Nanocrystalline spherical hydroxyapatite granules for bone repair: In vitro evaluation with osteoblast-like cells and osteoclasts

Journal of Materials Science: Materials in Medicine

Volumn 24, Issue 7, 2013, Pages 1755-1766

  Bernhardt, A ^a   Dittrich, R ^b   Lode, A ^a   Despang, F ^a   Gelinsky, M ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b TU BERGAKADEMIE FREIBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY MEASUREMENTS; ALKALINE PHOSPHATASE ACTIVITY; CALCIUM PHOSPHATE MATERIALS; GENE EXPRESSION ANALYSIS; HYDROXYAPATITE GRANULES; IN-VITRO EVALUATION; OSTEOBLAST-LIKE CELLS; THERMAL ELIMINATIONS;

GENE EXPRESSION; GRANULATION; HYDROXYAPATITE; PARTICLES (PARTICULATE MATTER); PHOSPHATASES; SINTERING; SOLS;

MATERIALS;

ACID PHOSPHATASE; ALGINIC ACID; ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; BONE SIALOPROTEIN II; CALCIUM PHOSPHATE; CATHEPSIN K; HYDROXYAPATITE; NANOCOATING; NANOCRYSTAL; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN; SILICON DIOXIDE; STEARIC ACID; TARTRATE SPECIFIC ACID PHOSPHATASE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ADULT; ARTICLE; BIOCOMPATIBILITY; BONE REGENERATION; BONE REMODELING; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GELATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEAT TREATMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; NANOFABRICATION; NORMAL HUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOSARCOMA CELL; POROSITY; POWDER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ANALYSIS;

ADULT; BONE REGENERATION; BONE SUBSTITUTES; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; DURAPATITE; GENE EXPRESSION; GUIDED TISSUE REGENERATION; HUMANS; NANOPARTICLES; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; PARTICLE SIZE; POWDERS; TISSUE ENGINEERING;

EID: 84879800644     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-013-4933-2     Document Type: Article

References (36)

1. Dorozhkin SV, Epple M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed Engl. 2002;41:3130-46.
2. Schwartzwalder K (1963) Method of making porous ceramic articles. US Patent 3090094.
3. Schwartz Z, Weesner T, van Dijk S, Cochran DL, Mellonig JT, Lohmann CH, Carnes DL, Goldstein M, Dean DD, Boyan BD. Ability of deproteinized cancellous bovine bone to induce new bone formation. J Periodontol. 2000;71:1258-69.
4. Taylor JC, Cuff SE, Leger JP, Morra A, Anderson GI. In vitro osteoclast resorption of bone substitute biomaterials used for implant site augmentation: a pilot study. Int J Oral Maxillofac Implants. 2002;17:321-30.
5. Bohner M. Calcium phosphate emulsions: possible applications. Key Eng Mater. 2001;192-195:765-8.
6. Gerike W, Bienengräber V, Henkel KO, Bayerlein T, Proff P, Gedrange T, Gerber T. The manufacture of synthetic non-sintered and degradable bone grafting substitutes. Folia Morphol (Warsz). 2006;65:54-5.
7. Bienengräber V, Gerber Th, Trykova T, Kundt G, Henkel KO. A new high porous silica-sol-gel-ceramics for bone grafting - in vivo long-time investigations, Mat.-wiss. u. Werkstofftech. 2004;35:234-239.
8. Tønnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm. 2002;28:621-30.
9. Santos E, Zarate J, Orive G, Hernández RM, Pedraz JL. Biomaterials in cell microencapsulation. Adv Exp Med Biol. 2010;670:5-21.
10. Ribeiro CC, Barrias CC, Barbosa MA. Preparation and characterisation of calcium-phosphate porous microspheres with a uniform size for biomedical applications. J Mater Sci Mater Med. 2006;17:455-63.
11. Mateus AY, Barrias CC, Ribeiro C, Ferraz MP, Monteiro FJ. Comparative study of nanohydroxyapatite microspheres for medical applications. J Biomed Mater Res A. 2008;86:483-93.
12. Misiek DJ, Kent JN, Carr RF. Soft tissue responses to hydroxylapatite particles of different shapes. J Oral Maxillofac Surg. 1984;42:150-60.
13. Douglas T, Liu Q, Humpe A, Wiltfang J, Sivananthan S, Warnke PH. Novel ceramic bone replacement material CeraBall seeded with human mesenchymal stem cells. Clin Oral Implants Res. 2010;21:262-7.
14. Janckila AJ, Takahashi K, Sun SZ, Yam LT. Naphthol-ASBI phosphate as a preferred substrate for tartrate-resistant acid phosphatase isoform 5b. J Bone Miner Res. 2001;16:788-93.
15. Vater C, Lode A, Bernhardt A, Reinstorf A, Heinemann C, Gelinsky M. Influence of different modifications of a calcium phosphate bone cement on adhesion, proliferation, and osteogenic differentiation of human bone marrow stromal cells. J Biomed Mater Res A. 2010;92:1452-60.
16. Despang F, Dittrich R, Gelinsky M. Novel biomaterials with parallel aligned pore channels by directed ionotropic gelation of alginate: mimicking the anisotropic structure of bone tissue. In: George A, editor. Advances in Biomimetics. Rijeka: InTech; 2011. p. 349-72.
17. Despang F, Bernhardt A, Lode A, Dittrich R, Hanke T, Shenoy J, Mani S, John A, Gelinsky M. Synthesis, physico-chemical and in vitro/vivo evaluation of an anistropic, nano-crystalline hydroxyapatite bisque scaffold with parallel aligned pores mimicking the microstructure of cortical bone. J Tissue Eng Regen Med. 2013;. doi: 10.1002/term.1729.
18. Detsch R, Mayr H, Ziegler G. Formation of osteoclast-like cells on HA and TCP ceramics. Acta Biomater. 2008;4:139-48.
19. Bose S, Dasgupta S, Tarafder S, Bandyopadhyay A. Microwave-processed nanocrystalline hydroxyapatite: simultaneous enhancement of mechanical and biological properties. Acta Biomater. 2010;6:3782-90.
20. Sato M, Aslani A, Sambito MA, Kalkhoran NM, Slamovich EB, Webster TJ. Nanocrystalline hydroxyapatite/titania coatings on titanium improves osteoblast adhesion. J Biomed Mater Res A. 2008;84:265-72.
21. Balasundaram G, Sato M, Webster TJ. Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD. Biomaterials. 2006;27:2798-805.
22. Webster TJ, Ergun C, Doremus RH, Siegel RW, Bizios R. Enhanced osteoclast-like cell functions on nanophase ceramics. Biomaterials. 2001;22:1327-33.
23. Christenson EM, Anseth KS, van den Beucken JJ, Chan CK, Ercan B, Jansen JA, Laurencin CT, Li WJ, Murugan R, Nair LS, Ramakrishna S, Tuan RS, Webster TJ, Mikos AG. Nanobiomaterial applications in orthopedics. J Orthop Res. 2007;25:11-22.
24. dePaula FL, Barreto IC, Rocha-Leão MH, Borojevic R, Rossi AM, Rosa FP, Farina M. Hydroxyapatite-alginate biocomposite promotes bone mineralization in different length scales in vivo. Front Mater Sci China. 2009;3:145-53.
25. Rossi AL, Barreto IC, Maciel WQ, Rosa FP, Rocha-Leão MH, Werckmann J, Rossi AM, Borojevic R, Farina M. Ultrastructure of regenerated bone mineral surrounding hydroxyapatite-alginate composite and sintered hydroxyapatite. Bone. 2012;50:301-10.
26. Bernhardt A, Despang F, Lode A, Demmler A, Hanke T, Gelinsky M. Proliferation and osteogenic differentiation of human bone marrow stromal cells on alginate-gelatine-hydroxyapatite scaffolds with anisotropic pore structure. J Tissue Eng Regen Med. 2009;3:54-62.
27. Bernhardt A, Lode A, Peters F, Gelinsky M. Comparative evaluation of different calcium phosphate-based bone graft granules - an in vitro study with osteoblast-like cells. Clin Oral Implants Res. 2013;24:441-9.
28. Horch HH, Sader R, Pautke C, Neff A, Deppe H, Kolk A. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws. Int J Oral Maxillofac Surg. 2006;35:708-13.
29. Nair MB, Bernhardt A, Lode A, Heinemann C, Thieme S, Hanke T, Varma H, Gelinsky M, John A. A bioactive triphasic ceramic-coated hydroxyapatite promotes proliferation and osteogenic differentiation of human bone marrow stromal cells. J Biomed Mater Res A. 2009;90:533-42.
30. Pietak AM, Reid JW, Stott MJ, Sayer M. Silicon substitution in the calcium phosphate bioceramics. Biomaterials. 2007;28:4023-32.
31. Bohner M. Silicon-substituted calcium phosphates - a critical view. Biomaterials. 2009;30:6403-6.
32. Heinemann C, Heinemann S, Worch H, Hanke T. Development of an osteoblast/osteoclast co-culture derived by human bone marrow stromal cells and human monocytes for biomaterials testing. Eur Cell Mater. 2011;21:80-93.
33. Lau KH, Onishi T, Wergedal JE, Singer FR, Baylink DJ. Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption. Clin Chem. 1987;33:458-62.
34. Detsch R, Hagmeyer D, Neumann M, Schaefer S, Vortkamp A, Wuelling M, Ziegler G, Epple M. The resorption of nanocrystalline calcium phosphates by osteoclast-like cells. Acta Biomater. 2010;6:3223-33.
35. Costa-Rodrigues J, Fernandes A, Lopes MA, Fernandes MH. Hydroxyapatite surface roughness: complex modulation of the osteoclastogenesis of human precursor cells. Acta Biomater. 2012;8:1137-45.
36. Rumpler M, Würger T, Roschger P, Zwettler E, Peterlik H, Fratzl P, Klaushofer K. Microcracks and osteoclast resorption activity in vitro. Calcif Tissue Int. 2012;90:230-8.