메뉴 건너뛰기




Volumn 63, Issue , 2013, Pages 421-431

Signaling through the vascular endothelial growth factor receptor VEGFR-2 protects hippocampal neurons from mitochondrial dysfunction and oxidative stress

Author keywords

Hippocampal neurons; Mitochondrial dysfunction; Oxidative stress; VEGF; VEGF B; VEGFR 2

Indexed keywords

ACETYLCYSTEINE; ACTIN; CASPASE 3; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 84879825829     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.05.036     Document Type: Article
Times cited : (28)

References (54)
  • 1
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • DOI 10.1038/nature05292, PII NATURE05292
    • Lin, M. T.; Beal, M. F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795; 2006. (Pubitemid 44622683)
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 2
    • 0037192788 scopus 로고    scopus 로고
    • Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system
    • DOI 10.1074/jbc.M111085200
    • Ogunshola, O. O.; Antic, A.; Donoghue, M. J.; Fan, S. Y.; Kim, H.; Stewart, W. B.; Madri, J. A.; Ment, L. R. Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J. Biol. Chem. 277: 114 10 -11415; 2002. (Pubitemid 34952908)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11410-11415
    • Ogunshola, O.O.1    Antic, A.2    Donoghue, M.J.3    Fan, S.-Y.4    Kim, H.5    Stewart, W.B.6    Madri, J.A.7    Ment, L.R.8
  • 4
    • 0035344017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades
    • Matsuzaki, H.; Tamatani, M.; Yamaguchi, A.; Namikawa, K.; Kiyama, H.; Vitek, M. P.; Mitsuda, N.; Tohyama, M. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15: 1218-1220; 2001.
    • (2001) FASEB J , vol.15 , pp. 1218-1220
    • Matsuzaki, H.1    Tamatani, M.2    Yamaguchi, A.3    Namikawa, K.4    Kiyama, H.5    Vitek, M.P.6    Mitsuda, N.7    Tohyama, M.8
  • 5
    • 0000481740 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischemia
    • Jin, K. L.; Mao, X. O.; Greenberg, D. A. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. USA 97: 10242-10247; 2000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10242-10247
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 6
    • 0036703627 scopus 로고    scopus 로고
    • Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt
    • Wick, A.; Wick, W.; Waltenberger, J.; Weller, M.; Dichgans, J.; Schulz, J. B. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J. Neurosci. 22: 6401-6407; 2002. (Pubitemid 35386396)
    • (2002) Journal of Neuroscience , vol.22 , Issue.15 , pp. 6401-6407
    • Wick, A.1    Wick, W.2    Waltenberger, J.3    Weller, M.4    Dichgans, J.5    Schulz, J.B.6
  • 8
    • 3542999278 scopus 로고    scopus 로고
    • VEGF links hippocampal activity with neurogenesis, learning and memory
    • DOI 10.1038/ng1395
    • Cao, L.; Jiao, X.; Zuzga, D. S.; Liu, Y.; Fong, D. M.; Young, D.; During, M. J. VEGF links hippocampal activity with neurogenesis, learning and memory. Nature Genet. 36: 827-835; 2004. (Pubitemid 39014099)
    • (2004) Nature Genetics , vol.36 , Issue.8 , pp. 827-835
    • Cao, L.1    Jiao, X.2    Zuzga, D.S.3    Liu, Y.4    Fong, D.M.5    Young, D.6    During, M.J.7
  • 9
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • DOI 10.1172/JCI200317977
    • Sun, Y.; Jin, K.; Xie, L.; Childs, J.; Mao, X. O.; Logvinova, A.; Greenberg, D. A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111 : 1843-18 51 ; 2 0 0 3 . (Pubitemid 38057729)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.12 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 10
    • 0036139515 scopus 로고    scopus 로고
    • The neuropilins: Multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis
    • DOI 10.1016/S1050-1738(01)00140-2, PII S1050173801001402
    • Neufeld, G.; Cohen, T.; Shraga, N.; Lange, T.; Kessler, O.; Herzog, Y. The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc. Med 12: 13-19; 20 02. (Pubitemid 34048706)
    • (2002) Trends in Cardiovascular Medicine , vol.12 , Issue.1 , pp. 13-19
    • Neufeld, G.1    Cohen, T.2    Shraga, N.3    Lange, T.4    Kessler, O.5    Herzog, Y.6
  • 14
    • 27844508565 scopus 로고    scopus 로고
    • Neuroprotective role of vascular endothelial growth factor: Signalling mechanisms, biological function, and therapeutic potential
    • DOI 10.1159/000088637
    • Zachary, I. Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential. Neuro-Signals 14: 207-221; 2005. (Pubitemid 41661355)
    • (2005) NeuroSignals , vol.14 , Issue.5 , pp. 207-221
    • Zachary, I.1
  • 15
    • 85047694286 scopus 로고    scopus 로고
    • VEGF: A critical player in neurodegeneration
    • DOI 10.1172/JCI200420682
    • Storkebaum, E.; Carmeliet, P. VEGF: a critical player in neurodegeneration. J. Clin. Invest. 11 3 : 14-18 ; 20 0 4 . (Pubitemid 38541624)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.1 , pp. 14-18
    • Storkebaum, E.1    Carmeliet, P.2
  • 16
    • 33846221802 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
    • DOI 10.1523/JNEUROSCI.4433-06.2007
    • Wang, Y.; Mao, X. O.; Xie, L.; Banwait, S.; Marti, H. H.; Greenberg, D. A.; Jin, K. Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J. Neurosci. 27: 304-307; 2007. (Pubitemid 46106003)
    • (2007) Journal of Neuroscience , vol.27 , Issue.2 , pp. 304-307
    • Wang, Y.1    Xiao, O.M.2    Xie, L.3    Banwait, S.4    Marti, H.H.5    Greenberg, D.A.6    Jin, K.7
  • 17
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    • DOI 10.1523/JNEUROSCI.0434-06.2006
    • Kilic, U.; Kilic, E.; Jarve, A.; Guo, Z.; Spudich, A.; Bieber, K.; Barzena, U.; Bassetti, C. L.; Marti, H. H.; Hermann, D. M. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J. Neurosci. 26: 12439-12446; 2006. (Pubitemid 44864508)
    • (2006) Journal of Neuroscience , vol.26 , Issue.48 , pp. 12439-12446
    • Kilic, U.1    Kilic, E.2    Jarve, A.3    Guo, Z.4    Spudich, A.5    Bieber, K.6    Barzena, U.7    Bassetti, C.L.8    Marti, H.H.9    Hermann, D.M.10
  • 18
    • 33845666847 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    • Kilic, E.; Kilic, U.; Wang, Y.; Bassetti, C. L.; Marti, H. H.; Hermann, D. M. The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF?s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J 20: 118 5 -1187; 2006.
    • (2006) FASEB J , vol.20 , pp. 1185-1187
    • Kilic, E.1    Kilic, U.2    Wang, Y.3    Bassetti, C.L.4    Marti, H.H.5    Hermann, D.M.6
  • 19
    • 0034638448 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3'-kinaseakt signaling by global cerebral ischemia in the rat
    • Jin, K. L.; Mao, X. O.; Nagayama, T.; Goldsmith, P. C.; Greenberg, D. A. Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3'-kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience 100: 713-717; 2000.
    • (2000) Neuroscience , vol.100 , pp. 713-717
    • Jin, K.L.1    Mao, X.O.2    Nagayama, T.3    Goldsmith, P.C.4    Greenberg, D.A.5
  • 20
    • 0035842544 scopus 로고    scopus 로고
    • Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor
    • DOI 10.1016/S0306-4522(01)00154-3, PII S0306452201001543
    • Jin, K.; Mao, X. O.; Batteur, S. P.; McEachron, E.; Leahy, A.; Greenberg, D. A. Caspase-3 and the regulation of hypoxic neuronal death by vascular endothe-lial growth factor. Neuroscience 108: 351-358; 2001. (Pubitemid 33152975)
    • (2001) Neuroscience , vol.108 , Issue.2 , pp. 351-358
    • Jin, K.1    Mao, X.O.2    Batteur, S.P.3    McEachron, E.4    Leahy, A.5    Greenberg, D.A.6
  • 21
    • 34948837854 scopus 로고    scopus 로고
    • The VEGFR2 and PKA pathways converge at MEK/ERK1/2 to promote survival in serum deprived neuronal cells
    • DOI 10.1007/s11010-007-9542-2
    • Gomes, E.; Papa, L.; Hao, T.; Rockwell, P. The VEGFR2 and PKA pathways converge at MEK/ERK1/2 to promote survival in serum deprived neuronal cells. Mol. Cell. Biochem 305: 17 9 -190; 2007. (Pubitemid 47517180)
    • (2007) Molecular and Cellular Biochemistry , vol.305 , Issue.1-2 , pp. 179-190
    • Gomes, E.1    Papa, L.2    Hao, T.3    Rockwell, P.4
  • 22
    • 0036270263 scopus 로고    scopus 로고
    • MEK and ERK protect-hypoxic cortical neurons via phosphorylation of Bad
    • DOI 10.1046/j.0022-3042.2001.00678.x
    • Jin, K.; Mao, X. O.; Zhu, Y.; Greenberg, D. A. MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J. Neurochem. 80: 119 -125; 2002. (Pubitemid 34614584)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.1 , pp. 119-125
    • Jin, K.1    Mao, X.O.2    Zhu, Y.3    Greenberg, D.A.4
  • 23
    • 0346996446 scopus 로고    scopus 로고
    • Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium
    • DOI 10.1016/j.cellsig.2003.08.006
    • Rockwell, P.; Martinez, J.; Papa, L.; Gomes, E. Redox regulates COX-2 upregula-tion and cell death in the neuronal response to cadmium. Cell Signal. 16: 343-353; 2004. (Pubitemid 37542409)
    • (2004) Cellular Signalling , vol.16 , Issue.3 , pp. 343-353
    • Rockwell, P.1    Martinez, J.2    Papa, L.3    Gomes, E.4
  • 24
    • 33751036065 scopus 로고    scopus 로고
    • Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: Detection of a non-endothelial function of VEGF in pituitary tumours
    • DOI 10.1677/joe.1.06992
    • Onofri, C.; Theodoropoulou, M.; Losa, M.; Uhl, E.; Lange, M.; Arzt, E.; Stalla, G. K.; Renner, U. Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours. J. Endocrinol. 191: 249-261; 2006. (Pubitemid 44756527)
    • (2006) Journal of Endocrinology , vol.191 , Issue.1 , pp. 249-261
    • Onofri, C.1    Theodoropoulou, M.2    Losa, M.3    Uhl, E.4    Lange, M.5    Arzt, E.6    Stalla, G.K.7    Renner, U.8
  • 25
    • 77957766233 scopus 로고    scopus 로고
    • Crosstalk between vegfr2 and muscarinic receptors regulates the mtor pathway in serum starved sk-n-sh human neuroblastoma cells
    • Edelstein, J.; Hao, T.; Cao, Q.; Morales, L.; Rockwell, P. Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. Cell Signal 23: 239-248; 2011.
    • (2011) Cell Signal , vol.23 , pp. 239-248
    • Edelstein, J.1    Hao, T.2    Cao, Q.3    Morales, L.4    Rockwell, P.5
  • 26
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-supplemented Neurobasal(TM), a new serum-free medium combination
    • Brewer, G. J.; Torricelli, J. R.; Evege, E. K.; Price, P. J. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35: 567-576; 1993. (Pubitemid 23215708)
    • (1993) Journal of Neuroscience Research , vol.35 , Issue.5 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4
  • 28
    • 0346118855 scopus 로고    scopus 로고
    • Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons
    • Rosenstein, J. M.; Mani, N.; Khaibullina, A.; Krum, J. M. Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J. Neurosci. 23: 11036-11044; 2003. (Pubitemid 37548937)
    • (2003) Journal of Neuroscience , vol.23 , Issue.35 , pp. 11036-11044
    • Rosenstein, J.M.1    Mani, N.2    Khaibullina, A.3    Krum, J.M.4
  • 29
    • 67649460932 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabili-zation in neuronal injury
    • Galluzzi, L.; Blomgren, K.; Kroemer, G. Mitochondrial membrane permeabili-zation in neuronal injury. Nat. Rev. Neurosci. 10: 481-494; 2009.
    • (2009) Nat. Rev. Neurosci , vol.10 , pp. 481-494
    • Galluzzi, L.1    Blomgren, K.2    Kroemer, G.3
  • 31
    • 77449104200 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt
    • Byeon, S. H.; Lee, S. C.; Choi, S. H.; Lee, H. K.; Lee, J. H.; Chu, Y. K.; Kwon, O. W. Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt. Invest. Ophthalmol. Vis. Sci. 51: 119 0 -11 9 7 ; 2 0 1 0 .
    • (2010) Invest. Ophthalmol. Vis. Sci , vol.51 , pp. 1190-1197
    • Byeon, S.H.1    Lee, S.C.2    Choi, S.H.3    Lee, H.K.4    Lee, J.H.5    Chu, Y.K.6    Kwon, O.W.7
  • 32
    • 42249107850 scopus 로고    scopus 로고
    • PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2
    • DOI 10.1161/ATVBAHA.107.156406
    • Mathews, M. T.; Berk, B. C. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2. Arterioscler. Thromb. Vasc. Biol 28: 711-717; 2008. (Pubitemid 351651331)
    • (2008) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.28 , Issue.4 , pp. 711-717
    • Mathews, M.T.1    Berk, B.C.2
  • 33
    • 15044350330 scopus 로고    scopus 로고
    • Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia
    • DOI 10.1016/j.neuroscience.2004.12.031
    • Shiote, M.; Nagano, I.; Ilieva, H.; Murakami, T.; Narai, H.; Ohta, Y.; Nagata, T.; Shoji, M.; Abe, K. Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 132: 17 5 -182; 2005. (Pubitemid 40380724)
    • (2005) Neuroscience , vol.132 , Issue.1 , pp. 175-182
    • Shiote, M.1    Nagano, I.2    Ilieva, H.3    Murakami, T.4    Narai, H.5    Ohta, Y.6    Nagata, T.7    Shoji, M.8    Abe, K.9
  • 34
    • 50949132320 scopus 로고    scopus 로고
    • Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics
    • Chen, M. H.; Kerkela, R.; Force, T. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 118 : 84-95; 2008.
    • (2008) Circulation , vol.118 , pp. 84-95
    • Chen, M.H.1    Kerkela, R.2    Force, T.3
  • 35
    • 79952095377 scopus 로고    scopus 로고
    • Cardiotoxicity associated with targeting kinase pathways in cancer
    • Mellor, H. R.; Bell, A. R.; Valentin, J. P.; Roberts, R. R. Cardiotoxicity associated with targeting kinase pathways in cancer. Toxicol. Sci. 120: 14-32; 2011.
    • (2011) Toxicol. Sci , vol.120 , pp. 14-32
    • Mellor, H.R.1    Bell, A.R.2    Valentin, J.P.3    Roberts, R.R.4
  • 36
    • 0033520937 scopus 로고    scopus 로고
    • RSK blocks bad-mediated cell death via a protein kinase C-dependent pathway
    • Tan, Y.; Ruan, H.; Demeter, M. R.; Comb, M. J. p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway. J. Biol. Chem. 274: 34859-34867; 1999. (Pubitemid 129509532)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.49 , pp. 34859-34867
    • Tan, Y.1    Ruan, H.2    Demeter, M.R.3    Comb, M.J.4
  • 37
  • 38
    • 1842608814 scopus 로고    scopus 로고
    • Heme oxygenase-1: Transducer of pathological brain iron sequestration under oxidative stress
    • DOI 10.1196/annals.1306.007
    • Schipper, H. M. Heme oxygenase-1: transducer of pathological brain iron sequestration under oxidative stress. Ann. N. Y. Acad. Sci. 1012: 84-93; 2004. (Pubitemid 38453517)
    • (2004) Annals of the New York Academy of Sciences , vol.1012 , pp. 84-93
    • Schipper, H.M.1
  • 39
    • 67649628772 scopus 로고    scopus 로고
    • Heme oxygenase-1 and neurodegeneration: Expanding frontiers of engagement
    • Schipper, H. M.; Song, W.; Zukor, H.; Hascalovici, J. R.; Zeligman, D. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J. Neurochem. 11 0 : 469-485; 2009.
    • (2009) J. Neurochem , vol.110 , pp. 469-485
    • Schipper, H.M.1    Song, W.2    Zukor, H.3    Hascalovici, J.R.4    Zeligman, D.5
  • 41
    • 43549091809 scopus 로고    scopus 로고
    • The homeostasis of iron and suppression of ho-1 involved in the protective effects of nimodipine on neurodegeneration induced by aluminum overloading in mice
    • Yuan, Y.; Guo, J. Z.; Zhou, Q. X. The homeostasis of iron and suppression of HO-1 involved in the protective effects of nimodipine on neurodegeneration induced by aluminum overloading in mice. Eur. J. Pharmacol 586: 10 0 -105; 20 0 8 .
    • (2008) Eur. J. Pharmacol , vol.586 , pp. 100-105
    • Yuan, Y.1    Guo, J.Z.2    Zhou, Q.X.3
  • 43
    • 74349111035 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease
    • Falk, T.; Zhang, S.; Sherman, S. J. Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson?s disease. Mol. Neurodegener 4: 49; 2009.
    • (2009) Mol. Neurodegener , vol.4 , pp. 49
    • Falk, T.1    Zhang, S.2    Sherman, S.J.3
  • 44
    • 34247135353 scopus 로고    scopus 로고
    • +/-) gene knockout leads to the disruption of VEGF-mediated signaling through the nitric oxide/heme oxygenase pathway in ischemic preconditioned myocardium
    • DOI 10.1016/j.freeradbiomed.2007.02.011, PII S0891584907001165
    • Thirunavukkarasu, M.; Juhasz, B.; Zhan, L.; Menon, V. P.; Tosaki, A.; Otani, H.; Maulik, N. VEGFR1 (Flt-1+/-) gene knockout leads to the disruption of VEGF-mediated signaling through the nitric oxide/heme oxygenase pathway in ischemic preconditioned myocardium. Free Radic. Biol. Med. 42: 1487-1495; 2007. (Pubitemid 46590611)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.10 , pp. 1487-1495
    • Thirunavukkarasu, M.1    Juhasz, B.2    Zhan, L.3    Menon, V.P.4    Tosaki, A.5    Otani, H.6    Maulik, N.7
  • 46
    • 76749124316 scopus 로고    scopus 로고
    • VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2
    • Zhang, Z.; Neiva, K. G.; Lingen, M. W.; Ellis, L. M.; Nor, J. E. VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2. Cell Death Differ. 17 : 499-512; 2010.
    • (2010) Cell Death Differ , vol.17 , pp. 499-512
    • Zhang, Z.1    Neiva, K.G.2    Lingen, M.W.3    Ellis, L.M.4    Nor, J.E.5
  • 48
    • 79957936182 scopus 로고    scopus 로고
    • Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death
    • Tornero, D.; Posadas, I.; Cena, V. Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death. PloS One 6:e20423; 2011.
    • (2011) PloS One , vol.6
    • Tornero, D.1    Posadas, I.2    Cena, V.3
  • 51
    • 84863316405 scopus 로고    scopus 로고
    • Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein
    • Arbel, N.; Ben-Hail, D.; Shoshan-Barmatz, V. Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein. J. Biol. Chem 287: 23152-23161; 2012.
    • (2012) J. Biol. Chem , vol.287 , pp. 23152-23161
    • Arbel, N.1    Ben-Hail, D.2    Shoshan-Barmatz, V.3
  • 53
    • 84856056846 scopus 로고    scopus 로고
    • Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration
    • Sheng, Z. H.; Cai, Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13: 77-93; 2012.
    • (2012) Nat. Rev. Neurosci , vol.13 , pp. 77-93
    • Sheng, Z.H.1    Cai, Q.2
  • 54
    • 34648859471 scopus 로고    scopus 로고
    • Oxidative damage in mild cognitive impairment and early Alzheimer's disease
    • DOI 10.1002/jnr.21346
    • Lovell, M. A.; Markesbery, W. R. Oxidative damage in mild cognitive impairment and early Alzheimer?s disease. J. Neurosci. Res. 85: 3036-3040; 2007. (Pubitemid 350057358)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.14 , pp. 3036-3040
    • Lovell, M.A.1    Markesbery, W.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.