Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models

Brain Research

Volumn 1259, Issue , 2009, Pages 90-97

  Matchett, Gerald A ^a   Fathali, Nancy ^b   Hasegawa, Yu ^b   Jadhav, Vikram ^b   Ostrowski, Robert P ^b   Martin, Robert D ^a   Dorotta, Ihab R ^a   Sun, Xuejun ^c   Zhang, John H ^a,b  

^a LOMA LINDA UNIVERSITY   (United States)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Free radical; H2; Hydrogen gas; Neonatal hypoxia ischemia

Indexed keywords

HYDROGEN; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; LIPID PEROXIDATION; MORTALITY; NISSL SUBSTANCE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; BRAIN; DISEASE MODELS, ANIMAL; HYDROGEN; HYPOXIA-ISCHEMIA, BRAIN; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NEUROPSYCHOLOGICAL TESTS; PHOTOMICROGRAPHY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 61549125721     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.12.066     Document Type: Article

References (26)

1. Belayev L., Alonso O.F., Busto R., Zhao W., and Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke 27 (1996) 1616-1622
2. Bucholz B.M., Kaczorowski D.J., Sugimoto R., Yang R., Wang Y., Billiar T.R., McCurry K.R., Bauer A.J., and Nakao A. Hydrogen inhalation ameliorates oxidative stress in transplantation-induced intestinal graft injury. Am. J. Transp. 8 (2008) 2015-2024
3. Cai J., Kang Z., Liu W.W., Luo Z., Qiang S., Zhang J.H., Ohta S., Sun X., Xu W., Tao H., and Li R. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci. Lett. 441 (2008) 167-172
4. Calvert J.W., and Zhang J.H. Pathophysiology of an hypoxic-ischemic insult during the perinatal period. Neurol. Res. 27 (2005) 246-260
5. Carloni S., Perrone S., Buonocore G., Longini M., Proietti F., and Balduini W. Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats. J. Pineal Res. 44 (2008) 157-164
6. Fawke J. Neurological outcomes following preterm birth. Semin. Fetal Neonatal Med. 12 (2007) 374-382
7. Field D.J., Dorling J.S., Manktelow B.N., and Draper E.S. Survival of extremely premature babies in a geographically defined population: prospective cohort study of 1994-9 compared with 2000-5. BMJ 336 (2008) 199-200
8. Garcia J.H., Wagner S., Liu K.F., and Hu X.J. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats: statistical validation. Stroke 26 (1995) 627-634
9. Hasegawa Y., Hamada J., Morioka M., Yano S., Kawano T., Kai Y., Fukunaga K., and Ushio Y. Neuroprotective effect of postischemic administration of sodium orthovanadate in rats with transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 23 (2003) 1040-1051
10. Hayashida K., Sano M., Ohsawa I., Shinmura K., Tamaki K., Kimura K., Endo J., Katayama T., Kawamura A., Kohsaka S., Makino S., Ohta S., Ogawa S., and Fukuda K. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 373 (2008) 30-35
11. Ikeda T., Xia Y.X., Kaneko M., Sameshima H., and Ikenoue T. Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats. Neurosci. Lett. 329 (2002) 33-36
12. Koizumi J., Yoshida Y., Nakazawa T., and Oneda G. Experimental studies of ischemic brain edema 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn. J. Stroke 8 (1986) 1-8
13. Kumar A., Mittal R., Khanna H.D., and Basu S. Free radical injury and blood-brain barrier permeability in hypoxic-ischemic encephalopathy. Pediatrics 122 (2008) e722-727
14. Lafemina M.J., Sheldon R.A., and Ferriero D.M. Acute hypoxia-ischemia results in hydrogen peroxide accumulation in neonatal but not adult mouse brain. Pediatric Res. 59 (2006) 680-683
15. Miura S., Ishida A., Nakajima W., Ohmura A., Kawamura M., and Takada G. Intraventricular ascorbic acid administration decreases hypoxic-ischemic brain injury in newborn rats. Brain Res. 1095 (2006) 159-166
16. Nagata K., Nakashima-Kamimura N., Mikami T., Ohsawa I., and Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 34 2 (2009) 501-508
17. Noor J.I., Ikeda T., Mishima K., Aoo N., Ohta S., Egashira N., Iwasaki K., Fujiwara M., and Ikenoue T. Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy. Stroke 36 (2005) 2468-2474
18. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., Nishimaki K., Yamagata K., Katsura K., Katayama Y., Asoh S., and Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat. Med. 13 (2007) 688-694
19. Pilcher J.E. Senn on the diagnosis of gastro-intestinal perforation by the rectal insufflation of hydrogen gas. Ann. Surg. 8 (1888) 190-204
20. Rennie J.M., Hagmann C.F., and Robertson N.J. Outcome after intrapartum hypoxic ischaemic at term. Semin. Fetal Neonatal Med. 12 (2007) 398-407
21. Sato Y., Kajiyama S., Amano A., Kondo Y., Sasaki T., Handa S., Takahashi R., Fukui M., Hasegawa G., Nakamura N., Fujinawa H., Mori T., Ohta M., Obayashi H., Maruyama N., and Ishigami A. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem. Biophys. Res. Commun. 375 (2008) 346-350
22. Towfighi J., Mauger D., Vannucci R.C., and Vannucci S.J. Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res. Dev. Brain Res. 100 (1997) 149-160
23. Tsubokawa T., Jadhav V., Solaroglu I., Shiokawa Y., Konishi Y., and Zhang J.H. Lecithinized superoxide dismutase improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Stroke 38 (2007) 1057-1062
24. Urita Y., Ishihara S., Akimoto T., Kato H., Hara N., Honda Y., Nagai Y., Nakanishi K., Shimada N., Sugimoto M., and Miki K. Hydrogen and methane gases are frequently detected in the stomach. World J. Gastroenterol. 12 (2006) 3088-3091
25. Vannucci R.C., and Vannucci J.S. A model of perinatal hypoxic-ischemic brain damage. Ann. N.Y. Acad. Sci. 835 (1997) 234-249
26. Wood K.C., and Gladwin M.T. The hydrogen highway to reperfusion therapy. Nat. Med. 13 (2007) 673-674