Endothelium-independent relaxant effect of rubus coreanus extracts in corpus cavernosum smooth muscle

Journal of Sexual Medicine

Volumn 10, Issue 7, 2013, Pages 1720-1729

  Lee, Jun Ho ^a   Chae, Mee Ree ^b,c   Sung, Hyun Hwan ^b,c   Ko, Mikyeong ^b,c   Kang, Su Jeong ^b,c   Lee, Sung Won ^b,c  

^a National Police Hospital   (South Korea)

^b Genitourinary Disease Oriented Translational Research   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Calcium Channels; Corpus Cavernosum Smooth Muscle; Erectile Dysfunction; Rubus Coreanus

Indexed keywords

FURA 2; ION CHANNEL; PHOSPHODIESTERASE V INHIBITOR; PLANT EXTRACT; RUBUS COREANUS EXTRACT; TETRYLAMMONIUM; UDENAFIL; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; FRUIT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RUBUS; RUBUS COREANUS; SMOOTH MUSCLE FIBER;

EID: 84879837445     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12183     Document Type: Article

References (32)

1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
2. Araña Rosaínz Mde J, Ojeda MO, Acosta JR, Elías-Calles LC, González NO, Herrera OT, García Álvarez CT, Rodríguez EM, Báez ME, Seijas EÁ, Valdés RF. Imbalanced low-grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction. J Sex Med 2011;8:2017-2030.
3. NIH Consensus Conference. Impotence. NIH consensus development panel on impotence. JAMA 1993;270:83-90.
4. Porst H. The future of erectile dysfunction (ED). Arch Esp Urol 2010;63:740-747.
5. Supuran CT, Mastrolorenzo A, Barbaro G, Scozzafava A. Phosphodiesterase 5 inhibitors-Drug design and differentiation based on selectivity, pharmacokinetic and efficacy profiles. Curr Pharm Des 2006;12:3459-3465.
6. Jiann BP, Yu CC, Su CC, Tsai JY. Compliance of sildenafil treatment for erectile dysfunction and factors affecting it. Int J Impot Res 2006;18:146-149.
7. Lee SJ. Korean fork medicine. Seoul: Seoul National University Press; 1966.
8. Zhao C, Kim HK, Kim SZ, Chae HJ, Cui WS, Lee SW, Jeon JH, Park JK. What is the role of unripe Rubus coreanus extract on penile erection? Phytother Res 2011;25:1046-1053.
9. Sohn DW, Kim HY, Kim SD, Lee EJ, Kim HS, Kim JK, Hwang SY, Cho YH, Kim SW. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats. J Ethnopharmacol 2008;120:176-180.
10. Kam SC, Do JM, Choi JH, Jeon BT, Roh GS, Hyun JS. In vivo and in vitro animal investigation of the effect of a mixture of herbal extracts from Tribulus terrestris and Cornus officinalis on penile erection. J Sex Med 2012;9:2544-2551.
11. Capel RO, Mónica FZ, Porto M, Barillas S, Muscará MN, Teixeira SA, Arruda AM, Pissinatti L, Pissinatti A, Schenka AA, Antunes E, Nahoum C, Cogo JC, de Oliveira MA, De Nucci G. Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus. J Sex Med 2011;8:1616-1625.
12. Oger S, Behr-Roussel D, Gorny D, Charles Tremeaux J, Combes M, Alexandre L, Giuliano F. Combination of alfuzosin and tadalafil exerts in vitro an additive relaxant effect on human corpus cavernosum. J Sex Med 2008;5:935-945.
13. Filippi S, Luconi M, Granchi S, Natali A, Tozzi P, Forti G, Ledda F, Maggi M. Endothelium-dependency of yohimbine-induced corpus cavernosum relaxation. Int J Impot Res 2002;14:295-307.
14. Owolabi MA, Jaja SI, Coker HA. Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta. Fitoterapia 2005;76:567-573.
15. Suenaga H, Kamata K. Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: Role of protein kinase C. J Smooth Muscle Res 2000;36:205-218.
16. Medeiros MA, Nunes XP, Barbosa-Filho JM, Lemos VS, Pinho JF, Roman-Campos D, de Medeiros IA, Araújo DA, Cruz JS. (S)-reticuline induces vasorelaxation through the blockade of L-type Ca(2+) channels. Naunyn Schmiedebergs Arch Pharmacol 2009;379:115-125.
17. Jiang HD, Cai J, Xu JH, Zhou XM, Xia Q. Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta. J Ethnopharmacol 2005;101:221-226.
18. Zhu XM, Fang LH, Li YJ, Du GH. Endothelium-dependent and -independent relaxation induced by pinocembrin in rat aortic rings. Vascul Pharmacol 2007;46:160-165.
19. Saponara R, Bosisio E. Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue. J Nat Prod 1998;61:1386-1387.
20. Clostre F. [Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000]. Ann Pharm Fr 1999;57(Suppl 1):1S8-88.
21. Braquet P, Touqui L, Shen TY, Vargaftig BB. Perspectives in platelet-activating factor research. Pharmacol Rev 1987;39:97-145.
22. Delaflotte S, Auguet M, DeFeudis FV, Baranes J, Clostre F, Drieu K, Braquet P. Endothelium-dependent relaxations of rabbit isolated aorta produced by carbachol and by Ginkgo biloba extract. Biomed Biochim Acta 1984;43:S212-216.
23. Chen X, Salwinski S, Lee TJ. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin Exp Pharmacol Physiol 1997;24:958-959.
24. Li Z, Nakaya Y, Niwa Y, Chen X. K(Ca) channel-opening activity of Ginkgo biloba extracts and ginsenosides in cultured endothelial cells. Clin Exp Pharmacol Physiol 2001;28:441-445.
25. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
26. Fan SF, Brink PR, Melman A, Christ GJ. An analysis of the Maxi-K+ (KCa) channel in cultured human corporal smooth muscle cells. J Urol 1995;153:818-825.
27. Ryu JK, Choi MJ, Kim TI, Jin HR, Kwon KD, Batbold D, Song KM, Kwon MH, Yin GN, Lee M, Kim SW, Suh JK. A guanidinylated bioreducible polymer as a novel gene carrier to the corpus cavernosum of mice with high-cholesterol diet-induced erectile dysfunction. Andrology 2013;1:216-222.
28. Han DH, Lee JH, Kim H, Ko MK, Chae MR, Kim HK, So I, Jeon JH, Park JK, Lee SW. Effects of Schisandra chinensis extract on the contractility of corpus cavernosal smooth muscle (CSM) and Ca2+ homeostasis in CSM cells. BJU Int 2012;109:1404-1413.
29. Zhang F, Ram JL, Standley PR, Sowers JR. 17 beta-estradiol attenuates voltage-dependent Ca2+ currents in A7r5 vascular smooth muscle cell line. Am J Physiol 1994;266:C975-980.
30. Sarikaya S, Asci R, Aybek Z, Yilmaz AF, Buyukalpelli R, Yildiz S. Effects of intracavernous calcium channel blockers in dogs. Int Urol Nephrol 1997;29:673-680.
31. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 1994;74:365-507.
32. Mani BK, Brueggemann LI, Cribbs LL, Byron KL. Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells. Cell Calcium 2009;45:400-411.