Auditory cortex is implicated in tinnitus distress: A voxel-based morphometry study

Brain Structure and Function

Volumn 218, Issue 4, 2013, Pages 1061-1070

  Schecklmann, Martin ^a   Lehner, Astrid ^a   Poeppl, Timm B ^a   Kreuzer, Peter M ^a   Rupprecht, Rainer ^a   Rackl, Julia ^a   Burger, Julia ^a   Frank, Elmar ^a   Hajak, Göran ^b   Langguth, Berthold ^a   Landgrebe, Michael ^a,b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b Social Foundation Bamberg   (Germany)

Author keywords

Auditory cortex; Distress; Duration; Grey matter volume; Laterality; Ringing in the ears; Structural imaging

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; AUDITORY CORTEX; BRAIN SIZE; FEMALE; GRAY MATTER; HESCHL GYRUS; HUMAN; INSULA; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; TINNITUS; VOXEL BASED MORPHOMETRY;

ADOLESCENT; ADULT; AGED; AUDITORY CORTEX; FEMALE; GERMANY; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROIMAGING; ORGAN SIZE; REGRESSION ANALYSIS; TINNITUS;

EID: 84879793458     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-013-0520-z     Document Type: Article

References (59)

1. Adjamian P, Sereda M, Hall DA (2009) The mechanisms of tinnitus: perspectives from human functional neuroimaging. Hear Res 253(1-2):15-31
2. Aldhafeeri FM, Mackenzie I, Kay T, Alghamdi J, Sluming V (2012) Neuroanatomical correlates of tinnitus revealed by cortical thickness analysis and diffusion tensor imaging. Neuroradiology 54:889-892
3. Andersson G, Juris L, Classon E, Fredrikson M, Furmark T (2006) Consequences of suppressing thoughts about tinnitus and the effects of cognitive distraction on brain activity in tinnitus patients. Audiol Neurootol 11(5):301-309
4. Axelsson A, Ringdahl A (1989) Tinnitus - a study of its prevalence and characteristics. Br J Audiol 23(1):53-62
5. Bamiou DE, Musiek FE, Luxon LM (2003) The insula (Island of Reil) and its role in auditory processing. Literature review. Brain Res Brain Res Rev 42(2):143-154
6. Boyen K, Langers DR, de Kleine E, van Dijk P (2013) Gray matter in the brain: differences associated with tinnitus and hearing loss. Hear Res 295:67-78
7. Burger J, Frank E, Kreuzer P, Kleinjung T, Vielsmeier V, Landgrebe M, Hajak G, Langguth B (2011) Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders - a retrospective analysis. Brain Stimul 4(4):222-227
8. De Ridder D, Elgoyhen AB, Romo R, Langguth B (2011a) Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci USA 108(20):8075-8080
9. De Ridder D, Vanneste S, Congedo M (2011b) The distressed brain: a group blind source separation analysis on tinnitus. PLoS ONE 6(10):e24273
10. Diesch E, Schummer V, Kramer M, Rupp A (2012) Structural changes of the corpus callosum in tinnitus. Front Syst Neurosci 6:17
11. Eickhoff SB, Paus T, Caspers S, Grosbras MH, Evans AC, Zilles K, Amunts K (2007) Assignment of functional activations to probabilistic cytoarchitectonic areas revisited. Neuroimage 36(3):511-521
12. Frank E, Landgrebe M, Kleinjung T, Hajak G, Langguth B (2010a) Burst transcranial magnetic stimulation for the treatment of tinnitus. CNS Spectr 15(8):536-537
13. Frank G, Kleinjung T, Landgrebe M, Vielsmeier V, Steffenhagen C, Burger J, Frank E, Vollberg G, Hajak G, Langguth B (2010b) Left temporal low-frequency rTMS for the treatment of tinnitus: clinical predictors of treatment outcome - a retrospective study. Eur J Neurol 17(7):951-956
14. Goebel G, Hiller W (1994) The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire. HNO 42(3):166-172
15. Hallam RS, Jakes SC, Hinchcliffe R (1988) Cognitive variables in tinnitus annoyance. Br J Clin Psychol 27(Pt 3):213-222
16. Husain FT, Medina RE, Davis CW, Szymko-Bennett Y, Simonyan K, Pajor NM, Horwitz B (2011) Neuroanatomical changes due to hearing loss and chronic tinnitus: a combined VBM and DTI study. Brain Res 1369:74-88
17. Khedr EM, Ahmed MA, Shawky OA, Mohamed ES, El Attar GS, Mohammad KA (2010) Epidemiological study of chronic tinnitus in Assiut, Egypt. Neuroepidemiology 35(1):45-52
18. Kim JH, Suh SI, Seol HY, Oh K, Seo WK, Yu SW, Park KW, Koh SB (2008) Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia 28(6):598-604
19. Kleinjung T, Langguth B (2009) Strategies for enhancement of transcranial magnetic stimulation effects in tinnitus patients. Int Tinnitus J 15(2):154-160
20. Kleinjung T, Steffens T, Sand P, Murthum T, Hajak G, Strutz J, Langguth B, Eichhammer P (2007) Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg 137(4):589-595
21. Kleinjung T, Steffens T, Landgrebe M, Vielsmeier V, Frank E, Burger J, Strutz J, Hajak G, Langguth B (2011) Repetitive transcranial magnetic stimulation for tinnitus treatment: no enhancement by the dopamine and noradrenaline reuptake inhibitor bupropion. Brain Stimul 4(2):65-70
22. Kreuzer PM, Landgrebe M, Schecklmann M, Poeppl TB, Vielsmeier V, Hajak G, Kleinjung T, Langguth B (2011) Can temporal repetitive transcranial magnetic stimulation be enhanced by targeting affective components of tinnitus with frontal rTMS? A randomized controlled pilot trial. Front Syst Neurosci 5:88
23. Kurth F, Zilles K, Fox PT, Laird AR, Eickhoff SB (2010) A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct 214(5-6):519-534
24. Landgrebe M, Barta W, Rosengarth K, Frick U, Hauser S, Langguth B, Rutschmann R, Greenlee MW, Hajak G, Eichhammer P (2008a) Neuronal correlates of symptom formation in functional somatic syndromes: a fMRI study. Neuroimage 41(4):1336-1344
25. Landgrebe M, Binder H, Koller M, Eberl Y, Kleinjung T, Eichhammer P, Graf E, Hajak G, Langguth B (2008b) Design of a placebo-controlled, randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinnitus. BMC Psychiatry 8:23
26. Landgrebe M, Langguth B, Rosengarth K, Braun S, Koch A, Kleinjung T, May A, de Ridder D, Hajak G (2009) Structural brain changes in tinnitus: grey matter decrease in auditory and non-auditory brain areas. Neuroimage 46(1):213-218
27. Lanting CP, de Kleine E, van Dijk P (2009) Neural activity underlying tinnitus generation: results from PET and fMRI. Hear Res 255(1-2):1-13
28. Leaver AM, Renier L, Chevillet MA, Morgan S, Kim HJ, Rauschecker JP (2011) Dysregulation of limbic and auditory networks in tinnitus. Neuron 69(1):33-43
29. Leaver AM, Seydell-Greenwald A, Turesky TK, Morgan S, Kim HJ, Rauschecker JP (2012) Cortico-limbic morphology separates tinnitus from tinnitus distress. Front Syst Neurosci 6:21
30. Lehner A, Schecklmann M, Landgrebe M, Kreuzer PM, Poeppl TB, Frank E, Vielsmeier V, Kleinjung T, Rupprecht R, Langguth B (2012) Predictors for rTMS response in chronic tinnitus. Front Syst Neurosci 6:11
31. Lemus L, Hernandez A, Romo R (2009) Neural codes for perceptual discrimination of acoustic flutter in the primate auditory cortex. Proc Natl Acad Sci USA 106(23):9471-9476
32. Letzkus JJ, Wolff SB, Meyer EM, Tovote P, Courtin J, Herry C, Luthi A (2011) A disinhibitory microcircuit for associative fear learning in the auditory cortex. Nature 480(7377):331-335
33. Mahoney CJ, Rohrer JD, Goll JC, Fox NC, Rossor MN, Warren JD (2011) Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia. J Neurol Neurosurg Psychiatry 82(11):1274-1278
34. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19(3):1233-1239
35. May A (2011) Experience-dependent structural plasticity in the adult human brain. Trends Cogn Sci 15(10):475-482
36. May A, Hajak G, Ganssbauer S, Steffens T, Langguth B, Kleinjung T, Eichhammer P (2007) Structural brain alterations following 5 days of intervention: dynamic aspects of neuroplasticity. Cereb Cortex 17(1):205-210
37. Menon V, Uddin LQ (2010) Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct 214(5-6):655-667
38. Miller GA, Chapman JP (2001) Misunderstanding analysis of covariance. J Abnorm Psychol 110(1):40-48
39. Moazami-Goudarzi M, Michels L, Weisz N, Jeanmonod D (2010) Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients. BMC Neurosci 11:40
40. Moller AR (2007) The role of neural plasticity in tinnitus. Prog Brain Res 166:37-45
41. Mühlau M, Rauschecker JP, Oestreicher E, Gaser C, Rottinger M, Wohlschlager AM, Simon F, Etgen T, Conrad B, Sander D (2006) Structural brain changes in tinnitus. Cereb Cortex 16(9):1283-1288
42. Plichta MM, Gerdes AB, Alpers GW, Harnisch W, Brill S, Wieser MJ, Fallgatter AJ (2011) Auditory cortex activation is modulated by emotion: a functional near-infrared spectroscopy (fNIRS) study. Neuroimage 55(3):1200-1207
43. Schecklmann M, Landgrebe M, Poeppl TB, Kreuzer P, Manner P, Marienhagen J, Wack DS, Kleinjung T, Hajak G, Langguth B (2013) Neural correlates of tinnitus duration and distress: a positron emission tomography study. Hum Brain Mapp 34:233-240
44. Schlee W, Weisz N, Bertrand O, Hartmann T, Elbert T (2008) Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS ONE 3(11):e3720
45. Schlee W, Hartmann T, Langguth B, Weisz N (2009a) Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci 10:11
46. Schlee W, Mueller N, Hartmann T, Keil J, Lorenz I, Weisz N (2009b) Mapping cortical hubs in tinnitus. BMC Biol 7:80
47. Schneider P, Andermann M, Wengenroth M, Goebel R, Flor H, Rupp A, Diesch E (2009) Reduced volume of Heschl's gyrus in tinnitus. Neuroimage 45(3):927-939
48. Shargorodsky J, Curhan GC, Farwell WR (2010) Prevalence and characteristics of tinnitus among US adults. Am J Med 123(8):711-718
49. Smits M, Kovacs S, de Ridder D, Peeters RR, van Hecke P, Sunaert S (2007) Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology 49(8):669-679
50. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15(1):273-289
51. Valfre W, Rainero I, Bergui M, Pinessi L (2008) Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache 48(1):109-117
52. van der Loo E, Gais S, Congedo M, Vanneste S, Plazier M, Menovsky T, Van de Heyning P, De Ridder D (2009) Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS ONE 4(10):e7396
53. van der Loo E, Congedo M, Vanneste S, Van De Heyning P, De Ridder D (2011) Insular lateralization in tinnitus distress. Auton Neurosci 165(2):191-194
54. Vanneste S, Plazier M, der Loo E, de Heyning PV, Congedo M, De Ridder D (2010) The neural correlates of tinnitus-related distress. Neuroimage 52(2):470-480
55. Vanneste S, Van de Heyning P, De Ridder D (2011a) Contralateral parahippocampal gamma-band activity determines noise-like tinnitus laterality: a region of interest analysis. Neuroscience 199:481-490
56. Vanneste S, van de Heyning P, De Ridder D (2011b) The neural network of phantom sound changes over time: a comparison between recent-onset and chronic tinnitus patients. Eur J Neurosci 34(5):718-731
57. Viinikainen M, Katsyri J, Sams M (2012) Representation of perceived sound valence in the human brain. Hum Brain Mapp 33:2295-2305
58. Weisz N, Moratti S, Meinzer M, Dohrmann K, Elbert T (2005) Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography. PLoS Med 2(6):e153
59. Wunderlich AP, Schonfeldt-Lecuona C, Wolf RC, Dorn K, Bachor E, Freund W (2010) Cortical activation during a pitch discrimination task in tinnitus patients and controls - an fMRI study. Audiol Neurootol 15(3):137-148