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Volumn 154, Issue 8, 2013, Pages 1170-1180

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

Author keywords

Allodynia; Back pain; Inflammation; Scn8a; Spontaneous activity

Indexed keywords

SMALL INTERFERING RNA; SODIUM CHANNEL NAV1.6;

EID: 84879782648     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.02.027     Document Type: Article
Times cited : (71)

References (43)
  • 1
    • 78650309320 scopus 로고    scopus 로고
    • The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines
    • P.J. Austin, and G. Moalem-Taylor The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines J Neuroimmunol 229 2010 26 50
    • (2010) J Neuroimmunol , vol.229 , pp. 26-50
    • Austin, P.J.1    Moalem-Taylor, G.2
  • 2
    • 77955463322 scopus 로고    scopus 로고
    • Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons
    • J.S. Bant, and I.M. Raman Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons Proc Natl Acad Sci USA 107 2010 12357 12362
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12357-12362
    • Bant, J.S.1    Raman, I.M.2
  • 3
    • 78049513095 scopus 로고    scopus 로고
    • Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury
    • S.S. Bedi, Q. Yang, R.J. Crook, J. Du, Z. Wu, H.M. Fishman, R.J. Grill, S.M. Carlton, and E.T. Walters Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury J Neurosci 30 2010 14870 14882
    • (2010) J Neurosci , vol.30 , pp. 14870-14882
    • Bedi, S.S.1    Yang, Q.2    Crook, R.J.3    Du, J.4    Wu, Z.5    Fishman, H.M.6    Grill, R.J.7    Carlton, S.M.8    Walters, E.T.9
  • 4
    • 79957959515 scopus 로고    scopus 로고
    • Cellular and molecular insights into neuropathy-induced pain hypersensitivity for mechanism-based treatment approaches
    • J.V. Berger, L. Knaepen, S.P. Janssen, R.J. Jaken, M.A. Marcus, E.A. Joosten, and R. Deumens Cellular and molecular insights into neuropathy-induced pain hypersensitivity for mechanism-based treatment approaches Brain Res Rev 67 2011 282 310
    • (2011) Brain Res Rev , vol.67 , pp. 282-310
    • Berger, J.V.1    Knaepen, L.2    Janssen, S.P.3    Jaken, R.J.4    Marcus, M.A.5    Joosten, E.A.6    Deumens, R.7
  • 5
    • 0037200807 scopus 로고    scopus 로고
    • Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction
    • J.A. Black, M. Renganathan, and S.G. Waxman Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction Brain Res Mol Brain Res 105 2002 19 28
    • (2002) Brain Res Mol Brain Res , vol.105 , pp. 19-28
    • Black, J.A.1    Renganathan, M.2    Waxman, S.G.3
  • 10
    • 67349270225 scopus 로고    scopus 로고
    • Ectopic discharge in Abeta afferents as a source of neuropathic pain
    • M. Devor Ectopic discharge in Abeta afferents as a source of neuropathic pain Exp Brain Res 196 2009 115 128
    • (2009) Exp Brain Res , vol.196 , pp. 115-128
    • Devor, M.1
  • 12
    • 77955590146 scopus 로고    scopus 로고
    • The evidence for pharmacological treatment of neuropathic pain
    • N.B. Finnerup, S.H. Sindrup, and T.S. Jensen The evidence for pharmacological treatment of neuropathic pain PAIN® 150 2010 573 581
    • (2010) PAIN® , vol.150 , pp. 573-581
    • Finnerup, N.B.1    Sindrup, S.H.2    Jensen, T.S.3
  • 13
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia PAIN® 32 1988 77 88
    • (1988) PAIN® , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3    Flores, C.4    Joris, J.5
  • 14
    • 78650607407 scopus 로고    scopus 로고
    • Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons
    • N.J. Hargus, E.C. Merrick, A. Nigam, C.L. Kalmar, A.R. Baheti, E.H. Bertram 3rd, and M.K. Patel Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons Neurobiol Dis 41 2011 361 376
    • (2011) Neurobiol Dis , vol.41 , pp. 361-376
    • Hargus, N.J.1    Merrick, E.C.2    Nigam, A.3    Kalmar, C.L.4    Baheti, A.R.5    Bertram III, E.H.6    Patel, M.K.7
  • 16
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • A.L. Jackson, and P.S. Linsley Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application Nat Rev Drug Discov 9 2010 57 67
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 17
    • 0034709201 scopus 로고    scopus 로고
    • Immunolocalization of sodium channel isoform NaCh6 in the nervous system
    • D.M. Krzemien, K.L. Schaller, S.R. Levinson, and J.H. Caldwell Immunolocalization of sodium channel isoform NaCh6 in the nervous system J Comp Neurol 420 2000 70 83
    • (2000) J Comp Neurol , vol.420 , pp. 70-83
    • Krzemien, D.M.1    Schaller, K.L.2    Levinson, S.R.3    Caldwell, J.H.4
  • 18
    • 0025775101 scopus 로고
    • Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons
    • S.N. Lawson, and P.J. Waddell Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons J Physiol 435 1991 41 63
    • (1991) J Physiol , vol.435 , pp. 41-63
    • Lawson, S.N.1    Waddell, P.J.2
  • 19
    • 33646342482 scopus 로고    scopus 로고
    • Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: An electrophysiological and modelling study
    • J. Magistretti, L. Castelli, L. Forti, and E. D'Angelo Kinetic and functional analysis of transient, persistent and resurgent sodium currents in rat cerebellar granule cells in situ: an electrophysiological and modelling study J Physiol 573 2006 83 106
    • (2006) J Physiol , vol.573 , pp. 83-106
    • Magistretti, J.1    Castelli, L.2    Forti, L.3    D'Angelo, E.4
  • 20
    • 0035076298 scopus 로고    scopus 로고
    • Sodium channels and neurological disease: Insights from Scn8a mutations in the mouse
    • M.H. Meisler, J. Kearney, A. Escayg, B.T. MacDonald, and L.K. Sprunger Sodium channels and neurological disease: insights from Scn8a mutations in the mouse Neuroscientist 7 2001 136 145
    • (2001) Neuroscientist , vol.7 , pp. 136-145
    • Meisler, M.H.1    Kearney, J.2    Escayg, A.3    Macdonald, B.T.4    Sprunger, L.K.5
  • 22
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • M.W. Pfaffl, G.W. Horgan, and L. Dempfle Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 30 2002 e36
    • (2002) Nucleic Acids Res , vol.30 , pp. 36
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 23
    • 1842483281 scopus 로고    scopus 로고
    • Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - Excel-based tool using pair-wise correlations
    • M.W. Pfaffl, A. Tichopad, C. Prgomet, and T.P. Neuvians Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper - excel-based tool using pair-wise correlations Biotechnol Lett 26 2004 509 515
    • (2004) Biotechnol Lett , vol.26 , pp. 509-515
    • Pfaffl, M.W.1    Tichopad, A.2    Prgomet, C.3    Neuvians, T.P.4
  • 24
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • S. Rozen, and H. Skaletsky Primer3 on the WWW for general users and for biologist programmers Methods Mol Biol 132 2000 365 386
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 28
    • 0033391029 scopus 로고    scopus 로고
    • Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia
    • X.J. Song, S.J. Hu, K.W. Greenquist, J.-M. Zhang, and R.H. LaMotte Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia J Neurophysiol 82 1999 3347 3358
    • (1999) J Neurophysiol , vol.82 , pp. 3347-3358
    • Song, X.J.1    Hu, S.J.2    Greenquist, K.W.3    Zhang, J.-M.4    Lamotte, R.H.5
  • 29
    • 70349303774 scopus 로고    scopus 로고
    • Behavioral models of pain states evoked by physical injury to the peripheral nerve
    • L.S. Sorkin, and T.L. Yaksh Behavioral models of pain states evoked by physical injury to the peripheral nerve Neurotherapeutics 6 2009 609 619
    • (2009) Neurotherapeutics , vol.6 , pp. 609-619
    • Sorkin, L.S.1    Yaksh, T.L.2
  • 31
    • 84864011434 scopus 로고    scopus 로고
    • Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain
    • J.A. Strong, W. Xie, D.E. Coyle, and J.M. Zhang Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain PLoS One 7 2012 e40779
    • (2012) PLoS One , vol.7 , pp. 40779
    • Strong, J.A.1    Xie, W.2    Coyle, D.E.3    Zhang, J.M.4
  • 32
    • 80053185917 scopus 로고    scopus 로고
    • Inhibition of Navbeta4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide
    • J.W. Theile, and T.R. Cummins Inhibition of Navbeta4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide Mol Pharmacol 80 2011 724 734
    • (2011) Mol Pharmacol , vol.80 , pp. 724-734
    • Theile, J.W.1    Cummins, T.R.2
  • 33
    • 75549091563 scopus 로고    scopus 로고
    • Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury
    • D. Vega-Avelaira, S.M. Geranton, and M. Fitzgerald Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury Mol Pain 5 2009 70
    • (2009) Mol Pain , vol.5 , pp. 70
    • Vega-Avelaira, D.1    Geranton, S.M.2    Fitzgerald, M.3
  • 34
    • 79955570495 scopus 로고    scopus 로고
    • Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons
    • R.G. Xie, D.W. Zheng, J.L. Xing, X.J. Zhang, Y. Song, Y.B. Xie, F. Kuang, H. Dong, S.W. You, H. Xu, and S.J. Hu Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons PLoS One 6 2011 e18681
    • (2011) PLoS One , vol.6 , pp. 18681
    • Xie, R.G.1    Zheng, D.W.2    Xing, J.L.3    Zhang, X.J.4    Song, Y.5    Xie, Y.B.6    Kuang, F.7    Dong, H.8    You, S.W.9    Xu, H.10    Hu, S.J.11
  • 35
    • 84859444870 scopus 로고    scopus 로고
    • Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion
    • W. Xie, J.A. Strong, J. Kays, G.D. Nicol, and J.M. Zhang Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neurosci Lett 515 2012 61 65
    • (2012) Neurosci Lett , vol.515 , pp. 61-65
    • Xie, W.1    Strong, J.A.2    Kays, J.3    Nicol, G.D.4    Zhang, J.M.5
  • 36
    • 84862777764 scopus 로고    scopus 로고
    • Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion
    • W. Xie, J.A. Strong, D. Kim, S. Shahrestani, and J.M. Zhang Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion Neuroscience 206 2012 212 223
    • (2012) Neuroscience , vol.206 , pp. 212-223
    • Xie, W.1    Strong, J.A.2    Kim, D.3    Shahrestani, S.4    Zhang, J.M.5
  • 37
    • 33846426870 scopus 로고    scopus 로고
    • Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block
    • W. Xie, J.A. Strong, H. Li, and J.-M. Zhang Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block J Neurophysiol 97 2007 492 502
    • (2007) J Neurophysiol , vol.97 , pp. 492-502
    • Xie, W.1    Strong, J.A.2    Li, H.3    Zhang, J.-M.4
  • 38
    • 79960681018 scopus 로고    scopus 로고
    • Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse
    • W. Xie, J.A. Strong, J. Mao, and J.M. Zhang Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse Mol Pain 7 2011 53
    • (2011) Mol Pain , vol.7 , pp. 53
    • Xie, W.1    Strong, J.A.2    Mao, J.3    Zhang, J.M.4
  • 39
    • 21844463298 scopus 로고    scopus 로고
    • Neuropathic pain: Early spontaneous afferent activity is the trigger
    • W. Xie, J.A. Strong, J.T. Meij, J.-M. Zhang, and L. Yu Neuropathic pain: early spontaneous afferent activity is the trigger PAIN® 116 2005 243 256
    • (2005) PAIN® , vol.116 , pp. 243-256
    • Xie, W.1    Strong, J.A.2    Meij, J.T.3    Zhang, J.-M.4    Yu, L.5
  • 40
    • 64649091102 scopus 로고    scopus 로고
    • Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    • W. Xie, J.A. Strong, and J.M. Zhang Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models Neuroscience 160 2009 847 857
    • (2009) Neuroscience , vol.160 , pp. 847-857
    • Xie, W.1    Strong, J.A.2    Zhang, J.M.3
  • 41
    • 33749254074 scopus 로고    scopus 로고
    • Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia
    • W.R. Xie, H. Deng, H. Li, T.L. Bowen, J.A. Strong, and J.-M. Zhang Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia Neuroscience 142 2006 809 822
    • (2006) Neuroscience , vol.142 , pp. 809-822
    • Xie, W.R.1    Deng, H.2    Li, H.3    Bowen, T.L.4    Strong, J.A.5    Zhang, J.-M.6
  • 42
    • 79960698168 scopus 로고    scopus 로고
    • A brief comparison of the pathophysiology of inflammatory versus neuropathic pain
    • Q. Xu, and T.L. Yaksh A brief comparison of the pathophysiology of inflammatory versus neuropathic pain Curr Opin Anaesthesiol 24 2011 400 407
    • (2011) Curr Opin Anaesthesiol , vol.24 , pp. 400-407
    • Xu, Q.1    Yaksh, T.L.2
  • 43
    • 0033233119 scopus 로고    scopus 로고
    • Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion
    • J.-M. Zhang, X.J. Song, and R.H. LaMotte Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion J Neurophysiol 82 1999 3359 3366
    • (1999) J Neurophysiol , vol.82 , pp. 3359-3366
    • Zhang, J.-M.1    Song, X.J.2    Lamotte, R.H.3


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