Proteinuria and outcome after renal transplantation: Ratios or fractions?

Transplantation

Volumn 96, Issue 1, 2013, Pages 65-69

  Stevens, Kathryn K ^a,b   Patel, Rajan K ^a,b   Methven, Shona ^b   Clancy, Marc J ^b   Fox, Jonathan G ^b   Jardine, Alan G ^a,b   Geddes, Colin C ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

Author keywords

Fractional excretion; Outcome; PCR; Proteinuria; Renal transplant

Indexed keywords

CREATININE;

ADULT; ARTICLE; CAUSE OF DEATH; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; FEMALE; FOLLOW UP; FRACTIONAL EXRECTION OF TOTAL PROTEIN; GRAFT SURVIVAL; HIGH RISK POPULATION; HUMAN; INTERMETHOD COMPARISON; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LOW RISK POPULATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN TO CREATININE RATIO; PROTEIN URINE LEVEL; PROTEINURIA; RENAL SYSTEM PARAMETERS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SURGICAL RISK; SURVIVAL TIME; TREATMENT FAILURE;

ADULT; CREATININE; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POSTOPERATIVE COMPLICATIONS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROTEINURIA; RISK FACTORS; ROC CURVE;

EID: 84879837712     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318295852c     Document Type: Article

References (21)

1. Glassock RJ, Winearls C. An epidemic of chronic kidney disease: fact or fiction? Nephrol Dial Transplant 2008; 23: 1117.
2. Kundhal K, Lok CE. Clinical epidemiology of cardiovascular disease in chronic kidney disease. Nephron Clin Pract 2005; 101: c47.
3. Fung F, Sherrard DJ, Gillen DL, et al. Increased risk for cardiovascular mortality among malnourished end-stage renal disease patients. Am J Kidney Dis 2002; 40: 307.
4. Kestenbaum B, Sampson JN, Rudser KD, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16: 520.
5. Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999; 341: 1725.
6. Schnuelle P, Lorenz D, Trede M, et al. Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. J Am Soc Nephrol 1998; 9: 2135.
7. Nauta FL, Bakker SJ, van OW, et al. Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients. Am J Kidney Dis 2011; 57: 733.
8. Hariharan S, Johnson CP, Bresnahan BA, et al. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000; 342: 605.
9. Wolfe RA. Long-term renal allograft survival: a cup both half-full and half-empty. Am J Transplant 2004; 4: 1215.
10. Kaplan B, Schold J, Meier-Kriesche HU. Poor predictive value of serum creatinine for renal allograft loss. Am J Transplant 2003; 3: 1560.
11. Halimi JM, Buchler M, Al-Najjar A, et al. Urinary albumin excretion and the risk of graft loss and death in proteinuric and nonproteinuric renal transplant recipients. Am J Transplant 2007; 7: 618.
12. van Ree RM, Oterdoom LH, de Vries AP, et al. Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients. Transplantation 2008; 86: 1713.
13. Kasiske BL. Risk factors for accelerated atherosclerosis in renal transplant recipients. Am J Med 1988; 84: 985.
14. Hernandez D, Perez G, Marrero D, et al. Early association of lowgrade albuminuria and allograft dysfunction predicts renal transplant outcomes. Transplantation 2012; 93: 297.
15. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000; 80: 1107.
16. Methven S, MacGregor MS, Traynor JP, et al. Assessing proteinuria in chronic kidney disease: protein-creatinine ratio versus albumincreatinine ratio. Nephrol Dial Transplant 2010; 25: 2991.
17. Akbari A, White CA, Shahbazi N, et al. Spot urine protein measurements: are these accurate in kidney transplant recipients? Transplantation 2012; 94: 389.
18. Stevens KK, Morgan IR, Patel RK, et al. Serum phosphate and outcome at one year after deceased donor renal transplantation. Clin Transplant 2011; 25: E199.
19. Connolly GM, Cunningham R, McNamee PT, et al. Elevated serum phosphate predicts mortality in renal transplant recipients. Transplantation 2009; 87: 1040.
20. Scotland's Population 2011-The Registrar General's Annual Review of Demographic Trends. Available at: http://gro-scotland.gov.uk/statistics/at-a- glance/annrev/2011/index.html. Accessed January 2013.
21. Letavernier E, Legendre C. mToR inhibitorsYinduced proteinuria: mechanisms, significance, and management. Transplant Rev (Orlando) 2008; 22: 125.