Role of the nuclear receptor tailless in adult neural stem cells

Mechanisms of Development

Volumn 130, Issue 6-8, 2013, Pages 388-390

  Wang, Yu ^a   Liu, Hai Kun ^a   Schütz, Günther ^a  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

Author keywords

Neural stem cells; Neurogenesis; Subgranular zone; Subventricular zone; Tailless (Tlx)

Indexed keywords

CELL NUCLEUS RECEPTOR; PROTEIN TAILLESS; UNCLASSIFIED DRUG;

ADULT STEM CELL; DENTATE GYRUS; GENE REPRESSION; MOLECULAR INTERACTION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SUBGRANULAR ZONE; SUBVENTRICULAR ZONE;

EID: 84879845324     PISSN: 09254773     EISSN: 18726356     Source Type: Journal    
DOI: 10.1016/j.mod.2013.02.001     Document Type: Review

References (27)

1. Bain, D.L., Heneghan, A.F., Connaghan-Jones, K.D., Miura, M.T., 2007. Nuclear receptor structure: implications for function. Annu. Rev. Physiol. 69, 201220.
2. Chavali, P.L., Saini, R.K., Matsumoto, Y., Agren, H., Funa, K., 2011. Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia. J. Biol. Chem. 286, 9393-9404.
3. Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M., Alvarez- Buylla, A., 1999. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716.
4. Estruch, S.B., Buzon, V., Carbo, L.R., Schorova, L., Luders, J., Estebanez-Perpina, E., 2012. The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function. PLoS ONE 7, e37963.
5. Haecker, A., Qi, D., Lilja, T., Moussian, B., Andrioli, L.P., Luschnig, S., Mannervik, M., 2007. Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos. PLoS Biol. 5, e145.
6. Kee, N., Teixeira, C.M., Wang, A.H., Frankland, P.W., 2007. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci. 10, 355-362.
7. Li S., Sun, G., Murai, K., Ye, P., Shi, Y., 2012. Characterization of TLX expression in neural stem cells and progenitor cells in adult brains. PLoS ONE 7, e43324.
8. Liu, H.K., Belz, T., Bock, D., Takacs, A., Wu, H., Lichter, P., Chai, M., Schutz, G., 2008. The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. Genes Dev. 22, 2473-2478.
9. Liu, H.K., Wang, Y., Belz, T., Bock, D., Takacs, A., Radlwimmer, B., Barbus, S., Reifenberger, G., Lichter, P., Schutz, G., 2010. The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev. 24, 683-695.
10. Monaghan, A.P., Grau, E., Bock, D., Schutz, G., 1995. The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development 121, 839-853.
11. Moran, E., Jimenez, G., 2006. The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo. Mol. Cell. Biol. 26, 3446-3454.
12. Park, H.J., Kim, J.K., Jeon, H.M., Oh, S.Y., Kim, S.H., Nam, D.H., Kim, H., 2010. The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells. Mol. Cells 30, 403-408.
13. Pignoni, F., Baldarelli, R.M., Steingrimsson, E., Diaz, R.J., Patapoutian, A., Merriam, J.R., Lengyel, J.A., 1990. The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor super family. Cell 62, 151-163.
14. Qu, Q., Sun, G., Li, W., Yang, S., Ye, P., Zhao, C., Yu, R.T., Gage, F.H., Evans, R.M., Shi, Y., 2009. Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat. Cell Biol. 12 (Suppl. 1-9), 31-40.
15. Saxe, M.D., Battaglia, F., Wang, J.W., Malleret, G., David, D.J., Monckton, J.E., Garcia, A.D., Sofroniew, M.V., Kandel, E.R., Santarelli, L., Hen, R., Drew, M.R., 2006. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl. Acad. Sci. USA 103, 17501-17506.
16. Shi, Y., Chichung Lie, D., Taupin, P., Nakashima, K., Ray, J., Yu, R.T., Gage, F.H., Evans, R.M., 2004. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427, 78-83.
17. Snyder, J.S., Hong, N.S., McDonald, R.J., Wojtowicz, J.M., 2005. A role for adult neurogenesis in spatial long-term memory. Neuroscience 130, 843-852.
18. Sun, G., Alzayady, K., Stewart, R., Ye, P., Yang, S., Li, W., Shi, Y., 2010. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30, 1997-2005.
19. Sun, G., Ye, P., Murai, K., Lang, M.F., Li, S., Zhang, H., Li, W., Fu, C., Yin, J., Wang, A., Ma, X., Shi, Y., 2011. MiR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat. Commun. 2, 529.
20. Sun, G., Yu, R.T., Evans, R.M., Shi, Y., 2007. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc. Natl. Acad. Sci. USA 104, 15282-15287.
21. Wang, L., Rajan, H., Pitman, J.L., McKeown, M., Tsai, C.C., 2006. Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors. Genes Dev. 20, 525-530.
22. Yokoyama, A., Takezawa, S., Schule, R., Kitagawa, H., Kato, S., 2008. Transrepressive function of TLX requires the histone demethylase LSD1. Mol. Cell. Biol. 28 3995-4003.
23. Yu, R.T., Chiang, M.Y., Tanabe, T., Kobayashi, M., Yasuda, K., Evans, R.M., Umesono, K., 2000. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc. Natl. Acad. Sci. USA 97, 2621-2625.
24. Yu, R.T., McKeown, M., Evans, R.M., Umesono, K., 1994. Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx. Nature 370, 375-379.
25. Zhang, C.L., Zou, Y., He,W., Gage, F.H., Evans, R.M., 2008. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451, 1004-1007.
26. Zhang, C.L., Zou, Y., Yu, R.T., Gage, F.H., Evans, R.M., 2006. Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 20, 1308-1320.
27. Zhao, C., Deng, W., Gage, F.H., 2008. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645-660