Polyclonal IgM influence oligodendrocyte precursor cells in mixed glial cell cultures: Implications for remyelination

Journal of Neuroimmunology

Volumn 138, Issue 1-2, 2003, Pages 25-30

  Stangel, Martin ^a,b   Bernard, Dirk ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CNS inflammation; Immunomodulation; Intravenous immunoglobulins; IVIg; Oligodendrocyte precursors

Indexed keywords

ALBUMIN; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTRAGLOBIN; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL INTERACTION; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; GLIA CELL; MICROGLIA; NEUROMODULATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; STEM CELL;

EID: 0038636588     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(03)00087-0     Document Type: Article

References (19)

1. Armstrong R.C., Le T.Q., Frost E.E., Borke R.C., Vana A.C. Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter. J. Neurosci. 22:2002;8574-8585.
2. Bieber A.J., Warrington A., Pease L.R., Rodriguez M. Humoral autoimmunity as a mediator of CNS repair. Trends Neurosci. 24:2001;S39-S44. (Supplement).
3. Bieber A.J., Warrington A., Asakura K., Ciric B., Kaveri S.V., Pease L.R., Rodriguez M. Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice. Glia. 37:2002;241-249.
4. Blakemore W.F., Keirstead H.S. The origin of remyelinating cells in the central nervous system. J. Neuroimmunol. 98:1999;69-76.
5. Compston A., Coles A. Multiple sclerosis. Lancet. 359:2002;1221-1231.
6. Kazatchkine M.D., Kaveri S.V. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N. Engl. J. Med. 345:2001;747-755.
7. McCarthy K.D., de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:1980;890-902.
8. McGavern D., Asakura K., Rodriguez M. Do antibodies stimulate myelin repair in multiple sclerosis? Neuroscientist. 5:1999;19-28.
9. Nitta T., Yagita H., Okumura K. Expression of Fc gamma receptors on astroglial cell lines and their role in the central nervous system. Neurosurgery. 31:1992;83-87.
10. Noseworthy J.H., Lucchinetti C., Rodriguez M., Weinshenker B.G. Multiple sclerosis. N. Engl. J. Med. 343:2000;938-952.
11. Noseworthy J.H., O'Brien P.C., Weinshenker B.G., Weis J.A., Petterson T.M., Erickson B.J., Windebank A.J., Whisnant J.P., Stolp-Smith K.A., Harper C.M., Low P.A., Romme L.J., Johnson M., An K.-N., Rodriguez M. IV immunoglobulin does not reverse established weakness in MS. A double-blind, placebo-controlled trial. Neurology. 55:2000;1135-1143.
12. Noseworthy J.H., O'Brien P.C., Petterson T.M., Weis J., Stevens L., Peterson W.K., Sneve D., Cross S.A., Leavitt J.A., Auger R.G., Weinshenker B.G., Dodick D.W., Wingerchuck D.M., Rodriguez M. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis. Neurology. 56:2001;1514-1522.
13. Pul R., Nguyen D., Schmitz U., Marx P., Stangel M. Comparison of intravenous immunoglobulin preparations on microglial function in vitro: more potent immunomodulatory capacity of an IgM/IgA-enriched preparation. Clin. Neuropharmacol. 25:2002;254-259.
14. Rieben R., Roos A., Muizert Y., Tinguely C., Gerritsen A.F., Daha M. Immunoglobulin M-enriched human intravenous immunoglobulin prevents complement activation in vitro and in vivo in a rat model of acute inflammation. Blood. 93:1999;942-951.
15. Stangel M., Compston A. Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors. J. Neuroimmunol. 112:2001;63-71.
16. Stangel M., Compston A., Scolding N.J. Polyclonal immunoglobulins for intravenous use do not influence the behaviour of cultured oligodendrocytes. J. Neuroimmunol. 96:1999;228-233.
17. Stangel M., Boegner F., Klatt C.H., Hofmeister C., Seyfert S. A placebo-controlled pilot trial to study the remyelinating potential of intravenous immunoglobulins in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 68:2000;89-92.
18. Stangel M., Compston A., Scolding N.J. Oligodendroglia are protected from antibody mediated complement injury by normal immunoglobulins ("IVIg"). J. Neuroimmunol. 103:2000;195-201.
19. Warrington A.E., Asakura K., Bieber A.J., Ciric B., Van Keulen V., Kaveri S.V., Kyle R.A., Pease L.R., Rodriguez M. Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis. Proc. Natl. Acad. Sci. 97:2000;6820-6825.