Antidepressive effect of paroxetine in a rat model: Upregulating expression of serotonin and norepinephrine transporter

NeuroReport

Volumn 24, Issue 10, 2013, Pages 520-525

  Qiu, Hong Mei ^a   Yang, Jun Xia ^a   Wu, Xiao Hong ^a   Li, Na ^a   Liu, Dan ^a   Wang, Li Jia ^a   Qin, Li Juan ^a   Zhou, Qi Xin ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

norepinephrine transporter; oxidative stress; paroxetine; serotonin transporter

Indexed keywords

CATALASE; MALONALDEHYDE; NORADRENALIN TRANSPORTER; PAROXETINE; SEROTONIN TRANSPORTER; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NONHUMAN; OPEN FIELD TEST; PONS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CATALASE; FOOD PREFERENCES; MALE; MALONDIALDEHYDE; MOTOR ACTIVITY; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PAROXETINE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 84879916686     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328362066d     Document Type: Article

References (26)

1. Koponen H, Jokelainen J, Keinänen-Kiukaanniemi S, Vanhala M. Depressive symptoms and 10-year risk for cardiovascular morbidity and mortality. World J Biol Psychiatry 2010; 11:834-839.
2. Yang C, Wang G, Wang H, Liu Z, Wang X. Cytoskeletal alterations in rat hippocampus following chronic unpredictable mild stress and re-exposure to acute and chronic unpredictable mild stress. Behav Brain Res 2009; 205:518-524.
3. Rudorfer MV, Risby ED, Osman OT, Gold PW, Potter WZ. Hypothalamic- pituitary-adrenal axis and monoamine transmitter activity in depression: a pilot study of central and peripheral effects of electroconvulsive therapy. Biol Psychiatry 1991; 29:253-264.
4. Iversen L. Neurotransmitter transporters and their impact on the development of psychopharmacology. Br J Pharmacol 2006; 147:82-88.
5. Jiang X, Wang J, Luo T, Li Q. Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice. Psychoneuroendocrinology 2009; 34:317-331.
6. Nutt DJ. The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 2002; 17 (Suppl 1):S1-S12.
7. Tagliari B, dos Santos TM, Cunha AA, Lima DD, Delwing D, Sitta A, et al. Chronic variable stress induces oxidative stress and decreases butyrylcholinesterase activity in blood of rats. J Neural Transm 2010; 117:1067-1076.
8. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003; 289:3095-3105.
9. Kramer K, Dijkstra H, Bast A. Control of physical exercise of rats in a swimming basin. Physiol Behav 1993; 53:271-276.
10. Lucca G, Comim CM, Valvassori SS, Réus GZ, Vuolo F, Petronilho F, et al. Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochem Int 2009; 54:358-362.
11. Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, et al. Neuropathological correlates of late-life depression in older people. Br J Psychiatry 2011; 198:109-114.
12. Banasr M, Dwyer JM, Duman RS. Cell atrophy and loss in depression: reversed by anti-depressant treatment. Curr Opin Cell Biol 2011; 23:730-737.
13. Heydorn WE. Paroxetine: a review of its pharmacology, pharmacokinetics and utility in the treatment of a variety of psychiatric disorders. Expert Opin Investig Drugs 1999; 8:417-441.
14. Chen L, Chen M, Wang F, Sun Z, Quanzhi H, Geng M, et al. Antidepressant-like effects of shuyusan in rats exposed to chronic stress: effects on hypothalamic-pituitary-adrenal function. Evid Based Complement Alternat Med 2012; 2012:940846.
15. Kompagne H, Bárdos G, Szénási G, Gacsályi I, Hársing LG, Lévay G. Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats. Behav Brain Res 2008; 193:311-314.
16. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358.
17. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984; 21:130-132.
18. Claiborne A. Catalase activity. In: Greenwald RA, editor. Handbook of methods for oxygen radical research. Boca Raton, Florida, USA: CRC Press; 1985; p. 542.
19. Krishnan V, Nestler EJ. Animal models of depression: molecular perspectives. Curr Top Behav Neurosci 2011; 7:121-147.
20. Willner P, Mitchell PJ. The validity of animal models of predisposition to depression. Behav Pharmacol 2002; 13:169-188.
21. Kumar B, Kuhad A, Chopra K. Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology (Berl) 2011; 214:819-828.
22. Brenes Sáenz JC, Villagra OR, Fornaguera-Trías J. Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats. Behav Brain Res 2006; 169:57-65.
23. Der-Avakian A, Markou A. The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci 2012; 35:68-77.
24. Strekalova T, Gorenkova N, Schunk E, Dolgov O, Bartsch D. Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress. Behav Pharmacol 2006; 17:271-287.
25. Kim H, Lim SW, Kim S, Kim JW, Chang YH, Carroll BJ, et al. Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression. JAMA 2006; 296:1609-1618.
26. Min W, Li T, Ma X, Li Z, Yu T, Gao D, et al. Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response. Psychopharmacology (Berl) 2009; 205:409-417.