, K.; Jänicke, F.; Jackson, S.; Gornet, T.; Cristofanilli, M.; Pantel, K. Clin. Cancer Res. 2007, 13 (3) 920-928