ER-α36, a novel isoform of ER-α66, is commonly over-expressed in apocrine and adenoid cystic carcinomas of the breast

Journal of Clinical Pathology

Volumn 64, Issue 1, 2011, Pages 54-57

  Vranic, Semir ^a,b   Gatalica, Zoran ^a   Deng, Hao ^c   Frkovic Grazio, Snjezana ^d   Lee, Lisa M J ^a,e   Gurjeva, Olga ^f   Wang, Zhao Yi ^g  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SARAJEVO   (Bosnia and Herzegovina)

^c JIANGHAN UNIVERSITY   (China)

^d INSTITUTE OF ONCOLOGY   (Slovenia)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^f Ukranian Strazhesko Institute of Cardiology   (Ukraine)

^g CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA 36; ESTROGEN RECEPTOR ALPHA 66; ISOPROTEIN; PROGESTERONE RECEPTOR; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ADENOID CYSTIC CARCINOMA; ADULT; AGED; APOCRINE CARCINOMA; ARTICLE; BREAST CARCINOMA; CELL MEMBRANE; CYTOPLASM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, ADENOID CYSTIC; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; PROTEIN ISOFORMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL;

EID: 78650812797     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2010.082776     Document Type: Article

References (19)

1. Katzenellenbogen BS, Frasor J. Therapeutic targeting in the estrogen receptor hormonal pathway. Semin Oncol 2004;31:28-38. (Pubitemid 38543938)
2. Nadji M, Gomez-Fernandez C, Ganjei-Azar P, et al. Immunohistochemistry of estrogen and progesterone receptors reconsidered: experience with 5,993 breast cancers. Am J Clin Pathol 2005;123:21-7.
3. Levin ER, Pietras RJ. Estrogen receptors outside the nucleus in breast cancer. Breast Cancer Res Treat 2008;108:351-61.
4. Allred DC. Issues and updates: evaluating estrogen receptor-α, progesterone receptor, and HER2 in breast cancer. Mod Pathol 2010;23:S52-9.
5. Bretschneider N. Regulation of estrogen responsive genes by the human Estrogen receptor alpha (ERα). Heidelberg: Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto Carola University of Heidelberg, 2007 (dissertation).
6. Hirata S, Shoda T, Kato J, et al. Isoform/variant mRNAs for sex steroid hormone receptors in humans. Trends Endocrinol Metab 2003;14:124-9.
7. Wang ZY, Zhang XT, Shen P, et al. Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66. Biochem Biophys Res Commun 2005;336:1023-7. (Pubitemid 41383424)
8. Wang ZY, Zhang XT, Shen P, et al. A variant of estrogen receptor-alpha, hER-alpha36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc Natl Acad Sci USA 2006;103:9063-8.
9. Lee LM, Cao J, Deng H, et al. ER-alpha36, a novel variant of ER-alpha, is expressed in ER-positive and -negative human breast carcinomas. Anticancer Res 2008;28:479-83.
10. Weigelt B, Horlings HM, Kreike B, et al. Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol 2008;216:141-50.
11. Vranic S, Tawfik O, Palazzo J, et al. EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breast. Mod Pathol 2010;23:644-53.
12. Vranic S, Frkovic-Grazio S, Lamovec J, et al. Adenoid cystic carcinomas of the breast have low topo IIa expression but frequently overexpress EGFR protein without EGFR gene amplification. Hum Pathol 2010;41:1617-23.
13. Kampa M, Pelekanou V, Castanas E, et al. Membrane-initiated steroid action in breast and prostate cancer. Steroids 2008;73:953-60.
14. Shi L, Dong B, Li Z, et al. Expression of ER-{alpha}36, a novel variant of estrogen receptor {alpha}, and resistance to tamoxifen treatment in breast cancer. J Clin Oncol 2009;27:3423-9.
15. Fowler AM, Santen RJ, Allred DC. "Dwarf" estrogen receptor in breast cancer and resistance to tamoxifen. J Clin Oncol 2009;27:3413-15.
16. Fan P, Wang JP, Santen RJ, et al. Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells. Cancer Res 2007;67:1352-60.
17. Bratthauer GL, Lininger RA, Man YG, et al. Androgen and estrogen receptor mRNA status in apocrine carcinomas. Diagn Mol Pathol 2002;11:113-18.
18. Tavassoli FA, Purcell CA, Bratthauer GL, et al. Androgen receptor expression along with loss of bcl-2, ER, and PR expression in benign and malignant apocrine lesions of the breast. Implications for therapy. Breast J 1996;2:261-9.
19. Zhang XT, Kang LG, Ding L. A positive feedback loop of ER-α36/EGFR promotes malignant growth of ER-negative breast cancer cells. Oncogene Published Online First: 11 October 2010. doi:10.1038/onc.2010.458.