Influence of sex on the outcome of autologous chondrocyte implantation in chondral defects of the knee

American Journal of Sports Medicine

Volumn 41, Issue 7, 2013, Pages 1541-1548

  Kreuz, Peter C ^a   Müller, Sebastian ^b   Von Keudell, Arvind ^c   Tischer, Thomas ^a   Kaps, Christian ^d   Niemeyer, Philipp ^e   Erggelet, Christoph ^e  

^a UNIVERSITY MEDICAL CENTER ROSTOCK   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

autologous chondrocyte implantation; cartilage lesion; cartilage repair; sex

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; ARTICULAR CARTILAGE; AUTOLOGOUS CHONDROCYTE IMPLANTATION; AUTOTRANSPLANTATION; CARTILAGE CELL; CARTILAGE LESION; CARTILAGE REPAIR; CHONDROPLASTY; FEMALE; HUMAN; INJURY; KNEE INJURY; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDY; SEX; SEX DIFFERENCE; TRANSPLANTATION; YOUNG ADULT; KNEE INJURIES;

AUTOLOGOUS CHONDROCYTE IMPLANTATION; CARTILAGE LESION; CARTILAGE REPAIR; SEX;

ADOLESCENT; ADULT; ARTHROPLASTY, SUBCHONDRAL; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; HUMANS; KNEE INJURIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEX FACTORS; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 84879755294     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513489262     Document Type: Article

References (46)

1. Aigner T, McKenna L. Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci. 2002 ; 59 (1). 5-18
2. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994 ; 331 (14). 889-895
3. Brittberg M, Winalski CS. Evaluation of cartilage injuries and repair. J Bone Joint Surg Am. 2003 ; 85: 58-69
4. Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect. 1998 ; 47: 487-504
5. Covassin T, Elbin RJ, Harris W, Parker T, Kontos A. The role of age and sex in symptoms, neurocognitive performance, and postural stability in athletes after concussion. Am J Sports Med. 2012 ; 40 (6). 1303-1312
6. Csintalan RP, Schulz MM, Woo J, McMahon PJ, Lee TQ. Gender differences in patellofemoral joint biomechanics. Clin Orthop Relat Res. 2002 ; 402: 260-269
7. Erggelet C, Sittinger M, Lahm A. The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. Arthroscopy. 2003 ; 19 (1). 108-110
8. Faber SC, Eckstein F, Lukasz S, et al. Gender differences in knee joint cartilage thickness, volume and articular surface areas: assessment with quantitative three-dimensional MR imaging. Skeletal Radiol. 2001 ; 30 (3). 144-150
9. Ford KR, Myer GD, Hewett TE. Valgus knee motion during landing in high school female and male basketball players. Med Sci Sports Exerc. 2003 ; 35 (10). 1745-1750
10. Gerlier L, Lamotte M, Wille M, et al. The cost utility of autologous chondrocytes implantation using ChondroCelect(R) in symptomatic knee cartilage lesions in Belgium. Pharmacoeconomics. 2010 ; 28 (12). 1129-1146
11. Gille J, Schuseil E, Wimmer J, Gellissen J, Schulz AP, Behrens P. Mid-term results of autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc. 2010 ; 18 (11). 1456-1464
12. Granata KP, Padua DA, Wilson SE. Gender differences in active musculoskeletal stiffness, part II: quantification of leg stiffness during functional hopping tasks. J Electromyogr Kinesiol. 2002 ; 12 (2). 127-135
13. Hangody L, Dobos J, Balo E, Panics G, Hangody LR, Berkes I. Clinical experiences with autologous osteochondral mosaicplasty in an athletic population: a 17-year prospective multicenter study. Am J Sports Med. 2010 ; 38 (6). 1125-1133
14. Henderson IJ, Tuy B, Connell D, Oakes B, Hettwer WH. Prospective clinical study of autologous chondrocyte implantation and correlation with MRI at three and 12 months. J Bone Joint Surg Br. 2003 ; 85 (7). 1060-1066
15. Hewett TE, Myer GD, Ford KR, et al. Biomechanical measures of neuromuscular control and valgus loading of the knee predict anterior cruciate ligament injury risk in female athletes: a prospective study. Am J Sports Med. 2005 ; 33 (4). 492-501
16. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage. 2002 ; 10 (6). 432-463
17. Hurst JM, Steadman JR, O'Brien L, Rodkey WG, Briggs KK. Rehabilitation following microfracture for chondral injury in the knee. Clin Sports Med. 2010 ; 29 (2). 257 viii - 265
18. Irrgang JJ, Anderson AF, Boland AL, et al. Development and validation of the International Knee Documentation Committee subjective knee form. Am J Sports Med. 2001 ; 29 (5). 600-613
19. Jenei-Lanzl Z, Straub RH, Dienstknecht T, et al. Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via nonclassic signaling. Arthritis Rheum. 2010 ; 62 (4). 1088-1096
20. Jungmann PM, Salzmann GM, Schmal H, Pestka JM, Sudkamp NP, Niemeyer P. Autologous chondrocyte implantation for treatment of cartilage defects of the knee: what predicts the need for reintervention?. Am J Sports Med. 2012 ; 40 (1). 58-67
21. Knutsen G, Drogset JO, Engebretsen L, et al. A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am. 2007 ; 89 (10). 2105-2112
22. Kon E, Filardo G, Berruto M, et al. Articular cartilage treatment in high-level male soccer players: a prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture. Am J Sports Med. 2011 ; 39 (12). 2549-2557
23. Kreuz PC, Muller S, Erggelet C, et al. Is gender influencing the biomechanical results after autologous chondrocyte implantation?. Knee Surg Sports Traumatol Arthrosc.:
24. Kreuz PC, Muller S, Freymann U, et al. Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: clinical and biomechanical results 48 months after transplantation. Am J Sports Med. 2011 ; 39 (8). 1697-1705
25. Kreuz PC, Steinwachs M, Erggelet C, et al. Classification of graft hypertrophy after autologous chondrocyte implantation of full-thickness chondral defects in the knee. Osteoarthritis Cartilage. 2007 ; 15 (12). 1339-1347
26. Kreuz PC, Steinwachs MR, Erggelet C, et al. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006 ; 14 (11). 1119-1125
27. Krishnan SP, Skinner JA, Bartlett W, et al. Who is the ideal candidate for autologous chondrocyte implantation?. J Bone Joint Surg Br. 2006 ; 88 (1). 61-64
28. Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982 ; 10 (3). 150-154
29. McNickle AG, L'Heureux DR, Yanke AB, Cole BJ. Outcomes of autologous chondrocyte implantation in a diverse patient population. Am J Sports Med. 2009 ; 37 (7). 1344-1350
30. Miller AE, MacDougall JD, Tarnopolsky MA, Sale DG. Gender differences in strength and muscle fiber characteristics. Eur J Appl Physiol Occup Physiol. 1993 ; 66 (3). 254-262
31. Minas T, Bryant T. The role of autologous chondrocyte implantation in the patellofemoral joint. Clin Orthop Relat Res. 2005 ; 436: 30-39
32. Myer GD, Ford KR, Palumbo JP, Hewett TE. Neuromuscular training improves performance and lower-extremity biomechanics in female athletes. J Strength Cond Res. 2005 ; 19 (1). 51-60
33. Myer GD, Ford KR, Paterno MV, Nick TG, Hewett TE. The effects of generalized joint laxity on risk of anterior cruciate ligament injury in young female athletes. Am J Sports Med. 2008 ; 36 (6). 1073-1080
34. Peterson L, Vasiliadis HS, Brittberg M, Lindahl A. Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med. 2010 ; 38 (6). 1117-1124
35. Saris DB, Vanlauwe J, Victor J, et al. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009 ; 37: 10S - 19S
36. Schneider U, Rackwitz L, Andereya S, et al. A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee. Am J Sports Med. 2011 ; 39 (12). 2558-2565
37. Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am. 1993 ; 75 (4). 532-553
38. Smith FW, Rosenlund EA, Aune AK, MacLean JA, Hillis SW. Subjective functional assessments and the return to competitive sport after anterior cruciate ligament reconstruction. Br J Sports Med. 2004 ; 38 (3). 279-284
39. Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy. 2003 ; 19 (5). 477-484
40. Steinwachs M, Kreuz PC. Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: a prospective study with a 3-year follow-up. Arthroscopy. 2007 ; 23 (4). 381-387
41. Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med. 2011 ; 39 (12). 2566-2574
42. Varadarajan KM, Freiberg AA, Gill TJ, Rubash HE, Li G. Relationship between three-dimensional geometry of the trochlear groove and in vivo patellar tracking during weight-bearing knee flexion. J Biomech Eng. 2010 ; 132 (6). 061008
43. Varadarajan KM, Gill TJ, Freiberg AA, Rubash HE, Li G. Gender differences in trochlear groove orientation and rotational kinematics of human knees. J Orthop Res. 2009 ; 27 (7). 871-878
44. Varadarajan KM, Gill TJ, Freiberg AA, Rubash HE, Li G. Patellar tendon orientation and patellar tracking in male and female knees. J Orthop Res. 2010 ; 28 (3). 322-328
45. Victor J, Labey L, Wong P, Innocenti B, Bellemans J. The influence of muscle load on tibiofemoral knee kinematics. J Orthop Res. 2010 ; 28 (4). 419-428
46. Wojtys EM, Huston LJ, Schock HJ, Boylan JP, Ashton-Miller JA. Gender differences in muscular protection of the knee in torsion in size-matched athletes. J Bone Joint Surg Am. 2003 ; 85 (5). 782-789