Immunogenicity and immunomodulatory properties of hepatocyte-like cells derived from human amniotic epithelial cells

Current Stem Cell Research and Therapy

Volumn 8, Issue 1, 2013, Pages 91-99

  Tee, Jing Yang ^a   Vaghjiani, Vijesh ^a   Liu, Yu Han ^a   Murthi, Padma ^b   Chan, James ^a   Manuelpillai, Ursula ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Amniotic epithelial cells; Anti inflammatory cytokines; Fetal membranes; Hepatocyte like cells; Immunogenicity; Immunomodulation

Indexed keywords

CD40 ANTIGEN; CYTOCHROME P450 3A4; DEXAMETHASONE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INDOMETACIN; INTERLEUKIN 6; PROSTAGLANDIN E2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 4; TRANSFORMING GROWTH FACTOR BETA1; UREA;

AMNION CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC LIVER DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; LYMPHOCYTE; MIXED LYMPHOCYTE REACTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; UREA CYCLE;

AMNION; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; FEMALE; FLOW CYTOMETRY; HEP G2 CELLS; HEPATOCYTES; HUMANS; IMMUNOMODULATION; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED C57BL; PREGNANCY; STEM CELLS;

EID: 84879772596     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X11308010011     Document Type: Article

References (50)

1. Kung JW, Forbes SJ. Stem cells and liver repair. Curr Opin Biotechnol 2009; 20(5): 568-74.
2. Fitzpatrick E, Mitry RR, Dhawan A. Human hepatocyte transplantation: state of the art. J Intern Med 2009; 266(4): 339-57.
3. Dalgetty DM, Medine CN, Iredale JP, Hay DC. Progress and future challenges in stem cell-derived liver technologies. Am J Physiol Gastrointest Liver Physiol 2009; 297(2): G241-8.
4. Navarro-Alvarez N, Soto-Gutierrez A, Kobayashi N. Stem Cell Research and Therapy for Liver Disease. Curr Stem Cell Res Ther 2009; 4: 141-6.
5. Ishikawa T, Banas A, Hagiwara K, Iwaguro H, Ochiya T. Stem cells for hepatic regeneration: the role of adipose tissue derived mesenchymal stem cells. Curr Stem Cell Res Thery 2010; 5: 182-9.
6. Soltys KA, Soto-Gutierrez A, Nagaya M, et al. Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol 2010; 53(4): 769-74.
7. Ilancheran S, Moodley Y, Manuelpillai U. Human fetal membranes: a source of stem cells for tissue regeneration and repair? Placenta 2009; 30(1): 2-10.
8. Manuelpillai U, Moodley Y, Borlongan CV, Parolini O. Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis? Placenta 2011; 32 Suppl 4: S320-5.
9. Parolini O, Alviano F, Bagnara GP, et al. Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells 2008; 26(2): 300-11.
10. Takashima S, Ise H, Zhao P, Akaike T, Nikaido T. Human amniotic epithelial cells possess hepatocyte-like characteristics and functions. Cell Structure and Function 2004; 29(3): 73-84.
11. Ilancheran S, Michalska A, Peh G, Wallace EM, Pera M, Manuelpillai U. Stem cells derived from human fetal membranes display multilineage differentiation potential. Biology of Reproduction 2007; 77(3): 577-88.
12. Miki T, Lehmann T, Cai H, Stolz DB, Strom SC. Stem cell characteristics of amniotic epithelial cells. Stem Cells 2005; 23(10): 1549-59.
13. Marongiu F, Gramignoli R, Dorko K, et al. Hepatic differentiation of amniotic epithelial cells. Hepatology 2011; 53(5): 1719-29.
14. Miki T, Marongiu F, Ellis EC, et al. Production of hepatocyte-like cells from human amnion. Methods in Molecular Biology 2009; 481: 155-68.
15. Toda A, Okabe M, Yoshida T, Nikaido T. The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues. Journal of Pharmacological Sciences 2007; 105(3): 215-28.
16. Banas RA, Trumpower C, Bentlejewski C, Marshall V, Sing G, Zeevi A. Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells. Human Immunology 2008; 69(6): 321-8.
17. Wolbank S, Peterbauer A, Fahrner M, et al. Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue. Tissue Eng 2007; 13(6): 1173-83.
18. Sakuragawa N, Yoshikawa H, Sasaki M. Amniotic tissue transplantation: clinical and biochemical evaluations for some lysosomal storage diseases. Brain & Development 1992; 14(1): 7-11.
19. Tang C, Drukker M. Potential barriers to therapeutics utilizing pluripotent cell derivatives: intrinsic immunogenicity of in vitro maintained and matured populations. Semin Immunopathol 2011; 33(6): 563-72.
20. Huang XP, Sun Z, Miyagi Y, et al. Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 2010; 122(23): 2419-29.
21. English K, Wood KJ. Immunogenicity of embryonic stem cellderived progenitors after transplantation. Curr Opin Organ Transplant 2010.
22. Pratama G, Vaghjiani V, Tee JY, et al. Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications. PLoS One 2011.
23. Liu YH, Vaghjiani V, Tee JY, et al. Amniotic epithelial cells from human placenta potenty suppress a mouse model of multiple sclerosis. PLoS One 2012.
24. Miki T, Marongiu F, Dorko K, Ellis EC, Strom SC. Isolation of amniotic epithelial stem cells. Current Protocols in Stem Cell Biology 2007; Chapter 1: Unit 1E 3.
25. Ottaviani D, Lever E, Mitter R, et al. Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex. Genome Res 2008; 18(11): 1778-86.
26. Mao WL, Chen Y, Chen YM, Li LJ. Changes of serum cytokine levels in patients with acute on chronic liver failure treated by plasma exchange. J Clin Gastroenterol 2011; 45: 551-5.
27. Castellano-Higuera A, Gonzalez-Reimers E, Aleman-Valls MR, et al. Cytokines and lipid peroxidation in alcoholics with chronic hepatitis C virus infection. Alcohol Alcohol 2008; 43(2): 137-42.
28. dos Santos DC, Neves PC, Azeredo EL, et al. Activated lymphocytes and high liver expression of IFN-gamma are associated with fulminant hepatic failure in patients. Liver International 2012; 32(1): 147-57.
29. Barron L, Wynn TA. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol 2011; 300(5): G723-8.
30. Muhanna N, Horani A, Doron S, Safadi R. Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol 2007; 148(2): 338-47.
31. Dame C, Sola MC, Lim KC, et al. Hepatic erythropoietin gene regulation by GATA-4. The Journal of Biological Chemistry 2004; 279(4): 2955-61.
32. Island ML, Fatih N, Leroyer P, Brissot P, Loreal O. GATA-4 transcription factor regulates hepatic hepcidin expression. Biochem J 2011; 437(3): 477-82.
33. Mwinyi J, Cavaco I, Pedersen RS, et al. Regulation of CYP2C19 expression by estrogen receptor alpha: implications for estrogendependent inhibition of drug metabolism. Molecular Pharmacology 2010; 78(5): 886-94.
34. Sund NJ, Ang SL, Sackett SD, et al. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 2000; 20(14): 5175-83.
35. Rausa FM, Tan Y, Zhou H, et al. Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol 2000; 20(21): 8264-82.
36. Akle CA, Adinolfi M, Welsh KI, Leibowitz S, McColl I. Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet 1981; 2(8254): 1003-5.
37. Suarez-Alvarez B, Rodriguez RM, Calvanese V, et al. Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells. PLoS One 2010; 5(4): e10192.
38. Technau A, Froelich K, Hagen R, Kleinsasser N. Adipose tissuederived stem cells show both immunogenic and immunosuppressive properties after chondrogenic differentiation. Cytotherapy 2011; 13(3): 310-7.
39. Liu H, Kemeny DM, Heng BC, Ouyang HW, Melendez AJ, Cao T. The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells. J Immunol 2006; 176(5): 2864-71.
40. Zhao Q, Ren H, Li X, et al. Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocytelike cells. Cytotherapy 2009; 11(4): 414-26.
41. Kronsteiner B, Wolbank S, Peterbauer A, et al. Human mesenchymal stem cells from adipose tissue and amnion influence T-cells depending on stimulation method and presence of other immune cells. Stem Cells and Development 2011; 20(12): 2115-26.
42. Li Y, Xia Z, Wang M. Dehydroepiandrosterone inhibits CD40/CD40L expression on human umbilical vein endothelial cells induced by interferon gamma. International Immunopharmacology 2009; 9(2): 168-72.
43. Drukker M, Katz G, Urbach A, et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proceedings of the National Academy of Sciences USA 2002; 99(15): 9864-9.
44. Karabekian Z, Posnack NG, Sarvazyan N. Immunological barriers to stem-cell based cardiac repair. Stem Cell Reviews 2011; 7(2): 315-25.
45. Bradley JA, Bolton EM, Pedersen RA. Stem cell medicine encounters the immune system. Nat Rev Immunol 2002; 2(11): 859-71.
46. Li H, Niederkorn JY, Neelam S, et al. Immunosuppressive factors secreted by human amniotic epithelial cells. Investigative Ophthalmology & Visual Science 2005; 46(3): 900-7.
47. Mirazi N, Alfaidy N, Martin R, Challis JR. Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro. Journal of the Society for Gynecologic Investigation 2004; 11(1): 22-6.
48. Lefebvre S, Adrian F, Moreau P, et al. Modulation of HLA-G expression in human thymic and amniotic epithelial cells. Human Immunology 2000; 61(11): 1095-101.
49. Souto FJ, Crispim JC, Ferreira SC, et al. Liver HLA-G expression is associated with multiple clinical and histopathological forms of chronic hepatitis B virus infection. Journal of Viral Hepatitis 2011; 18(2): 102-5.
50. Manuelpillai U, Lourensz D, Vaghjiani V, et al. Human amniotic epithelial cell transplantation induces markers of alternative macrophage activation and reduces established hepatic fibrosis. PLoS One 2012; 7(6): e38631.