Stereoselective excretion and first-pass metabolism of clausenamide enantiomers

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 4, 2013, Pages 761-766

  Zhu, Chuan Jiang ^a   Wang, Ling Juan ^a   Hua, Fang ^a   Yu, Xiao Ming ^a   Zhang, Jun Tian ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Clausenamide enantiomers; Cytochrome P450 3A; Excretion; First pass effect; Metabolism; Stereoselectivity

Indexed keywords

CLAUSENAMIDE; CYTOCHROME P450 3A; CYTOCHROME P450 3A1;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; BLOOD SAMPLING; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EXCRETION; ENANTIOMER; ENZYME SUBSTRATE; FECES; FEMALE; FIRST PASS EFFECT; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER BLOOD FLOW; LIVER CELL; LIVER MICROSOME; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RAT; STEREOCHEMISTRY; URINARY EXCRETION;

EID: 84879833169     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.04.033     Document Type: Article

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