Povidone-iodine combined with antibiotic topical irrigation to reduce capsular contracture in cosmetic breast augmentation: A comparative study

Aesthetic Surgery Journal

Volumn 33, Issue 5, 2013, Pages 675-680

  Giordano, Salvatore ^a   Peltoniemi, Hilkka ^b   Lilius, Peter ^b   Salmi, Asko ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

augmentation mammaplasty; biofilm; breast implant; capsular contracture; dual plane breast augmentation; prosthesis; topical antibiotics

Indexed keywords

ANTIBIOTIC AGENT; CEFALEXIN; CEFALOTIN; CEFAZOLIN; CEFUROXIME; GENTAMICIN; LEVOFLOXACIN; POVIDONE IODINE; SODIUM CHLORIDE;

ADULT; ARTICLE; BREAST AUGMENTATION; COMPARATIVE STUDY; ESTHETIC SURGERY; FEMALE; FOLLOW UP; HEMATOMA; HOSPITAL DISCHARGE; HUMAN; IMPLANT CAPSULAR CONTRACTURE; INFECTION COMPLICATION; MAJOR CLINICAL STUDY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEROMA; WOUND INFECTION; WOUND IRRIGATION;

AUGMENTATION MAMMAPLASTY; BIOFILM; BREAST IMPLANT; CAPSULAR CONTRACTURE; DUAL-PLANE BREAST AUGMENTATION; PROSTHESIS; TOPICAL ANTIBIOTICS;

ADMINISTRATION, TOPICAL; ADULT; ANTI-BACTERIAL AGENTS; BIOFILMS; BREAST IMPLANTATION; BREAST IMPLANTS; CASE-CONTROL STUDIES; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMPLANT CAPSULAR CONTRACTURE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; POVIDONE-IODINE; REFERENCE VALUES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; THERAPEUTIC IRRIGATION; TREATMENT OUTCOME;

EID: 84879736429     PISSN: 1090820X     EISSN: 1527330X     Source Type: Journal    
DOI: 10.1177/1090820X13491490     Document Type: Article

References (48)

1. Dancey A, Nassimizadeh A, Levick P. Capsular contracture - what are the risk factors? A 14 year series of 1400 consecutive augmentations. J Plast Reconstr Aesthetic Surg. 2012 ; 65: 213-218
2. Kjøller K, Hölmich LR, Jacobsen PH, et al. Epidemiological investigation of local complications after cosmetic breast implant surgery in Denmark. Ann Plast Surg. 2002 ; 48: 229-237
3. Adams WP. Capsular contracture: what is it? What causes it? How can it be prevented and managed?. Clin Plast Surg. 2009 ; 36: 119-126
4. Araco A, Gravante G, Araco F, Delogu D, Cervelli V, Walgenbach K. Infections of breast implants in aesthetic breast augmentations: a single-center review of 3,002 patients. Aesthetic Plast Surg. 2007 ; 31: 325-329
5. Chundamala J, Wright JG. The efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection: an evidence-based review. Can J Surg. 2007 ; 50: 473-481
6. Burkhardt BR, Dempsey PD, Schnur PL, Tofield JJ. Capsular contracture: a prospective study of the effect of local antibacterial agents. Plast Reconstr Surg. 1986 ; 77: 919-932
7. Burkhardt BR, Eades E. The effect of Biocell texturing and povidone-iodine irrigation on capsular contracture around saline-inflatable breast implants. Plast Reconstr Surg. 1995 ; 96: 1317-1325
8. Wiener TC. The role of Betadine irrigation in breast augmentation. Plast Reconstr Surg. 2007 ; 119: 12-15
9. Adams WP, Rios JL, Smith SJ. Enhancing patient outcomes in aesthetic and reconstructive breast surgery using triple antibiotic breast irrigation: six-year prospective clinical study. Plast Reconstr Surg. 2006 ; 117: 30-36
10. Pfeiffer P, Jørgensen S, Kristiansen TB, Jørgensen A, Hölmich LR. Protective effect of topical antibiotics in breast augmentation. Plast Reconstr Surg. 2009 ; 124: 629-634
11. Ramirez OM, Heller MDL, Tebbetts JB. Dual plane breast augmentation: avoiding pectoralis major displacement. Plast Reconstr Surg. 2002 ; 110: 1198-1199
12. Wiener TC. Relationship of incision choice to capsular contracture. Aesthetic Plast Surg. 2008 ; 32: 303-306
13. Tebbetts JB. Achieving a predictable 24-hour return to normal activities after breast augmentation, part II: patient preparation, refined surgical techniques, and instrumentation. Plast Reconstr Surg. 2002 ; 109: 293-305
14. Tebbetts JB. Achieving a predictable 24-hour return to normal activities after breast augmentation, part I: refining practices by using motion and time study principles. Plast Reconstr Surg. 2002 ; 109: 273-290
15. Tebbetts JB. A system for breast implant selection based on patient tissue characteristics and implant-soft tissue dynamics. Plast Reconstr Surg. 2002 ; 109: 1396-1409
16. Tebbetts JB. Achieving a predictable 24-hour return to normal activities after breast augmentation: part II. Patient preparation, refined surgical techniques, and instrumentation. Plast Reconstr Surg. 2006 ; 118: 115S - 127S
17. Tebbetts JB, Adams WP. Five critical decisions in breast augmentation using five measurements in 5 minutes: the high five decision support process. Plast Reconstr Surg. 2006 ; 118: 35S - 45S
18. Jacoby J, Lille ST. The role of pocket dissection in breast implant contracture: a single surgeon's review. Plast Reconstr Surg. 2011 ; 127: 155e - 156e
19. Barnsley GP, Sigurdson LF, Barnsley SE. Textured surface breast implants in the prevention of capsular contracture among breast augmentation patients: a meta-analysis of randomized controlled trials. Plast Reconstr Surg. 2006 ; 117: 2182-2190
20. Baker J Symposium on Aesthetic Surgery of the Breast: Proceedings of the Symposium of the Educational Foundation of the American Society of Plastic and Reconstructive Surgeons, and the American Society for Aesthetic Plastic Surgery, in Scottsdale, AZ, November 23-26, 1975. Owsley JW, ed. St Louis, MO: Mosby ; 256-263.
21. Tebbetts JB. Diagnosis and management of seroma following breast augmentation: an update. Plast Reconstr Surg. 2011 ; 128: 17-25
22. Araco A, Caruso R, Araco F, Overton J, Gravante G. Capsular contractures: a systematic review. Plast Reconstr Surg. 2009 ; 124: 1808-1819
23. Pajkos A, Deva AK, Vickery K, Cope C, Chang L, Cossart YE. Detection of subclinical infection in significant breast implant capsules. Plast Reconstr Surg. 2003 ; 111: 1605-1611
24. Handel N, Cordray T, Gutierrez J, Jensen JA. A long-term study of outcomes, complications, and patient satisfaction with breast implants. Plast Reconstr Surg. 2006 ; 117: 757-767
25. Tamboto H, Vickery K, Deva AK. Subclinical (biofilm) infection causes capsular contracture in a porcine model following augmentation mammaplasty. Plast Reconstr Surg. 2010 ; 126: 835-842
26. Hölmich LR, Vejborg IM, Conrad C, et al. Untreated silicone breast implant rupture. Plast Reconstr Surg. 2004 ; 114: 204-214
27. Chandler PJ. Talc and capsular contracture. Ann Plast Surg. 2004 ; 52: 288-292
28. Pajkos A, Deva AK, Vickery K, Cope C, Chang L, Cossart YE. Detection of subclinical infection in significant breast implant capsules. Plast Reconstr Surg. 2003 ; 111: 1605-1611
29. Del Pozo JL, Tran NV, Petty PM, et al. Pilot study of association of bacteria on breast implants with capsular contracture. J Clin Microbiol. 2009 ; 47: 1333-1337
30. Ahn CY, Ko CY, Wagar EA, Wong RS, Shaw WW. Microbial evaluation: 139 implants removed from symptomatic patients. Plast Reconstr Surg. 1996 ; 98: 1225-1229
31. Burkhardt BR, Fried M, Schnur PL, Tofield JJ. Capsules, infection, and intraluminal antibiotics. Plast Reconstr Surg. 1981 ; 68: 43-49
32. Bartsich S, Ascherman JA, Whittier S, Yao CA, Rohde C. The breast: a clean-contaminated surgical site. Aesthetic Surg J. 2011 ; 31: 802-806
33. Wixtrom RN, Stutman RL, Burke RM, Mahoney AK, Codner MA. Risk of breast implant bacterial contamination from endogenous breast flora, prevention with nipple shields, and implications for biofilm formation. Aesthetic Surg J. 2012 ; 32: 956-963
34. Ruiz-Tovar J, Santos J, Arroyo A, et al. Effect of peritoneal lavage with clindamycin-gentamicin solution on infections after elective colorectal cancer surgery. J Am Coll Surg. 2012 ; 214: 202-207
35. Dirschl DR, Wilson FC. Topical antibiotic irrigation in the prophylaxis of operative wound infections in orthopedic surgery. Orthop Clin North Am. 1991 ; 22: 419-426
36. Nelson KJ, Gallup DG, Gibbs R, Paulk W. Intraoperative antibiotic irrigation as prophylaxis in abdominal hysterectomy: a preliminary report. South Med J. 1984 ; 77: 700-702
37. Adams WP, Conner WC, Barton FE, Rohrich RJ. Optimizing breast pocket irrigation: an in vitro study and clinical implications. Plast Reconstr Surg. 2000 ; 105: 334-338
38. Adams WP, Conner WC, Barton FE, Rohrich RJ. Optimizing breast-pocket irrigation: the post-Betadine era. Plast Reconstr Surg. 2001 ; 107: 1596-1601
39. Rohrich RJ, Kenkel JM, Adams WP. Preventing capsular contracture in breast augmentation: in search of the Holy Grail. Plast Reconstr Surg. 1999 ; 103: 1759-1760
40. Fanous N, Salem I, Tawile C, Bassas A. Absence of capsular contracture in 319 consecutive augmentation mammaplasties: Dependant drains as a possible factor. Can J Plast Surg. 2004 ; 12: 193-197
41. Jacombs A, Allan J, Hu H, Valente PM, Wessels WL, Deva AK, Vickery K. Prevention of biofilm-induced capsular contracture with antibiotic-impregnated mesh in a porcine model. Aesthetic Surg J. 2012 ; 32: 886-891
42. Khan UD. Breast augmentation, antibiotic prophylaxis, and infection: comparative analysis of 1,628 primary augmentation mammoplasties assessing the role and efficacy of antibiotics prophylaxis duration. Aesthetic Plast Surg. 2010 ; 34: 42-47
43. Mirzabeigi MN, Mericli AF, Ortlip T, et al. Evaluating the role of postoperative prophylactic antibiotics in primary and secondary breast augmentation: a retrospective review. Aesthetic Surg J. 2012 ; 32: 61-68
44. Marques M, Brown SA, Oliveira I, et al. Long-term follow-up of breast capsule contracture rates in cosmetic and reconstructive cases. Plast Reconstr Surg. 2010 ; 126: 769-778
45. Brandon HJ, Young VL, Jerina KL, Wolf CJ, Adams WP, Watson ME. Mechanical analysis of explanted saline-filled breast implants exposed to Betadine pocket irrigation. Aesthetic Surg J. 2002 ; 22: 438-445
46. Zambacos GJ, Nguyen D, Morris RJ. Effect of povidone iodine on silicone gel breast implants in vitro: implications for clinical practice. Plast Reconstr Surg. 2004 ; 114: 706-710
47. Balin AK, Pratt L. Dilute povidone-iodine solutions inhibit human skin fibroblast growth. Dermatol Surg. 2002 ; 28: 210-214
48. Sammartino G, Tia M, Tete S, Perillo L, Trosino O. Adverse reaction to irrigation with povidone-iodine after deep-impacted, lower third molar extraction. J Biol Regul Homeost Agents. 2012 ; 26: 145-149