Regulation of fatty acid oxidation in untrained vs. trained men during exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 3 37-3, 1998, Pages

  Sidossis, Labros S ^a   Wolfe, Robert R ^a   Coggan, Andrew R ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Carnitine palmitoyltransferase; Endurance training; Malonyl coenzyme A; Medium chain fatty acids; Mitochondria; Muscle

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; MALONYL COENZYME A;

ADAPTATION; ADULT; ARTICLE; CARBOHYDRATE METABOLISM; ENDURANCE; ENZYME SUBSTRATE; EXERCISE; FATTY ACID OXIDATION; GLUCOSE UTILIZATION; GLYCOLYSIS; HUMAN; HUMAN EXPERIMENT; MITOCHONDRIAL MEMBRANE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 0031981109     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.3.e510     Document Type: Article

References (27)

1. Banchio, C., and H. C. Gramajo. Medium- and long-chain fatty acid uptake and utilization by Streptomyces coelicolor A3(2): first characterization of a gram-positive bacterial system. Microbiology 143: 2439-2447, 1997.
2. Coggan, A. R., R. J. Spina, W. M. Kohrt, and J. O. Holloszy. Effect of prolonged exercise on muscle citrate concentration before and after endurance training in men. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E215-E220, 1993.
3. Coggan, A. R., and B. D. Williams. Metabolic adaptations to endurance training: substrate metabolism during exercise. In: Exercise Metabolism, edited by M. Hargreaves. Champaign, IL: Human Kinetics, 1995, p. 177-210.
4. Coyle, E. F., A. E. Jeukendrup, A. J. M. Wagenmakers, and W. H. M. Saris. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E268-E275, 1997.
5. Frayn, K. N. Calculation of substrate oxidation rates in vivo from gaseous exchange. J. Appl. Physiol. 55: 628-634, 1983.
6. Fritz, I. B. Action of carnitine on long chain fatty acid oxidation by liver. Am. J. Physiol. 197: 297-304, 1959.
7. Helge, J. W., and B. Kiens. Muscle enzyme activity in humans: role of substrate availability and training. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R1620-R1624, 1997.
8. Holloszy, J. O., and E. F. Coyle. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J. Appl. Physiol. 56: 831-838, 1984.
9. Hurley, B. F., P. M. Nemeth, W. H. Martin III, J. M. Hagberg, G. P. Dalsky, and J. O. Holloszy. Muscle triglyceride utilization during exercise: effect of training. J. Appl. Physiol. 60: 562-567, 1986.
10. Ibrahimi, A., Z. Sfeir, H. Magharaie, E. Z. Amri, P. Grimaldi, and N. A. Abumrad. Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport. Proc. Natl. Acad. Sci. USA 97: 2646-2651, 1996.
11. Jansson, E., and L. Kaijser. Substrate utilization and enzymes in skeletal muscle of extremely endurance-trained men. J. Appl. Physiol. 62: 999-1005, 1987.
12. Kanaley, J. A., C. D. Mottram, P. D. Scanlon, and M. D. Jensen. Fatty acid kinetic responses to running above and below lactate threshold. J. Appl. Physiol. 79: 439-447, 1995.
13. Martin, W. H., III, G. P. Dalsky, B. F. Hurley, D. E. Matthews, D. M. Bier, J. M. Hagberg, M. A. Rogers, D. S. King, and J. O. Holloszy. Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E708-E714, 1993.
14. McGarry, J. D., and N. F. Brown. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244: 1-14, 1997.
15. McGarry, J. D., and D. W. Foster. The metabolism of (-)-octanoylcarnitine in perfused livers from fed and fasted rats: evidence for a possible regulatory role of carnitine acyltransferase in the control of ketogenesis. J. Biol. Chem. 249: 7984-7990, 1974.
16. McGarry, J. D., G. P. Mannaerts, and D. W. Foster. A possible role for malonyl-CoA in the regulation of hepatic acid oxidation and ketogenesis. J. Clin. Invest. 60: 265-270, 1977.
17. Pande, S. V. A mitochondrial carnitine acyltransferase translocase system. Proc. Natl. Acad. Sci. USA 72: 883-887, 1975.
18. Randle, P. J., E. A. Newsholme, and P. B. Garland. Regulation of glucose uptake by muscle. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem. J. 93: 652-664, 1964.
19. 12C ratio method during strenuous exercise. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E64-E71, 1992.
20. Romijn, J. A., E. F. Coyle, L. S. Sidossis, A. Gastaldelli, J. F. Horowitz, E. Endert, and R. R. Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E380-E391, 1993.
21. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies. J. Clin. Invest. 95: 278-284, 1995.
22. Sidossis, L. S., A. R. Coggan, A. Gastaldelli, and R. R. Wolfe. A new correction factor for use in tracer estimations of plasma fatty acid oxidation. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E649-E656, 1995.
23. Sidossis, L. S., A. Gastaldelli, S. Klein, and R. R. Wolfe. Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E1065-E1070, 1997.
24. Sidossis, L. S., C. A. Stuart, G. I. Shulman, G. D. Lopaschuk, and R. R. Wolfe. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 98: 2244-2250, 1996.
25. Wasserman, K. The anaerobic threshold: definition, physiological significance and identification. Adv. Cardiol. 35: 1-23, 1986.
26. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine. New York: Wiley-Liss, 1992, p. 422-424.
27. 2 enrichment. J. Appl. Physiol. 56: 230-234, 1984.