Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years

Pediatrics

Volumn 132, Issue 1, 2013, Pages

  Wald, Ellen R ^a   Applegate, Kimberly E ^a   Bordley, Clay ^b   Darrow, David H ^a   Glode, Mary P ^c   Marcy, S Michael ^a   Nelson, Carrie E ^a   Rosenfeld, Richard M ^a   Shaikh, Nader ^a   Smith, Michael J ^a   Williams, Paul V ^a   Weinberg, Stuart T ^a  

^a Department of Pediatric Infectious ^*

^b Pediatric Emergency and Hospitalist Medicine   (United States)

^c Pediatric Infectious Disease Physician   (United States)

Author keywords

Acute bacterial sinusitis; Antibiotics; Imaging; Sinus aspiration; Sinusitis

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; AZITHROMYCIN; CEFDINIR; CEFIXIME; CEFOTAXIME; CEFPODOXIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; CONTRAST MEDIUM; CORTICOSTEROID; COTRIMOXAZOLE; DECONGESTIVE AGENT; LEVOFLOXACIN; LINEZOLID; PENICILLIN DERIVATIVE; PLACEBO; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ACUTE BACTERIAL SINUSITIS; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL SINUSITIS; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; COUGHING; DISEASE COURSE; DRUG MEGADOSE; ECHOGRAPHY; FEVER; HAEMOPHILUS INFLUENZAE; HUMAN; MORAXELLA CATARRHALIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATION; ORBIT DISEASE; PARANASAL SINUS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; RHINORRHEA; STREPTOCOCCUS PNEUMONIAE; VIRAL UPPER RESPIRATORY TRACT INFECTION;

ACUTE DISEASE; ADOLESCENT; AMOXICILLIN; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HUMANS; INFANT; MALE; OBSERVATION; PARANASAL SINUSES; PROGNOSIS; RESPIRATORY TRACT INFECTIONS; SINUSITIS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME; UNITED STATES;

EID: 84879964098     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2013-1071     Document Type: Review

References (104)

1. Aitken M, Taylor JA. Prevalence of clinical sinusitis in young children followed up by primary care pediatricians. Arch Pediatr Adolesc Med. 1998;152(3):244-248
2. Kakish KS, Mahafza T, Batieha A, Ekteish F, Daoud A. Clinical sinusitis in children attending primary care centers. Pediatr Infect Dis J. 2000;19(11):1071-1074
3. Ueda D, Yoto Y. The ten-day mark as a practical diagnostic approach for acute paranasal sinusitis in children. Pediatr Infect Dis J. 1996;15(7):576-579
4. Wald ER, Nash D, Eickhoff J. Effectiveness of amoxicillin/clavulanate potassium in the treatment of acute bacterial sinusitis in children. Pediatrics. 2009;124(1):9-15
5. American Academy of Pediatrics, Subcommittee on Management of Sinusitis and Committee on Quality Improvement. Clinical practice guideline: Management of sinusitis. Pediatrics. 2001;108(3):798-808
6. Smith MJ. AAP technical report: Evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: A systematic review. 2013, In press.
7. Shiffman RN, Michel G, Rosenfeld RM, Davidson C. Building better guidelines with BRIDGE-Wiz: Development and evaluation of a software assistant to promote clarity, transparency, and implementability. J Am Med Inform Assoc. 2012;19 (1):94-101
8. American Academy of Pediatrics, Steering Committee on Quality Improvement and Management. Classifying recommendations for clinical practice guidelines. Pediatrics. 2004;114(3):874-877
9. Gwaltney JM, Jr, Hendley JO, Simon G, Jordan WS Jr. Rhinovirus infections in an industrial population. II. Characteristics of illness and antibody response. JAMA. 1967;202(6):494-500
10. Pappas DE, Hendley JO, Hayden FG, Winther B. Symptom profile of common colds in school-aged children. Pediatr Infect Dis J. 2008;27(1):8-11
11. Wald ER, Guerra N, Byers C. Frequency and severity of infections in day care: Threeyear follow-up. J Pediatr. 1991;118(4 pt 1): 509-514
12. Wald ER, Guerra N, Byers C. Upper respiratory tract infections in young children: Duration of and frequency of complications. Pediatrics. 1991;87(2):129-133
13. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: Establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114(6 suppl): 155-212
14. Shaikh N, Wald ER. Signs and symptoms of acute sinusitis in children. Pediatr Infect Dis J. 2013; in press
15. Wald ER. The diagnosis and management of sinusitis in children: Diagnostic considerations. Pediatr Infect Dis. 1985;4(6 suppl):S61-S64
16. Wald ER, Milmoe GJ, Bowen A, Ledesma-Medina J, Salamon N, Bluestone CD. Acute maxillary sinusitis in children. N Engl J Med. 1981;304(13):749-754
17. Lindbaek M, Hjortdahl P, Johnsen UL. Use of symptoms, signs, and blood tests to diagnose acute sinus infections in primary care: Comparison with computed tomography. Fam Med. 1996;28(3):183-188
18. Wald ER. Beginning antibiotics for acute rhinosinusitis and choosing the right treatment. Clin Rev Allergy Immunol. 2006; 30(3):143-152
19. Maresh MM, Washburn AH. Paranasal sinuses from birth to late adolescence. II. Clinical and roentgenographic evidence of infection. Am J Dis Child. 1940;60:841-861
20. Glasier CM, Mallory GB, Jr, Steele RW. Significance of opacification of the maxillary and ethmoid sinuses in infants. J Pediatr. 1989;114(1):45-50
21. Kovatch AL, Wald ER, Ledesma-Medina J, Chiponis DM, Bedingfield B. Maxillary sinus radiographs in children with nonrespiratory complaints. Pediatrics. 1984; 73(3):306-308
22. Shopfner CE, Rossi JO. Roentgen evaluation of the paranasal sinuses in children. Am J Roentgenol Radium Ther Nucl Med. 1973;118(1):176-186
23. Diament MJ, Senac MO, Jr, Gilsanz V, Baker S, Gillespie T, Larsson S. Prevalence of incidental paranasal sinuses opacification in pediatric patients: A CT study. J Comput Assist Tomogr. 1987;11(3):426-431
24. Glasier CM, Ascher DP, Williams KD. Incidental paranasal sinus abnormalities on CT of children: Clinical correlation. AJNR Am J Neuroradiol. 1986;7(5):861-864
25. Gwaltney JM, Jr, Phillips CD, Miller RD, Riker DK. Computed tomographic study of the common cold. N Engl J Med. 1994;330 (1):25-30
26. Manning SC, Biavati MJ, Phillips DL. Correlation of clinical sinusitis signs and symptoms to imaging findings in pediatric patients. Int J Pediatr Otorhinolaryngol. 1996;37(1):65-74
27. Gordts F, Clement PA, Destryker A, Desprechins B, Kaufman L. Prevalence of sinusitis signs on MRI in a non-ENT paediatric population. Rhinology. 1997;35(4): 154-157
28. Kristo A, Uhari M, Luotonen J, et al. Paranasal sinus findings in children during respiratory infection evaluated with magnetic resonance imaging. Pediatrics. 2003;111(5 pt 1):e586-e589
29. Brook I. Microbiology and antimicrobial treatment of orbital and intracranial complications of sinusitis in children and their management. Int J Pediatr Otorhinolaryngol. 2009;73(9):1183-1186
30. Sultesz M, Csakanyi Z, Majoros T, Farkas Z, Katona G. Acute bacterial rhinosinusitis and its complications in our pediatric otolaryngological department between 1997 and 2006. Int J Pediatr Otorhinolaryngol. 2009;73(11):1507-1512
31. Wald ER. Periorbital and orbital infections. Infect Dis Clin North Am. 2007;21(2):393-408
32. Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80(9):1414-1428
33. Kombogiorgas D, Seth R, Modha J, Singh J. Suppurative intracranial complications of sinusitis in adolescence. Single institute experience and review of the literature. Br J Neurosurg. 2007;21(6):603-609
34. Rosenfeld EA, Rowley AH. Infectious intracranial complications of sinusitis, other than meningitis in children: 12 year review. Clin Infect Dis. 1994;18(5):750-754
35. American College of Radiology. Appropriateness criteria for sinonasal disease. 2009. Available at: Www.acr.org//media/ 8172B4DE503149248E64856857674BB5.pdf. Accessed November 6, 2012
36. Triulzi F, Zirpoli S. Imaging techniques in the diagnosis and management of rhinosinusitis in children. Pediatr Allergy Immunol. 2007;18(suppl 18):46-49
37. McIntosh D, Mahadevan M. Failure of contrast enhanced computed tomography scans to identify an orbital abscess. The benefit of magnetic resonance imaging. J Laryngol Otol. 2008;122(6):639-640
38. Younis RT, Anand VK, Davidson B. The role of computed tomography and magnetic resonance imaging in patients with sinusitis with complications. Laryngoscope. 2002;112(2):224-229
39. Shapiro DJ, Gonzales R, Cabana MD, Hersh AL. National trends in visit rates and antibiotic prescribing for children with acute sinusitis. Pediatrics. 2011;127(1): 28-34
40. Wald ER, Reilly JS, Casselbrant M, et al. Treatment of acute maxillary sinusitis in childhood: A comparative study of amoxicillin and cefaclor. J Pediatr. 1984;104(2): 297-302
41. Wald ER, Chiponis D, Ledesma-Medina J. Comparative effectiveness of amoxicillin and amoxicillin-clavulanate potassium in acute paranasal sinus infections in children: A double-blind, placebo-controlled trial. Pediatrics. 1986;77(6):795-800
42. Garbutt JM, Goldstein M, Gellman E, Shannon W, Littenberg B. A randomized, placebo-controlled trial of antimicrobial treatment for children with clinically diagnosed acute sinusitis. Pediatrics. 2001; 107(4):619-625
43. Kristo A, Uhari M, Luotonen J, Ilkko E, Koivunen P, Alho OP. Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: A randomized, controlled trial. Acta Paediatr. 2005;94(9): 1208-1213
44. Hoberman A, Paradise JL, Rockette HE, et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med. 2011;364(2):105-115
45. Tahtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A. A placebocontrolled trial of antimicrobial treatment for acute otitis media. N Engl J Med. 2011;364(2):116-126
46. Gordts F, Abu Nasser I, Clement PA, Pierard D, Kaufman L. Bacteriology of the middle meatus in children. Int J Pediatr Otorhinolaryngol. 1999;48(2):163-167
47. Parsons DS, Wald ER. Otitis media and sinusitis: Similar diseases. Otolaryngol Clin North Am. 1996;29(1):11-25
48. Revai K, Dobbs LA, Nair S, Patel JA, Grady JJ, Chonmaitree T. Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: The effect of age. Pediatrics. 2007;119(6). Available at: Www.pediatrics.org/cgi/content/full/119/6/e1408
49. Klein JO, Bluestone CD. Textbook of Pediatric Infectious Diseases. 6th ed. Philadelphia, PA: Saunders; 2009
50. Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2010;29(4): 304-309
51. Brook I, Gober AE. Frequency of recovery of pathogens from the nasopharynx of children with acute maxillary sinusitis before and after the introduction of vaccination with the 7-valent pneumococcal vaccine. Int J Pediatr Otorhinolaryngol. 2007;71(4):575-579
52. Wald ER. Microbiology of acute and chronic sinusitis in children. J Allergy Clin Immunol. 1992;90(3 pt 2):452-456
53. Centers for Disease Control and Prevention. Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae-United States, 2006-2007. MMWR Morb Mortal Wkly Rep. 2008;57 (50):1353-1355
54. Centers for Disease Control and Prevention. Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network. 2011. Available at: Www.cdc.gov/abcs/reports-findings/survreports/spneu09.html. Accessed November 6, 2012
55. Garbutt J, St Geme JW, III, May A, Storch GA, Shackelford PG. Developing communityspecific recommendations for first-line treatment of acute otitis media: Is highdose amoxicillin necessary? Pediatrics. 2004;114(2):342-347
56. Harrison CJ, Woods C, Stout G, Martin B, Selvarangan R. Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. J Antimicrob Chemother. 2009; 63(3):511-519
57. Critchley IA, Jacobs MR, Brown SD, Traczewski MM, Tillotson GS, Janjic N. Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem. Antimicrob Agents Chemother. 2008;52(7):2639-2643
58. Jacobs MR, Good CE, Windau AR, et al. Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. Antimicrob Agents Chemother. 2010;54(6):2716-2719
59. Tristram S, Jacobs MR, Appelbaum PC. Antimicrobial resistance in Haemophilus influenzae. Clin Microbiol Rev. 2007;20(2): 368-389
60. Levine OS, Farley M, Harrison LH, Lefkowitz L, McGeer A, Schwartz B. Risk factors for invasive pneumococcal disease in children: A population-based case-control study in North America. Pediatrics. 1999; 103(3). Available at: Www.pediatrics.org/cgi/content/full/103/3/e28
61. Seikel K, Shelton S, McCracken GH Jr. Middle ear fluid concentrations of amoxicillin after large dosages in children with acute otitis media. Pediatr Infect Dis J. 1997;16(7):710-711
62. Cohen R, Navel M, Grunberg J, et al. One dose ceftriaxone vs. ten days of amoxicillin/clavulanate therapy for acute otitis media: Clinical efficacy and change in nasopharyngeal flora. Pediatr Infect Dis J. 1999;18(5):403-409
63. Green SM, Rothrock SG. Single-dose intramuscular ceftriaxone for acute otitis media in children. Pediatrics. 1993;91(1): 23-30
64. Leibovitz E, Piglansky L, Raiz S, Press J, Leiberman A, Dagan R. Bacteriologic and clinical efficacy of one day vs. three day intramuscular ceftriaxone for treatment of nonresponsive acute otitis media in children. Pediatr Infect Dis J. 2000;19(11): 1040-1045
65. DePestel DD, Benninger MS, Danziger L, et al. Cephalosporin use in treatment of patients with penicillin allergies. J Am Pharm Assoc. 2008;48(4):530-540
66. Pichichero ME. A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillinallergic patients. Pediatrics. 2005;115(4): 1048-1057
67. Pichichero ME, Casey Jr. Safe use of selected cephalosporins in penicillinallergic patients: A meta-analysis. Otolaryngol Head Neck Surg. 2007;136(3): 340-347
68. Park MA, Koch CA, Klemawesch P, Joshi A, Li JT. Increased adverse drug reactions to cephalosporins in penicillin allergy patients with positive penicillin skin test. Int Arch Allergy Immunol. 2010;153(3): 268-273
69. Jacobs MR. Antimicrobial-resistant Streptococcus pneumoniae: Trends and management. Expert Rev Anti Infect Ther. 2008; 6(5):619-635
70. Chow AW, Benninger MS, Brook I, et al Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012;54(8):e72-e112
71. Brook I, Gober AE. Resistance to antimicrobials used for therapy of otitis media and sinusitis: Effect of previous antimicrobial therapy and smoking. Ann Otol Rhinol Laryngol. 1999;108(7 pt 1):645-647
72. Brook I, Gober AE. Antimicrobial resistance in the nasopharyngeal flora of children with acute maxillary sinusitis and maxillary sinusitis recurring after amoxicillin therapy. J Antimicrob Chemother. 2004;53(2):399-402
73. Dohar J, Canton R, Cohen R, Farrell DJ, Felmingham D. Activity of telithromycin and comparators against bacterial pathogens isolated from 1,336 patients with clinically diagnosed acute sinusitis. Ann Clin Microbiol Antimicrob. 2004;3(3): 15-21
74. Jacobs MR, Bajaksouzian S, Zilles A, Lin G, Pankuch GA, Appelbaum PC. Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. surveillance study. Antimicrob Agents Chemother. 1999;43(8):1901-1908
75. Jacobs MR, Felmingham D, Appelbaum PC, Gruneberg RN. The Alexander Project 1998-2000: Susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents. J Antimicrob Chemother. 2003;52(2):229-246
76. Lynch JP, III, Zhanel GG. Streptococcus pneumoniae: Epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines. Curr Opin Pulm Med. 2010;16(3):217-225
77. Sahm DF, Jones ME, Hickey ML, Diakun DR, Mani SV, Thornsberry C. Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe, 1997-1998. J Antimicrob Chemother. 2000; 45(4):457-466
78. Sokol W. Epidemiology of sinusitis in the primary care setting: Results from the 1999-2000 respiratory surveillance program. Am J Med. 2001;111(suppl 9A):19S-24S
79. Shaikh N, Wald ER, Pi M. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev. 2010;(12):CD007909
80. Dolor RJ, Witsell DL, Hellkamp AS, Williams JW, Jr, Califf RM, Simel DL. Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: A randomized controlled trial. JAMA. 2001;286(24):3097-3105
81. Meltzer EO, Bachert C, Staudinger H. Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo. J Allergy Clin Immunol. 2005;116(6):1289-1295
82. Meltzer EO, Charous BL, Busse WW, Zinreich SJ, Lorber RR, Danzig MR. Added relief in the treatment of acute recurrent sinusitis with adjunctive mometasone furoate nasal spray. The Nasonex Sinusitis Group. J Allergy Clin Immunol. 2000;106 (4):630-637
83. Meltzer EO, Orgel HA, Backhaus JW, et al. Intranasal flunisolide spray as an adjunct to oral antibiotic therapy for sinusitis. J Allergy Clin Immunol. 1993;92(6):812-823
84. Nayak AS, Settipane GA, Pedinoff A, et al. Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis. Ann Allergy Asthma Immunol. 2002;89(3):271-278
85. Williamson IG, Rumsby K, Benge S, et al. Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: A randomized controlled trial. JAMA. 2007; 298(21):2487-2496
86. Zalmanovici A, Yaphe J. Intranasal steroids for acute sinusitis. Cochrane Database Syst Rev. 2009;(4):CD005149
87. Yilmaz G, Varan B, Yilmaz T, Gurakan B. Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. Eur Arch Otorhinolaryngol. 2000;257(5):256-259
88. Barlan IB, Erkan E, Bakir M, Berrak S, Basaran MM. Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. Ann Allergy Asthma Immunol. 1997;78(6):598-601
89. Bruni FM, De Luca G, Venturoli V, Boner AL. Intranasal corticosteroids and adrenal suppression. Neuroimmunomodulation. 2009;16 (5):353-362
90. Kim KT, Rabinovitch N, Uryniak T, Simpson B, O'Dowd L, Casty F. Effect of budesonide aqueous nasal spray on hypothalamicpituitary-adrenal axis function in children with allergic rhinitis. Ann Allergy Asthma Immunol. 2004;93(1):61-67
91. Meltzer EO, Tripathy I, Maspero JF, Wu W, Philpot E. Safety and tolerability of fluticasone furoate nasal spray once daily in paediatric patients aged 6-11 years with allergic rhinitis: Subanalysis of three randomized, double-blind, placebo-controlled, multicentre studies. Clin Drug Investig. 2009;29(2):79-86
92. Murphy K, Uryniak T, Simpson B, O'Dowd L. Growth velocity in children with perennial allergic rhinitis treated with budesonide aqueous nasal spray. Ann Allergy Asthma Immunol. 2006;96(5):723-730
93. Ratner PH, Meltzer EO, Teper A. Mometasone furoate nasal spray is safe and effective for 1-year treatment of children with perennial allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2009;73(5):651-657
94. Skoner DP, Gentile DA, Doyle WJ. Effect on growth of long-term treatment with intranasal triamcinolone acetonide aqueous in children with allergic rhinitis. Ann Allergy Asthma Immunol. 2008;101(4): 431-436
95. Weinstein S, Qaqundah P, Georges G, Nayak A. Efficacy and safety of triamcinolone acetonide aqueous nasal spray in children aged 2 to 5 years with perennial allergic rhinitis: A randomized, double-blind, placebo-controlled study with an open-label extension. Ann Allergy Asthma Immunol. 2009;102(4):339-347
96. Zitt M, Kosoglou T, Hubbell J. Mometasone furoate nasal spray: A review of safety and systemic effects. Drug Saf. 2007;30(4): 317-326
97. Adam P, Stiffman M, Blake RL Jr. A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis. Arch Fam Med. 1998;7(1):39-43
98. Wang YH, Yang CP, Ku MS, Sun HL, Lue KH. Efficacy of nasal irrigation in the treatment of acute sinusitis in children. Int J Pediatr Otorhinolaryngol. 2009;73(12): 1696-1701
99. Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;(3):CD006394
100. Kassel JC, King D, Spurling GK. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2010;(3):CD006821
101. Shapiro GG, Virant FS, Furukawa CT, Pierson WE, Bierman CW. Immunologic defects in patients with refractory sinusitis. Pediatrics. 1991;87(3):311-316
102. Wood AJ, Douglas RG. Pathogenesis and treatment of chronic rhinosinusitis. Postgrad Med J. 2010;86(1016):359-364
103. Liao S, Durand ML, Cunningham MJ. Sinogenic orbital and subperiosteal abscesses: Microbiology and methicillinresistant Staphylococcus aureus incidence. Otolaryngol Head Neck Surg. 2010;143(3):392-396
104. Oxford LE, McClay J. Medical and surgical management of subperiosteal orbital abscess secondary to acute sinusitis in children. Int J Pediatr Otorhinolaryngol. 2006;70(11):1853-1861