AKAPs integrate genetic findings for autism spectrum disorders

Translational Psychiatry

Volumn 3, Issue , 2013, Pages

  Poelmans, G ^a,b   Franke, B ^a,b   Pauls, D L ^c   Glennon, J C ^a   Buitelaar, J K ^a  

^a RADBOUD UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

A kinase anchor proteins; Autism spectrum disorders; Genetics; Genome wide association studies

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MICRORNA;

ARTICLE; AUTISM; BIOINFORMATICS; CELL MEMBRANE; COPY NUMBER VARIATION; CYTOPLASM; EXOME; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE FUNCTION; GENE REPLICATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; LEYDIG CELL; MEDICAL LITERATURE; MUTATIONAL ANALYSIS; NERVE FIBER GROWTH; PROTEIN TARGETING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STEROIDOGENESIS; SYNAPTIC TRANSMISSION; UNTRANSLATED REGION; CHILD; FEMALE; GENE; GENETIC PREDISPOSITION; GENETICS; MALE; PHYSIOLOGY;

A KINASE ANCHOR PROTEINS; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; FEMALE; GENES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE;

EID: 84879908825     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2013.48     Document Type: Article

References (108)

1. Chakrabarti S, Fombonne E. Pervasive developmental disorders in preschool children: confirmation of high prevalence. Am J Psychiatry 2005; 162: 1133-1141. (Pubitemid 40770696)
2. Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006; 368: 210-215. (Pubitemid 44037796)
3. Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr Res 2009; 65: 591-598.
4. Volkmar FR, Pauls D. Autism. Lancet 2003; 362: 1133-1141. (Pubitemid 37222341)
5. Volkmar FR, Lord C, Bailey A, Schultz RT, Klin A. Autism and pervasive developmental disorders. J Child Psychol Psychiatry 2004; 45: 135-170. (Pubitemid 38196258)
6. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 1995; 25: 63-77.
7. Freitag CM. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol Psychiatry 2007; 12: 2-22. (Pubitemid 44973659)
8. Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008; 9: 341-355. (Pubitemid 351556064)
9. Freitag CM, Staal W, Klauck SM, Duketis E, Waltes R. Genetics of autistic disorders: review and clinical implications. Eur Child Adolesc Psychiatry 2010; 19: 169-178.
10. Betancur C. Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Res 2011; 1380: 42-77.
11. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 2009; 459: 528-533.
12. Ma D, Salyakina D, Jaworski JM, Konidari I, Whitehead PL, Andersen AN et al. A genome-wide association study of autism reveals a common novel risk locus at 5p14. Ann Hum Genet 2009; 73: 263-273.
13. Weiss LA, Arking DE, Brune CW, West K, O'Connor A, Hilton G et al. A genome-wide linkage and association scan reveals novel loci for autism. Nature 2009; 461: 802-808.
14. Salyakina D, Ma DQ, Jaworski JM, Konidari I, Whitehead PL, Henson R et al. Variants in several genomic regions associated with asperger disorder. Autism Res 2010; 3: 303-310.
15. Hussman JP, Chung RH, Griswold AJ, Jaworski JM, Salyakina D, Ma D et al. A noisereduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism. Mol Autism 2011; 2: 1.
16. Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR et al. A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet 2010; 19: 4072-4082.
17. Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH et al. Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics 2008; 9: 153-161.
18. Talebizadeh Z, Butler MG, Theodoro MF. Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res 2008; 1: 240-250.
19. Sarachana T, Zhou R, Chen G, Manji HK, Hu VW. Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Med 2010; 2: 23.
20. Ghahramani Seno MM, Hu P, Gwadry FG, Pinto D, Marshall CR, Casallo G et al. Gene and miRNA expression profiles in autism spectrum disorders. Brain Res 2011; 1380: 85-97.
21. Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C et al. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2009; 2: 157-177.
22. Hu VW, Nguyen A, Kim KS, Steinberg ME, Sarachana T, Scully MA et al. Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. PLoS One 2009; 4: e5775.
23. Piton A, Gauthier J, Hamdan FF, Lafrenière RG, Yang Y, Henrion E et al. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Mol Psychiatry 2011; 16: 867-880.
24. Cuscó I, Medrano A, Gener B, Vilardell M, Gallastegui F, Villa O et al. Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder. Hum Mol Genet 2009; 18: 1795-1804.
25. Gilman SR, Iossifov I, Levy D, Ronemus M, Wigler M, Vitkup D. Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 2011; 70: 898-907.
26. Veyrieras JB, Kudaravalli S, Kim SY, Dermitzakis ET, Gilad Y, Stephens M et al. Highresolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet 2008; 4: e1000214.
27. Gherman A, Wang R, Avramopoulos D. Orientation, distance, regulation and function of neighbouring genes. Hum Genomics 2009; 3: 143-156.
28. Pickrell JK, Marioni JC, Pai AA, Degner JF, Engelhardt BE, Nkadori E et al. Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature 2010; 464: 768-772.
29. Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet 2010; 6: e1000888.
30. O'Roak BJ, Deriziotis P, Lee C, Vives L, Schwartz JJ, Girirajan S et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nat Genet 2011; 43: 585-589.
31. Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ,Willsey AJ et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 2012; 485: 237-241.
32. Neale BM, Kou Y, Liu L, Ma'ayan A, Samocha KE, Sabo A et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 2012; 485: 242-245.
33. O'Roak BJ, Vives L, Girirajan S, Karakoc E, Krumm N, Coe BP et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 2012; 485: 246-250.
34. Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J et al. De novo gene disruptions in children on the autistic spectrum. Neuron 2012; 74: 285-299.
35. Tan GC, Doke TF, Ashburner J, Wood NW, Frackowiak RS. Normal variation in frontooccipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. Neuroimage 2010; 53: 1030-1042.
36. Scott-Van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, Ghahremani D et al. Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci Transl Med 2010; 2: 56ra80.
37. Campbell DB, Warren D, Sutcliffe JS, Lee EB, Levitt P. Association of MET with social and communication phenotypes in individuals with autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet 2010; 153B: 438-446.
38. Campbell DB, D'Oronzio R, Garbett K, Ebert PJ, Mirnics K, Levitt P et al. Disruption of cerebral cortex MET signaling in autism spectrum disorder. Ann Neurol 2007; 62: 243-250. (Pubitemid 47525400)
39. Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y et al. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet 2008; 82: 199-207. (Pubitemid 351735950)
40. Glessner JT, Wang K, Cai G, Korvatska O, Kim CE, Wood S et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 2009; 459: 569-573.
41. Holmans P, Green EK, Pahwa JS, Ferreira MA, Purcell SM, Sklar P et al. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet 2009; 85: 13-24.
42. Strachan T, Read AP. Human Molecular Genetics. Garland Publishing: New York, USA, 2004. p 253.
43. Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010; 467: 832-838.
44. Lee SH, Decandia TR, Ripke S, Yang J, Sullivan PF, Goddard ME et al. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 2012; 44: 247-250.
45. Auyeung B, Taylor K, Hackett G, Baron-Cohen S. Foetal testosterone and autistic traits in 18 to 24-month-old children. Mol Autism 2010; 1: 11.
46. Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E et al. Sexspecific serum biomarker patterns in adults with Asperger's syndrome. Mol Psychiatry 2011; 16: 1213-1220.
47. Schipul SE, Keller TA, Just MA. Inter-regional brain communication and its disturbance in autism. Front Syst Neurosci 2011; 5: 10.
48. French L, Pavlidis P. Relationships between gene expression and brain wiring in the adult rodent brain. PLoS Comput Biol 2011; 7: e1001049.
49. Poelmans G, Buitelaar JK, Pauls DL, Franke B. A theoretical molecular network for dyslexia: integrating available genetic findings. Mol Psychiatry 2011; 16: 365-382.
50. Poelmans G, Pauls DL, Buitelaar JK, Franke B. Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder. Am J Psychiatry 2011; 168: 365-377.
51. Chadwick O, Taylor E, Taylor A, Heptinstall E, Danckaerts M. Hyperactivity and reading disability: a longitudinal study of the nature of the association. J Child Psychol Psychiatry 1999; 40: 1039-1050. (Pubitemid 29481611)
52. Jones CR, Happé F, Golden H, Marsden AJ, Tregay J, Simonoff E et al. Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainment. Neuropsychology 2009; 23: 718-728.
53. Miniscalco C, Dahlgren SA. Basic reading skills in Swedish children with late developing language and with or without autism spectrum disorder or ADHD. Res Dev Disabil 2010; 31: 1054-1061.
54. Rommelse NN, Franke B, Geurts HM, Hartman CA, Buitelaar JK. Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry 2010; 19: 281-295.
55. Penzes P, Cahill ME, Jones KA, Vanleeuwen JE, Woolfrey KM. Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci 2011; 14: 285-293.
56. Ingason A, Kirov G, Giegling I, Hansen T, Isles AR, Jakobsen KD et al. Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness. Am J Psychiatry 2011; 168: 408-417.
57. Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ. Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells. J Neurosci Res 2009; 87: 2245-2254.
58. Martin LA, Goldowitz D, Mittleman G. Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci 2010; 31: 544-555.
59. Skroblin P, Grossmann S, Schafer G, Rosenthal W, Klussmann E. Mechanisms of protein kinase a anchoring. Int Rev Cell Mol Biol 2010; 283: 235-330.
60. Konopka G, Wexler E, Rosen E, Mukamel Z, Osborn GE, Chen L et al. Modeling the functional genomics of autism using human neurons. Mol Psychiatry 2012; 17: 202-214.
61. Lin M, Pedrosa E, Shah A, Hrabovsky A, Maqbool S, Zheng D et al. RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS One 2011; 6: e23356.
62. Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet 2012; 131: 565-579.
63. Griswold AJ, Ma D, Cukier HN, Nations LD, Schmidt MA, Chung RH et al. Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder associated pathways. Hum Mol Genet 2012; 21: 3513-3523.
64. Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011; 70: 863-885.
65. Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J et al. Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet 2008; 82: 477-488.
66. Prasad A, Merico D, Thiruvahindrapuram B, Wei J, Lionel AC, Sato D et al. A discovery resource of rare copy number variations in individuals with autism spectrum disorder. G3 (Bethesda) 2012; 2: 1665-1685.
67. Rosenfeld JA, Ballif BC, Torchia BS, Sahoo T, Ravnan JB, Schultz R et al. Copy number variations associated with autism spectrum disorders contribute to a spectrum of neurodevelopmental disorders. Genet Med 2010; 12: 694-702.
68. Bremer A, Giacobini M, Eriksson M, Gustavsson P, Nordin V, Fernell E et al. Copy number variation characteristics in subpopulations of patients with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 2011; 156: 115-124.
69. Potocki L, Bi W, Treadwell-Deering D, Carvalho CM, Eifert A, Friedman EM et al. Characterization of Potocki-Lupski syndrome (dup(17)(p11.2p11.2)) and delineation of a dosage-sensitive critical interval that can convey an autism phenotype. Am J Hum Genet 2007; 80: 633-649. (Pubitemid 46564401)
70. Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2010; 466: 368-372.
71. Kaya N, Colak D, Albakheet A, Al-Owain M, Abu-Dheim N, Al-Younes B et al. A novel X-linked disorder with developmental delay and autistic features. Ann Neurol 2012; 71: 498-508.
72. Celestino-Soper PB, Shaw CA, Sanders SJ, Li J, Murtha MT, Ercan-Sencicek AG et al. Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE. Hum Mol Genet 2011; 20: 4360-4370.
73. Castermans D, Volders K, Crepel A, Backx L, De Vos R, Freson K et al. SCAMP5, NBEA and AMISYN: three candidate genes for autism involved in secretion of large dense-core vesicles. Hum Mol Genet 2010; 19: 1368-1378.
74. Barrett S, Beck JC, Bernier R, Bisson E, Braun TA, Casavant TL et al. An autosomal genomic screen for autism. Collaborative linkage study of autism. Am J Med Genet 1999; 88: 609-615.
75. Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 2011; 474: 380-384.
76. Mukaetova-Ladinska EB, Arnold H, Jaros E, Perry R, Perry E. Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals. Neuropathol Appl Neurobiol 2004; 30: 615-623. (Pubitemid 39564181)
77. Royland JE, Kodavanti PR. Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action. Toxicol Appl Pharmacol 2008; 231: 179-196.
78. Jolous-Jamshidi B, Cromwell HC, McFarland AM, Meserve LA. Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats. Toxicol Lett 2010; 199: 136-143.
79. Nuytens K, Gantois I, Stijnen P, Iscru E, Laeremans A, Serneels L et al. Haploinsufficiency of the autism candidate gene Neurobeachin induces autism-like behaviors and affects cellular and molecular processes of synaptic plasticity in mice. Neurobiol Dis 2012; 51: 144-151.
80. Hu VW, Addington A, Hyman A. Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS data. PLoS One 2011; 6: e19067.
81. St Pourcain B, Wang K, Glessner JT, Golding J, Steer C, Ring SM et al. Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population. Am J Psychiatry 2010; 167: 1364-1372.
82. Wilgenbus KK, Hsieh CL, Lankes WT, Milatovich A, Francke U, Furthmayr H. Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN). Genomics 1994; 19: 326-333. (Pubitemid 24059325)
83. Kerin T, Ramanathan A, Rivas K, Grepo N, Coetzee GA, Campbell DB. A noncoding RNA antisense to moesin at 5p14.1 in autism. Sci Transl Med 2012; 4: 128ra40.
84. Kim SH, Serezani CH, Okunishi K, Zaslona Z, Aronoff DM, Peters-Golden M. Distinct protein kinase a anchoring proteins direct prostaglandin E2 modulation of toll-like receptor signaling in alveolar macrophages. J Biol Chem 2011; 286: 8875-8883.
85. Shibolet O, Giallourakis C, Rosenberg I, Mueller T, Xavier RJ, Podolsky DK. AKAP13, a RhoAGTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling. J Biol Chem 2007; 282: 35308-35317. (Pubitemid 350232485)
86. Zawawi KH, Kantarci A, Schulze-Späte U, Fujita T, Batista EL Jr, Amar S et al. Moesininduced signaling in response to lipopolysaccharide in macrophages. J Periodontal Res 2010; 45: 589-601.
87. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H. Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J Neuroinflammation 2008; 5: 52.
88. Gupta S, Samra D, Agrawal S. Adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin. J Clin Immunol 2010; 30: S90-S96.
89. Koch M, Korf HW. Distribution of regulatory subunits of protein kinase A and A kinase anchor proteins (AKAP 95, 150) in rat pinealocytes. Cell Tissue Res 2002; 310: 331-338. (Pubitemid 35435777)
90. Melke J, Goubran Botros H, Chaste P, Betancur C, Nygren G, Anckarsäter H et al. Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry 2008; 13: 90-98. (Pubitemid 350275181)
91. Rossignol DA. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann Clin Psychiatry 2009; 21: 213-236.
92. Liu J, Hu JY, Schacher S, Schwartz JH. The two regulatory subunits of aplysia cAMP-dependent protein kinase mediate distinct functions in producing synaptic plasticity. J Neurosci 2004; 24: 2465-2474. (Pubitemid 38327960)
93. Gé nin A, French P, Doyère V, Davis S, Errington ML, Maroun M et al. LTP but not seizure is associated with up-regulation of AKAP-150. Eur J Neurosci 2003; 17: 331-340. (Pubitemid 36459513)
94. Smith KE, Gibson ES, Dell'Acqua ML. cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J Neurosci 2006; 26: 2391-2402. (Pubitemid 44698998)
95. Cantrell AR, Tibbs VC, Westenbroek RE, Scheuer T, Catterall WA. Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase. J Neurosci 1999; 19: RC21.
96. Cantrell AR, Tibbs VC, Yu FH, Murphy BJ, Sharp EM, Qu Y et al. Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol Cell Neurosci 2002; 21: 63-80. (Pubitemid 35178500)
97. Tarazi FI, Baldessarini RJ, Kula NS, Zhang K. Long-term effects of olanzapine, risperidone, and quetiapine on ionotropic glutamate receptor types: implications for antipsychotic drug treatment. J Pharmacol Exp Ther 2003; 306: 1145-1151. (Pubitemid 37025325)
98. Pehek EA, Nocjar C, Roth BL, Byrd TA, Mabrouk OS. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology 2006; 31: 265-277. (Pubitemid 43113392)
99. Kuroki T, Nagao N, Nakahara T. Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis. Prog Brain Res 2008; 172: 199-212.
100. Law AJ, Hutchinson LJ, Burnet PW, Harrison PJ. Antipsychotics increase microtubuleassociated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex. J Neurosci Res 2004; 76: 376-382. (Pubitemid 38580132)
101. Alimohamad H, Rajakumar N, Seah YH, Rushlow W. Antipsychotics alter the protein expression levels of beta-catenin and GSK-3 in the rat medial prefrontal cortex and striatum. Biol Psychiatry 2005; 57: 533-542. (Pubitemid 40311989)
102. Quincozes-Santos A, Abib RT, Leite MC, Bobermin D, Bambini-Junior V, Gonçalves CA et al. Effect of the atypical neuroleptic risperidone on morphology and S100B secretion in C6 astroglial lineage cells. Mol Cell Biochem 2008; 314: 59-63.
103. Lenz KM, Wright CL, Martin RC, McCarthy MM. Prostaglandin E regulates AMPA receptor phosphorylation and promotes membrane insertion in preoptic area neurons and glia during sexual differentiation. PLoS One 2011; 6: e18500.
104. Dean SL, McCarthy MM. Steroids, sex and the cerebellar cortex: implications for human disease. Cerebellum 2008; 7: 38-47.
105. Stoffel-Wagner B. Neurosteroid biosynthesis in the human brain and its clinical implications. Ann NY Acad Sci 2003; 1007: 64-78. (Pubitemid 38253655)
106. Nie T, McDonough CB, Huang T, Nguyen PV, Abel T. Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. J Neurosci 2007; 27: 10278-10288. (Pubitemid 47450469)
107. Cheh MA, Millonig JH, Roselli LM, Ming X, Jacobsen E, Kamdar S et al. En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Brain Res 2006; 1116: 166-176. (Pubitemid 44485007)
108. Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C et al. Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci 2010; 30: 2115-2129.