Early association of low-grade albuminuria and allograft dysfunction predicts renal transplant outcomes

Transplantation

Volumn 93, Issue 3, 2012, Pages 297-303

  Hernández, Domingo ^a   Pérez, Germán ^b   Marrero, Domingo ^b   Porrini, Esteban ^b   Rufino, Margarita ^b   Manuel González Posada, José ^b   Delgado, Patricia ^b   Torres, Armando ^b  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

Author keywords

Albuminuria; Glomerular filtration rate; Graft survival; Kidney transplantation; Patient survival

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; AZATHIOPRINE; CALCINEURIN INHIBITOR; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTEROID; CYCLOSPORIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; POLYCLONAL ANTIBODY; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ADULT; ALBUMINURIA; ARTICLE; CADAVER KIDNEY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLOMERULUS FILTRATION RATE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEINURIA; RENAL GRAFT DYSFUNCTION; SURGICAL MORTALITY; SURGICAL RISK;

ADULT; AGED; ALBUMINURIA; COHORT STUDIES; FEMALE; GLOMERULAR FILTRATION RATE; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84856471656     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31823ec0a7     Document Type: Article

References (31)

1. Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Lack of improvement in allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004; 4: 378.
2. Pascual M, Theruvath T, Kawai T, et al. Strategies to improve longterm outcomes after renal transplantation.NEngl J Med 2002; 346: 580.
3. Pérez Fontán M, Rodríguez-Carmona A, García Falcón T, et al. Early proteinuria in renal transplant recipients treated with cyclosporin. Transplantation 1999; 67: 561.
4. Yildiz A, Erkoc R, Sever MS, et al. The prognostic importance of severity and type of post-transplant proteinuria. Clin Transplant 1999; 13: 241.
5. Roodnat JI, Mulder PG, Rischen-Vos J, et al. Proteinuria after renal transplantation affects not only graft survival but also patient survival. Transplantation 2001; 72: 438.
6. Fernandez-Fresnedo G, Escallada R, Rodrigo E, et al. The risk of cardiovascular disease associated with proteinuria in renal transplant patients. Transplantation 2002; 73: 1345.
7. Fernandez-Fresnedo G, Plaza JJ, Sanchez-Plumed J, et al. Proteinuria: A new marker of long-term graft and patient survival in kidney transplantation. Nephrol Dial Transplant 2004; 19(suppl 3): iii47.
8. Halimi JM, Laouad I, Buchler M, et al. Early low-grade proteinuria: Causes, short-term evolution and long-term consequences in renal transplantation. Am J Transplant 2005; 5: 2281.
9. Halimi JM, Buchler M, Al-Najjar A, et al. Urinary albumin excretion and the risk of graft loss and death in proteinuric and non-proteinuric renal transplant recipients. Am J Transplant 2007; 7: 618.
10. Halimi JM, Matthias B, Al-Najjar A, et al. Respective predictive role of urinary albumin excretion and nonalbumin proteinuria on graft loss and death in renal transplant recipients. Am J Transplant 2007; 7: 2775.
11. Amer H, Fidler ME, Myslak M, et al. Proteinuria after kidney transplantation, relationship to allograft histology and survival. Am J Transplant 2011; 7: 2748.
12. Cantarovich F, Martinez F, Heguilen R, et al. Proteinuria-0.5 g/day, a prevalent prognostic factor for patient and graft survival in kidney transplantation. Clin Transplant 2010; 24: 175.
13. Cherukuri A, Welberry-Smith MP, Tattersall JE, et al. The clinical significance of early proteinuria after renal transplantation. Transplantation 2010; 89: 200.
14. Nauta FL, Bakker SJ, van Oeveren W, et al. Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients. Am J Kidney Dis 2011; 57: 733.
15. Panek R, Lawen T, Kiberd BA. Screening for proteinuria in kidney transplant recipients. Nephrol Dial Transplant 2011; 26: 1385.
16. Hariharan S, McBride MA, Cherikh WS, et al. Post-transplant renal function in the first year predicts long-term kidney transplant survival. Kidney Int 2002; 62: 311.
17. Kasiske BL, Israni AK, Snyder JJ, et al. The relationship between kidney function and long-term graft survival after kidney transplant. Am J Kidney Dis 2011; 57: 466.
18. Matsushita K, van der Velde M, Astor BC, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality. Lancet 2010; 375: 2073.
19. Gansevoort RT, Matsushita K, van der Velde M, et al. Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts. Kidney Int 2011; 80: 93.
20. HallanSI, Ritz E,LydersenS, et al.CombiningGFRandalbuminuriato classify CKDimproves prediction of ESRD. J AmSoc Nephrol 2011; 20: 1069.
21. Burton C, Harris KPG. The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 1996; 27: 765.
22. Cruzado JM, Rico J, Grinyo JM. The renin angiotensin system blockade in kidney transplantation: Pros and cons. Transpl Int 2008; 21: 304.
23. Donadelli R, Zanchi C, Morigi M, et al. Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB-and p38 mitogen-activated protein kinase-dependent pathways protein overload. J Am Soc Nephrol 2003; 14: 2436.
24. Heinze G, Mitterbauer C, Regele H, et al. Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation. J Am Soc Nephrol 2006; 17: 889.
25. Hernández D, Muriel A, Abraira V, et al. Renin-angiotensin system blockade and kidney transplantation: Longitudinal cohort study. Nephrol Dial Transplant [published online ahead of print May 28, 2011; doi:10.1093/ndt/ gfr276].
26. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130: 461.
27. Port FK, Bragg-Gresham JL, Metzger RA, et al. Donor characteristics associated with reduced graft survival: An approach to expanding the pool of kidney donors. Transplantation 2002; 74: 1281.
28. Solez K, Axelsen RA, Benediktsson H, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411.
29. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
30. Davidson J, Wilkinson A, Dantal J, et al. New-onset diabetes after transplantation: 2003 International consensus guidelines. Transplantation 2003; 75(10 suppl): SS3.
31. Kasiske BL, Guijarro C, Massy ZA, et al. Cardiovascular disease after renal transplantation. J Am Soc Nephrol 1996; 7: 158.