Human herpesviruses 6, 7 and 8 in solid organ transplant recipients

American Journal of Transplantation

Volumn 13, Issue SUPPL. 3, 2013, Pages 67-78

  Razonable, Raymund R ^a,b  

^a Information Technology   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Human herpesvirus 6; Human herpesvirus 7; Human herpesvirus 8; Kaposi's sarcoma; Roseola infantum

Indexed keywords

ANTIVIRUS AGENT; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN;

ARTICLE; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; HUMAN HERPESVIRUS 7; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; METABOLISM; ORGAN TRANSPLANTATION;

ANTIVIRAL AGENTS; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HERPESVIRUS 7, HUMAN; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ORGAN TRANSPLANTATION; SARCOMA, KAPOSI; SIROLIMUS;

MLCS; MLOWN;

EID: 84879928439     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12008     Document Type: Article

References (101)

1. Razonable RR, Zerr DM. HHV-6, HHV-7 and HHV-8 in solid organ transplant recipients. Am J Transplant 2009; 9(Suppl 4): S97- S100.
2. Zerr DM, Meier AS, Selke SS, et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352: 768-776.
3. Pruksananonda P, Hall CB, Insel RA, et al. Primary human herpesvirus 6 infection in young children. N Engl J Med 1992; 326: 1445-1450.
4. Caserta MT, Hall CB, Schnabel K, Long CE, D'Heron N. Primary human herpesvirus 7 infection: A comparison of human herpesvirus 7 and human herpesvirus 6 infections in children. J Pediatr 1998; 133: 386-389.
5. Razonable RR, Fanning C, Brown RA, et al. Selective reactivation of human herpesvirus 6 variant a occurs in critically ill immunocompetent hosts. J Infect Dis 2002; 185: 110-113.
6. Yoshikawa T, Suga S, Asano Y, et al. A prospective study of human herpesvirus-6 infection in renal transplantation. Transplantation 1992; 54: 879-883.
7. Pellett PE, Ablashi DV, Ambros PF, et al. Chromosomally integrated human herpesvirus 6: Questions and answers. Rev Med Virol 2012; 22: 144-155.
8. Lee SO, Brown RA, Eid AJ, Razonable RR. Chromosomally integrated human herpesvirus-6 in kidney transplant recipients. Nephrol Dial Transplant 2011; 26: 2391-2393.
9. Lee SO, Brown RA, Razonable RR. Clinical significance of pretransplant chromosomally integrated human herpesvirus-6 in liver transplant recipients. Transplantation 2011; 92: 224-229.
10. Lee SO, Brown RA, Razonable RR. Chromosomally integrated human herpesvirus-6 in transplant recipients. Transpl Infect Dis 2012; 14: 346-354.
11. Lautenschlager I, Razonable RR. Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: Review. Transpl Int 2012; 25: 493-502.
12. Potenza L, Luppi M, Barozzi P, et al. HHV-6A in syncytial giant-cell hepatitis. N Engl J Med 2008; 359: 593-602.
13. Feldstein AE, Razonable RR, Boyce TG, et al. Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients. Pediatr Transplant 2003; 7: 125-129.
14. Cervera C, Marcos MA, Linares L, et al. A prospective survey of human herpesvirus-6 primary infection in solid organ transplant recipients. Transplantation 2006; 82: 979-982.
15. Humar A, Kumar D, Caliendo AM, et al. Clinical impact of human herpesvirus 6 infection after liver transplantation. Transplantation 2002; 73: 599-604.
16. Razonable RR, Rivero A, Brown RA, et al. Detection of simultaneous beta-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection. Clin Transplant 2003; 17: 114-120.
17. Singh N, Carrigan DR, Gayowski T, Singh J, Marino IR. Variant B human herpesvirus-6 associated febrile dermatosis with thrombocytopenia and encephalopathy in a liver transplant recipient. Transplantation 1995; 60: 1355-1357.
18. Randhawa PS, Jenkins FJ, Nalesnik MA, et al. Herpesvirus 6 variant A infection after heart transplantation with giant cell transformation in bile ductular and gastroduodenal epithelium. Am J Surg Pathol 1997; 21: 847-853.
19. Delbridge MS, Karim MS, Shrestha BM, McKane W. Colitis in a renal transplant patient with human herpesvirus-6 infection. Transpl Infect Dis 2006; 8: 226-228.
20. Nash PJ, Avery RK, TangWH, Starling RC, Taege AJ, YamaniMH. Encephalitis owing to human herpesvirus-6 after cardiac transplant. Am J Transplant 2004; 4: 1200-1203.
21. Vinnard C, Barton T, Jerud E, Blumberg E. A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases. Liver Transplant 2009; 15: 1242-1246.
22. Rossi C, Delforge ML, Jacobs F, et al. Fatal primary infection due to human herpesvirus 6 variant A in a renal transplant recipient. Transplantation 2001; 71: 288-292.
23. Dockrell DH, Prada J, Jones MF, et al. Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease. J Infect Dis 1997; 176: 1135-1140.
24. Mendez JC, Dockrell DH, Espy MJ, et al. Human beta-herpesvirus interactions in solid organ transplant recipients. J Infect Dis 2001; 183: 179-184.
25. Dockrell DH, Mendez JC, Jones M, et al. Human herpesvirus 6 seronegativity before transplantation predicts the occurrence of fungal infection in liver transplant recipients. Transplantation 1999; 67: 399-403.
26. Lautenschlager I, Hockerstedt K, Linnavuori K, Taskinen E. Human herpesvirus-6 infection after liver transplantation. Clin Infect Dis 1998; 26: 702-707.
27. Singh N, Husain S, Carrigan DR, et al. Impact of human herpesvirus-6 on the frequency and severity of recurrent hepatitis C virus hepatitis in liver transplant recipients. Clin Transplant 2002; 16: 92-96.
28. Jacobs F, Knoop C, Brancart F, et al. Human herpesvirus-6 infection after lung and heart-lung transplantation: A prospective longitudinal study. Transplantation 2003; 75: 1996-2001.
29. Rogers J, Rohal S, Carrigan DR, et al. Human herpesvirus-6 in liver transplant recipients: Role in pathogenesis of fungal infections, neurologic complications, and outcome. Transplantation 2000; 69: 2566-2573.
30. Singh N, Bentlejewski C, Carrigan DR, Gayowski T, Knox KK, Zeevi A. Persistent lack of human herpesvirus-6 specific T-helper cell response in liver transplant recipients. Transpl Infect Dis 2002; 4: 59-63.
31. Peleg AY, Husain S, Kwak EJ, et al. Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody. Clin Infect Dis 2007; 44: 204-212.
32. HarmaM, Hockerstedt K, Krogerus L, Lautenschlager I. Pretransplant human herpesvirus 6 infection of patients with acute liver failure is a risk factor for posttransplant human herpesvirus 6 infection of the liver. Transplantation 2006; 81: 367-372.
33. Razonable RR, Brown RA, Humar A, Covington E, Alecock E, Paya CV. Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease. J Infect Dis 2005; 192: 1331-1339.
34. Manuel O, Kumar D, Moussa G, et al. Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis. Transplantation 2009; 87: 719-725.
35. Neurohr C, Huppmann P, Leuchte H, et al. Human herpesvirus 6 in bronchalveolar lavage fluid after lung transplantation: A risk factor for bronchiolitis obliterans syndrome? Am J Transplant 2005; 5: 2982-2991.
36. Yoshida M, Yamada M, Tsukazaki T, et al. Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral Res 1998; 40: 73-84.
37. Frenkel N, Schirmer EC, Wyatt LS, et al. Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci USA 1990; 87: 748-752.
38. Tanaka K, Kondo T, Torigoe S, Okada S,Mukai T, Yamanishi K. Human herpesvirus 7: Another causal agent for roseola (exanthem subitum). J Pediatr 1994; 125: 1-5.
39. Wyatt LS, Rodriguez WJ, Balachandran N, Frenkel N. Human herpesvirus 7: Antigenic properties and prevalence in children and adults. J Virol 1991; 65: 6260-6265.
40. Suga S, Yoshikawa T, Nagai T, Asano Y. Clinical features and virological findings in children with primary human herpesvirus 7 infection. Pediatrics 1997; 99: E4.
41. Katsafanas GC, Schirmer EC, Wyatt LS, Frenkel N. In vitro activation of human herpesviruses 6 and 7 from latency. Proc Natl Acad Sci USA 1996; 93: 9788-9792.
42. Yoshikawa T. Human herpesvirus-6 and -7 infections in transplantation. Pediatr Transplant 2003; 7: 11-17.
43. Anton A, Cervera C, Pumarola T, et al. Human herpesvirus 7 primary infection in kidney transplant recipients. Transplantation 2008; 85: 298-302.
44. Ward KN,White RP,Mackinnon S, Hanna M. Human herpesvirus- 7 infection of the CNS with acutemyelitis in an adult bone marrow recipient. Bone Marrow Transplant 2002; 30: 983-985.
45. Tong CY, Bakran A,Williams H, Cheung CY, Peiris JS. Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients. Transplantation 2000; 70: 213-216.
46. Griffiths PD, Ait-Khaled M, Bearcroft CP, et al. Human herpesviruses 6 and 7 as potential pathogens after liver transplant: Prospective comparison with the effect of cytomegalovirus. J Med Virol 1999; 59: 496-501.
47. Fernandez C, Boutolleau D, Manichanh C, Mangeney N, Agut H, Gautheret-Dejean A. Quantitation of HHV-7 genome by real-time polymerase chain reaction assay using MGB probe technology. J Virol Methods 2002; 106: 11-16.
48. Franti M, Aubin JT, De Saint-Maur G, et al. Immune reactivity of human sera to the glycoprotein B of human herpesvirus 7. J Clin Microbiol 2002; 40: 44-51.
49. Brennan DC, Storch GA, Singer GG, Lee L, Rueda J, Schnitzler MA. The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir. J Infect Dis 2000; 181: 1557-1561.
50. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865-1869.
51. Andreoni M, Sarmati L, Nicastri E, et al. Primary human herpesvirus 8 infection in immunocompetent children. Jama 2002; 287: 1295-1300.
52. Pauk J, Huang ML, Brodie SJ, et al. Mucosal shedding of human herpesvirus 8 in men. N Engl J Med 2000; 343: 1369-1377.
53. Vieira J, Huang ML, Koelle DM, Corey L. Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma. J Virol 1997; 71: 7083-7087.
54. Blackbourn DJ, Lennette ET, Ambroziak J, Mourich DV, Levy JA. Human herpesvirus 8 detection in nasal secretions and saliva. J Infect Dis 1998; 177: 213-216.
55. Wang QJ, Jenkins FJ, Jacobson LP, et al. Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins. Blood 2001; 97: 2366-2373.
56. Hassman LM, Ellison TJ, Kedes DH. KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation. J Clin Invest 2011; 121: 752-768.
57. Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med 2000; 342: 1027-1038.
58. Sirianni MC, Vincenzi L, Topino S, et al. NK cell activity controls human herpesvirus 8 latent infection and is restored upon highly active antiretroviral therapy in AIDS patients with regressing Kaposi's sarcoma. Eur J Immunol 2002; 32: 2711-2720.
59. Kimball LE, Casper C, Koelle DM, Morrow R, Corey L, Vieira J. Reduced levels of neutralizing antibodies to Kaposi sarcomaassociated herpesvirus in persons with a history of Kaposi sarcoma. J Infect Dis 2004; 189: 2016-2022.
60. Ariza-Heredia EJ, Razonable RR. Human herpes virus 8 in solid organ transplantation. Transplantation 2011; 92: 837-844.
61. Butler LM, Were WA, Balinandi S, et al. Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda. J Infect Dis 2011; 203: 625-634.
62. Luppi M, Barozzi P, Schulz TF, et al. Bone marrow failure associated with human herpesvirus 8 infection after transplantation. N Engl J Med 2000; 343: 1378-1385.
63. Freitas RB, Freitas MR, Linhares AC. Prevalence of human herpesvirus 8 antibodies in the population of Belem, Para, Brazil. Rev Inst Med Trop Sao Paulo 2002; 44: 309-313.
64. Chen N, Nelson KE, Jenkins FJ, et al. Seroprevalence of human herpesvirus 8 infection in Northern Thailand. Clin Infect Dis 2004; 39: 1052-1058.
65. Casper C, Meier AS, Wald A, Morrow RA, Corey L, Moscicki AB. Human herpesvirus 8 infection among adolescents in the REACH cohort. Arch Pediatr Adolesc Med 2006; 160: 937-942.
66. Babel N, Eibl N, Ulrich C, et al. Development of Kaposi's sarcoma under sirolimus-based immunosuppression and successful treatment with imiquimod. Transpl Infect Dis 2008; 10: 59-62.
67. Dudderidge TJ, Khalifa M, Jeffery R, Amlot P, Al-Akraa M, Sweny P. Donor-derived human herpes virus 8-related Kaposi's sarcoma in renal allograft ureter. Transpl Infect Dis 2008; 10: 221-226.
68. Lebbe C, Legendre C, Frances C. Kaposi sarcoma in transplantation. Transplant Rev 2008; 22: 252-261.
69. Martinez S, McAdams HP, Youens KE. Kaposi sarcoma after bilateral lung transplantation. J Thorac Imaging 2008; 23: 50-53.
70. Al-Khader AA, Suleiman M, Al-Hasani M, Haleem A. Posttransplant Kaposi sarcoma: Staging as a guide to therapy and prognosis. Nephron 1988; 48: 165.
71. Boulanger E, Afonso PV, Yahiaoui Y, Adle-Biassette H, Gabarre J, Agbalika F. Human herpesvirus-8 (HHV-8)-associated primary effusion lymphoma in two renal transplant recipients receiving rapamycin. Am J Transplant 2008; 8: 707-710.
72. Dotti G, Fiocchi R, Motta T, et al. Primary effusion lymphoma after heart transplantation: A new entity associated with human herpesvirus-8. Leukemia 1999; 13: 664-670.
73. Uldrick TS, Wang V, O'Mahony D, et al. An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease. Clin Infect Dis 2010; 51: 350-358.
74. Luppi M, Barozzi P, Rasini V, et al. Severe pancytopenia and hemophagocytosis after HHV-8 primary infection in a renal transplant patient successfully treated with foscarnet. Transplantation 2002; 74: 131-132.
75. Regamey N, Hess V, Passweg J, et al. Infection with human herpesvirus 8 and transplant-associated gammopathy. Transplantation 2004; 77: 1551-1554.
76. Regamey N, Tamm M, Wernli M, et al. Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med 1998; 339: 1358-1363.
77. Di Benedetto F, Di Sandro S, De Ruvo N, et al. Kaposi's sarcoma after liver transplantation. J Cancer Res Clin Oncol 2008; 134: 653-658.
78. Luppi M, Barozzi P, Santagostino G, et al. Molecular evidence of organ-related transmission of Kaposi sarcoma-associated herpesvirus or human herpesvirus-8 in transplant patients. Blood 2000; 96: 3279-3281.
79. Marcelin AG, Roque-Afonso AM, Hurtova M, et al. Fatal disseminated Kaposi's sarcoma following human herpesvirus 8 primary infections in liver-transplant recipients. Liver Transpl 2004; 10: 295-300.
80. Wasywich CA, Croxson MC, van Doornum GJ, Coverdale HA, Ruygrok PN. Sirolimus for Kaposi's sarcoma. J Heart Lung Transplant 2006; 25: 726-729.
81. Barozzi P, Luppi M, Facchetti F, et al. Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors. Nat Med 2003; 9(5): 554-561.
82. Farge D. Kaposi's sarcoma in organ transplant recipients. The Collaborative Transplantation Research Group of Ile de France. Eur J Med 1993; 2: 339-343.
83. Qunibi W, Akhtar M, Sheth K, et al. Kaposi's sarcoma: The most common tumor after renal transplantation in Saudi Arabia. Am J Med 1988; 84: 225-232.
84. Ahmadpoor P, Ilkhanizadeh B, Sharifzadeh P, et al. Seroprevalence of human herpes virus-8 in renal transplant recipients: A single center study from Iran. Transplant Proc 2007; 39: 1000-1002.
85. Cattani P, Capuano M, Graffeo R, et al. Kaposi's sarcoma associated with previous human herpesvirus 8 infection in kidney transplant recipients. J Clin Microbiol 2001; 39: 506-508.
86. Frances C, Mouquet C, Marcelin AG, et al. Outcome of kidney transplant recipients with previous human herpesvirus-8 infection. Transplantation 2000; 69: 1776-1779.
87. Farge D, Lebbe C, Marjanovic Z, et al. Human herpes virus-8 and other risk factors for Kaposi's sarcoma in kidney transplant recipients. Groupe Cooperatif de Transplantation d' Ile de France (GCIF). Transplantation 1999; 67: 1236-1242.
88. Barozzi P, Bonini C, Potenza L et al. Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcoma. Transplantation 2008; 86: 738-744.
89. Mbulaiteye SM, Engels EA. Kaposi's sarcoma risk among transplant recipients in the United States (1993-2003). Int J Cancer 2006; 119: 2685-2691.
90. Laney AS, Peters JS, Manzi SM, Kingsley LA, Chang Y, Moore PS. Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol 2006; 44: 3734-3741.
91. Spira TJ, Lam L, Dollard SC, et al. Comparison of serologic assays and PCR for diagnosis of human herpesvirus 8 infection. J Clin Microbiol 2000; 38: 2174-2180.
92. Pietrosi G, Vizzini G, Pipitone L, et al. Primary and reactivated HHV8 infection and disease after liver transplantation: A prospective study. Am J Transplant 2011; 11: 2715-2723.
93. Mendez JC, Procop GW, Espy MJ, Smith TF, McGregor CG, Paya CV. Relationship of HHV8 replication and Kaposi's sarcoma after solid organ transplantation. Transplantation 1999; 67: 1200-1201.
94. Pozo F, Tenorio A, de la Mata M, de Ory F, Torre-Cisneros J. Persistent human herpesvirus 8 viremia before Kaposi's sarcoma development in a liver transplant recipient. Transplantation 2000; 70: 395-397.
95. Pellet C, Chevret S, Frances C, et al. Prognostic value of quantitative Kaposi sarcoma-associated herpesvirus load in posttransplantation Kaposi sarcoma. J Infect Dis 2002; 186: 110-113.
96. Casper C, Krantz EM, Corey L, et al. Valganciclovir for suppression of human herpesvirus-8 replication: A randomized, doubleblind, placebo-controlled, crossover trial. J Infect Dis 2008; 198: 23-30.
97. Kolhe N, Mamode N, Van der Walt J, Pattison J. Regression of post-transplant Kaposi's sarcoma using sirolimus. Int J Clin Pract 2006; 60: 1509-1512.
98. Stallone G, Schena A, Infante B, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 1317-1323.
99. Montagnino G, Bencini PL, Tarantino A, Caputo R, Ponticelli C. Clinical features and course of Kaposi's sarcoma in kidney transplant patients: Report of 13 cases. Am J Nephrol 1994; 14: 121-126.
100. Al Otaibi T, Al Sagheir A, Ludwin D,Meyer R. Post renal transplant Castleman's disease resolved after graft nephrectomy: A case report. Transplant Proc 2007; 39: 1276-1277.
101. Lim EJ, Crowley P, Mitchell CA, Angus PW. Post-liver transplantation multicentric Castleman disease treated with valganciclovir and weaning of immunosuppression. Am J Transplant 2011; 11: 169-172.