The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain

Journal of Cell Science

Volumn 126, Issue 12, 2013, Pages 2571-2576

  Bader, R ^a   Sarraf Zadeh, L ^b   Peters, M ^a   Moderau, N ^a   Stocker, H ^b   Ko hler K ^b   Pankratz, M J ^a   Hafen, E ^b  

^a UNIVERSITY OF BONN   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Brain; Drosophila; Imp L2; Insulin signaling

Indexed keywords

BINDING PROTEIN; BINDING PROTEIN IMP L2; INSULIN; NERVE PROTEIN; NERVE PROTEIN DILP2; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 7; UNCLASSIFIED DRUG;

ARTICLE; BRAIN CELL; DROSOPHILA; FETUS; FLUORESCENCE MICROSCOPY; INSULIN PRODUCING CELL; INSULIN SIGNALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BRAIN; DROSOPHILA; IMP-L2; INSULIN SIGNALING;

ANIMALS; BRAIN; DROSOPHILA; DROSOPHILA PROTEINS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; LARVA; MORPHOGENESIS; NEURONS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84879857522     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.120261     Document Type: Article

References (27)

1. Arai, T., Parker, A., Busby, W., Jr and Clemmons, D. R. (1994). Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes. J. Biol. Chem. 269, 20388- 20393.
2. Arai, T., Clarke, J., Parker, A., Busby, W., Jr, Nam, T. and Clemmons, D. R. (1996). Substitution of specific amino acids in insulin-like growth factor (IGF) binding protein 5 alters heparin binding and its change in affinity for IGF-I response to heparin. J. Biol. Chem. 271, 6099-6106.
3. Bischof, J., Maeda, R. K., Hediger, M., Karch, F. and Basler, K. (2007). An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc. Natl. Acad. Sci. USA 104, 3312-3317.
4. Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R. and Hafen, E. (2001). An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11, 213-221.
5. Colombani, J., Andersen, D. S. and Léopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 336, 582- 585.
6. Edgar, B. A. (2006). How flies get their size: genetics meets physiology. Nat. Rev. Genet. 7, 907-916.
7. Garelli, A., Gontijo, A. M., Miguela, V., Caparros, E. and Dominguez, M. (2012). Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Science 336, 579-582.
8. Geminard, C., Arquier, N., Layalle, S., Bourouis, M., Slaidina, M., Delanoue, R., Bjordal, M., Ohanna, M., Ma, M., Colombani, J. et al. (2006). Control of metabolism and growth through insulin-like peptides in Drosophila. Diabetes 55 Suppl, S5-S8.
9. Géminard, C., Rulifson, E. J. and Léopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10, 199-207.
10. Gordon, M. D. and Scott, K. (2009). Motor control in a Drosophila taste circuit. Neuron 61, 373-384.
11. Grönke, S., Müller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., Jäckle, H. and Kühnlein, R. P. (2007). Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol. 5, e137.
12. Honegger, B., Galic, M., Köhler, K., Wittwer, F., Brogiolo, W., Hafen, E. and Stocker, H. (2008). Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J. Biol. 7, 10.
13. Hsu, D. and Olefsky, J. M. (1992). Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells. J. Biol. Chem. 267, 25576-25582.
14. Hwa, V., Oh, Y. and Rosenfeld, R. G. (1999). The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr. Rev. 20, 761-787.
15. Ikeya, T., Galic, M., Belawat, P., Nairz, K. and Hafen, E. (2002). Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12, 1293-1300.
16. Jones, J. I. and Clemmons, D. R. (1995). Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16, 3-34.
17. Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. and Waterfield, M. D. (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15, 6584-6594.
18. McCusker, R. H., Camacho-Hubner, C., Bayne, M. L., Cascieri, M. A. and Clemmons, D. R. (1990). Insulin-like growth factor (IGF) binding to human fibroblast and glioblastoma cells: the modulating effect of cell released IGF binding proteins (IGFBPs). J. Cell. Physiol. 144, 244-253.
19. Melcher, C. and Pankratz, M. J. (2005). Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. PLoS Biol. 3, e305.
20. Parker, A., Rees, C., Clarke, J., Busby, W. H., Jr and Clemmons, D. R. (1998). Binding of insulin-like growth factor (IGF)-binding protein-5 to smooth-muscle cell extracellular matrix is a major determinant of the cellular response to IGF-I. Mol. Biol. Cell 9, 2383-2392.
21. Pfeiffer, B. D., Ngo, T. T., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W. and Rubin, G. M. (2010). Refinement of tools for targeted gene expression in Drosophila. Genetics 186, 735-755.
22. Rulifson, E. J., Kim, S. K. and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120.
23. Wang, T., Hung, C. C. and Randall, D. J. (2006). The comparative physiology of food deprivation: from feast to famine. Annu. Rev. Physiol. 68, 223-251.
24. Wittwer, F., Jaquenoud, M., Brogiolo, W., Zarske, M., Wüstemann, P., Fernandez, R., Stocker, H., Wymann, M. P. and Hafen, E. (2005). Susi, a negative regulator of Drosophila PI3-kinase. Dev. Cell 8, 817-827.
25. Wu, Q., Wen, T., Lee, G., Park, J. H., Cai, H. N. and Shen, P. (2003). Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron 39, 147-161.
26. Wu, Q., Zhao, Z. and Shen, P. (2005). Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems. Nat. Neurosci. 8, 1350-1355.
27. Yin, P., Xu, Q. and Duan, C. (2004). Paradoxical actions of endogenous and exogenous insulin-like growth factor-binding protein-5 revealed by RNA interference analysis. J. Biol. Chem. 279, 32660-32666.