MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway

Molecular and Cellular Biochemistry

Volumn 380, Issue 1-2, 2013, Pages 107-119

  Li, Nan ^a,b   Tang, Anliu ^a,b   Huang, Shuo ^a,f   Li, Zeng ^a,g   Li, Xiayu ^a,b   Shen, Shourong ^a,b   Ma, Jian ^b,c,d,e   Wang, Xiaoyan ^a,b  

^a THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^b Hunan Key Laboratory of Nonresolving Inflammation and Cancer   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d BEIJING HOSPITAL   (China)

^e BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^f Xiangtan First People's Hospital   (China)

^g Xiangtan Central Hospital   (China)

Author keywords

Cancer metastasis; Cancer proliferation; Colon cancer; MiR 126; RhoA

Indexed keywords

MICRORNA 126; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BIOINFORMATICS; CANCER CELL; CANCER INHIBITION; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; COLON CANCER; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; HCT116 CELLS; HT29 CELLS; HUMANS; IN SITU HYBRIDIZATION; MICRORNAS; MODELS, GENETIC; NEOPLASM INVASIVENESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84879795301     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1664-0     Document Type: Article

References (46)

1. Alwan A (2007) World Health Organization. Disaster Med Public Health Prep 1:7-8
2. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10-29
3. Din FV, Theodoratou E, Farrington SM, Tensa A, Barnetson RA, Cetnarskyj R, Stark L, Porteous ME, Campbell H, Dumlop MG (2010) Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut 59:1670-1679
4. Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress and timing. Cell 113:673-676
5. Brennecke J, Hipfner AS, Russell RB, Cohen SM (2003) Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in drosophila. Cell 113:25-36
6. Chen C, Li L, Lodish HF, Bartel DP (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303:83-86
7. Croce CM, Calin GA (2005) miRNAs, cancer and stem cell division. Cell 122:6-7
8. Zhang B, Pan X, Cobb GP, Anderson TA (2007) MicroRNAs as oncogenes and tumor suppressors. Dev Biol 302:1-12
9. Iorio MV, Croce CM (2009) MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol 27:5848-5856
10. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yune ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC (2008) MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299:425-436
11. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103:2257-2261
12. Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, Shen SR (2010) Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. Mol Cell Biochem 345:283-290
13. Wang S, Aurora AB, Jonason BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN (2008) The endothelial specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15:261-271
14. Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-152
15. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin GA, Liu CG, Croce CM, Harris CC (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189-198
16. Cho WC, Chow AS, Au JS (2009) Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer 45:2197-2206
17. Feng R, Chen X, Yu Y, Su L, Yu B, Li J, Cai Q, Yan M, Liu B, Zhu Z (2010) miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett 298:50-63
18. Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C, Zheng ZM (2008) Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3:e2557
19. Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G (2009) Epigenetic therapy up-regulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 379:726-731
20. Sahai E, Marshall CJ (2002) RHO-GTPases and cancer. Nat Rev Cancer 2:133-142
21. Schee K, Boye K, Abrahamsen TW, Fodstad Ø, Flatmark K (2012) Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer. BMC Cancer 12:505
22. Vega FM, Ridley AJ (2008) Rho GTPases in cancer cell biology. FEBS Lett 582(14):2093
23. Tang Y, Olufemi L, Wang MT, Nie D (2008) Role of Rho GTPases in breast cancer. Front Biosci 13:759-776
24. Cheng KW, Agarwal R, Mills GB (2009) Ras-superfamily GTPases in ovarian cancer. Cancer Treat Res 149:229-240
25. Grise F, Bidaud A, Moreau V (2009) Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 1795(2):137-151
26. Struckhoff AP, Rana MK, Worthylake RA (2011) RhoA can lead the way in tumor cell invasion and metastasis. Front Biosci 1:1915-1926
27. Chang YW, Marlin JW, Chance TW, Jakobi R (2006) RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. Cancer Res 66:11700-11708
28. Cavallaro U, Christofori G (2004) Cell adhesion and signaling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4:118-132
29. Fagan-Solis KD, Schneider SS, Pentecost BT, Bentley BA, Otis CN, Gierthy JF, Arcaro KF (2012) The ras homolog gene family, member A (RhoA) pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem 17:1002
30. Olson MF (2008) Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20:242-248
31. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K (1997) Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275:1308-1311
32. Matsuoka T, Yashiro M, Kato Y, Shinto O, Kashiwagi S, Hirakawa K (2011) RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility. Clin Exp Metastasis 28:627-636
33. Lane J, Martin TA, Watkins G, Mansel RE, Jiang WG (2008) The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer. Int J Oncol 33:585-593
34. Kamai T, Tsujii T, Arai K, Takagi K, Asami H, Ito Y, Oshima H (2003) Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 9:2632-2641
35. Li B, Zhao WD, Tan ZM, Fang WG, Zhu L, Chen YH (2006) Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells. FEBS Lett 580:4252-4260
36. Joshi B, Strugnell SS, Goetz JG, Kojic LD, Cox ME, Griffith OL, Chan SK, Jones SJ, Leung SP, Masoudi H, Leung S, Wiseman SM, Nabi IR (2008) Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res 68:8210-8820
37. Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ (2005) Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol Biol Cell 16:3117-3127
38. Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R (2007) Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion. Genes Dev 21:1478-1483
39. 1 cell cycle arrest by inhibiting the expression and activity of RhoA protein. J Virol 87(6):3039-3052
40. Lee MH, Cho YS, Han YM (2007) Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. Stem Cells 25:1654-1663
41. Benitah SA, Valerón PF, van Aelst L, Marshall CJ, Lacal JC (2004) Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta 1705:121-132
42. Li Y, Chen Y, Tao Y, Xu J, Chen M (2010) RhoA protein is generally distributed in the nuclei of cancer cells. Oncol Rep 24:1005-1009
43. Musgrove EA, Caldon CE, Barraclough J, Stone A, Sutherland RL (2011) Cyclin D as a therapeutic target in cancer. Nat Rev Cancer 11:558-572
44. Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, Chluba J, Langsley G, Weitzman JB (2012) SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res 72:810-820
45. Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM (2009) Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell 20:4070-4082
46. Furukawa K, Kumon Y, Harada H, Kohno S, Nagato S, Teraola M, Fujiwara S, Nakagawa K, Hamada K, Ohnishi T (2006) PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules. Int J Oncol 29(1):73-81