메뉴 건너뛰기




Volumn 111, Issue , 2013, Pages 203-210

Microfluidic devices for continuous production of pDNA/cationic liposome complexes for gene delivery and vaccine therapy

Author keywords

Cationic liposomes; DNA; Gene delivery; Microfluidics; Micromixer

Indexed keywords

CATIONIC LIPOSOMES; CONTINUOUS PRODUCTION; GENE DELIVERY; HYDRODYNAMIC FLOWS; MICRO FLUIDIC SYSTEM; MICRO MIXERS; MICRO-FLUIDIC DEVICES; MICROFLUIDIC MIXING;

EID: 84879744585     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2013.04.003     Document Type: Article
Times cited : (61)

References (60)
  • 1
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides G.M. The origins and the future of microfluidics. Nature 2006, 442(7101):368-373.
    • (2006) Nature , vol.442 , Issue.7101 , pp. 368-373
    • Whitesides, G.M.1
  • 2
    • 24944498780 scopus 로고    scopus 로고
    • Microfluidics: fluid physics at the nanoliter scale
    • Squires T.M., Quake S.R. Microfluidics: fluid physics at the nanoliter scale. Rev. Mod. Phys. 2005, 77(3):977-1026.
    • (2005) Rev. Mod. Phys. , vol.77 , Issue.3 , pp. 977-1026
    • Squires, T.M.1    Quake, S.R.2
  • 3
    • 77953138861 scopus 로고    scopus 로고
    • Manipulation of nanoparticles within a microfluidic system based on SU-8 polymer for bio-applications
    • Draghiciu L., et al. Manipulation of nanoparticles within a microfluidic system based on SU-8 polymer for bio-applications. Mater. Sci. Eng. B: Adv. Funct. Solid-State Mater. 2010, 169(1-3):186-192.
    • (2010) Mater. Sci. Eng. B: Adv. Funct. Solid-State Mater. , vol.169 , Issue.1-3 , pp. 186-192
    • Draghiciu, L.1
  • 4
    • 78651397185 scopus 로고    scopus 로고
    • Investigation of indium phosphide nanocrystal synthesis using a high-temperature and high-pressure continuous flow microreactor
    • Baek J., et al. Investigation of indium phosphide nanocrystal synthesis using a high-temperature and high-pressure continuous flow microreactor. Angew. Chem. Int. Ed. 2011, 50(3):627-630.
    • (2011) Angew. Chem. Int. Ed. , vol.50 , Issue.3 , pp. 627-630
    • Baek, J.1
  • 5
    • 79251598948 scopus 로고    scopus 로고
    • Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip
    • Yamashita T., et al. Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip. Biomaterials 2011, 32(10):2459-2465.
    • (2011) Biomaterials , vol.32 , Issue.10 , pp. 2459-2465
    • Yamashita, T.1
  • 6
    • 75749106257 scopus 로고    scopus 로고
    • Accurate optical analysis of single-molecule entrapment in nanoscale vesicles
    • Reiner J.E., et al. Accurate optical analysis of single-molecule entrapment in nanoscale vesicles. Anal. Chem. 2010, 82(1):180-188.
    • (2010) Anal. Chem. , vol.82 , Issue.1 , pp. 180-188
    • Reiner, J.E.1
  • 8
    • 0037036166 scopus 로고    scopus 로고
    • Microfluidic control using colloidal devices
    • Terray A., Oakey J., Marr D.W.M. Microfluidic control using colloidal devices. Science 2002, 296(5574):1841-1844.
    • (2002) Science , vol.296 , Issue.5574 , pp. 1841-1844
    • Terray, A.1    Oakey, J.2    Marr, D.W.M.3
  • 9
    • 79957875120 scopus 로고    scopus 로고
    • Microfluidic mixing: a review
    • Lee C.Y., et al. Microfluidic mixing: a review. Int. J. Mol. Sci. 2011, 12(5):3263-3287.
    • (2011) Int. J. Mol. Sci. , vol.12 , Issue.5 , pp. 3263-3287
    • Lee, C.Y.1
  • 10
    • 0037102261 scopus 로고    scopus 로고
    • Mixing processes in a zigzag microchannel: finite element simulations and optical study
    • Mengeaud V., Josserand J., Girault H.H. Mixing processes in a zigzag microchannel: finite element simulations and optical study. Anal. Chem. 2002, 74(16):4279-4286.
    • (2002) Anal. Chem. , vol.74 , Issue.16 , pp. 4279-4286
    • Mengeaud, V.1    Josserand, J.2    Girault, H.H.3
  • 11
    • 80051475500 scopus 로고    scopus 로고
    • Macro- and micromixing in a novel sonochemical reactor using high frequency ultrasound
    • Parvizian F., Rahimi M., Faryadi M. Macro- and micromixing in a novel sonochemical reactor using high frequency ultrasound. Chem. Eng. Process. 2011, 50(8):732-740.
    • (2011) Chem. Eng. Process. , vol.50 , Issue.8 , pp. 732-740
    • Parvizian, F.1    Rahimi, M.2    Faryadi, M.3
  • 12
    • 84856232986 scopus 로고    scopus 로고
    • Analysis on micro-mixing enhancement through a constriction under time periodic electroosmotic flow
    • Lim C.Y., Lam Y.C. Analysis on micro-mixing enhancement through a constriction under time periodic electroosmotic flow. Microfluid. Nanofluid. 2012, 12(1-4):127-141.
    • (2012) Microfluid. Nanofluid. , vol.12 , Issue.1-4 , pp. 127-141
    • Lim, C.Y.1    Lam, Y.C.2
  • 13
    • 79959502605 scopus 로고    scopus 로고
    • Controlling mass transport in microfluidic devices
    • Kuo J.S., Chiu D.T. Controlling mass transport in microfluidic devices. Ann. Rev. Anal. Chem. 2011, 4(4):275-296.
    • (2011) Ann. Rev. Anal. Chem. , vol.4 , Issue.4 , pp. 275-296
    • Kuo, J.S.1    Chiu, D.T.2
  • 14
    • 77954659809 scopus 로고    scopus 로고
    • Evaluation of the performance of a constructal mixer with the iodide-iodate reaction system
    • Fan Z., et al. Evaluation of the performance of a constructal mixer with the iodide-iodate reaction system. Chem. Eng. Process. 2010, 49(6):628-632.
    • (2010) Chem. Eng. Process. , vol.49 , Issue.6 , pp. 628-632
    • Fan, Z.1
  • 15
    • 0037169046 scopus 로고    scopus 로고
    • Chaotic mixer for microchannels
    • Stroock A.D., et al. Chaotic mixer for microchannels. Science 2002, 295(5555):647-651.
    • (2002) Science , vol.295 , Issue.5555 , pp. 647-651
    • Stroock, A.D.1
  • 16
    • 0033684370 scopus 로고    scopus 로고
    • Passive mixing in a three-dimensional serpentine microchannel
    • Liu R.H., et al. Passive mixing in a three-dimensional serpentine microchannel. J. Microelectromech. Syst. 2000, 9(2):190-197.
    • (2000) J. Microelectromech. Syst. , vol.9 , Issue.2 , pp. 190-197
    • Liu, R.H.1
  • 17
    • 79551687886 scopus 로고    scopus 로고
    • Bioreducible polymers for gene delivery
    • Kim T.-i., Kim S.W. Bioreducible polymers for gene delivery. React. Funct. Polym. 2011, 71(3):344-349.
    • (2011) React. Funct. Polym. , vol.71 , Issue.3 , pp. 344-349
    • Kim, T.-I.1    Kim, S.W.2
  • 18
    • 0038725718 scopus 로고    scopus 로고
    • Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle
    • Ozbas-Turan S., et al. Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle. J. Pharm. Pharm. Sci. 2003, 6(1):27-32.
    • (2003) J. Pharm. Pharm. Sci. , vol.6 , Issue.1 , pp. 27-32
    • Ozbas-Turan, S.1
  • 19
    • 0037340617 scopus 로고    scopus 로고
    • Mesenchymal stem cells: MG63 and HEK293 transfection using chitosan-DNA nanoparticles
    • Corsi K., et al. Mesenchymal stem cells: MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials 2003, 24(7):1255-1264.
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1255-1264
    • Corsi, K.1
  • 21
    • 77951742428 scopus 로고    scopus 로고
    • Microfluidic mixing and the formation of nanoscale lipid vesicles
    • Jahn A., et al. Microfluidic mixing and the formation of nanoscale lipid vesicles. ACS Nano 2010, 4(4):2077-2087.
    • (2010) ACS Nano , vol.4 , Issue.4 , pp. 2077-2087
    • Jahn, A.1
  • 22
    • 34249977091 scopus 로고    scopus 로고
    • Microfluidic directed formation of liposomes of controlled size
    • Jahn A., et al. Microfluidic directed formation of liposomes of controlled size. Langmuir 2007, 23(11):6289-6293.
    • (2007) Langmuir , vol.23 , Issue.11 , pp. 6289-6293
    • Jahn, A.1
  • 23
    • 1542347972 scopus 로고    scopus 로고
    • Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing
    • Jahn A., et al. Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing. J. Am. Chem. Soc. 2004, 126(9):2674-2675.
    • (2004) J. Am. Chem. Soc. , vol.126 , Issue.9 , pp. 2674-2675
    • Jahn, A.1
  • 24
    • 42649131375 scopus 로고    scopus 로고
    • A facile microfluidic method for production of liposomes
    • Pradhan P., et al. A facile microfluidic method for production of liposomes. Anticancer Res. 2008, 28(2A):943-947.
    • (2008) Anticancer Res. , vol.28 , Issue.2 A , pp. 943-947
    • Pradhan, P.1
  • 25
    • 79951664047 scopus 로고    scopus 로고
    • Effects of temperature, acyl chain length, and flow-rate ratio on liposome formation and size in a microfluidic hydrodynamic focusing device
    • Zook J.M., Vreeland W.N. Effects of temperature, acyl chain length, and flow-rate ratio on liposome formation and size in a microfluidic hydrodynamic focusing device. Soft Matter 2010, 6(6):1352-1360.
    • (2010) Soft Matter , vol.6 , Issue.6 , pp. 1352-1360
    • Zook, J.M.1    Vreeland, W.N.2
  • 26
    • 68649103693 scopus 로고    scopus 로고
    • The synergy between structural stability and DNA-binding controls the antibody production in EPC/DOTAP/DOPE liposomes and DOTAP/DOPE lipoplexes
    • de la Torre L.G., et al. The synergy between structural stability and DNA-binding controls the antibody production in EPC/DOTAP/DOPE liposomes and DOTAP/DOPE lipoplexes. Colloids Surf. B: Biointerfaces 2009, 73(2):175-184.
    • (2009) Colloids Surf. B: Biointerfaces , vol.73 , Issue.2 , pp. 175-184
    • de la Torre, L.G.1
  • 27
    • 48749107419 scopus 로고    scopus 로고
    • Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes
    • Rosada R.S., et al. Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes. BMC Immunol. 2008, 9.
    • (2008) BMC Immunol. , vol.9
    • Rosada, R.S.1
  • 28
    • 84858281305 scopus 로고    scopus 로고
    • Effectiveness, against tuberculosis, of pseudo-ternary complexes: peptide-DNA-cationic liposome
    • Rosada R.S., et al. Effectiveness, against tuberculosis, of pseudo-ternary complexes: peptide-DNA-cationic liposome. J. Colloid Interface Sci. 2012, 373:102-109.
    • (2012) J. Colloid Interface Sci. , vol.373 , pp. 102-109
    • Rosada, R.S.1
  • 29
    • 84864686641 scopus 로고    scopus 로고
    • Correlation between physicochemical and structural properties with in vitro transfection of pDNA/cationic liposomes complexes
    • Balbino T.A., et al. Correlation between physicochemical and structural properties with in vitro transfection of pDNA/cationic liposomes complexes. Langmuir 2012, 28:11535-11545.
    • (2012) Langmuir , vol.28 , pp. 11535-11545
    • Balbino, T.A.1
  • 30
    • 33646162872 scopus 로고    scopus 로고
    • How lipid hydration and temperature affect the structure of DC-Chol-DOPE/DNA lipoplexes
    • Pozzi D., et al. How lipid hydration and temperature affect the structure of DC-Chol-DOPE/DNA lipoplexes. Chem. Phys. Lett. 2006, 422(4-6):439-445.
    • (2006) Chem. Phys. Lett. , vol.422 , Issue.4-6 , pp. 439-445
    • Pozzi, D.1
  • 31
    • 0033370524 scopus 로고    scopus 로고
    • A multi-step lipid mixing assay to model structural changes in cationic lipoplexes used for in vitro transfection
    • Wasan E.K., et al. A multi-step lipid mixing assay to model structural changes in cationic lipoplexes used for in vitro transfection. Biochim. Biophys. Acta: Biomembr. 1999, 1461(1):27-46.
    • (1999) Biochim. Biophys. Acta: Biomembr. , vol.1461 , Issue.1 , pp. 27-46
    • Wasan, E.K.1
  • 32
    • 0034019945 scopus 로고    scopus 로고
    • Cationic polymer based gene delivery systems
    • De Smedt S.C., Demeester J., Hennink W.E. Cationic polymer based gene delivery systems. Pharm. Res. 2000, 17(2):113-126.
    • (2000) Pharm. Res. , vol.17 , Issue.2 , pp. 113-126
    • De Smedt, S.C.1    Demeester, J.2    Hennink, W.E.3
  • 33
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    • Rejman J., et al. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 2004, 377:159-169.
    • (2004) Biochem. J. , vol.377 , pp. 159-169
    • Rejman, J.1
  • 34
    • 35548968849 scopus 로고    scopus 로고
    • Lipoplex morphologies and their influences on transfection efficiency in gene delivery
    • Ma B., et al. Lipoplex morphologies and their influences on transfection efficiency in gene delivery. J. Control. Release 2007, 123(3):184-194.
    • (2007) J. Control. Release , vol.123 , Issue.3 , pp. 184-194
    • Ma, B.1
  • 35
    • 46549090126 scopus 로고    scopus 로고
    • Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
    • Morille M., et al. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 2008, 29(24/25):3477-3496.
    • (2008) Biomaterials , vol.29 , Issue.24-25 , pp. 3477-3496
    • Morille, M.1
  • 36
    • 69549087912 scopus 로고    scopus 로고
    • Nonviral gene vector formation in monodispersed picolitre incubator for consistent gene delivery
    • Hsieh A.T.-H., et al. Nonviral gene vector formation in monodispersed picolitre incubator for consistent gene delivery. Lab Chip 2009, 9(18):2638-2643.
    • (2009) Lab Chip , vol.9 , Issue.18 , pp. 2638-2643
    • Hsieh, A.T.-H.1
  • 37
    • 33644788667 scopus 로고    scopus 로고
    • Microfluidics of soft matter investigated by small-angle X-ray scattering
    • Otten A., et al. Microfluidics of soft matter investigated by small-angle X-ray scattering. J. Synchrotron Radiat. 2005, 12:745-750.
    • (2005) J. Synchrotron Radiat. , vol.12 , pp. 745-750
    • Otten, A.1
  • 38
    • 70350053403 scopus 로고    scopus 로고
    • Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device
    • Koh C.G., et al. Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device. Mol. Pharm. 2009, 6(5):1333-1342.
    • (2009) Mol. Pharm. , vol.6 , Issue.5 , pp. 1333-1342
    • Koh, C.G.1
  • 39
    • 70849083668 scopus 로고    scopus 로고
    • Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing
    • Koh C.G., et al. Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing. J. Control. Release 2010, 141(1):62-69.
    • (2010) J. Control. Release , vol.141 , Issue.1 , pp. 62-69
    • Koh, C.G.1
  • 40
    • 77955071343 scopus 로고    scopus 로고
    • Transfection efficiency of lipoplexes for site-directed delivery
    • Jellema R.K., et al. Transfection efficiency of lipoplexes for site-directed delivery. J. Liposome Res. 2010, 20(3):258-267.
    • (2010) J. Liposome Res. , vol.20 , Issue.3 , pp. 258-267
    • Jellema, R.K.1
  • 41
    • 84860344186 scopus 로고    scopus 로고
    • Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation
    • Chen D., et al. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. J. Am. Chem. Soc. 2012, 134(16).
    • (2012) J. Am. Chem. Soc. , vol.134 , Issue.16
    • Chen, D.1
  • 42
    • 84868338479 scopus 로고    scopus 로고
    • Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA
    • Belliveau N.M., et al. Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA. Mol. Ther. Nucleic Acids 2012, 1:e37.
    • (2012) Mol. Ther. Nucleic Acids , vol.1
    • Belliveau, N.M.1
  • 43
    • 79955907483 scopus 로고    scopus 로고
    • Tuning physical properties of nanocomplexes through microfluidics-assisted confinement
    • Ho Y.-P., et al. Tuning physical properties of nanocomplexes through microfluidics-assisted confinement. Nano Lett. 2011, 11(5):2178-2182.
    • (2011) Nano Lett. , vol.11 , Issue.5 , pp. 2178-2182
    • Ho, Y.-P.1
  • 44
    • 57449094400 scopus 로고    scopus 로고
    • Fabrication of a multichannel PDMS/glass analytical microsystem with integrated electrodes for amperometric detection
    • Moreira N.H., et al. Fabrication of a multichannel PDMS/glass analytical microsystem with integrated electrodes for amperometric detection. Lab Chip 2009, 9(1):115-121.
    • (2009) Lab Chip , vol.9 , Issue.1 , pp. 115-121
    • Moreira, N.H.1
  • 45
    • 84861095871 scopus 로고    scopus 로고
    • Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery
    • Toledo M.A.S., et al. Development of a recombinant fusion protein based on the dynein light chain LC8 for non-viral gene delivery. J. Control. Release 2012, 159(2):222-231.
    • (2012) J. Control. Release , vol.159 , Issue.2 , pp. 222-231
    • Toledo, M.A.S.1
  • 46
    • 84878196411 scopus 로고    scopus 로고
    • Continuous flow production of cationic liposomes at high lipid concentration in microfluidic devices for gene delivery applications
    • Balbino T.A., et al. Continuous flow production of cationic liposomes at high lipid concentration in microfluidic devices for gene delivery applications. Chem. Eng. J. 2013, 10.1016/j.cej.2013.04.053.
    • (2013) Chem. Eng. J.
    • Balbino, T.A.1
  • 48
    • 0041733562 scopus 로고    scopus 로고
    • Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies
    • Wong S.H., et al. Investigation of mixing in a cross-shaped micromixer with static mixing elements for reaction kinetics studies. Sens. Actuators B: Chem. 2003, 95(1-3):414-424.
    • (2003) Sens. Actuators B: Chem. , vol.95 , Issue.1-3 , pp. 414-424
    • Wong, S.H.1
  • 49
    • 79751525522 scopus 로고    scopus 로고
    • Effect of micro-channel geometry on fluid flow and mixing
    • Naher S., et al. Effect of micro-channel geometry on fluid flow and mixing. Simulat. Model. Pract. Theor. 2011, 19(4):1088-1095.
    • (2011) Simulat. Model. Pract. Theor. , vol.19 , Issue.4 , pp. 1088-1095
    • Naher, S.1
  • 51
    • 77950537850 scopus 로고    scopus 로고
    • Ultrasound-enhanced microfluidic synthesis of liposomes
    • Huang X.M., et al. Ultrasound-enhanced microfluidic synthesis of liposomes. Anticancer Res. 2010, 30(2):463-466.
    • (2010) Anticancer Res. , vol.30 , Issue.2 , pp. 463-466
    • Huang, X.M.1
  • 52
    • 77954561647 scopus 로고    scopus 로고
    • Controlled self-assembly of monodisperse niosomes by microfluidic hydrodynamic focusing
    • Lo C.T., et al. Controlled self-assembly of monodisperse niosomes by microfluidic hydrodynamic focusing. Langmuir 2010, 26(11):8559-8566.
    • (2010) Langmuir , vol.26 , Issue.11 , pp. 8559-8566
    • Lo, C.T.1
  • 54
    • 47749107219 scopus 로고    scopus 로고
    • On dimensionless numbers
    • Ruzicka M.C. On dimensionless numbers. Chem. Eng. Res. Des. 2008, 86(8A):835-868.
    • (2008) Chem. Eng. Res. Des. , vol.86 , Issue.8 A , pp. 835-868
    • Ruzicka, M.C.1
  • 55
    • 2442453779 scopus 로고    scopus 로고
    • Transition from laminar to turbulent flow in liquid filled microtubes
    • Sharp K.V., Adrian R.J. Transition from laminar to turbulent flow in liquid filled microtubes. Exp. Fluids 2004, 36(5):741-747.
    • (2004) Exp. Fluids , vol.36 , Issue.5 , pp. 741-747
    • Sharp, K.V.1    Adrian, R.J.2
  • 56
    • 58249143780 scopus 로고    scopus 로고
    • Effects of confinement on the motion of a single sphere in a sheared viscoelastic liquid
    • D'Avino G., et al. Effects of confinement on the motion of a single sphere in a sheared viscoelastic liquid. J. Non-Newton. Fluid Mech. 2009, 157(1/2):101-107.
    • (2009) J. Non-Newton. Fluid Mech. , vol.157 , Issue.1-2 , pp. 101-107
    • D'Avino, G.1
  • 57
    • 0000799974 scopus 로고
    • Effect of shear on a lyotropic lamellar phase
    • Diat O., Roux D., Nallet F. Effect of shear on a lyotropic lamellar phase. J. Phys. II 1993, 3(9):1427-1452.
    • (1993) J. Phys. II , vol.3 , Issue.9 , pp. 1427-1452
    • Diat, O.1    Roux, D.2    Nallet, F.3
  • 58
    • 0035951244 scopus 로고    scopus 로고
    • Effects of shear on the lamellar phase of a dialkyl cationic surfactant
    • Soubiran L., et al. Effects of shear on the lamellar phase of a dialkyl cationic surfactant. Langmuir 2001, 17(26):7988-7994.
    • (2001) Langmuir , vol.17 , Issue.26 , pp. 7988-7994
    • Soubiran, L.1
  • 59
    • 34047259539 scopus 로고    scopus 로고
    • Influence of the electrical interface properties on the rheological behavior of sonicated soy lecithin dispersions
    • Alvarez M.A., et al. Influence of the electrical interface properties on the rheological behavior of sonicated soy lecithin dispersions. J. Colloid Interface Sci. 2007, 309(2):279-282.
    • (2007) J. Colloid Interface Sci. , vol.309 , Issue.2 , pp. 279-282
    • Alvarez, M.A.1
  • 60
    • 0035312248 scopus 로고    scopus 로고
    • Trends in lipoplex physical properties dependent on cationic lipid structure: vehicle and complexation procedure do not correlate with biological activity
    • Ferrari M.E., et al. Trends in lipoplex physical properties dependent on cationic lipid structure: vehicle and complexation procedure do not correlate with biological activity. Nucleic Acids Res. 2001, 29(7):1539-1548.
    • (2001) Nucleic Acids Res. , vol.29 , Issue.7 , pp. 1539-1548
    • Ferrari, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.