Melatonin protects against lead-induced cardio toxicity: Involvement of antioxidant mechanism

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue 3, 2013, Pages 806-813

  Ghosh, Debosree ^a   Mitra, Elina ^a   Firdaus, Syed Benazir ^a   Ghosh, Arnab K ^a   Chattopadhyay, Aindrila ^b   Pattari, Sanjib K ^c   Bandyopadhyay, Debasish ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b Vidyasagar College   (India)

^c Narayana Health   (India)

Author keywords

Antioxidant; Lead acetate; Melatonin; Oxidative stress; Tissue injury

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; LACTATE DEHYDROGENASE; MELATONIN; MITOCHONDRIAL ENZYME; PYRUVATE DEHYDROGENASE; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY WEIGHT; CARDIOTOXICITY; CONTROLLED STUDY; HEART INJURY; HEART PROTECTION; HEART SIZE; HEART WEIGHT; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RESPIRATORY CHAIN;

EID: 84879913979     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Ortega-Gutierrez S, Fuentes-Brotol et al. Melatonin Reduces Protein And Lipid Oxidative Damage Induced By Homocysteine In Rat Brain Homogenate. J Cell Biochem. 2007; 102:729-735.
2. Sugawara E, Nakamura K, Miyake T et al., Lipid Peroxidation And Concentration Of Glutathione In Erythrocytes From Workers Exposed To Lead. Brit J Indust Med. 1991; 48: 239-242.
3. Solliway B M, Schaffer A, Pratt H, Yannai S. Effects Of Exposure To Lead On Selected Biochemical and Hematological Variables. Pharmacol tox. 1996;78:18-22.
4. Hardeland R, Fuhrberg B. Ubiquitous Melatonin-Presence And Effects In Unicells, Plants And Animals. Trends Comp Biochem Physiol.1996; 2: 25-45.
5. Hardeland R, Poeggeler B. Non-Vertebrate Melatonin. J Pineal Res. 2003; 34: 233-241.
6. Korkmaz A, Reiter R J, Topal T et al. Melatonin, An Established Antioxidant Worthy of Use In Clinical Trials. Mol Med. 2009; 15: 43-50.
7. Amao M D, Hemandez-Ruiz J. Protective Effect Of Melatonin Against Chlorophyll Degradation During Senescence Of Barley Leaves. J Pineal Res. 2009; 46: 58-63.
8. Agez L, Laurent V, Guerrero H Y et al. Endogenous Melatonin Provides An Effective Circadian Message To Both The Suprchiasmatic Nuclei And The Pars Tuberalis Of The Rat. J Pineal Res.2009; 46: 95-105.
9. Wasdell MB, Jan J E, Bomden MM et al. A Randomized, Placebo-Controlled Trial Of Controlled Release Melatonin Treatment Of Delayed Sleep Phase Syndrome And Impaired Sleep Maintenance In Children With Neurodevelopmental Disabilities. Pineal Res. 2008; 44: 57-64.
10. Marino A, Di Paolo R, CristaFulli C et al. Protective Effect Of Melatonin Against The Inflammatory Response Elicited By Crude Venom From Isolated Nematocysts Of Pelagianoctiluca (Cnidaria, Scyphozoa). J Pineal Res. 2009; 47: 56-69.
11. Reiter R J, Tan D X, Manchester L C et al. Melatonin And Reproduction Revisited. Bio Reprod. 2009; 81:445-456.
12. Jung-Hynes B, Reiter R J, Ahmad N. Sirtuins. Melatonin and Circadian Rhythm. Building A Bridge Between Aging And Cancer. J Pineal Res. 2009; 48: 9-19.
13. Maldonado M D, Perez-San Gregorio M A, Reiter R J. The Role Of Melatonin In the Immune-Neuro-Psychology of Mental Disorders. Rec Patents Cns Drug Disc. 2009; 4:61-69.
14. Konturek P C, Konturek S J, Celinski K et al. Role Of Melatonin In Mucosal Gastroprotection Against Aspirin-Induced Gastric Lesions In Humans. J Pineal Res. 2010; 48: 318-323.
15. Posmyk M M, Balabusta M, Wieczorek M et al. Melatonin Applied To Cucumber (Cucumissativus L.) Seeds Improves Germination During Chilling Stress. J Pineal Res. 2009; 46: 214-223.
16. Tan DX, Chen L D, Poeggeler B et al. Melatonin. A Potent Endogenous Hydroxyl Radical Scavenger. Endocrine J. 1993; 1: 57-60.
17. Bandyopadhyay D, Biswas K, Bandyopadhyay U et al. Melatonin Protects Against Stress-Induced Gastric Lesions By Scavenging Hydroxyl Radicals. J Pineal Res. 2000; 29:143-151.
18. Rodriguez C, Mayo J C, Sainz R M et al. Regulation Of Antioxidant Enzymes: A Significant Role For Melatonin. J Pineal Res. 2004; 36: 1-9.
19. Winiarska K, Fraczyk T, Malinska D et al. Melatonin Attenuates Diabetes-Induced Oxidative Stress in Rabbits. J Pineal Res. 2006; 40: 168-176.
20. Tan D X, Manchester L C, Terron M P et al. One Molecule Many Derivatives: A Never-Ending Interaction of Melatonin With Reactive Oxygen And Nitrogen Species? J Pineal Res. 2007; 42: 28-42.
21. +, NO And HNO (Protonated NO)With The Melatonin Metabolite N1-Acetyl-5-Methoxykynuramine. J Pineal Res. 2007; 43: 382-388.
22. Valko M, Morris H, Cronin M T. Metals. Toxicity and Oxidative Stress. Curr Med Chem. 2005; 12: 1161-1208.
23. Suresh C, Dennis AO, Heinz J, Vemuri MC, Chetty CS. Melatonin protection against lead-induced changes in human neuroblastoma cell cultures. Int J Toxicol. 2006; 25:459-64.
24. El-Sokkary GH, Kamel ES, Reiter RJ. Prophylactic effect of melatonin in reducing lead-induced neurotoxicity in the rat. CellMol Biol Lett. 2003; 8: 461-70.
25. Othman AI, al Sharawy S, el-Missiry MA. Role of melatonin in ameliorating lead induced haematotoxicity. Pharmacol Res. 2004; 50: 301-7.
26. Ustundag A, Duydu Y. The influence of melatonin and N-acetylcysteine in delta-aminolevulinic acid and lead induced genotoxicity in lymphocytes in vitro. Biol Trace Elem Res. 2007; 117: 53-64.
27. Martínez-Alfaro M, Hernández-Cortés D, Wrobel K, Cruz-Jiménez G, Rivera-Leyva JC, Piña-Zentella RM, Cárabez Trejo A. Effect of melatonin administration on DNA damage and repair responses in lymphocytes of rats subchronically exposed to lead. Mutat Res. 2012; 742: 37-42.
28. Mitra E, Ghosh AK, Ghosh D, Mukherjee D, Chattopadhyay A, Dutta S, Pattari S K, Bandyopadhyay D. Protective Effect Of Aqueous Curry Leaf (Murraya Koenigii) Extract Against Cadmium-Induced Oxidative Stress In Rat Heart. Food Chem Toxicol. 2012; 50:1340-1353.
29. Strittmatter C. Studies on avian xanthine dehydrogenases: properties and patterns of appearance during development. J Biol Chem.1965; 240: 2557-2564.
30. Buege JA, Aust S G. Microsomal Lipid Peroxidation. Methods. Enzymol.1978; 52:302-310.
31. Bandyopadhyay D, Ghosh G, Bandyopadhyay A, Reiter R J. Melatonin protects against piroxicam-induced gastric ulceration. J Pineal Res 2004; 36:195-203.
32. Sedlak J, Lindsay RH. Estimation of total, protein-bound, nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem.1968; 25: 192-205.
33. Marklund S, Marklund G. Involvement of the superoxide anione radical in the autoxidation of pyragallol and a convenient assay for superoxide dismutase. Eur J Biochem.1974; 47: 469-474.
34. Beers Jr, RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem.1952.195: 133-140.
35. Greenlee L, Handler P. Xanthine oxidase. IV. Influence of pH on substrate specificity. J Biol Chem.1964. 239: 1090-1095.
36. Chretien D, Pourrier M, Bourgeron T, Séné M, Rötig A, Munnich A, Rustin P. An improved spectrophotometric assay of pyruvate dehydrogenase in lactate dehydrogenase contaminated mitochondrial preparations from human skeletal muscles. Clin Chim Acta. 1995; 240: 129-136.
37. Duncan MJ, Fraenkel DG. Alpha-ketoglutarate dehydrogenase mutant of Rhizobium meliloti. J Bacteriol.1979; 137: 415-419.
38. Veeger C, DerVartanian DV, Zeylemaker WP. Succinate dehydrogenase. Methods Enzymol.1969;13: 81-90.
39. Goyal N, Srivastava VM. Oxidation and reduction of cytochrome c by mitochondrial enzymes of Setaria cervi. J. Helminthol.1995; 69: 13-17.
40. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
41. Gurer H, Ercal N. Can Antioxidants Be Beneficial In The Treatment Of Lead Poisoning? Free Radic Biol Med. 2000; 29: 927-945.
42. Flora S J S, Pande M, G M Kannan, A Mehta. Lead Induced Oxidative Stress And Its Recovery Following Co-Administration Of Melatonin Or N-Acetylcysteine During Chelation With Succimer In Male Rats. Cell Mol Biol. 2004; 50: 543-551.
43. Reghuvanshi R, Kaul A, Bhakuni P, Mishra A, Mishra MK. Xanthine oxidase as a marker of myocardial infarction. Indian J. Clin Biochem. 2007;22: 90-92.
44. Desco MC, Ascensi M, Marquez R et al. Xanthine Oxidase Is Involved In Free Radical Production In Type 1 Diabetes. Diabetes. 2002; 51: 1118-1124.
45. Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 2003; 278: 36027-36031.
46. Ghosh D, Firdaus SB, Mitra E, Dey M, Chattopadhyay A, Pattari SK, Dutta S, Jana K, Bandyopadhyay D. Hepatoprotective activity of aqueous leaf extract of Murraya koenigii against lead-induced hepatotoxicity in male wistar rat. Int J Pharm Pharm Sci. 2013; 5 (1): 285-295.
47. Ghosh D, Firdaus SB, Mitra E, Dey M, Chattopadhyay A, Pattari SK, Dutta S, Jana K, Bandyopadhyay D. Aqueous leaf extract of Murraya koenigii protects against lead-induced cardio toxicity in male Wistar rats. IJP. 2013;4(2):119-132.
48. Basu A, Mitra E, Mukherjee D, Ghosh AK, Firdaus SB, Ghosh D, Chattopadhyay A, Pattari SK, Dutta S, Jana K, Bandyopadhyay D. Aqueous tulsi leaf (Ocimum sanctum l.) extract protects against piroxicam-induced gastric ulceration in rats: involvement of antioxidant mechanisms. Int J Pharm Pharm Sci. 2013; 5(1): 438-447.
49. Mitra E, Ghosh AK, Ghosh D, Firdaus SB, Mukherjee D, Chattopadhyay A, Pattari SK, Dutta S, Bandyopadhyay D. Ameliorative Effect Of Aqueous Curry Leaf (Murraya Koenigii) Extract Against Cadmium Induced Oxidative Stress In Rat Liver: Involvement Of Antioxidant Mechanisms. Int J Pharm Pharm Sci. 2013; 5(2): 570-583.
50. Reiter RJ, Tan DX, Manchester LC, El-Sawi MR. Melatonin Reduces Oxidant Damage And Promotes Mitochondrial Respiration: Implications For Aging. Ann N Y Acadsci. 2002; 959: 238-250.
51. Leon J, Acuna-Castroviejo D, Escames G, Tan DX, Reiter RJ. Melatonin Mitigates Mitochondrial Malfunction. J Pineal Res. 2005; 38: 1-9.
52. Bandyopadhyay D, Chattopadhyay A. Reactive Oxygen Species-Induced Gastric Ulceration: Protection By Melatonin. Curr med chem.2006;13:1187-1202.
53. Ghosh D, Mitra E, Dey M, Firdaus SB, Ghosh AK, Mukherjee D, Chattopadhyay A, Pattari SK, Dutta S, Bandyopadhyay D. Melatonin Protects Against Lead-Induced Oxidative Stress In Rat Liver And Kidney. Asian Journal of Pharmaceutical and Clinical Research. 2013;6 (2): 137-145.