Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2)

Cell and Tissue Research

Volumn 353, Issue 1, 2013, Pages 173-187

  Morales, María Gabriela ^a,b   Cabrera, Daniel ^b   Céspedes, Carlos ^b   Vio, Carlos P ^b   Vazquez, Yaneisi ^a   Brandan, Enrique ^b   Cabello Verrugio, Claudio ^a  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Angiotensin converting enzyme; Duchenne muscular dystrophy (DMD); Extracellular matrix; Fibrosis; Mouse (mdx model of DMD); Skeletal muscle

Indexed keywords

ADENOVIRUS VECTOR; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRIL; LOSARTAN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CTGF GENE; DRUG EFFECT; DUCHENNE MUSCULAR DYSTROPHY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GASTROCNEMIUS MUSCLE; GENE OVEREXPRESSION; MALE; MOUSE; MUSCLE EXERCISE; MUSCLE STRENGTH; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SITTING; SKELETAL MUSCLE;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CONNECTIVE TISSUE GROWTH FACTOR; ENALAPRIL; FIBROSIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCLE STRENGTH; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; PEPTIDYL-DIPEPTIDASE A; PHYSICAL CONDITIONING, ANIMAL; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

MURINAE; MUS;

EID: 84879786097     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-013-1642-6     Document Type: Article

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