The relationship between aerobic fitness level and metabolic profiles in healthy adults

Molecular Nutrition and Food Research

Volumn 57, Issue 7, 2013, Pages 1246-1254

  Morris, Ciara ^a   Grada, Colm O ^a   Ryan, Miriam ^a   Roche, Helen M ^a   De Vito, Giuseppe ^a   Gibney, Michael J ^a   Gibney, Eileen R ^a   Brennan, Lorraine ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Branched chain amino acids; Exercise; Fitness; Insulin resistance; Metabolomics

Indexed keywords

BRANCHED CHAIN AMINO ACID;

ADOLESCENT; ADULT; ARTICLE; BLOOD; BODY COMPOSITION; BRANCHED CHAIN AMINO ACIDS; COHORT ANALYSIS; DIET RESTRICTION; ENERGY METABOLISM; EXERCISE; FEMALE; FITNESS; HUMAN; INSULIN RESISTANCE; MALE; METABOLOME; METABOLOMICS; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSIOLOGY; URINE; YOUNG ADULT;

BRANCHED CHAIN AMINO ACIDS; EXERCISE; FITNESS; INSULIN RESISTANCE; METABOLOMICS;

ADOLESCENT; ADULT; AMINO ACIDS, BRANCHED-CHAIN; BODY COMPOSITION; COHORT STUDIES; ENERGY METABOLISM; EXERCISE; FASTING; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; METABOLOME; METABOLOMICS; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSICAL FITNESS; YOUNG ADULT;

EID: 84879800267     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200629     Document Type: Article

References (38)

1. Rezzi, S., Ramadan, Z., Fay, L. B., Kochhar, S., Nutritional metabonomics: applications and perspectives. J. Proteome. Res. 2007, 6, 513-525.
2. Kochhar, S., Jacobs, D. M., Ramadan, Z., Berruex, F. et al., Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics. Anal. Biochem. 2006, 352, 274-281.
3. Slupsky, C. M., Rankin, K. N., Wagner, J., Fu, H. et al., Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal. Chem. 2007, 79, 6995-7004.
4. Psihogios, N. G., Gazi, I. F., Elisaf, M. S., Seferiadis, K. I. et al., Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics. NMR Biomed. 2008, 21, 195-207.
5. Walsh, M. C., Brennan, L., Malthouse, J. P., Roche, H. M. et al., Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am. J. Clin. Nutr. 2006, 84, 531-539.
6. Lenz, E. M., Bright, J., Wilson, I. D., Hughes, A. et al., Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects. J. Pharm. Biomed. Anal. 2004, 36, 841-849.
7. Holmes, E., Loo, R. L., Stamler, J., Bictash, M. et al., Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008, 453, 396-400.
8. Yan, B., A, J., Wang, G., Lu, H. et al., Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training. J. Appl. Physiol. 2009, 106, 531-538.
9. Enea, C., Seguin, F., Petitpas-Mulliez, J., Boildieu, N. et al., (1)H NMR-based metabolomics approach for exploring urinary metabolome modifications after acute and chronic physical exercise. Anal. Bioanal. Chem. 2009, 396, 1167-1176.
10. Lewis, G. D., Farrell, L., Wood, M. J., Martinovic, M. et al., Metabolic signatures of exercise in human plasma. Sci. Transl. Med. 2010, 2, 33ra37.
11. Lehmann, R., Zhao, X., Weigert, C., Simon, P. et al., Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation. PLoS One 2010, 5, e11519.
12. Chorell, E., Svensson, M. B., Moritz, T., Antti, H., Physical fitness level is reflected by alterations in the human plasma metabolome. Molecular Biosystems 2012, 8, 1187-1196.
13. McArdle, W., Katch, F., Katch, V., Essentials of Exercise Physiology, Lippincott Williams & Wilkins, Pennsylvania 2010.
14. Amara, C. E., Koval, J. J., Johnson, P. J., Paterson, D. H. et al., Modelling the influence of fat-free mass and physical activity on the decline in maximal oxygen uptake with age in older humans. Exp. Physiol. 2000, 85, 877-886.
15. Kriketos, A. D., Sharp, T. A., Seagle, H. M., Peters, J. C. et al., Effects of aerobic fitness on fat oxidation and body fatness. Med. Sci. Sports Exerc. 2000, 32, 805-811.
16. Perez, M., Lucia, A., Santalla, A., Chicharro, J. L., Effects of electrical stimulation on VO2 kinetics and delta efficiency in healthy young men. Br. J. Sports Med. 2003, 37, 140-143.
17. Pialoux, V., Brown, A. D., Leigh, R., Friedenreich, C. M. et al., Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women. Hypertension 2009, 54, 1014-1020.
18. Wasserman, K., Hansen, J. (Eds.), Whipp, B., Principles of Exercise Testing and Interpretation, Lea & Febiger, Philadelphia 1986.
19. Peronnet, F., Massicotte, D., Table of nonprotein respiratory quotient: an update. Can. J. Sport. Sci. 1991, 16, 23-29.
20. Nanas, S., Nanas, J., Kassiotis, C., Nikolaou, C. et al., Early recovery of oxygen kinetics after submaximal exercise test predicts functional capacity in patients with chronic heart failure. Eur. J. Heart Fail. 2001, 3, 685-692.
21. Storey, J. D., Tibshirani, R., Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 2003, 100, 9440-9445.
22. Fruchterman, T. M., Reingold, E. M, Graph drawing by force-directed placement. Software: Pract. Exp. 1991, 21, 1129-1164.
23. Bastian, M., Heymann S., Jacomy, M., Third International AAAI Conference on Weblogs and Social Media, May 17-20, 2009, San Jose, California, 2009.
24. Sidossis, L. S., Wolfe, R. R., Coggan, A. R., Regulation of fatty acid oxidation in untrained vs. trained men during exercise. Am. J. Physiol. 1998, 274, E510-E515.
25. Hagberg, J. M., Hickson, R. C., Ehsani, A. A., Holloszy, J. O., Faster adjustment to and recovery from submaximal exercise in the trained state. J. Appl. Physiol. 1980, 48, 218-224.
26. Frey, G. C., Byrnes, W. C., Mazzeo, R. S., Factors influencing excess postexercise oxygen consumption in trained and untrained women. Metabolism 1993, 42, 822-828.
27. Short, K. R., Sedlock, D. A., Excess postexercise oxygen consumption and recovery rate in trained and untrained subjects. J. Appl. Physiol. 1997, 83, 153-159.
28. Liappis, N., Janssen, E., Kesseler, K., Hildenbrand, G., A quantitative study of free amino acids in eccrine sweat collected from the forearms of healthy young men during sauna bathing. Eur. J. Appl. Physiol. Occup. Physiol. 1980, 45, 63-67.
29. Shimomura, Y., Yamamoto, Y., Bajotto, G., Sato, J. et al., Nutraceutical effects of branched-chain amino acids on skeletal muscle. J. Nutr. 2006, 136, 529S-532S.
30. Shimomura, Y., Murakami, T., Nakai, N., Nagasaki, M. et al., Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J. Nutr. 2004, 134, 1583S-1587S.
31. Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J. et al., A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009, 9, 311-326.
32. Wang, T. J., Larson, M. G., Vasan, R. S., Cheng, S. et al., Metabolite profiles and the risk of developing diabetes. Nat. Med. 2011, 17, 448-453.
33. Laferrere, B., Reilly, D., Arias, S., Swerdlow, N. et al., Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci. Transl. Med. 2011, 3, 80re82.
34. Shah, S. H., Crosslin, D. R., Haynes, C. S., Nelson, S. et al., Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia 2012, 55, 321-330.
35. Huffman, K. M., Shah, S. H., Stevens, R. D., Bain, J. R. et al., Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care 2009, 32, 1678-1683.
36. Adams, S. H., Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv. Nutr. 2012, 2, 445-456.
37. Kamaura, M., Nishijima, K., Takahashi, M., Ando, T. et al., Lifestyle modification in metabolic syndrome and associated changes in plasma amino acid profiles. Circ. J. 2010, 74, 2434-2440.
38. Donovan, C. M., Sumida, K. D., Training enhanced hepatic gluconeogenesis: the importance for glucose homeostasis during exercise. Med. Sci. Sports Exerc. 1997, 29, 628-634.