A novel anticancer agent Broussoflavonol B downregulates estrogen receptor (ER)-α36 expression and inhibits growth of ER-negative breast cancer MDA-MB-231 cells

European Journal of Pharmacology

Volumn 714, Issue 1-3, 2013, Pages 56-64

  Guo, Mingxi ^a   Wang, Molin ^a,b   Deng, Hao ^a,c   Zhang, Xintian ^a   Wang, Zhao Yi ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHANDONG UNIVERSITY   (China)

^c JIANGHAN UNIVERSITY   (China)

Author keywords

Breast cancer stem cells; Broussoflavonol B; EGFR; ER negative breast cancer; ER 36

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; BROUSSOFLAVONOL B; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2D; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA 36; MYC PROTEIN; PROGESTERONE RECEPTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BROUSSONETIA PAPYRIFERA; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BREAST CANCER STEM CELLS; BROUSSOFLAVONOL B; EGFR; ER-NEGATIVE BREAST CANCER; ER-Α36;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ESTROGEN RECEPTOR ALPHA; FLAVONOLS; HUMANS; NEOPLASTIC STEM CELLS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84879823815     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.05.047     Document Type: Article

References (39)

1. Bao, Q., Shi, Y., 2007. Apoptosome: A platform for the activation of initiator caspases. Cell Death Differ. 14, 56-65. (Pubitemid 44911894)
2. Charafe-Jauffret, E., Ginestier, C, Iovino, F., Wicinski, J., Cervera, N., Finetti, P., Hur, M.H., Diebel, M.E., Monville, F., Dutcher, J., Brown, M., Viens, P., Xerri, L., Bertucci, F., Stassi, G., Dontu, G., Birnbaum, D., Wicha, M.S., 2009. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 69, 1302-1313.
3. Chen, R.M., Hu, L.H., An, T.Y., Li, J., Shen, Q., 2002. Natural PTP1B inhibitors from Broussonetia papyrifera. Bioorg. Med. Chem. Lett. 12, 3387-3390. (Pubitemid 35292453)
4. Cheng, Z.J., Lin, C.N., Hwang, T.L, Teng, C.M., 2001. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem. Pharmacol. 61, 939-946.
5. Clarke, M.F., Dick, J.E., Dirks, P.B., Eaves, C.J., Jamieson, C.H., Jones, D.L, Visvader, J., Weissman, I.L., Wahl, G.M., 2006. Cancer stem cells - perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 66, 9339-9344. (Pubitemid 44623625)
6. Dean, M., 2006. Cancer stem cells: redefining the paradigm of cancer treatment strategies. Mol. Interv. 6, 140-148. (Pubitemid 43998812)
7. Diehn, M., Clarke, M.F., 2006. Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J. Nat. Cancer Inst. 98, 1755-1757. (Pubitemid 46017927)
8. Feng, W., Li, H., Zheng, X., 2008. Researches of constituents of Broussonetia papyrifera. Chin. J. New Drugs 17, 272-278.
9. Guo, F.J., Feng, L, Huang, C., Ding, H.X, Zhang, X.T., Wang, Z.Y., Li, Y.M., 2013. Prenylflavone derivatives from Broussonetia papyrifera, inhibit maliganant growth of breast cancer cells in vitro and in vivo. Phytochem. Lett. 6, 331-336.
10. Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., and Lander., E. S., 2009. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 21, 645-659.
11. Hambardzumyan, D., Squatrito, M., Holland, E.C., 2006. Radiation resistance and stem-like cells in brain tumors. Cancer Cell 10, 454-456. (Pubitemid 44854752)
12. Johnson, T., 1998. CRC Ethnobotany Desk Reference. CRC Press, Boca Raton, FL.
13. Kang, L.G., Wang, Z.Y., 2010. Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36. J. Cell. Mol. Med 14, 1485-1493.
14. Kang, L.G., Guo, Y.M, Zhang, X.T., Meng, J., Wang, Z.Y., 2011. A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells. J. Steroid Biochem. Mol. Biol. 127, 262-268.
15. Kim, S.H., Sehrawat, A., Singh, S.V., 2013. Dietary chemopreventive benzyl iso-thiocyate inhibits breast cancer stem cell in vitro and in vivo. Cancer Prev. Res. (Epub ahead of print).
16. Ko, H.H., Yu, S.M., Ko, F.N., Teng, C.M., Lin, C.N., 1997. Bioactive constituents of Morus australis and Broussonetia papyrifera. J. Nat. Prod. 60, 1008-1011.
17. Kwak, W.J., Moon, T.C., Lin, C.X., Rhyn, H.G., Jung, H., Lee, E., Kwon, D.Y., Son, K.H., Kim, H.P., Kang, S.S., Murakami, M., Kudo, I., Chang, H.W., 2003. Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A-2 inhibitory activity. Biol. Pharm. Bull. 26, 299-302. (Pubitemid 39663613)
18. Lee, D.H., Kinghorn, A.D., 2003. Bioactive compounds from Broussonetia. In: Rahman, A. (Ed.), Studies in Natural Products Chemistry, Bioactive Natural Products, Part 1. Elsevier B.V. Amsterdam, Netherlands, pp. 3-331286-1293.
19. Lee, D.H., Bhat, K.P.L., Fong, H.H.S., Farnsworth, N.R., Pezzuto, J.M., Kinghorn, A.D., 2001. Aromatase inhibitors from Broussonetia papyrifera. J. Nat. Prod. 64, 1286-1293. (Pubitemid 33029208)
20. Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H.F., Newman, B., Yu, Y., Clouthier, S.G., Schwartz, S.J., Wicha, M.S., Sun, D., 2010. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin. Cancer Res. 16, 2580-2590.
21. Lin, C.N., Lu, C.M., Lin, H.C., Fang, S.C., Shieh, B.J., Hsu, M.F., Wang, J.P., Ko, F.N., Teng, C.M., 1996. Novel antiplatelet constituents from formosan Moraceous plants. J. Nat. Prod. 59, 834-838.
22. Liu, S., Dontu, G., Wicha, M.S., 2005. Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast Cancer Res. 7, 86-95. (Pubitemid 40704127)
23. Matsuda, H., Cai, H., Kubo, M., Tosa, H., linuma, M., 1995. Study on anti-cataract drugs from natural sources. II. Effects of buddlejae flos on in vitro aldose reductase activity. Biol. Pharm. Bull 18, 463-466.
24. Matsumoto, J., Fujimoto, T., Takino, C., Saitoh, M., Hano, Y., Fukai, T., Nomura, T., 1985. Components of Broussonetia papyrifera (L.) VENT. I. Structures of two new isoprenylated flavonols and two chalcone derivatives. Chem. Pharm. Bull. 33 3250-325.
25. Nguyen, P.H., Sharma, G., Dao, T.T., Uddin, M.N., Kang, K.W., Ndinteh, D.T., and Mbafor., J. T., Oha, W.K., 2012. New prenylated isoflavonoids as protein tyrosine phospha-tase 1B (PTP1B) inhibitors from Erythrina addisoniae. Bioorg. Med. Chem. 20, 6459-6464.
26. O'Brien, C.S., Howell, S.J., Farnie, G., Clarke, R.B., 2009. Resistance to endocrine therapy: are breast cancer stem cells the culprits? J. Mammary Gland Biol. Neoplasia 14, 45-54.
27. Pelekanou, V., Notas, G., Kampa, M., Tsentelierou, E., Radojicic, J., Leclercq, G., Castanas, E., Stathopoulos, E.N., 2012. ERalpha36, a new variant of the ERalpha is expressed in triple negative breast carcinomas and has a specific transcrip-tomic signature in breast cancer cell lines. Steroids 77, 928-934.
28. Shafee, N., Smith, C.R., Wei, S., Kim, Y., Mills, G.B., Hortobagyi, G.N., Stanbridge, E.J., Lee, E.Y., 2008. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 68, 3243-3250.
29. Sherr, C.J., Roberts, J.M., 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512. (Pubitemid 29297917)
30. Shi, L., Dong, B., Li, Z., Lu, Y., Ouyang, T., Li, J., Wang, T., Fan, Z., Fan, T., Lin, B., Wang, Z.Y., Xie, Y.T., 2009. Expression of ER-{alpha}36, a novel variant of estrogen receptor {alpha}, and resistance to tamoxifen treatment in breast cancer. J. Clin. Oncol. 27, 3423-3429.
31. Sohn, H.Y., Son, K.H., Kwon, C.S., Kang, S.S., 2004. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morusm ongolica Schneider, Broussonetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11, 666-672. (Pubitemid 40007752)
32. Takasugi, M., Kumagai, Y., Nagao, S., Masamune, T., Shirata, A., Takahashi, K., 1980. The cooccurrence of flavan and 1,3-diphenylpropane derivatives in wounded paper mulberry. Chem. Lett. 9, 1459-1460.
33. Takasugi, M., Niino, N., Nagao, S., Anetai, M., Masamune, T., Shirata, A., Takahashi, K., 1984. Eight minor phytoalexins from diseased paper mulberry. Chem. Lett. 13, 689-692.
34. Vranic, S., Gatalica, Z., Deng, H., Frkovic-Grazio, S., Lee, L.M., Gurjeva, O., Wang, Z.Y., 2011. ER-alpha36, a novel isoform of ER-alpha66, is commonly over-expressed in apocrine and adenoid cystic carcinomas of the breast. J. Clin. Pathol. 64, 54-57.
35. Wang, Z.Y., Zhang, X.T., Shen, P., Loggie, B.W., Chang, Y., Deuel, T.F., 2005. Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66. Biochem. Biophys. Res. Commun. 336, 1023-1027. (Pubitemid 41383424)
36. Wang, Z.Y., Zhang, X.T., Shen, P., Loggie, B.W., Chang, Y., Deuel, T.F., 2006. A variant of estrogen receptor-{alpha}, hER-{alpha}36: Transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc. Nat. Acad. Sci. U.S.A. 103, 9063-9068. (Pubitemid 43902533)
37. Zhang, X.T., Kang, L.G., Ding, L., Vranic, S., Gatalica, Z., Wang, Z.Y., 2011. A positive feedback loop of ER-alpha36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene 30, 770-780.
38. Zheng, Z., Cheng, K., Chao, J., Wu, J., Wang, M., 2008. Tyrosinase inhibitors from paper mulberry (Broussonetia papyrifera). Food Chem. 106, 529-535. (Pubitemid 47332864)
39. Zou, Y., Ding, L., Coleman, M., Wang, Z.Y., 2009. Estrogen receptor-alpha (ER-alpha) suppresses expression of its variant ER-alpha 36. FEBS Lett. 583, 1368-1374.