메뉴 건너뛰기




Volumn 23, Issue 4, 2013, Pages 659-666

Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in ovarian cancer

Author keywords

Apoptosis; Cisplatin resistance; Gene silencing; Ovarian cancer; Ribonucleotide reductase M2; RNA interference

Indexed keywords

CISPLATIN; GEMCITABINE; LIPOFECTAMINE; MESSENGER RNA; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE M2 SUBUNIT; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84879909379     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e318287e2b3     Document Type: Article
Times cited : (21)

References (25)
  • 2
    • 42249094731 scopus 로고    scopus 로고
    • Pharmaceutical management of ovarian cancer: Current status
    • Markman M. Pharmaceutical management of ovarian cancer: current status. Drugs. 2008;68:771-789.
    • (2008) Drugs , vol.68 , pp. 771-789
    • Markman, M.1
  • 3
    • 40849139532 scopus 로고    scopus 로고
    • Second-line randomized trials in epithelial ovarian cancer
    • suppl 1)
    • Vermorken JB. Second-line randomized trials in epithelial ovarian cancer. Int J Gynecol Cancer. 2008;18(suppl 1):59-66.
    • (2008) Int J Gynecol Cancer , vol.18 , pp. 59-66
    • Vermorken, J.B.1
  • 4
    • 0021908232 scopus 로고
    • Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells
    • Thelander M, Graslund A, Thelander L. Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells. J Biol Chem. 1985;260:2737-2741.
    • (1985) J Biol Chem , vol.260 , pp. 2737-2741
    • Thelander, M.1    Graslund, A.2    Thelander, L.3
  • 6
    • 0019819578 scopus 로고
    • Ribonucleotide reductase incultured mouse lymphoma cells. Cell cycle-dependent variation in the activity of subunit protein M2
    • Eriksson S, Martin DW Jr. Ribonucleotide reductase incultured mouse lymphoma cells. Cell cycle-dependent variation in the activity of subunit protein M2. J Biol Chem. 1981;256:9436-9440.
    • (1981) J Biol Chem , vol.256 , pp. 9436-9440
    • Eriksson, S.1    Martin Jr., D.W.2
  • 7
    • 60249091269 scopus 로고    scopus 로고
    • Regulation of p53 R2 and its role as potential target for cancer therapy
    • Wang X, Zhenchuk A, Wiman KG, et al. Regulation of p53 R2 and its role as potential target for cancer therapy. Cancer Lett. 2009;276:1-7.
    • (2009) Cancer Lett , vol.276 , pp. 1-7
    • Wang, X.1    Zhenchuk, A.2    Wiman, K.G.3
  • 8
    • 0022260274 scopus 로고
    • Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits
    • Engström Y, Eriksson S, Jildevik I, et al. Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits. J Biol Chem. 1985;260:9114-9116.
    • (1985) J Biol Chem , vol.260 , pp. 9114-9116
    • Engström, Y.1    Eriksson, S.2    Jildevik, I.3
  • 9
    • 70149119002 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of gemcitabine
    • Wong A, Soo RA, Yong WP, et al. Clinical pharmacology and pharmacogenetics of gemcitabine. Drug Metab Rev. 2009;41:77-88.
    • (2009) Drug Metab Rev , vol.41 , pp. 77-88
    • Wong, A.1    Soo, R.A.2    Yong, W.P.3
  • 10
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • Duxbury MS, Ito H, Zinner MJ, et al. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene. 2004;23:1539-1548.
    • (2004) Oncogene , vol.23 , pp. 1539-1548
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3
  • 11
    • 34447503264 scopus 로고    scopus 로고
    • Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas
    • Itoi T, Sofuni A, Fukushima N, et al. Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas. J Gastroenterol. 2007;42:389-394.
    • (2007) J Gastroenterol , vol.42 , pp. 389-394
    • Itoi, T.1    Sofuni, A.2    Fukushima, N.3
  • 12
    • 33846296549 scopus 로고    scopus 로고
    • RRM2 induces NF-kappaB-dependent MM P-9 activation and enhances cellular invasivenenss
    • Duxbury MS, Whang EE. RRM2 induces NF-kappaB-dependent MM P-9 activation and enhances cellular invasivenenss. Biochem Biophys Res Commun. 2007;354:190-196.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 190-196
    • Duxbury, M.S.1    Whang, E.E.2
  • 13
    • 33847417505 scopus 로고    scopus 로고
    • Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer
    • Liu X, Zhou B, Xue L, et al. Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. Clin Colorectal Cancer. 2007;6:374-381.
    • (2007) Clin Colorectal Cancer , vol.6 , pp. 374-381
    • Liu, X.1    Zhou, B.2    Xue, L.3
  • 14
    • 63849188689 scopus 로고    scopus 로고
    • Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: Implication of RRM2 in angiogenesis
    • Zhang K, Hu S, Wu J, et al. Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis. Mol Cancer. 2009;8:11.
    • (2009) Mol Cancer , vol.8 , pp. 11
    • Zhang, K.1    Hu, S.2    Wu, J.3
  • 15
    • 43649096317 scopus 로고    scopus 로고
    • Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine
    • Souglakos J, Boukovinas I, Taron M, et al. Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine. Br J Cancer. 2008;98:1710-1715.
    • (2008) Br J Cancer , vol.98 , pp. 1710-1715
    • Souglakos, J.1    Boukovinas, I.2    Taron, M.3
  • 16
    • 0032522647 scopus 로고    scopus 로고
    • The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation
    • Fan H, Villegas C, Huang A, et al. The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation. Cancer Res. 1998;58:1650-1653.
    • (1998) Cancer Res , vol.58 , pp. 1650-1653
    • Fan, H.1    Villegas, C.2    Huang, A.3
  • 17
    • 0030450403 scopus 로고    scopus 로고
    • Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential
    • Fan H, Villegas C, Wright JA. Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential. Proc Natl Acad Sci USA. 1996;93:14036-14040.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14036-14040
    • Fan, H.1    Villegas, C.2    Wright, J.A.3
  • 18
    • 0042173218 scopus 로고    scopus 로고
    • SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth
    • Filleur S, Courtin A, Ait-Si-Ali S, et al. SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth. Cancer Res. 2003;63:3919-3922.
    • (2003) Cancer Res , vol.63 , pp. 3919-3922
    • Filleur, S.1    Courtin, A.2    Ait-Si-Ali, S.3
  • 19
    • 0038756442 scopus 로고    scopus 로고
    • Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma
    • Li K, Lin SY, Brunicardi FC, et al. Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res. 2003;63:3593-3597.
    • (2003) Cancer Res , vol.63 , pp. 3593-3597
    • Li, K.1    Lin, S.Y.2    Brunicardi, F.C.3
  • 20
    • 0037526598 scopus 로고    scopus 로고
    • Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi)
    • Nieth C, Priebsch A, Stege A, et al. Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS Lett. 2003;545:144-150.
    • (2003) FEBS Lett , vol.545 , pp. 144-150
    • Nieth, C.1    Priebsch, A.2    Stege, A.3
  • 21
    • 3843087480 scopus 로고    scopus 로고
    • Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer
    • Duxbury MS, Ito H, Benoit E, et al. Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in pancreatic cancer. Surgery. 2004;136:261-269.
    • (2004) Surgery , vol.136 , pp. 261-269
    • Duxbury, M.S.1    Ito, H.2    Benoit, E.3
  • 22
    • 19044394312 scopus 로고    scopus 로고
    • Overview of ribonucleotide reductase inhibitors: An appealing target in anti-tumour therapy
    • Cerqueira NM, Pereira S, Fernandes PA, et al. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy. Curr Med Chem. 2005;12:1283-1294.
    • (2005) Curr Med Chem , vol.12 , pp. 1283-1294
    • Cerqueira, N.M.1    Pereira, S.2    Fernandes, P.A.3
  • 23
    • 84872031610 scopus 로고    scopus 로고
    • Overexpression of catalytic subunit M2 in patients with ovarian cancer
    • Wang LM, Lu FF, Zhang SY, et al. Overexpression of catalytic subunit M2 in patients with ovarian cancer. Chin Med J (Engl). 2012;125:2151-2156.
    • (2012) Chin Med J (Engl) , vol.125 , pp. 2151-2156
    • Wang, L.M.1    Lu, F.F.2    Zhang, S.Y.3
  • 24
    • 0009633094 scopus 로고    scopus 로고
    • Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter
    • He C. Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter. Cancer Lett. 1996;106:185-191.
    • (1996) Cancer Lett , vol.106 , pp. 185-191
    • He, C.1
  • 25
    • 0035735691 scopus 로고    scopus 로고
    • Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance
    • Zhou B, Mo X, Liu X, et al. Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance. Cytogenet Cell Genet. 2001;95:34-42. Science & Technology Commission
    • (2001) Cytogenet Cell Genet , vol.95 , pp. 34-42
    • Zhou, B.1    Mo, X.2    Liu, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.