Lactulose: An effective preventive and therapeutic option for ischemic stroke by production of hydrogen

Medical Gas Research

Volumn 2, Issue 1, 2012, Pages

  Chen, Xiao ^a   Zhai, Xiao ^b   Kang, Zhimin ^b   Sun, Xuejun ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

antioxidant; hydrogen; ischemia reperfusion; lactulose; stroke

Indexed keywords

5 ACETAMIDOSALICYLIC ACID; ACARBOSE; CURCUMIN; HYDROGEN; LACTULOSE;

ANTIOXIDANT ACTIVITY; BRAIN ISCHEMIA; CONCENTRATION RESPONSE; CONSTIPATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HEPATIC ENCEPHALOPATHY; HUMAN; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; TREATMENT RESPONSE;

EID: 84879839466     PISSN: None     EISSN: 20459912     Source Type: Journal    
DOI: 10.1186/2045-9912-2-3     Document Type: Review

References (35)

1. Stroke. Donnan GA, Fisher M, Macleod M, Davis SM, Lancet 2008 371 1612 1623 10.1016/S0140-6736(08)60694-7 18468545 (Pubitemid 351626845)
2. Rib metastasis revealing hepatocellular carcinoma. Soto S, Artaza T, Gomez R, Camacho FI, Rodriguez I, Gonzalez C, Potenciano JLM, Rodriguez R, Scand J Gastroenterol 2000 35 333 336 10.1080/003655200750024245 10766331 (Pubitemid 30217190)
3. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Murray CJ, Lopez AD, Lancet 1997 349 1269 1276 10.1016/S0140-6736(96)07493-4 9142060 (Pubitemid 27192468)
4. Mitochondria, oxidative metabolism and cell death in stroke. Sims NR, Muyderman H, Biochim Biophys Acta 1802 80 91
5. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Boveris A, Chance B, Biochem J 1973 134 707 716 4749271
6. Oxygen radicals in focal cerebral ischemia. Chan PH, Brain Pathol 1994 4 59 65 8025703 (Pubitemid 24077892)
7. Oxidative stress in acute ischemic stroke. Ozkul A, Akyol A, Yenisey C, Arpaci E, Kiylioglu N, Tataroglu C, J Clin Neurosci 2007 14 1062 1066 10.1016/j.jocn.2006.11.008 17884504 (Pubitemid 47588935)
8. Oxidative stress in ischaemic stroke. Nanetti L, Raffaelli F, Vignini A, Perozzi C, Silvestrini M, Bartolini M, Provinciali L, Mazzanti L, Eur J Clin Invest 2011
9. Neuroprotective effects of estrogens: potential mechanisms of action. Green PS, Simpkins JW, Int J Dev Neurosci 2000 18 347 358 10.1016/S0736-5748(00) 00017-4 10817919 (Pubitemid 30243066)
10. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S, Nat Med 2007 13 688 694 10.1038/nm1577 17486089 (Pubitemid 46889750)
11. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Matchett GA, Fathali N, Hasegawa Y, Jadhav V, Ostrowski RP, Martin RD, Dorotta IR, Sun X, Zhang JH, Brain Res 2009 1259 90 97 19168038
12. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Cai JM, Kang ZM, Liu K, Liu WW, Li RP, Zhang JH, Luo X, Sun XJ, Brain Research 2009 1256 129 137 19063869
13. Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Chen CW, Chen QB, Mao YF, Xu SM, Xia CY, Shi XY, Zhang JH, Yuan HB, Sun XJ, Neurochemical Research 2010 35 1111 1118 10.1007/s11064-010-0162-y 20354783
14. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Mao YF, Zheng XF, Cai JM, You XM, Deng XM, Zhang JH, Jiang L, Sun XJ, Biochem Biophys Res Commun 2009 381 602 605 10.1016/j.bbrc.2009.02.105 19249288
15. The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced by Ischemia-Reperfusion in Rats. Chen H, Sun YP, Hu PF, Liu WW, Xiang HG, Li Y, Yan RL, Su N, Ruan CP, Sun XJ, Wang QA, Journal of Surgical Research 2009 167 316 322 19932899
16. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Fukuda KI, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S, Biochemical and Biophysical Research Communications 2007 361 670 674 10.1016/j.bbrc.2007.07.088 17673169 (Pubitemid 47238041)
17. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, Makino S, Ohta S, Ogawa S, Fukuda K, Biochemical and Biophysical Research Communications 2008 373 30 35 10.1016/j.bbrc.2008.05.165 18541148
18. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Huang Y, Xie KL, Li JP, Xu N, Gong G, Wang GL, Yu YH, Dong HL, Xiong LZ, Brain Research 2010 1378 125 136 21195696
19. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Cai JM, Kang ZM, Liu WW, Luo X, Qiang S, Zhang JH, Ohta SG, Sun XJ, Xu WG, Tao HY, Li RP, Neuroscience Letters 2008 441 167 172 10.1016/j.neulet.2008. 05.077 18603371
20. Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, Temesvari P, Bart F, Pediatric Research 2010 68 387 392 20657346
21. The Effect of Hydrogen-Rich Saline on the Brain of Rats with Transient Ischemia. Ji Q, Hui KL, Zhang LD, Sun XJ, Li WY, Duan ML, Journal of Surgical Research 2010 168 95 E101
22. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappa B activation in a rat model of amyloid-beta-induced Alzheimer's disease. Wang C, Li JA, Liu QA, Yang R, Zhang JH, Cao YP, Sun XJ, Neuroscience Letters 2011 491 127 132 10.1016/j.neulet.2011.01.022 21238541
23. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Fu Y, Ito M, Fujita Y, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K, Neuroscience Letters 2009 453 81 85 10.1016/j.neulet.2009.02.016 19356598
24. Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M, Plos One 2009 4 DOI:e724710.721371/journal.pone.0007247
25. Production and excretion of hydrogen gas in man. Levitt MD, N Engl J Med 1969 281 122 127 10.1056/NEJM196907172810303 5790483
26. Birth-related increase in intracolonic hydrogen gas and nitric oxide as indicator of host-microbial interactions. Sobko T, Norman M, Norin E, Gustafsson LE, Lundberg JO, Allergy 2005 60 396 400 10.1111/j.1398-9995.2005.00737.x 15679729 (Pubitemid 40293360)
27. Lactose intolerance, detected by the hydrogen breath test, in infants and children with chronic diarrhoea. Maffei HV, Metz G, Bampoe V, Shiner M, Herman S, Brook CG, Arch Dis Child 1977 52 766 771 10.1136/adc.52.10.766 931422 (Pubitemid 8218797)
28. Molecular hydrogen as an energy source for Helicobacter pylori. Olson JW, Maier RJ, Science 2002 298 1788 1790 10.1126/science.1077123 12459589 (Pubitemid 35404122)
29. Are the effects of alpha-glucosidase inhibitors on cardiovascular events related to elevated levels of hydrogen gas in the gastrointestinal tract? Suzuki Y, Sano M, Hayashida K, Ohsawa I, Ohta S, Fukuda K, Febs Letters 2009 583 2157 2159 10.1016/j.febslet.2009.05.052 19505462
30. Effect of dietary turmeric on breath hydrogen. Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T, Dig Dis Sci 2009 54 1725 1729 10.1007/s10620-008-0550-1 19034660
31. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Kajiya M, Sato K, Silva MJB, Ouhara K, Do PM, Shanmugam KT, Kawai T, Biochemical and Biophysical Research Communications 2009 386 316 321 10.1016/j.bbrc.2009.06.024 19523450
32. PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial. Voskuijl W, de Lorijn F, Verwijs W, Hogeman P, Heijmans J, Makel W, Taminiau J, Benninga M, Gut 2004 53 1590 1594 10.1136/gut.2004.043620 15479678 (Pubitemid 39434101)
33. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). Florent C, Flourie B, Leblond A, Rautureau M, Bernier JJ, Rambaud JC, J Clin Invest 1985 75 608 613 10.1172/JCI111738 3973020 (Pubitemid 15142071)
34. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Rhodes JM, Middleton P, Jewell DP, Scand J Gastroenterol 1979 14 333 336 10.3109/00365527909179892 441681 (Pubitemid 9185710)
35. Protective effect of lactulose on dextran sulfate sodium-induced colonic inflammation in rats. Rumi G, Tsubouchi R, Okayama M, Kato S, Mozsik G, Takeuchi K, Dig Dis Sci 2004 49 1466 1472 15481321 (Pubitemid 39273624)