Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2)

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 7, 2013, Pages 4548-4554

  Danis, Ronald P ^a   Domalpally, Amitha ^a   Chew, Emily Y ^b   Clemons, Traci E ^c   Armstrong, Jane ^a   SanGiovanni, John Paul ^b   Ferris III, Frederick L ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c EMMES CORPORATION   (United States)

Author keywords

AMD; Color photographic imaging; Reproducibility

Indexed keywords

ADULT; AGED; ARTICLE; DISEASE SEVERITY; DRUSEN; FOLLOW UP; FUNDUS CAMERA; HUMAN; IMAGE QUALITY; MAJOR CLINICAL STUDY; NEOVASCULARIZATION (PATHOLOGY); OUTCOME ASSESSMENT; PHOTOGRAPHY; PRIORITY JOURNAL; QUALITY CONTROL; RATING SCALE; REPRODUCIBILITY; RETINA DETACHMENT; RETINA MACULA AGE RELATED DEGENERATION; STEREOSCOPIC VISION;

AMD; COLOR PHOTOGRAPHIC IMAGING; REPRODUCIBILITY;

AGED; AGED, 80 AND OVER; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; FEMALE; FUNDUS OCULI; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; PHOTOGRAPHY; REPRODUCIBILITY OF RESULTS; SEVESO ACCIDENTAL RELEASE;

EID: 84879970945     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-11804     Document Type: Article

References (30)

1. Chew EY, Clemons T, Sangiovanni JP, et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology. 2012;119:2282-2289.
2. Age-Related Eye Disease Study Group. A randomized, placebocontrolled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119:1417-1436.
3. Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991;98:1128-1134.
4. Davis MD, Gangnon RE, Lee LY, et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol. 2005;123:1484-1498.
5. Ferris FL, Davis MD, Clemons TE, et al. A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol. 2005;123:1570-1574.
6. Hubbard LD, Sun W, Cleary PA, et al. Comparison of digital and film grading of diabetic retinopathy severity in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Arch Ophthalmol. 2011;129:718-726.
7. Gangaputra S, Won Pak J, Peng Q, et al. Transition from film to digital fundus photography in the Longitudinal Studies of the Ocular Complications of AIDS. Retina. 2012;32:600-605.
8. Hubbard LD, Danis RP, Neider MW, et al. Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2. Invest Ophthalmol Vis Sci. 2008;49:3269-3282.
9. The Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. Am J Ophthalmol. 2001;132:668-681.
10. Ip MS, Scott IU, Brown GC, et al. Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration: a report by the American Academy of Ophthalmology. Ophthalmology. 2008;115:1837-1846.
11. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GO. Variability of the real dimensions of normal human optic discs. Graefes Arch Clin Exp Ophthalmol. 1988;226:332-336.
12. Danis RP, Scott IU, Qin H, et al. Association of fluorescein angiographic features with visual acuity and with optical coherence tomographic and stereoscopic color fundus photographic features of diabetic macular edema in a randomized clinical trial. Retina. 2010;30:1627-1637.
13. Davis MD, Bressler SB, Aiello LP, et al. Comparison of timedomain OCT and fundus photographic assessments of retinal thickening in eyes with diabetic macular edema. Invest Ophthalmol Vis Sci. 2008;49:1745-1752.
14. Sunness JS, Ziegler MD, Applegate CA. Issues in quantifying atrophic macular disease using retinal autofluorescence. Retina. 2006;26:666-672.
15. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463-472.
16. Yehoshua Z, Rosenfeld PJ, Gregori G, Penha F. Spectral domain optical coherence tomography imaging of dry age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2010;41(suppl):S6-S14.
17. Shin DS, Javornik NB, Berger JW. Computer-assisted, interactive fundus image processing for macular drusen quantitation. Ophthalmology. 1999;106:1119-1125.
18. Smith RT, Sohrab MA, Pumariega NM, et al. Drusen analysis in a human-machine synergistic framework. Arch Ophthalmol. 2011;129:40-47.
19. Quellec G, Russell SR, Scheetz TE, Stone EM, Abramoff MD. Computational quantification of complex fundus phenotypes in age-related macular degeneration and Stargardt disease. Invest Ophthalmol Vis Sci. 2011;52:2976-2981.
20. Yi K, Mujat M, Park BH, et al. Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular agerelated macular degeneration. Br J Ophthalmol. 2009;93:176-181.
21. Khanifar AA, Koreishi AF, Izatt JA, Toth CA. Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. Ophthalmology. 2008;115:1883-1890.
22. Jain N, Farsiu S, Khanifar AA, et al. Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs. Invest Ophthalmol Vis Sci. 2010;51:4875-4883.
23. Iwama D, Tsujikawa A, Ojima Y, et al. Relationship between retinal sensitivity and morphologic changes in eyes with confluent soft drusen. Clin Experiment Ophthalmol. 2010;38:483-488.
24. Freeman SR, Kozak I, Cheng L, et al. Optical coherence tomography-raster scanning and manual segmentation in determining drusen volume in age-related macular degeneration. Retina. 2010;30:431-435.
25. Leng T, Rosenfeld PJ, Gregori G, Puliafito CA, Punjabi OS. Spectral domain optical coherence tomography characteristics of cuticular drusen. Retina. 2009;29:988-993.
26. Bindewald A, Bird AC, Dandekar SS, et al. Classification of fundus autofluorescence patterns in early age-related macular disease. Invest Ophthalmol Vis Sci. 2005;46:3309-3314.
27. Bindewald A, Schmitz-Valckenberg S, Jorzik JJ, et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration. Br J Ophthalmol. 2005;89:874-878.
28. Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey CK. Autofluorescence distribution associated with drusen in agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2000;41:496-504.
29. Spaide RF. Fundus autofluorescence and age-related macular degeneration. Ophthalmology. 2003;110:392-399.
30. Sunness J, Bressler N, Tian Y, Alexander J, Applegate C. Measuring geographic atrophy in advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 1999;40:1761-1769.