-
1
-
-
70549109318
-
Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein
-
Kunos C, Chiu S, Pink J, et al. Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein. Radiat Res. 2009;172:666-676.
-
(2009)
Radiat Res
, vol.172
, pp. 666-676
-
-
Kunos, C.1
Chiu, S.2
Pink, J.3
-
2
-
-
77958091728
-
Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers
-
Kunos C, Radivoyevitch T, Pink J, et al. Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers. Radiat Res. 2010;174:574-581.
-
(2010)
Radiat Res
, vol.174
, pp. 574-581
-
-
Kunos, C.1
Radivoyevitch, T.2
Pink, J.3
-
3
-
-
79959363029
-
Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: Enhanced radiation response at low dose rates
-
Kunos C, Colussi V, Pink J, et al. Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low dose rates. Int J Radiat Oncol Biol Phys. 2011;80:1198-1204.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.80
, pp. 1198-1204
-
-
Kunos, C.1
Colussi, V.2
Pink, J.3
-
4
-
-
80053236914
-
Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers
-
Kunos C, Ferris G, Pyatka N, et al. Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers. Radiat Res. 2011;176:425-433.
-
(2011)
Radiat Res
, vol.176
, pp. 425-433
-
-
Kunos, C.1
Ferris, G.2
Pyatka, N.3
-
5
-
-
76749092292
-
Phase I trial of intravenous 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in combination with pelvic radiation therapy and weekly cisplatin chemotherapy for locally advanced cervical cancer
-
Kunos C, Waggoner S, Von Gruenigen V, et al. Phase I trial of intravenous 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in combination with pelvic radiation therapy and weekly cisplatin chemotherapy for locally advanced cervical cancer. Clin Cancer Res. 2010;16:1298-1306.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1298-1306
-
-
Kunos, C.1
Waggoner, S.2
Von Gruenigen, V.3
-
6
-
-
84879978622
-
Phase 2 trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical and vaginal cancer
-
abstract #5034
-
Kunos C, Waggoner S, Zanotti K, et al. Phase 2 trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical and vaginal cancer. J ClinOncol. 2011;29: abstract #5034.
-
(2011)
J ClinOncol
, vol.29
-
-
Kunos, C.1
Waggoner, S.2
Zanotti, K.3
-
7
-
-
77957334056
-
Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: A Gynecologic Oncology Group Study
-
Kunos C,Ali S, Abdul-KarimF, et al. Posttherapy residual disease associates with long-term survival after chemoradiation for bulky stage 1B cervical carcinoma: a Gynecologic Oncology Group Study. Am J Obstet Gynecol. 2010;203:351.e1-351.e8.
-
(2010)
Am J Obstet Gynecol
, vol.203
-
-
Kunos, C.1
Ali, S.2
Abdul-Karim, F.3
-
8
-
-
79957498485
-
Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: A Gynecologic Oncology Group study
-
Rose P, Ali S, Whitney C, et al. Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. Gynecol Oncol. 2011;121:542-545.
-
(2011)
Gynecol Oncol
, vol.121
, pp. 542-545
-
-
Rose, P.1
Ali, S.2
Whitney, C.3
-
9
-
-
84872346050
-
Therapeutic mechanisms of treatment in cervical and vaginal cancer
-
Kunos C. Therapeutic mechanisms of treatment in cervical and vaginal cancer. Oncol Hematol Rev. 2012;8:55-60.
-
(2012)
Oncol Hematol Rev
, vol.8
, pp. 55-60
-
-
Kunos, C.1
-
10
-
-
33646359442
-
Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
-
Hakansson P, Hofer A, Thelander L. Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells. J Biol Chem. 2006;281:7834-7841.
-
(2006)
J Biol Chem
, vol.281
, pp. 7834-7841
-
-
Hakansson, P.1
Hofer, A.2
Thelander, L.3
-
11
-
-
0018761622
-
Hydroxyurea or placebo combinedwith radiation to treat stages IIIB and IV cervical cancer confined to the pelvis
-
HreshchyshynMM, Aron BS, Boronow RC, et al. Hydroxyurea or placebo combinedwith radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. Int J Radiat Oncol Biol Phys. 1979; 5:317-322.
-
(1979)
Int J Radiat Oncol Biol Phys
, vol.5
, pp. 317-322
-
-
Hreshchyshyn, M.M.1
Aron, B.S.2
Boronow, R.C.3
-
12
-
-
0032895783
-
Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: A Gynecologic Oncology Group and Southwest Oncology Group study
-
Whitney CW, SauseW, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol. 1999; 17:1339-1348.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1339-1348
-
-
Whitney, C.W.1
Sause, W.2
Bundy, B.N.3
-
13
-
-
34447562948
-
Long-termfollow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: A GynecologicOncologyGroup Study
-
Rose P, Ali S,Watkins E, et al. Long-termfollow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a GynecologicOncologyGroup Study. J Clin Oncol. 2007;25:2804-2810.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2804-2810
-
-
Rose, P.1
Ali, S.2
Watkins, E.3
-
14
-
-
1542398694
-
Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: An update of radiation therapy oncology group trial (RTOG) 90-01
-
Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol. 2004; 22:872-880.
-
(2004)
J Clin Oncol
, vol.22
, pp. 872-880
-
-
Eifel, P.J.1
Winter, K.2
Morris, M.3
-
15
-
-
79955582400
-
A phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix
-
Duenas-Gonzalez A, Zarba J, Patel F, et al. A phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J Clin Oncol. 2011;29:1678-1685.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1678-1685
-
-
Duenas-Gonzalez, A.1
Zarba, J.2
Patel, F.3
-
16
-
-
34447265272
-
Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: Results of Arm 1 of RTOG 0116
-
Small W Jr, Winter K, Levenback C, et al. Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive para-aortic or high common iliac lymph nodes: results of Arm 1 of RTOG 0116. Int J Radiat Oncol Biol Phys. 2007;68:1081-1087.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.68
, pp. 1081-1087
-
-
Small Jr., W.1
Winter, K.2
Levenback, C.3
-
17
-
-
33845682489
-
A phase 2 study of acute toxicity of Celebrexi (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: Primary endpoint analysis of RTOG 0128
-
Gaffney D, Winter K, Dicker A, et al. A phase 2 study of acute toxicity of Celebrexi (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG 0128. Int J Radiat Oncol Biol Phys. 2007;67: 104-109.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 104-109
-
-
Gaffney, D.1
Winter, K.2
Dicker, A.3
-
18
-
-
34547842086
-
Efficacy and patterns of failure for locally advanced cancer of the cervix treated with Celebrex (celecoxib) and chemoradiotherapy in RTOG 0128
-
Gaffney D, Winter K, Dicker A, et al. Efficacy and patterns of failure for locally advanced cancer of the cervix treated with Celebrex (celecoxib) and chemoradiotherapy in RTOG 0128. Int J Radiat Oncol Biol Phys. 2007;69:111-117.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.69
, pp. 111-117
-
-
Gaffney, D.1
Winter, K.2
Dicker, A.3
-
19
-
-
84872288212
-
Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers
-
doi:10.097/IGC.0b013e318270577f
-
Kunos C, Radivoyevitch T, Kresak A, et al. Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers. Int J Gynecol Cancer. 2012;22:1463-1469. doi:10.097/IGC. 0b013e318270577f.
-
(2012)
Int J Gynecol Cancer
, vol.22
, pp. 1463-1469
-
-
Kunos, C.1
Radivoyevitch, T.2
Kresak, A.3
-
20
-
-
79953232741
-
Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase
-
Pontarin G, Ferraro P, Rampazzo C, et al. Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase. J Biol Chem. 2011;286:11132-11140.
-
(2011)
J Biol Chem
, vol.286
, pp. 11132-11140
-
-
Pontarin, G.1
Ferraro, P.2
Rampazzo, C.3
-
21
-
-
56649111359
-
Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage
-
Pontarin G, Fijolek A, Pizzo P, et al. Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. Proc Natl Acad Sci U S A. 2008;105:17801-17806.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17801-17806
-
-
Pontarin, G.1
Fijolek, A.2
Pizzo, P.3
-
22
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 457-481
-
-
Kaplan, E.1
Meier, P.2
-
23
-
-
0000336139
-
Regression models and life tables (with discussion)
-
Cox D. Regression models and life tables (with discussion). J R Stat Soc. 1972;34:187-220.
-
(1972)
J R Stat Soc
, vol.34
, pp. 187-220
-
-
Cox, D.1
-
24
-
-
0022260274
-
Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits
-
Engstrom Y, Erriksson S, Jildevik I, et al. Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits. J Biol Chem. 1985;26: 9114-9116.
-
(1985)
J Biol Chem
, vol.26
, pp. 9114-9116
-
-
Engstrom, Y.1
Erriksson, S.2
Jildevik, I.3
-
25
-
-
0023712808
-
Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation
-
Mann G, Musgrove E, Fox R, et al. Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. Cancer Res. 1988;48:5151-5156.
-
(1988)
Cancer Res
, vol.48
, pp. 5151-5156
-
-
Mann, G.1
Musgrove, E.2
Fox, R.3
-
26
-
-
0034625375
-
Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks
-
Chabes A, Thelander L. Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks. J Biol Chem. 2000;275: 17747-17753.
-
(2000)
J Biol Chem
, vol.275
, pp. 17747-17753
-
-
Chabes, A.1
Thelander, L.2
-
27
-
-
0242317756
-
Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting comploex-Cdh1-mediated proteolysis
-
Chabes A, Pfleger C, Kirschner M, et al. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting comploex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A. 2003;100:3925-3929.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 3925-3929
-
-
Chabes, A.1
Pfleger, C.2
Kirschner, M.3
-
28
-
-
0034594978
-
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
-
Tanaka H, Arakawa H, Yamaguchi T, et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature. 2000;404:42-49.
-
(2000)
Nature
, vol.404
, pp. 42-49
-
-
Tanaka, H.1
Arakawa, H.2
Yamaguchi, T.3
-
29
-
-
0037374051
-
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits
-
Xue L, Zhou B, Liu X, et al. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits. Cancer Res. 2003;63: 980-986.
-
(2003)
Cancer Res
, vol.63
, pp. 980-986
-
-
Xue, L.1
Zhou, B.2
Liu, X.3
-
30
-
-
0142250911
-
The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53
-
Zhou B, Liu X, Mo X, et al. The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53. Cancer Res. 2003;63:6583-6594.
-
(2003)
Cancer Res
, vol.63
, pp. 6583-6594
-
-
Zhou, B.1
Liu, X.2
Mo, X.3
|