Altered hepatic gene expression profiles associated with improved fatty liver, insulin resistance, and intestinal permeability after hydroxypropyl methylcellulose (HPMC) supplementation in diet-induced obese mice

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 26, 2013, Pages 6404-6411

  Kim, Hyunsook ^a,b   Bartley, Glenn E ^b   Young, Scott A ^c   Seo, Kun Ho ^d   Yokoyama, Wallace ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WESTERN REGIONAL RESEARCH CENTER   (United States)

^c DOW CHEMICAL COMPANY   (United States)

^d Konkuk University   (South Korea)

Author keywords

insulin sensitivity; intestinal permeability; lipid metabolism; soluble dietary fiber; steatosis

Indexed keywords

INSULIN SENSITIVITY; INTESTINAL PERMEABILITIES; LIPID METABOLISMS; SOLUBLE DIETARY FIBER; STEATOSIS;

BODY FLUIDS; CHOLESTEROL; GENE EXPRESSION; GLUCOSE; INSULIN; MAMMALS; METABOLISM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; POLYUNSATURATED FATTY ACIDS; RECYCLING;

NUTRITION;

CELLULOSE; DRUG DERIVATIVE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; PREBIOTIC AGENT;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DIET THERAPY; ENZYMOLOGY; FATTY LIVER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INSULIN RESISTANCE; INTESTINE ABSORPTION; LIPID DIET; LIVER; METABOLISM; MOUSE; NONALCOHOLIC FATTY LIVER; OBESITY; PATHOPHYSIOLOGY;

ANIMALS; CELLULOSE; DIET, HIGH-FAT; FATTY LIVER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INSULIN RESISTANCE; INTESTINAL ABSORPTION; LIVER; METHYLCELLULOSE; MICE; OBESITY; PREBIOTICS;

MUS;

EID: 84879778867     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf400545w     Document Type: Article

References (52)

1. Page, J. Nonalcoholic fatty liver disease: the hepatic metabolic syndrome J. Am. Acad. Nurse. Pract. 2012, 24 (6) 345-351
2. Marchesini, G.; Bugianesi, E.; Forlani, G.; Cerrelli, F.; Lenzi, M.; Manini, R.; Natale, S.; Vanni, E.; Villanova, N.; Melchionda, N.; Rizzetto, M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome Hepatology 2003, 37 (4) 917-923
3. Adams, L. A.; Lymp, J. F.; St Sauver, J.; Sanderson, S. O.; Lindor, K. D.; Feldstein, A.; Angulo, P. The natural history of nonalcoholic fatty liver disease: a population-based cohort study Gastroenterology 2005, 129 (1) 113-121
4. Ilan, Y. Leaky gut and the liver: a role for bacterial translocation in nonalcoholic steatohepatitis World J. Gastroenterol. 2012, 18 (21) 2609-2618
5. Suzuki, T.; Hara, H. Role of flavonoids in intestinal tight junction regulation J. Nutr. Biochem. 2011, 22 (5) 401-408
6. Hoareau, L.; Bencharif, K.; Rondeau, P.; Murumalla, R.; Ravanan, P.; Tallet, F.; Delarue, P.; Cesari, M.; Roche, R.; Festy, F. Signaling pathways involved in LPS induced TNFalpha production in human adipocytes J. Inflamm. (London) 2010, 7, 1
7. Brown, J.; Wang, H.; Hajishengallis, G. N.; Martin, M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk J. Dent. Res. 2011, 90 (4) 417-427
8. Imajo, K.; Fujita, K.; Yoneda, M.; Nozaki, Y.; Ogawa, Y.; Shinohara, Y.; Kato, S.; Mawatari, H.; Shibata, W.; Kitani, H.; Ikejima, K.; Kirikoshi, H.; Nakajima, N.; Saito, S.; Maeyama, S.; Watanabe, S.; Wada, K.; Nakajima, A. Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling Cell Metab. 2012, 16 (1) 44-54
9. Hebbard, L.; George, J. Animal models of nonalcoholic fatty liver disease Nat. Rev. Gastroenterol. Hepatol. 2011, 8 (1) 35-44
10. Spruss, A.; Bergheim, I. Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease J. Nutr. Biochem. 2009, 20 (9) 657-662
11. McCarthy, E. M.; Rinella, M. E. The role of diet and nutrient composition in nonalcoholic fatty liver disease J. Acad. Nutr. Diet. 2012, 112 (3) 401-409
12. Huang, H.; Liu, T.; Rose, J. L.; Stevens, R. L.; Hoyt, D. G. Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet J. Inflamm. (London) 2007, 4, 22
13. Reimer, R. A.; Grover, G. J.; Koetzner, L.; Gahler, R. J.; Lyon, M. R.; Wood, S. The soluble fiber complex PolyGlycopleX lowers serum triglycerides and reduces hepatic steatosis in high-sucrose-fed rats Nutr. Res. (N.Y.) 2011, 31, 296-301
14. Choi, J. S.; Kim, H.; Jung, M. H.; Hong, S.; Song, J. Consumption of barley beta-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet Mol. Nutr. Food Res. 2010, 54 (7) 1004-1013
15. Delzenne, N. M.; Daubioul, C.; Neyrinck, A.; Lasa, M.; Taper, H. S. Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects Br. J. Nutr. 2002, 87 (Suppl. 2) S255-S259
16. Beylot, M. Effects of inulin-type fructans on lipid metabolism in man and in animal models Br. J. Nutr. 2005, 93 (Suppl. 1) S163-S168
17. Qi, L.; van Dam, R. M.; Liu, S.; Franz, M.; Mantzoros, C.; Hu, F. B. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women Diabetes Care 2006, 29 (2) 207-211
18. Cani, P. D.; Bibiloni, R.; Knauf, C.; Waget, A.; Neyrinck, A. M.; Delzenne, N. M.; Burcelin, R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 2008, 57 (6) 1470-1481
19. Cani, P. D.; Possemiers, S.; Van de Wiele, T.; Guiot, Y.; Everard, A.; Rottier, O.; Geurts, L.; Naslain, D.; Neyrinck, A.; Lambert, D. M.; Muccioli, G. G.; Delzenne, N. M. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability Gut 2009, 58 (8) 1091-1103
20. Sanchez, D.; Quinones, M.; Moulay, L.; Muguerza, B.; Miguel, M.; Aleixandre, A. Soluble fiber-enriched diets improve inflammation and oxidative stress biomarkers in Zucker fatty rats Pharmacol. Res. 2011, 64 (1) 31-35
21. Galisteo, M.; Sánchez, M.; Vera, R.; González, M.; Anguera, A.; Duarte, J.; Zarzuelo, A. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-α in obese Zucker rats J. Nutr. 2005, 135, 2399-2404
22. Maki, K. C.; Carson, M. L.; Kerr Anderson, W. H.; Geohas, J.; Reeves, M. S.; Farmer, M. V.; Turowski, M.; Miller, M.; Kaden, V. N.; Dicklin, M. R.; Rains, T. M. Lipid-altering effects of different formulations of hydroxypropylmethylcellulose J. Clin. Lipidol. 2009, 3 (3) 159-166
23. Hung, S. C.; Bartley, G.; Young, S. A.; Albers, D. R.; Dielman, D. R.; Anderson, W. H.; Yokoyama, W. Dietary fiber improves lipid homeostasis and modulates adipocytokines in hamsters J. Diabetes 2009, 1 (3) 194-206
24. Hung, S. C.; Anderson, W. H.; Albers, D. R.; Langhorst, M. L.; Young, S. A. Effect of hydroxypropyl methylcellulose on obesity and glucose metabolism in a diet-induced obesity mouse model J. Diabetes 2011, 3 (2) 158-167
25. Hong, Y. J.; Turowski, M.; Lin, J. T.; Yokoyama, W. H. Simultaneous characterization of bile acid, sterols, and determination of acylglycerides in feces from soluble cellulose-fed hamsters using HPLC with evaporative light-scattering detection and APCI-MS J. Agric. Food Chem. 2007, 55 (24) 9750-9757
26. Bartley, G. E.; Yokoyama, W.; Young, S. A.; Anderson, W. H.; Hung, S. C.; Albers, D. R.; Langhorst, M. L.; Kim, H. Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters J. Nutr. 2010, 140 (7) 1255-1260
27. Cox, L. M.; Cho, I.; Young, S. A.; Anderson, W. H.; Waters, B. J.; Hung, S. C.; Gao, Z.; Mahana, D.; Bihan, M.; Alekseyenko, A. V.; Methe, B. A.; Blaser, M. J. The nonfermentable dietary fiber hydroxypropyl methylcellulose modulates intestinal microbiota FASEB J. 2013, 27 (2) 692-702
28. Horton, J. D.; Cuthbert, J. A.; Spady, D. K. Regulation of hepatic 7 α-hydroxylase expression by dietary psyllium in the hamster J. Clin. Invest. 1994, 93 (5) 2084-2092
29. Kim, H.; Turowski, M.; Anderson, W. H.; Young, S. A.; Kim, Y.; Yokoyama, W. Supplementation of hydroxypropyl methylcellulose into yeast leavened all-whole grain barley bread potentiates cholesterol-lowering effect J. Agric. Food Chem. 2011, 59 (14) 7672-7678
30. German, J. B.; Xu, R.; Walzem, R.; Kinsella, J. E.; Knuckles, B.; Nakamura, M.; Yokoyama, W. H. Effect of dietary fats and barley fiber on total cholesterol and lipoprotein cholesterol distribution in plasma of hamsters Nutr. Res. (N.Y.) 1996, 16 (7) 1239-1249
31. Ortis, F.; Naamane, N.; Flamez, D.; Ladriere, L.; Moore, F.; Cunha, D. A.; Colli, M. L.; Thykjaer, T.; Thorsen, K.; Orntoft, T. F.; Eizirik, D. L. Cytokines interleukin-1β and tumor necrosis factor-α regulate different transcriptional and alternative splicing networks in primary β-cells Diabetes 2010, 59 (2) 358-374
32. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method Methods 2001, 25 (4) 402-408
33. Larocca, M. C.; Soria, L. R.; Espelt, M. V.; Lehmann, G. L.; Marinelli, R. A. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296 (1) G93-G100
34. Rahman, M. F.; Wang, J.; Patterson, T. A.; Saini, U. T.; Robinson, B. L.; Newport, G. D.; Murdock, R. C.; Schlager, J. J.; Hussain, S. M.; Ali, S. F. Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles Toxicol. Lett. 2009, 187 (1) 15-21
35. Mouzaki, M.; Allard, J. P. The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease J. Clin. Gastroenterol. 2012, 46 (6) 457-467
36. Duval, C.; Thissen, U.; Keshtkar, S.; Accart, B.; Stienstra, R.; Boekschoten, M. V.; Roskams, T.; Kersten, S.; Muller, M. Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice Diabetes 2010, 59 (12) 3181-3191
37. Wang, Q.; Perrard, X. D.; Perrard, J. L.; Mansoori, A.; Raya, J. L.; Hoogeveen, R.; Smith, C. W.; Ballantyne, C. M.; Wu, H. Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity Atherosclerosis 2011, 219 (1) 100-108
38. Suzuki, T.; Hara, H. Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats Nutr. Metab. (London) 2010, 7, 19
39. Raimondi, F.; Santoro, P.; Barone, M. V.; Pappacoda, S.; Barretta, M. L.; Nanayakkara, M.; Apicella, C.; Capasso, L.; Paludetto, R. Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 294 (4) G906-G913
40. Houdijk, A. P.; Meijer, C.; Cuesta, M. A.; Meyer, S.; Van Leeuwen, P. A. Perioperative anti-endotoxin strategies Scand. J. Gastroenterol. Suppl. 1997, 222, 93-97
41. Lewis, J. G.; Bagley, C. J.; Elder, P. A.; Bachmann, A. W.; Torpy, D. J. Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin Clin. Chim. Acta 2005, 359 (1-2) 189-194
42. Shpilberg, Y.; Beaudry, J. L.; D'Souza, A.; Campbell, J. E.; Peckett, A.; Riddell, M. C. A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding Dis. Model. Mech. 2012, 5 (5) 671-680
43. Anstee, Q. M.; Goldin, R. D. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research Int. J. Exp. Pathol. 2006, 87 (1) 1-16
44. Lemke, U.; Krones-Herzig, A.; Berriel Diaz, M.; Narvekar, P.; Ziegler, A.; Vegiopoulos, A.; Cato, A. C.; Bohl, S.; Klingmuller, U.; Screaton, R. A.; Muller-Decker, K.; Kersten, S.; Herzig, S. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1 Cell Metab. 2008, 8 (3) 212-223
45. Vegiopoulos, A.; Herzig, S. Glucocorticoids, metabolism and metabolic diseases Mol. Cell. Endocrinol. 2007, 275 (1-2) 43-61
46. Manco, M.; Fernandez-Real, J. M.; Valera-Mora, M. E.; Dechaud, H.; Nanni, G.; Tondolo, V.; Calvani, M.; Castagneto, M.; Pugeat, M.; Mingrone, G. Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon? Diabetes Care 2007, 30 (6) 1494-1500
47. Fernandez-Real, J. M.; Pugeat, M.; Grasa, M.; Broch, M.; Vendrell, J.; Brun, J.; Ricart, W. Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study J. Clin. Endocrinol. Metab. 2002, 87 (10) 4686-4690
48. Seckl, J. R. 11β-hydroxysteroid dehydrogenases: changing glucocorticoid action Curr. Opin. Pharmacol. 2004, 4 (6) 597-602
49. Liu, Y.; Havinga, R.; van der Leij, F. R.; Boverhof, R.; Sauer, P. J.; Kuipers, F.; Stellaard, F. Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics Pediatr. Res. 2008, 63 (4) 375-381
50. Rose, A. J.; Diaz, M. B.; Reimann, A.; Klement, J.; Walcher, T.; Krones-Herzig, A.; Strobel, O.; Werner, J.; Peters, A.; Kleyman, A.; Tuckermann, J. P.; Vegiopoulos, A.; Herzig, S. Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor Cell Metab. 2011, 14 (1) 123-130
51. Wang, J. C.; Gray, N. E.; Kuo, T.; Harris, C. Regulation of triglyceride metabolism by glucocorticoid receptor Cell Biosci. 2012, 2 (1) 19
52. Nathan, D. M.; Davidson, M. B.; DeFronzo, R. A.; Heine, R. J.; Henry, R. R.; Pratley, R.; Zinman, B. Impaired fasting glucose and impaired glucose tolerance: implications for care Diabetes Care 2007, 30 (3) 753-759