TiO2-doped phosphate glass microcarriers: A stable bioactive substrate for expansion of adherent mammalian cells

Journal of Biomaterials Applications

Volumn 28, Issue 1, 2013, Pages 3-11

  Guedes, Joana C ^a,b   Park, Jeong Hui ^c,d   Lakhkar, Nilay J ^e   Kim, Hae Won ^c,d   Knowles, Jonathan C ^d,e   Wall, Ivan B ^a,d  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c BK21 Plus NBM Global Research Center for Regenerative Medicine   (South Korea)

^d Dankook University   (South Korea)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

bioactive phosphate based glass; cell expansion; Microcarriers; titanium

Indexed keywords

BIOACTIVE SUBSTRATES; BIOFUNCTIONALIZATION; BIOMATERIAL SCAFFOLDS; CELL CULTURE PROCESS; CELL EXPANSION; CELL THERAPY PRODUCTS; HIGH-THROUGHPUT SCREENING; MICROCARRIERS;

BIOACTIVE GLASS; BIOCOMPATIBILITY; CELL CULTURE; CELLS; TITANIUM;

SCAFFOLDS (BIOLOGY);

BIOMATERIAL; GLASS; MOLECULAR SCAFFOLD; TITANIUM DIOXIDE;

ARTICLE; BIOCOMPATIBILITY; BIOLOGICAL ACTIVITY; CELL EXPANSION; CELL GROWTH; CELL PROLIFERATION; CELL THERAPY; FIBROBLAST; MAMMAL CELL; MICROCARRIER CULTURE; PHENOTYPE; PRIMARY CELL CULTURE;

BIOACTIVE PHOSPHATE-BASED GLASS; CELL EXPANSION; MICROCARRIERS; TITANIUM;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; FIBROBLASTS; GLASS; MATERIALS TESTING; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PHOSPHATES; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TITANIUM;

EID: 84879762652     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328212459093     Document Type: Article

References (23)

1. Langer R, Vacanti JP. Tissue engineering. Science. 1993 ; 260: 920-926
2. Banfi A, Bianchi G, Notaro R, et al. Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells. Tissue Eng. 2002 ; 8: 901-910
3. Reddig PJ, Juliano RL. Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev. 2005 ; 24: 425-439
4. Eibes G, dos Santos F, Andrade PZ, et al. Maximizing the ex vivo expansion of human mesenchymal stem cells using a microcarrier-based stirred culture system. J Biotechnol. 2010 ; 146: 194-197
5. Santos F, Andrade PZ, Abecasis MM, et al. Toward a clinical-grade expansion of mesenchymal stem cells from human sources: a microcarrier-based culture system under xeno-free conditions. Tissue Eng Part C Methods. 2011 ; 17: 1201-1210
6. Hammond TG, Hammond JM. Optimized suspension culture: the rotating-wall vessel. Am J Physiol Renal Physiol. 2001 ; 281: F12 - F25
7. Kokubo T, Kim HM, Kawashita M, et al. Bioactive metals: preparation and properties. J Mater Sci Mater Med. 2004 ; 15: 99-107
8. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity?. Biomaterials. 2006 ; 27: 2907-2915
9. Ahmed I, Collins CA, Lewis MP, et al. Processing, characterisation and biocompatibility of iron-phosphate glass fibres for tissue engineering. Biomaterials. 2004 ; 25: 3223-3232
10. Bitar M, Salih V, Mudera V, et al. Soluble phosphate glasses: in vitro studies using human cells of hard and soft tissue origin. Biomaterials. 2004 ; 25: 2283-2292
11. Neel EA, Ahmed I, Pratten J, et al. Characterisation of antibacterial copper releasing degradable phosphate glass fibres. Biomaterials. 2005 ; 26: 2247-2254
12. Lakhkar NJ, Park JH, Mordan NJ, et al. Titanium phosphate glass microspheres for bone tissue engineering. Acta Biomater. 2012 ;:
13. Abou Neel EA, Mizoguchi T, Ito M, et al. In vitro bioactivity and gene expression by cells cultured on titanium dioxide doped phosphate-based glasses. Biomaterials. 2007 ; 28: 2967-2977
14. Abou Neel EA, Chrzanowski W, Knowles JC. Effect of increasing titanium dioxide content on bulk and surface properties of phosphate-based glasses. Acta Biomater. 2008 ; 4: 523-534
15. Wall IB, Moseley R, Baird DM, et al. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. J Invest Dermatol. 2008 ; 128: 2526-2540
16. Ahmadi R, Mordan N, Forbes A, et al. Enhanced attachment, growth and migration of smooth muscle cells on microcarriers produced using thermally induced phase separation. Acta Biomater. 2011 ; 7: 1542-1549
17. Lakhkar NJ, Lee IH, Kim HW, et al. Bone formation controlled by biologically relevant inorganic ions: Role and controlled delivery from phosphate-based glasses. Adv Drug Deliv Rev. 2012 ;:
18. Yun YR, Jang JH, Jeon E, et al. Administration of growth factors for bone regeneration. Regen Med. 2012 ; 7: 369-385
19. Nichol JW, Khademhosseini A. Modular tissue engineering: engineering biological tissues from the bottom up. Soft Matter. 2009 ; 5: 1312-1319
20. Donos N, Retzepi M, Wall I, et al. In vivo gene expression profile of guided bone regeneration associated with a microrough titanium surface. Clin Oral Implants Res. 2011 ; 22: 390-398
21. Ivanovski S, Hamlet S, Retzepi M, et al. Transcriptional profiling of «guided bone regeneration» in a critical-size calvarial defect. Clin Oral Implants Res. 2011 ; 22: 382-389
22. Retzepi M, Lewis MP, Donos N. Effect of diabetes and metabolic control on de novo bone formation following guided bone regeneration. Clin Oral Implants Res. 2010 ; 21: 71-79
23. Senuma Y, Franceschin S, Hilborn JG, et al. Bioresorbable microspheres by spinning disk atomization as injectable cell carrier: from preparation to in vitro evaluation. Biomaterials. 2000 ; 21: 1135-1144