메뉴 건너뛰기




Volumn 29, Issue 10, 2014, Pages 1895-1902

Current evidence for the role of complement in the pathogenesis of Shiga toxin haemolytic uraemic syndrome

Author keywords

Complement; Eculizumab; Haemolytic uraemic syndrome; Shiga toxin; Thrombotic microangiopathy

Indexed keywords


EID: 84879861848     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-013-2561-1     Document Type: Review
Times cited : (24)

References (68)
  • 1
    • 51549116628 scopus 로고    scopus 로고
    • Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS)
    • PID: 18704506
    • Scheiring J, Andreoli SP, Zimmerhackl LB (2008) Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS). Pediatr Nephrol 23:1749–1760
    • (2008) Pediatr Nephrol , vol.23 , pp. 1749-1760
    • Scheiring, J.1    Andreoli, S.P.2    Zimmerhackl, L.B.3
  • 2
    • 27744564894 scopus 로고    scopus 로고
    • Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion
    • PID: 15930195
    • Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI (2005) Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion. Pediatrics 115:e673–680
    • (2005) Pediatrics , vol.115 , pp. e673-e680
    • Ake, J.A.1    Jelacic, S.2    Ciol, M.A.3    Watkins, S.L.4    Murray, K.F.5    Christie, D.L.6    Klein, E.J.7    Tarr, P.I.8
  • 3
    • 84864402709 scopus 로고    scopus 로고
    • Thrombotic microangiopathy and associated renal disorders
    • PID: 22802583, COI: 1:CAS:528:DC%2BC38Xhtl2iu7bL
    • Barbour T, Johnson S, Cohney S, Hughes P (2012) Thrombotic microangiopathy and associated renal disorders. Nephrol Dial Transplant 27:2673–2685
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 2673-2685
    • Barbour, T.1    Johnson, S.2    Cohney, S.3    Hughes, P.4
  • 4
    • 0041411081 scopus 로고    scopus 로고
    • Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression
    • PID: 12966129, COI: 1:CAS:528:DC%2BD3sXnt1aju70%3D
    • Garg AX, Suri RS, Barrowman N, Rehman F, Matsell D, Rosas-Arellano MP, Salvadori M, Haynes RB, Clark WF (2003) Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression. JAMA 290:1360–1370
    • (2003) JAMA , vol.290 , pp. 1360-1370
    • Garg, A.X.1    Suri, R.S.2    Barrowman, N.3    Rehman, F.4    Matsell, D.5    Rosas-Arellano, M.P.6    Salvadori, M.7    Haynes, R.B.8    Clark, W.F.9
  • 7
    • 16244385269 scopus 로고    scopus 로고
    • Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination
    • PID: 15780100
    • Garg AX, Clark WF, Salvadori M, Macnab J, Suri RS, Haynes RB, Matsell D, Investigators WHS (2005) Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination. Kidney Int 67:1476–1482
    • (2005) Kidney Int , vol.67 , pp. 1476-1482
    • Garg, A.X.1    Clark, W.F.2    Salvadori, M.3    Macnab, J.4    Suri, R.S.5    Haynes, R.B.6    Matsell, D.7    Investigators, W.H.S.8
  • 10
    • 84867993202 scopus 로고    scopus 로고
    • Renal and neurological involvement in typical Shiga toxin-associated HUS
    • PID: 22986362, COI: 1:CAS:528:DC%2BC38XhsFOntbbL
    • Trachtman H, Austin C, Lewinski M, Stahl RA (2012) Renal and neurological involvement in typical Shiga toxin-associated HUS. Nat Rev Nephrol 8:658–669
    • (2012) Nat Rev Nephrol , vol.8 , pp. 658-669
    • Trachtman, H.1    Austin, C.2    Lewinski, M.3    Stahl, R.A.4
  • 12
    • 77957587756 scopus 로고    scopus 로고
    • Treatment of typical (enteropathic) hemolytic uremic syndrome
    • PID: 20865636, COI: 1:CAS:528:DC%2BC3cXhtFyit7vF
    • Bitzan M, Schaefer F, Reymond D (2010) Treatment of typical (enteropathic) hemolytic uremic syndrome. Semin Thromb Hemost 36:594–610
    • (2010) Semin Thromb Hemost , vol.36 , pp. 594-610
    • Bitzan, M.1    Schaefer, F.2    Reymond, D.3
  • 13
    • 84856505271 scopus 로고    scopus 로고
    • Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS)
    • PID: 22300510
    • Goldwater PN, Bettelheim KA (2012) Treatment of enterohemorrhagic Escherichia coli (EHEC) infection and hemolytic uremic syndrome (HUS). BMC Med 10:12
    • (2012) BMC Med , vol.10 , pp. 12
    • Goldwater, P.N.1    Bettelheim, K.A.2
  • 14
    • 71449117854 scopus 로고    scopus 로고
    • Clinical practice. Today’s understanding of the haemolytic uraemic syndrome
    • PID: 19707787
    • Scheiring J, Rosales A, Zimmerhackl LB (2010) Clinical practice. Today’s understanding of the haemolytic uraemic syndrome. Eur J Pediatr 169:7–13
    • (2010) Eur J Pediatr , vol.169 , pp. 7-13
    • Scheiring, J.1    Rosales, A.2    Zimmerhackl, L.B.3
  • 15
    • 84867911677 scopus 로고    scopus 로고
    • Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies
    • PID: 22888220, COI: 1:CAS:528:DC%2BC38XhtFeju7jF
    • Keir LS, Marks SD, Kim JJ (2012) Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies. Drug Des Devel Ther 6:195–208
    • (2012) Drug Des Devel Ther , vol.6 , pp. 195-208
    • Keir, L.S.1    Marks, S.D.2    Kim, J.J.3
  • 16
    • 41749101957 scopus 로고    scopus 로고
    • Pathogenesis of thrombotic microangiopathies
    • PID: 18215115, COI: 1:CAS:528:DC%2BD1cXjsFersL8%3D
    • Zheng XL, Sadler JE (2008) Pathogenesis of thrombotic microangiopathies. Annu Rev Pathol 3:249–277
    • (2008) Annu Rev Pathol , vol.3 , pp. 249-277
    • Zheng, X.L.1    Sadler, J.E.2
  • 17
    • 0035722282 scopus 로고    scopus 로고
    • Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura
    • PID: 11532079, COI: 1:CAS:528:DC%2BD3MXmvFKjtrY%3D
    • Ruggenenti P, Noris M, Remuzzi G (2001) Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 60:831–846
    • (2001) Kidney Int , vol.60 , pp. 831-846
    • Ruggenenti, P.1    Noris, M.2    Remuzzi, G.3
  • 18
    • 79954441390 scopus 로고    scopus 로고
    • Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
    • PID: 20949284
    • Keir L, Coward RJ (2011) Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy. Pediatr Nephrol 26:523–533
    • (2011) Pediatr Nephrol , vol.26 , pp. 523-533
    • Keir, L.1    Coward, R.J.2
  • 19
    • 70350279315 scopus 로고    scopus 로고
    • Atypical hemolytic uremic syndrome
    • PID: 19846853, COI: 1:CAS:528:DC%2BD1MXhtlWgs77J
    • Noris M, Remuzzi G (2009) Atypical hemolytic uremic syndrome. N Engl J Med 361:1676–1687
    • (2009) N Engl J Med , vol.361 , pp. 1676-1687
    • Noris, M.1    Remuzzi, G.2
  • 21
    • 59449088846 scopus 로고    scopus 로고
    • Eculizumab for congenital atypical hemolytic-uremic syndrome
    • PID: 19179329, COI: 1:CAS:528:DC%2BD1MXht1aiurw%3D
    • Gruppo RA, Rother RP (2009) Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360:544–546
    • (2009) N Engl J Med , vol.360 , pp. 544-546
    • Gruppo, R.A.1    Rother, R.P.2
  • 23
    • 84855256386 scopus 로고    scopus 로고
    • Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?
    • PID: 21852019, COI: 1:CAS:528:DC%2BC38XhtFCqsg%3D%3D
    • Johnson S, Waters A (2012) Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome? Immunobiology 217:235–243
    • (2012) Immunobiology , vol.217 , pp. 235-243
    • Johnson, S.1    Waters, A.2
  • 24
    • 84867000608 scopus 로고    scopus 로고
    • Complement genetics, deficiencies, and disease associations
    • PID: 22773339, COI: 1:CAS:528:DC%2BC38XpvFeluro%3D
    • Mayilyan KR (2012) Complement genetics, deficiencies, and disease associations. Protein Cell 3:487–496
    • (2012) Protein Cell , vol.3 , pp. 487-496
    • Mayilyan, K.R.1
  • 28
    • 84865428866 scopus 로고    scopus 로고
    • Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway
    • PID: 22802338, COI: 1:CAS:528:DC%2BC38Xhtlalu77O
    • Krisinger MJ, Goebeler V, Lu Z, Meixner SC, Myles T, Pryzdial EL, Conway EM (2012) Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway. Blood 120:1717–1725
    • (2012) Blood , vol.120 , pp. 1717-1725
    • Krisinger, M.J.1    Goebeler, V.2    Lu, Z.3    Meixner, S.C.4    Myles, T.5    Pryzdial, E.L.6    Conway, E.M.7
  • 30
    • 77954313737 scopus 로고    scopus 로고
    • Complement activation on platelets: implications for vascular inflammation and thrombosis
    • PID: 20621693, COI: 1:CAS:528:DC%2BC3cXpslSqs7c%3D
    • Peerschke EI, Yin W, Ghebrehiwet B (2010) Complement activation on platelets: implications for vascular inflammation and thrombosis. Mol Immunol 47:2170–2175
    • (2010) Mol Immunol , vol.47 , pp. 2170-2175
    • Peerschke, E.I.1    Yin, W.2    Ghebrehiwet, B.3
  • 31
    • 73349110958 scopus 로고    scopus 로고
    • Platelet-associated complement factor H in healthy persons and patients with atypical HUS
    • PID: 19704120, COI: 1:CAS:528:DC%2BD1MXhsVGrsLnM
    • Licht C, Pluthero FG, Li L, Christensen H, Habbig S, Hoppe B, Geary DF, Zipfel PF, Kahr WH (2009) Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood 114:4538–4545
    • (2009) Blood , vol.114 , pp. 4538-4545
    • Licht, C.1    Pluthero, F.G.2    Li, L.3    Christensen, H.4    Habbig, S.5    Hoppe, B.6    Geary, D.F.7    Zipfel, P.F.8    Kahr, W.H.9
  • 32
    • 0018851755 scopus 로고
    • The complement system in hemolytic-uremic syndrome in childhood
    • PID: 7379368, COI: 1:STN:280:DyaL3c3gtVGjug%3D%3D
    • Monnens L, Molenaar J, Lambert PH, Proesmans W, van Munster P (1980) The complement system in hemolytic-uremic syndrome in childhood. Clin Nephrol 13:168–171
    • (1980) Clin Nephrol , vol.13 , pp. 168-171
    • Monnens, L.1    Molenaar, J.2    Lambert, P.H.3    Proesmans, W.4    van Munster, P.5
  • 33
    • 0017595341 scopus 로고
    • Breakdown products of C3 and factor B in hemolytic-uremic syndrome
    • PID: 845484, COI: 1:CAS:528:DyaE2sXhvVOiu78%3D
    • Kim Y, Miller K, Michael AF (1977) Breakdown products of C3 and factor B in hemolytic-uremic syndrome. J Lab Clin Med 89:845–850
    • (1977) J Lab Clin Med , vol.89 , pp. 845-850
    • Kim, Y.1    Miller, K.2    Michael, A.F.3
  • 34
    • 0026666338 scopus 로고
    • Hypocomplementemia and leukocytosis in diarrhea-associated hemolytic uremic syndrome
    • PID: 1436342, COI: 1:STN:280:DyaK3s%2FmtlKntA%3D%3D
    • Robson WL, Leung AK, Fick GH, McKenna AI (1992) Hypocomplementemia and leukocytosis in diarrhea-associated hemolytic uremic syndrome. Nephron 62:296–299
    • (1992) Nephron , vol.62 , pp. 296-299
    • Robson, W.L.1    Leung, A.K.2    Fick, G.H.3    McKenna, A.I.4
  • 36
    • 79956293593 scopus 로고    scopus 로고
    • Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome
    • PID: 21447825
    • Ståhl AL, Sartz L, Karpman D (2011) Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome. Blood 117:5503–5513
    • (2011) Blood , vol.117 , pp. 5503-5513
    • Ståhl, A.L.1    Sartz, L.2    Karpman, D.3
  • 37
    • 70349180857 scopus 로고    scopus 로고
    • Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome
    • PID: 19750223
    • Ståhl AL, Sartz L, Nelsson A, Békássy ZD, Karpman D (2009) Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. PLoS One 4:e6990
    • (2009) PLoS One , vol.4 , pp. e6990
    • Ståhl, A.L.1    Sartz, L.2    Nelsson, A.3    Békássy, Z.D.4    Karpman, D.5
  • 38
    • 38349172121 scopus 로고    scopus 로고
    • Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome
    • PID: 17914026, COI: 1:CAS:528:DC%2BD1cXns1CnsQ%3D%3D
    • Fang CJ, Fremeaux-Bacchi V, Liszewski MK, Pianetti G, Noris M, Goodship TH, Atkinson JP (2008) Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood 111:624–632
    • (2008) Blood , vol.111 , pp. 624-632
    • Fang, C.J.1    Fremeaux-Bacchi, V.2    Liszewski, M.K.3    Pianetti, G.4    Noris, M.5    Goodship, T.H.6    Atkinson, J.P.7
  • 43
    • 0032766678 scopus 로고    scopus 로고
    • Markers of endothelial cell activation and injury in childhood haemolytic uraemic syndrome
    • PID: 10452276, COI: 1:STN:280:DyaK1MznvFentw%3D%3D
    • Nevard CH, Blann AD, Jurd KM, Haycock GB, Hunt BJ (1999) Markers of endothelial cell activation and injury in childhood haemolytic uraemic syndrome. Pediatr Nephrol 13:487–492
    • (1999) Pediatr Nephrol , vol.13 , pp. 487-492
    • Nevard, C.H.1    Blann, A.D.2    Jurd, K.M.3    Haycock, G.B.4    Hunt, B.J.5
  • 44
    • 84866544002 scopus 로고    scopus 로고
    • Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice
    • PID: 22942429, COI: 1:CAS:528:DC%2BC38XhtlOmurjN
    • Zoja C, Locatelli M, Pagani C, Corna D, Zanchi C, Isermann B, Remuzzi G, Conway EM, Noris M (2012) Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice. J Immunol 189:3661–3668
    • (2012) J Immunol , vol.189 , pp. 3661-3668
    • Zoja, C.1    Locatelli, M.2    Pagani, C.3    Corna, D.4    Zanchi, C.5    Isermann, B.6    Remuzzi, G.7    Conway, E.M.8    Noris, M.9
  • 45
    • 0036419885 scopus 로고    scopus 로고
    • Differential tissue targeting and pathogenesis of verotoxins 1 and 2 in the mouse animal model
    • PID: 12164865, COI: 1:CAS:528:DC%2BD38XntFSrsr8%3D
    • Rutjes NW, Binnington BA, Smith CR, Maloney MD, Lingwood CA (2002) Differential tissue targeting and pathogenesis of verotoxins 1 and 2 in the mouse animal model. Kidney Int 62:832–845
    • (2002) Kidney Int , vol.62 , pp. 832-845
    • Rutjes, N.W.1    Binnington, B.A.2    Smith, C.R.3    Maloney, M.D.4    Lingwood, C.A.5
  • 46
    • 33845243385 scopus 로고    scopus 로고
    • A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease
    • PID: 17082244, COI: 1:CAS:528:DC%2BD28XhtlGiu7bN
    • Keepers TR, Psotka MA, Gross LK, Obrig TG (2006) A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease. J Am Soc Nephrol 17:3404–3414
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3404-3414
    • Keepers, T.R.1    Psotka, M.A.2    Gross, L.K.3    Obrig, T.G.4
  • 47
    • 83155175370 scopus 로고    scopus 로고
    • Plasma therapy for atypical haemolytic uraemic syndrome associated with heterozygous factor H mutations
    • PID: 21717289
    • Kim JJ, Goodship TH, Tizard J, Inward C (2011) Plasma therapy for atypical haemolytic uraemic syndrome associated with heterozygous factor H mutations. Pediatr Nephrol 26:2073–2076
    • (2011) Pediatr Nephrol , vol.26 , pp. 2073-2076
    • Kim, J.J.1    Goodship, T.H.2    Tizard, J.3    Inward, C.4
  • 48
    • 84858705735 scopus 로고    scopus 로고
    • Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange
    • PID: 22309967
    • Clark WF (2012) Thrombotic microangiopathy: current knowledge and outcomes with plasma exchange. Semin Dial 25:214–219
    • (2012) Semin Dial , vol.25 , pp. 214-219
    • Clark, W.F.1
  • 49
    • 79151471122 scopus 로고    scopus 로고
    • aHUS caused by complement dysregulation: new therapies on the horizon
    • PID: 20556434
    • Waters AM, Licht C (2011) aHUS caused by complement dysregulation: new therapies on the horizon. Pediatr Nephrol 26:41–57
    • (2011) Pediatr Nephrol , vol.26 , pp. 41-57
    • Waters, A.M.1    Licht, C.2
  • 50
    • 0023689035 scopus 로고
    • Treatment of the childhood haemolytic uraemic syndrome with plasma. A multicentre randomized controlled trial. The French Society of Paediatric Nephrology
    • PID: 3153025, COI: 1:STN:280:DyaK3M%2Fgt1Sntg%3D%3D
    • Loirat C, Sonsino E, Hinglais N, Jais JP, Landais P, Fermanian J (1988) Treatment of the childhood haemolytic uraemic syndrome with plasma. A multicentre randomized controlled trial. The French Society of Paediatric Nephrology. Pediatr Nephrol 2:279–285
    • (1988) Pediatr Nephrol , vol.2 , pp. 279-285
    • Loirat, C.1    Sonsino, E.2    Hinglais, N.3    Jais, J.P.4    Landais, P.5    Fermanian, J.6
  • 52
    • 58249107186 scopus 로고    scopus 로고
    • Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials
    • PID: 18950913
    • Michael M, Elliott EJ, Craig JC, Ridley G, Hodson EM (2009) Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials. Am J Kidney Dis 53:259–272
    • (2009) Am J Kidney Dis , vol.53 , pp. 259-272
    • Michael, M.1    Elliott, E.J.2    Craig, J.C.3    Ridley, G.4    Hodson, E.M.5
  • 53
    • 84857123086 scopus 로고    scopus 로고
    • Outbreak of hemolytic uremic syndrome caused by E. coli O104:H4 in Germany: a pediatric perspective
    • PID: 22160440
    • Kemper MJ (2012) Outbreak of hemolytic uremic syndrome caused by E. coli O104:H4 in Germany: a pediatric perspective. Pediatr Nephrol 27:161–164
    • (2012) Pediatr Nephrol , vol.27 , pp. 161-164
    • Kemper, M.J.1
  • 59
    • 84878501864 scopus 로고    scopus 로고
    • Treatment of typical hemolytic-uremic syndrome : Knowledge gained from analyses of the 2011 E. coli outbreak
    • COI: 1:STN:280:DC%2BC3s7mtFKitg%3D%3D
    • Menne J, Kielstein JT, Wenzel U, Stahl RA (2012) Treatment of typical hemolytic-uremic syndrome: Knowledge gained from analyses of the 2011 E. coli outbreak. Internist (Berl) 53:1420–1430
    • (2012) Internist (Berl) , vol.53 , pp. 1420-1430
    • Menne, J.1    Kielstein, J.T.2    Wenzel, U.3    Stahl, R.A.4
  • 64
    • 0034080984 scopus 로고    scopus 로고
    • Cytotoxic effect of Shiga toxin-1 on human glomerular epithelial cells
    • PID: 10844605, COI: 1:CAS:528:DC%2BD3cXkt1Cgtbk%3D
    • Hughes AK, Stricklett PK, Schmid D, Kohan DE (2000) Cytotoxic effect of Shiga toxin-1 on human glomerular epithelial cells. Kidney Int 57:2350–2359
    • (2000) Kidney Int , vol.57 , pp. 2350-2359
    • Hughes, A.K.1    Stricklett, P.K.2    Schmid, D.3    Kohan, D.E.4
  • 67
    • 4744342973 scopus 로고    scopus 로고
    • Decay-accelerating factor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-alpha/epsilon (PKCalpha/epsilon)-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A
    • PID: 15284224, COI: 1:CAS:528:DC%2BD2cXnvFWgsLw%3D
    • Mason JC, Steinberg R, Lidington EA, Kinderlerer AR, Ohba M, Haskard DO (2004) Decay-accelerating factor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-alpha/epsilon (PKCalpha/epsilon)-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A. J Biol Chem 279:41611–41618
    • (2004) J Biol Chem , vol.279 , pp. 41611-41618
    • Mason, J.C.1    Steinberg, R.2    Lidington, E.A.3    Kinderlerer, A.R.4    Ohba, M.5    Haskard, D.O.6
  • 68
    • 33744519950 scopus 로고    scopus 로고
    • Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    • PID: 16476743, COI: 1:CAS:528:DC%2BD28Xjt1Knsr8%3D
    • Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, Wiels J, Urano T, Tajima O, Furukawa K (2006) Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem 281:10230–10235
    • (2006) J Biol Chem , vol.281 , pp. 10230-10235
    • Okuda, T.1    Tokuda, N.2    Numata, S.3    Ito, M.4    Ohta, M.5    Kawamura, K.6    Wiels, J.7    Urano, T.8    Tajima, O.9    Furukawa, K.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.