Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11523-11528

  Thliveris, Andrew T ^a   Schwefel, Brittany ^b   Clipson, Linda ^a   Plesh, Lauren ^a   Zahm, Christopher D ^a   Leystra, Alyssa A ^a   Washington, Mary Kay ^c   Sullivan, Ruth ^d,e   Deming, Dustin A ^a   Newton, Michael A ^a,b,e   Halberg, Richard B ^a,e  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Madison   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF WISCONSIN   (United States)

Author keywords

Clonal interactions; Colon cancer; Mouse model; Spatial statistics

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL AGGREGATION; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; INTESTINE TUMOR; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL;

CLONAL INTERACTIONS; COLON CANCER; MOUSE MODEL; SPATIAL STATISTICS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GENES, APC; HUMANS; INTESTINAL NEOPLASMS; MICE; MICE, INBRED C57BL;

MUS;

EID: 84879971217     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303064110     Document Type: Article

References (21)

1. Pietras A (2011) Cancer stem cells in tumor heterogeneity. Adv Cancer Res 112:255-281.
2. Parsons BL (2008) Many different tumor types have polyclonal tumor origin: Evidence and implications. Mutat Res 659(3):232-247.
3. Merritt AJ, Gould KA, Dove WF (1997) Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages. Proc Natl Acad Sci USA 94(25):13927-13931.
4. Thliveris AT, et al. (2011) Clonal structure of carcinogen-induced intestinal tumors in mice. Cancer Prev Res (Phila) 4(6):916-923.
5. Novelli MR, et al. (1996) Polyclonal origin of colonic adenomas in an XO/XY patient with FAP. Science 272(5265):1187-1190. (Pubitemid 26169475)
6. Thirlwell C, et al. (2010) Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas. Gastroenterology 138(4): 1441-1454, 1454.e1-7.
7. Thliveris AT, et al. (2005) Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc Natl Acad Sci USA 102(19):6960-6965. (Pubitemid 40675424)
8. Uronis JM, Threadgill DW (2009) Murine models of colorectal cancer. Mamm Genome 20(5):261-268.
9. Gould KA, Dove WF (1997) Localized gene action controlling intestinal neoplasia in mice. Proc Natl Acad Sci USA 94(11):5848-5853. (Pubitemid 27241860)
10. Haigis KM, Dove WF (2003) A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet 33(1):33-39. (Pubitemid 36068679)
11. Kuraguchi M, et al. (2001) The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis. Cancer Res 61(21):7934-7942. (Pubitemid 33049384)
12. Roberts RB, et al. (2002) Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci USA 99(3):1521-1526. (Pubitemid 34136525)
13. Zhang Z, et al. (2009) Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol 46(3):370-377.
14. Shimizu H, et al. (1997) Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 8(12):1349-1358. (Pubitemid 28008731)
15. Mester J, Wagenaar E, Sluyser M, Nusse R (1987) Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice. J Virol 61(4):1073-1078. (Pubitemid 17044018)
16. Jue SF, Bradley RS, Rudnicki JA, Varmus HE, Brown AM (1992) The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 12(1):321-328.
17. Vermeulen L, et al. (2010) Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 12(5):468-476.
18. Franco OE, Shaw AK, Strand DW, Hayward SW (2010) Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol 21(1):33-39.
19. González-Sancho JM, et al. (2005) The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene 24(6):1098-1103. (Pubitemid 40313887)
20. Fodde R, et al. (1994) A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci USA 91(19): 8969- 8973.
21. Sklyar O, Pau G, Smith M, HuberW(2012) EBImage: Image processing toolbox for R. R package version 3.8.0. Available at http://www.bioconductor.org/.