Effects of PGF2αon the Expression of Uterine Activation Proteins in Pregnant Human Myometrial Cells from Upper and Lower Segment

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 7, 2013, Pages 2975-2983

  Xu, Chen ^b   Long, Alicia ^a   Fang, Xin ^a   Wood, Stephen L ^c   Slater, Donna M ^c   Ni, Xin ^b   Olson, David M ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; MEMBRANE PROTEIN; OXYTOCIN RECEPTOR; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2 ALPHA RECEPTOR; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN SYNTHASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UTERINE ACTIVATION PROTEIN; AL 8810 ETHYLAMIDE; DRUG DERIVATIVE; GJA1 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; OXTR PROTEIN, HUMAN; PROSTAGLANDIN F2ALPHA RECEPTOR; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; LABOR ONSET; MYOMETRIUM; PREGNANCY; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; PROTEIN EXPRESSION; PROTEIN FUNCTION; UTERUS CONTRACTION; WESTERN BLOTTING; ADULT; BIOSYNTHESIS; CELL CULTURE; CESAREAN SECTION; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ELECTIVE SURGERY; GENETICS; METABOLISM; RNA INTERFERENCE; UPREGULATION;

ADULT; CELLS, CULTURED; CESAREAN SECTION; CONNEXIN 43; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DINOPROST; DOWN-REGULATION; FEMALE; HUMANS; INTERLEUKIN-1BETA; MYOMETRIUM; PREGNANCY; RECEPTORS, OXYTOCIN; RECEPTORS, PROSTAGLANDIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; SURGICAL PROCEDURES, ELECTIVE; UP-REGULATION;

EID: 84879950175     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2829     Document Type: Article

References (31)

1. Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev. 2000; 21:514-550.
2. Miyoshi H, Boyle MB, MacKay LB, Garfield RE. Gap junction currents in cultured muscle cells from human myometrium. Am J Obstet Gynecol. 1998;178:588-593. (Pubitemid 28207515)
3. Kumar NM, Gilula NB. The gap junction communication channel. Cell. 1996;84:381-388. (Pubitemid 26060720)
4. Fuchs AR, Fields MJ, Freidman S, Shemesh M, Ivell R. Oxytocin and the timing of parturition. Influence of oxytocin receptor gene expression, oxytocin secretion, and oxytocin-induced prostaglandin F2α and E2 release. Adv Exp Med Biol. 1995;395:405-420.
5. Kamel RM. The onset of human parturition. Arch Gynecol Obstet. 2010;281:975-982.
6. Romero R, Munoz H, Gomez R, et al. Increase in prostaglandin bioavailability precedes the onset of human parturition. Prostaglandins Leukot Essent Fatty Acids. 1996;54:187-191. (Pubitemid 26145305)
7. Luckas MJ, Taggart MJ, Wray S. Intracellular calcium stores and agonist-induced contractions in isolated human myometrium. Am J Obstet Gynecol. 1999;181:468-476. (Pubitemid 29409933)
8. 1 in plasma and amniotic fluid during human pregnancy and labor. Endocrinol Jpn. 1977;24:155-162.
9. Ulug U, Goldman S, Ben-Shlomo I, Shalev E. Matrix metalloproteinase (MMP)-2 and MMP-9 and their inhibitor, TIMP-1, in human term decidua and fetal membranes: the effect of prostaglandin F2α and indomethacin. Mol Hum Reprod. 2001;7:1187-1193. (Pubitemid 33150215)
10. Guo CM, Kasaraneni N, Sun K, Myatt L. Cross talk between PKC and CREB in the induction of COX-2 by PGF2α in human amnion fibroblasts. Endocrinology. 2012;153:4938-4945.
11. Myatt L, Lye SJ. Expression, localization and function of prostaglandin receptors in myometrium. Prostaglandins Leukot Essent Fatty Acids. 2004;70:137-148. (Pubitemid 38141902)
12. sα proteins in the upper and lower segments of the human uterus during pregnancy and labor. J Clin Endocrinol Metab. 1999;84:1705-1710.
13. Mosher AA, Rainey KJ, Bolstad SS, Lye SJ, et al. Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC Pregnancy Childbirth. 2013;13( Suppl 1):S7.
14. 2alpha receptor messenger RNA in human myometrial-derived ULTR cells requires the transcription factor, NFkappaB. Biol Reprod. 2006;75:697-704.
15. Arthur P, Taggart MJ, Zielnik B, Wong S, Mitchell BF. Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J Physiol. 2008;586:6063-6076.
16. Herschman HR. Regulation of prostaglandin synthase-1 and prostaglandin synthase-2. Cancer Metastasis Rev. 1994;13:241-256.
17. Zakar T, Hertelendy F. Regulation of prostaglandin synthesis in the human uterus. J Matern Fetal Med. 2001;10:223-235.
18. Astle S, Newton R, Thornton S, Vatish M, Slater DM. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. Mol Hum Reprod. 2007;13:69-75. (Pubitemid 44942726)
19. 2α activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. Mol Cell Endocrinol. 2008;285:51-61.
20. Khanam T, Burnstock G. Changes in expression of P2X1 receptors and connexin 43 in the rat myometrium during pregnancy. Fertil Steril. 2007;88:1174-1179. (Pubitemid 47513056)
21. MacKenzie LW, Garfield RE. Hormonal control of gap junctions in the myometrium. Am J Physiol. 1985;248:C296-C308. (Pubitemid 15077797)
22. Cook JL, Shallow MC, Zaragoza DB, Anderson KI, Olson DM. Mouse placental prostaglandins are associated with uterine activation and the timing of birth. Biol Reprod. 2003;68:579-587. (Pubitemid 36139324)
23. Brodt-Eppley J, Myatt L. Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum. Biol Reprod. 1998;59:878-883. (Pubitemid 28463340)
24. 2α receptor genes are expressed in human myometrium and are down-regulated during pregnancy. Biochem Biophys Res Commun. 1997;238:838-841.
25. 2α receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. Mol Hum Reprod. 2010;16:752-760.
26. 2α, but not thromboxane, responsiveness in pregnant human myometrium during labour. J Endocrinol. 2008;197:171-179.
27. 2 binding to rat myometrium during gestation, parturition, and postpartum. Am J Physiol. 1990;258:E740-E747.
28. Phaneuf S, Asbóth G, Carrasco MP, et al. Desensitization of oxytocin receptors in human myometrium. HumReprod Update. 1998; 4:625-633. (Pubitemid 29041476)
29. Sugimoto Y, Yamasaki A, Segi E, et al. Failure of parturition in mice lacking the prostaglandin F receptor. Science. 1997;277:681-683. (Pubitemid 27373912)
30. Chevillard G, Derjuga A, Devost D, Zingg HH, Blank V. Identification of interleukin-1β regulated genes in uterine smooth muscle cells. Reproduction. 2007;134:811-822.
31. Friebe-Hoffmann U, Baston DM, Hoffmann TK, Chiao JP, Rauk PN. The influence of interleukin-1β on oxytocin signalling in primary cells of human decidua. Regul Pept. 2007;142:78-85. (Pubitemid 46899237)