Psychopharmacological medication use among older adults with dementia in nursing homes

Journal of Gerontological Nursing

Volumn 39, Issue 4, 2013, Pages 8-14

  Brandt, Nicole J ^a   Pyhtila, Jessica ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROLEPTIC AGENT;

AGED; ARTICLE; DEMENTIA; GOVERNMENT; HUMAN; NURSING HOME; UNITED STATES;

AGED; ANTIPSYCHOTIC AGENTS; CENTERS FOR MEDICARE AND MEDICAID SERVICES (U.S.); DEMENTIA; HUMANS; NURSING HOMES; UNITED STATES;

MLCS; MLOWN;

EID: 84879700379     PISSN: 00989134     EISSN: None     Source Type: Journal    
DOI: 10.3928/00989134-20130315-05     Document Type: Article

References (44)

1. Alexopoulos, G.S. (2005). Depression in the elderly. Lancet, 365, 1961-1970. doi:10.1016/ S0140-6736(05)66665-2
2. Alzheimer's Association. (2012). Alzheimer's facts and figures. Retrieved from http:// www.alz.org/alzheimers_disease_facts_ and_figures.asp
3. American Geriatrics Society, & American Association for Geriatric Psychiatry. (2003). Consensus statement on improving the quality of mental health care in U.S. nursing homes: Management of depression and behavioral symptoms associated with dementia. Journal of the American Geriatrics Society, 51, 1287-1298.
4. Ballard, C.G., Waite, J., & Birks, J. (2008). Atypical antipsychotics for aggression and psychosis in Alzheimer's disease (Article CD003476). Cochrane Database of Systematic Reviews. doi:10.1002/14651858. CD003476.pub2
5. Briesacher, B.A., Limcangco, M.R., Simoni- Wastila, L., Doshi, J.A., Levens, S.R., Shea, D.G., & Stuart, B. (2005). The quality of antipsychotic drug prescribing in nursing homes. Archives of Internal Medicine, 165, 1280-1285. doi:10.1001/ archinte.165.11.1280
6. Centers for Medicare & Medicaid Services. (2012, March 28). Nursing home initiative on behavioral health & antipsychotic medication reduction [Video file]. Retrieved from http://www.youtube.com/watch?v=U1_rp O0bwbM&list=UUhHTRPxz8awulGaTM h3SAkA&index=3&feature=plcp
7. Cohen-Mansfield, J., & Jensen, B. (2008). Nursing home physicians' knowledge of and attitudes toward nonpharmacological interventions for treatment of behavioral disturbances associated with dementia. Journal of the American Medical Directors Association, 9, 491-498. doi:10.1016/j. jamda.2008.04.009
8. Cummings, J.L. (2004). Alzheimer's disease. New England Journal of Medicine, 351, 56- 67. doi:10.1056/NEJMra040223
9. Eguale, T., Buckeridge, D.L., Winslade, N.E., Benedetti, A., Hanley, J.A., & Tamblyn, R. (2012). Drug, patient, and physician characteristics associated with off-label prescribing in primary care. Archives of Internal Medicine, 172, 781-788. doi:10.1001/ archinternmed.2012.340.
10. Erkinjuntti, T., Kurz, A., Gauthier, S., Bullock, R., Lilienfeld, S., & Damaraju, C.V. (2002). Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: A randomized trial. Lancet, 359, 1283-1290.
11. Feldman, H., Gauthier, S., Hecker, J., Vellas, B., Subbiah, P., & Whalen, E. (2001). A 24- week, randomized, doubleblind study of donepezil in moderate to severe Alzheimer's disease. Neurology, 57, 613-620.
12. Glick, I.D., Murray, S.R., Vasudevan, P., Marder, S.R., & Hu, R.J. (2001). Treatment with atypical antipsychotics: New indications and new populations. Journal of Psychiatric Research, 35, 187-191.
13. Hanlon, J.T., Handler, S.M., & Castle, N.G. (2010). Antidepressant prescribing in US nursing homes between 1996 and 2006 and its relationship to staffing patterns and use of other psychotropic medications. Journal of the American Medical Directors Association, 11, 320-324. doi:10.1016/j.jamda. 2010.01.007
14. Harms, S.L., Eberly, L.E., Garrard, J.M., Hardie, N.A., Bland, P.C., & Leppik, I.E. (2005). Prevalence of appropriate and problematic antiepileptic combination therapy in older people in the nursing home. Journal of the American Geriatrics Society, 53, 1023-1028.
15. Huber, M., Kolzsch, M., Rapp, M.A., Wulff, I., Kalinowski, S., Bolbrinker, J., Kreutz, R. (2012). Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia. Pharmacopsychiatry, 45, 182-188. doi:10.1055/s-0031-1301285
16. Khan, F., & Curtice, M. (2011). Non-pharmacological management of behavioural symptoms of dementia. British Journal of Community Nursing, 16, 441-449.
17. Kverno, K.S., Black, B.S., Nolan, M.T., & Rabins, P.V. (2009). Research on treating neuropsychiatric symptoms of advanced dementia with non-pharmacological strategies, 1998-2008: A systematic literature review. International Psychogeriatrics, 21, 825-843. doi:10.1017/S1041610209990196
18. Majic, T., Pluta, J.P., Mell, T., Treusch, Y., Gutzmann, H., & Rapp, M.A. (2012). Correlates of agitation and depression in nursing home residents with dementia. International Psychogeriatrics, 24, 1779-1789. doi:10.1017/S104161021200066X
19. McKeith, I., Del Ser, T., Spano, P., Emre, M., Wesnes, K., Anand, R., Spiegel, R. (2000). Efficacy of rivastigmine in dementia with Lewy bodies: A randomized, double blind, placebo-controlled international study. Lancet, 356, 2031-2036.
20. Monette, J., Alessa, W., McCusker, J., Cole, M., Voyer, P., Champoux, N., Belzile, E. (2012). Association of resident and room characteristics with antipsychotic use in long-term care facilities (LTCF). Archives of Gerontology and Geriatrics, 55, 66-69. doi:10.1016/j.archger.2011.06.011
21. Office of Inspector General. (2011). Medicare atypical antipsychotic drug claims for elderly nursing home residents (Report No. OEI-07-08-00150). Retrieved from https:// oig.hhs.gov/oei/reports/oei-07-08-00150. pdf
22. The Patient Protection and Affordable Care Act, Pub. L. No. 111-148, 124 Stat. 148 (2010).
23. Paton, C. (2002). Benzodiazepines and disinhibition: A review. The Psychiatrist, 26, 460- 462. doi:10.1192/pb.26.12.460
24. Pollock, B.G., Mulsant, B.H., Rosen, J., Mazumdar, S., Blackesly, L.E., Houck, P.R., & Huber, K.A. (2007). A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. American Journal of Geriatric Psychiatry, 15, 942-952.
25. Pollock, B.G., Mulsant, B.H., Rosen, J., Sweet, R.A., Mazumdar, S., Bharucha, A., Chew, M.L. (2002). Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavior disturbances in hospitalized, demented patients. American Journal of Psychiatry, 159, 460- 465.
26. Pomara, N., Facelle, T.M., Roth, A.E., Willoughby, L.M., Greenblatt, D.J., & Sidtis, J.J. (2006). Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration. Psychopharmacology, 185, 487-494.
27. Porsteinsson, A.P. (2006) Divalproex sodium for the treatment of behavioural problems associated with dementia in the elderly. Drugs and Aging, 23, 877-886.
28. Ray, W.A., Chung, C.P., Murray, K.T., Hall, K., & Stein, C.M. (2009). Atypical antipsychotic drugs and the risk of sudden cardiac death. New England Journal of Medicine, 360, 225-235. doi:10.1056/NEJMoa0806994
29. Rochon, P.A., Normand, S.L., Gomes, T., Gill, S.S., Anderson, G.M., Melo, M., Gurwitz, J.H. (2008). Antipsychotic therapy and short-term serious events in older adults with dementia. Archives of Internal Medicine, 168, 1090-1096. doi:10.1001/ archinte.168.10.1090
30. Runci, S.J., Eppingstall, B.J., & O'Connor, D.W. (2012). A comparison of verbal communication and psychiatric medication use by Greek and Italian residents with dementia in Australian ethno-specific and mainstream aged care facilities. International Psychogeriatrics, 24, 733-741. doi:10.1017/ S1041610211002134
31. Schneider, L.S., Dagerman, K., & Insel, P.S. (2006). Efficacy and adverse effects of atypical antipsychotics for dementia: Metaanalysis of randomized, placebo-controlled trials. American Journal of Geriatric Psychiatry, 14, 191-210.
32. Schneider, L.S., Tariot, P.N., Dagerman, K.S., Davis, S.M., Hsiao, J.K., Ismail, M.S., Lieberman, J.A. (2006). Effectiveness of atypical antipsychotic drugs in residents with Alzheimer's disease. New England Journal of Medicine, 355, 1525-1538.
33. Sørensen, L., Foldspang, A., Gulmann, N.C., & Munk-Jørgensen, P. (2001). Determinants for the use of psychotropics among nursing home residents. International Journal of Geriatric Psychiatry, 16, 147-154.
34. Steis, M.R., Evans, L., Hirschman, K.B., Hanlon, A., Fick, D.M., Flanagan, N., & Inouye, S.K. (2012). Screening for delirium using family caregivers: Convergent validity of the Family Confusion Assessment Method and interviewer-rated Confusion Assessment Method. Journal of the American Geriatrics Society, 60, 2121-2126. doi:10.1111/j.1532- 5415.2012.04200.x
35. Sterke, C.S., van Beeck, E.F., van der Velde, N., Ziere, G., Petrovic, M., Looman, C.W., & van der Cammen, T.J. (2012). New insights: Dose-response relationship between psychotropic drugs and falls: A study in nursing home residents with dementia. Journal of Clinical Pharmacology, 52, 947-955. doi:10.1177/0091270011405665
36. Stevenson, D.G., Decker, S.L., Dwyer, L.L., Huskamp, H.A., Grabowski, D.C., Metzger, E.D., & Mitchell, S.L. (2010). Antipsychotic and benzodiazepine use among nursing home residents: Findings from the 2004 National Nursing Home Survey. American Journal of Geriatric Psychiatry, 18, 1078-1092. doi:10.1097/ JGP.0b013e3181d6c0c6
37. Sunderland, T., Weingartner, H., Cohen, R.M., Tariot, P.N., Newhouse, P.A., Thompson, K.E.,Mueller, E.A. (1989). Low-dose oral lorazepam administration in Alzheimer subjects and age-matched controls. Psychopharmacology, 99, 129-133.
38. Tariot, P.N., Erb, R., Podgorski, C.A., Cox, C., Patel, S., Jakimovich, L., & Irvine, C. (1998). Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. American Journal of Psychiatry, 155, 54-61.
39. Tariot, P.N., Farlow, M.R., Grossberg, G.T., Graham, S.M., McDonald, S., & Gergel, I. (2004). Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. Journal of the American Medical Association, 291, 317-324.
40. Tariot, P.N., Schneider, L.S., Mintzer, J., Cutler, A.J., Cunningham, M.R., Thomas, J.W., & Sommerville, K.W. (2001). Safety and tolerability of divalproex sodium in the treatment of signs and symptoms of mania in elderly patients with dementia: Results of a double-blind, placebo controlled trial. Current Therapeutic Research, 62, 51-67. doi:10.1016/S0011-393X(01)80042-4
41. Teri, L., Logsdon, R.G., Peskind, E., Raskind, M., Weiner, M.F., Tractenberg, R.E.,Thal, L.J. (2000). Treatment of agitation in AD: A randomized, placebo-controlled clinical trial. Neurology, 55, 1271-1278.
42. Uchida, H., Suzuki, T., Mamo, D.C., Mulsant, B.H., Kikuchi, T., Takeuchi, H.,Kashima, H. (2009). Benzodiazepine and antidepressant use in elderly patients with anxiety disorders: A survey of 796 outpatients in Japan. Journal of Anxiety Disorders, 23, 477-481. doi:10.1016/j.janxdis.2008.10.003
43. Wetzels, R.B., Zuidema, S.U., de Jonghe, J.F., Verhey, F.R., & Koopmans, R.T. (2011). Prescribing pattern of psychotropic drugs in nursing home residents with dementia. International Psychogeriatrics, 23, 1249-1259. doi:10.1017/S1041610211000755
44. Work Group on Alzheimer's Disease and Other Dementias. (2007). American Psychiatric Association practice guideline for the treatment of patients with Alzheimer's disease and other dementias, second edition. American Journal of Psychiatry, 164(12 Suppl.), 5-56. doi:10.1176/appi. books.9780890423967.152139.