Cuprizone [bis(cyclohexylidenehydrazide)] is selectively toxic for mature oligodendrocytes

Neurotoxicity Research

Volumn 24, Issue 2, 2013, Pages 244-250

  Bénardais, Karelle ^a,b   Kotsiari, Alexandra ^a   Škuljec, Jelena ^a,b   Koutsoudaki, Paraskevi N ^a,b,c   Gudi, Viktoria ^a   Singh, Vikramjeet ^a,b   Vulinović, Franca ^a,d   Skripuletz, Thomas ^a   Stangel, Martin ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Centre for Systems Neuroscience   (Germany)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Cuprizone; Demyelination; In vitro; Mitochondrial transmembrane potential; Oligodendrocytes

Indexed keywords

CUPRIZONE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEMYELINATION; HUMAN; HUMAN CELL; MICROGLIA; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELLS, CULTURED; CHELATING AGENTS; CUPRIZONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; MUS; RATTUS;

EID: 84879795251     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-013-9380-9     Document Type: Article

References (20)

1. Benetti F, Ventura M, Salmini B, Ceola S, Carbonera D, Mammi S, Zitolo A, D'Angelo P, Urso E, Maffia M, Salvato B, Spisni E (2011) Cuprizone neurotoxicity, copper deficiency and neurodegeneration. Neurotoxicology 31:509-517
2. Blakemore WF (1972) Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice. J Neurocytol 1:413-426
3. Blakemore WF (1973) Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone. J Neurol Sci 20:63-72
4. Cammer W (1999) The neurotoxicant, cuprizone, retards the differentiation of oligodendrocytes in vitro. J Neurol Sci 168:116-120
5. Carlton WW (1967) Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity. Life Sci 6:11-19
6. Denic A, Johnson AJ, Bieber AJ, Warrington AE, Rodriguez M, Pirko I (2011) The relevance of animal models in multiple sclerosis research. Pathophysiology 18:21-29
7. Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309-1312
8. Gudi V, Moharregh-Khiabani D, Skripuletz T, Koutsoudaki PN, Kotsiari A, Skuljec J, Trebst C, Stangel M (2009) Regional differences between grey and white matter in cuprizone induced demyelination. Brain Res 1283:127-138
9. Komoly S, Jeyasingham MD, Pratt OE, Lantos PL (1987) Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination. J Neurol Sci 79:141-148
10. Lindner M, Fokuhl J, Linsmeier F, Trebst C, Stangel M (2009) Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination. Neurosci Lett 453:120-125
11. Matsushima GK, Morell P (2001) The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 11:107-116
12. McCarthy KD, de Vellis J (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902
13. Messori L, Casini A, Gabbiani C, Sorace L, Muniz-Miranda M, Zatta P (2007) Unravelling the chemical nature of copper cuprizone. Dalton Trans 21:2112-2114
14. Nociari MM, Shalev A, Benias P, Russo C (1998) A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods 213:157-167
15. Pasquini LA, Calatayud CA, Bertone Una AL, Millet V, Pasquini JM, Soto EF (2007) The neurotoxic effect of cuprizone on oligodendrocytes depends on the presence of pro-inflammatory cytokines secreted by microglia. Neurochem Res 32:279-292
16. Skripuletz T, Gudi V, Hackstette D, Stangel M (2011) De- and remyelination in the CNS white and grey matter induced by cuprizone: the old, the new, and the unexpected. Histol Histopathol 26:1585-1597
17. Stangel M, Bernard D (2003) Polyclonal IgM influence oligodendrocyte precursor cells in mixed glial cell cultures: implications for remyelination. J Neuroimmunol 138:25-30
18. Stangel M, Compston A, Scolding NJ (2000) Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins ("IVIg"). J Neuroimmunol 103:195-201
19. Werner SR, Saha JK, Broderick CL, Zhen EY, Higgs RE, Duffin KL, Smith RC (2010) Proteomic analysis of demyelinated and remyelinating brain tissue following dietary cuprizone administration. J Mol Neurosci 42:210-225
20. Zatta P, Raso M, Zambenedetti P, Wittkowski W, Messori L, Piccioli F, Mauri PL, Beltramini M (2005) Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment. Cell Mol Life Sci 62:1502-1513