Molecular angiogenic events of a two-herb wound healing formula involving MAPK and Akt signaling pathways in human vascular endothelial cells

Wound Repair and Regeneration

Volumn 21, Issue 4, 2013, Pages 579-587

  Liu, Cheuk Lun ^a   Tam, Jacqueline Chor Wing ^a   Sanders, Andrew J ^b   Ko, Chun Hay ^a   Fung, Kwok Pui ^a   Leung, Ping Chung ^a   Harding, Keith G ^b   Jiang, Wen G ^b   Lau, Clara Bik San ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANGIOGENESIS; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHRONIC WOUND; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; WESTERN BLOTTING; WOUND HEALING;

ANGIOGENESIS INDUCING AGENTS; ASTRAGALUS PLANT; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL SURVIVAL; DRUGS, CHINESE HERBAL; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; NEOVASCULARIZATION, PHYSIOLOGIC; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; REHMANNIA; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 84879782688     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/wrr.12055     Document Type: Article

References (42)

1. Medina A, Scott P, Ghahary A, Tredget E,. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehabil 2005; 26: 306-319.
2. Tonnesen M, Feng X, Clark R,. Angiogenesis in wound healing. J Investig Dermatol Symp Proc 2000; 5: 40-46.
3. Leung P, Wong M, Wong W,. Limb salvage in extensive diabetic foot ulceration: an extended study using a herbal supplement. Hong Kong Med J 2008; 14: 29-33.
4. Tam JCW, Lau KM, Liu CL, To MH, Kwok HF, Lai KK, et al. The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action. J Ethnopharmacol 2011; 134: 831-838.
5. Zhang Q, Wei F, Fong CC, Yu WK, Chen Y, Koon CM, et al. Transcriptional profiling of human skin fibroblast cell line Hs27 Induced by herbal formula Astragali radix and Rehmanniae radix. J Ethnopharmacol 2011; 138: 668-675.
6. Tse HYG, Hui MNY, Li L, Lee SMY, Leung AYH, Cheng SH,. Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. J Ethnopharmacol 2012; 139: 447-453.
7. Lau TW, Lam FFY, Lau KM, Chan YW, Lee KM, Sahota DS, et al. Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer. J Ethnopharmacol 2009; 123: 155-162.
8. Bauer SM, Bauer RJ, Velazquez OC,. Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. Vasc Endovasc Surg 2005; 39: 293-306.
9. Muñoz-Chápuli R, Quesada AR, Ángel Medina M,. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 2004; 61: 2224-2243.
10. Herbert SP, Stainier DYR,. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 2011; 12: 551-564.
11. Gailit J, Clark RAF,. Studies in vitro on the role of [Agr]v and [Beta]1 integrins in the adhesion of human dermal fibroblasts to provisional matrix proteins fibronectin, vitronectin, and fibrinogen. J Investig Dermatol 1996; 106: 102-108.
12. Hsu C, Tsai W, Chen CP, Lu Y, Wang J,. Effects of negative pressures on epithelial tight junctions and migration in wound healing. Am J Physiol Cell Ph 2010; 299: C528-534.
13. Lo C, Keese CR, Giaever I,. Monitoring motion of confluent cells in tissue culture. Exp Cell Res 1993; 204: 102-109.
14. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China. Beijing, China: People's Medical Publishing House, 2005.
15. Or PMY, Lam FFY, Kwan YW, Cho CH, Lau CP, Yu H, et al. Effects of radix astragali and radix rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms. Phytomedicin 2012; 19: 535-544.
16. Gebäck T, Schulz M, Koumoutsakos P, Detmar M,. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 2009; 46: 265-274.
17. Sanders AJ, Jiang DG, Jiang WG, Harding KG, Patel GK,. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. Int Wound J 2011; 8: 500-507.
18. Arnaoutova I, George J, Kleinman H, Benton G,. The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art. Angiogenesis 2009; 12: 267-274.
19. Lau KM, Lai KK, Liu CL, Tam JCW, To MH, Kwok HF, et al. Synergistic interaction between astragali radix and rehmanniae radix in a Chinese herbal formula to promote Diabetic Wound Healing. J Ethnopharmacol 2012; 141: 250-256.
20. Bischoff J,. Cell adhesion and angiogenesis. J Clin Invest 1997; 99: 373-376.
21. Brooks PC, Clark RA, Cheresh DA,. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264: 569-571.
22. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, et al. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 1999; 97: 221-231.
23. Lamalice L, Le Boeuf F, Huot J,. Endothelial cell migration during angiogenesis. Circ Res 2007; 100: 782-794.
24. Klemke RL, Cai S, Giannini AL, Gallagher PJ, Lanerolle PD, Cheresh DA,. Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol 1997; 137: 481-492.
25. Lee M, Evans M, Hla T,. The inducible G protein-coupled receptor Edg-1 signals via the G/mitogen-activated protein kinase pathway. J Biol Chem 1996; 271: 11272-11279.
26. Tanaka K, Abe M, Sato Y,. Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis. Cancer Sci 1999; 90: 647-654.
27. Becker PM, Verin AD, Booth MA, Liu F, Birukova A, Garcia JGN,. Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells. Am J Physiol-Lung C 2001; 281: L1500-1511.
28. Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC, VanSluys J,. Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. Blood 2008; 111: 2647-2656.
29. Ennis BW, Fultz KE, Smith KA, Westwick JK, Zhu D, Boluro-Ajayi M, et al. Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. J Pharmacol Exp The 2005; 313: 325-332.
30. Rousseau S, Houle F, Landry J, Huot J,. P38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 1997; 15: 2169-2177.
31. Zhu W, Han J, Nicosia R,. Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model. J Vasc Res 2003; 40: 140-148.
32. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000; 6: 1004-1010.
33. Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K, et al. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 2000; 86: 892-896.
34. Carracedo A, Pandolfi PP,. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008; 2: 5527-5541.
35. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV,. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893-901.
36. Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, et al. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 2002; 35: 697-709.
37. Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, et al. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 2007; 11: 555-569.
38. Go Y, Boo YC, Park H, Maland MC, Patel R, Pritchard KA, et al. Protein kinase B/Akt activates c-Jun NH2-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol 2001; 91: 1574-1581.
39. Kaikai S, Yuchen S, Lili J, Zhengtao W,. Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro. J Biochem 2011; 150: 189-197.
40. Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC,. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100: 3131-3139.
41. Zhang Y, Hu G, Li S, Li ZH, Lam CO, Hong SJ, et al. Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo. Mol Med Rep 2012; 5: 805-811.
42. Zhang Y, Hu G, Lin HC, Hong SJ, Deng YH, Tang JY, et al. Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-kinase/Akt-dependent pathway in human endothelial cells. Phytother Res 2009; 23: 1205-1213.