Prevalence of appropriate and problematic antiepileptic combination therapy in older people in the nursing home

Journal of the American Geriatrics Society

Volumn 53, Issue 6, 2005, Pages 1023-1028

  Harms, Susan L ^a,b   Eberly, Lynn E ^b   Garrard, Judith M ^a   Hardie, Nancy A ^c,d   Bland, Pat C ^a   Leppik, Ilo E ^a,e  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NONE   (United States)

Author keywords

Anticonvulsants; Epilepsy; Geriatrics; Nursing homes

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; GABAPENTIN; LAMOTRIGINE; MESUXIMIDE; PHENOBARBITAL; PHENSUXIMIDE; PHENYTOIN; TIAGABINE; TOPIRAMATE; VALPROIC ACID;

AGED; ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; EPILEPSY; FEMALE; GERIATRIC CARE; HEALTH STATUS; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NURSING HOME; PHYSICIAN; PREVALENCE; SEIZURE; AGE DISTRIBUTION; ALZHEIMER DISEASE; CEREBROVASCULAR ACCIDENT; CROSS-SECTIONAL STUDY; DRUG COMBINATION; DRUG UTILIZATION; MULTIVARIATE ANALYSIS; PATHOLOGIC FRACTURE; PHARMACOEPIDEMIOLOGY; POLYPHARMACY; RETROSPECTIVE STUDY; STATISTICAL MODEL; STATISTICS; UNITED STATES;

AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; ANTICONVULSANTS; CEREBROVASCULAR ACCIDENT; CROSS-SECTIONAL STUDIES; DRUG THERAPY, COMBINATION; DRUG UTILIZATION; EPILEPSY; FEMALE; FRACTURES, SPONTANEOUS; HUMANS; LOGISTIC MODELS; MALE; MINNESOTA; MULTIVARIATE ANALYSIS; NURSING HOMES; PHARMACOEPIDEMIOLOGY; POLYPHARMACY; PREVALENCE; RETROSPECTIVE STUDIES;

EID: 23444443221     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2005.53323.x     Document Type: Article

References (30)

1. Garrard J, Cloyd J, Gross C et al. Factors associated with antiepileptic drug use among elderly nursing home residents. J Gerontol A Biol Sci Med Sci 2000;55A:M384-M392.
2. Garrard J, Harms S, Hardie N et al. Antiepileptic drug use in nursing home admissions. Ann Neurol 2003;54:75-85.
3. Rochat P, Hallas J, Gaist D et al. Antiepileptic drug utilization: A Danish prescription database analysis. Acta Neurol Scand 2001;104:6-11.
4. MICROMEDEX Healthcare Series, 2004. Greenwood Village, CO: Thomson MICROMEDEX, 2004.
5. Leppik IE. Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Ed. Newton, PA: Handbooks in Healthcare, 2000.
6. Carbonin P, Pahor M, Bernabei R et al. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients? J Am Geriatr Soc 1991;39:1093-1099.
7. Gerety MB, Cornell JE, Plichta DT et al. Adverse events related to drugs and drug withdrawal in nursing home residents. J Am Geriatr Soc 1993;41:1326-1332.
8. Grymonpre RE, Mitenko PA, Sitar DS et al. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988;36:1092-1098.
9. Faught E. Epidemiology and drug treatment of epilepsy in elderly people. Drugs Aging 1999;15:255-269.
10. Eisenschenk S, Gilmore R. Strategies for successful management of older patients with seizures. Geriatrics 1999;54:31,34,39-40, passim.
11. Cameron H, Macphee GJ. Anticonvulsant therapy in the elderly-a need for placebo controlled trials. Epilepsy Res 1995;21:149-157.
12. Guberman A. Monotherapy or polytherapy for epilepsy? Can J Neurol Sci 1998;25:S3-S8.
13. Aguwa CN, Yaqub B, Murungi J et al. Pharmacotherapeutic trends in epilepsy. Curr Ther Res 1990;47:990-996.
14. Shorvon SD, Reynolds EH. Reduction in polypharmacy for epilepsy. BMJ 1979;2:1023-1025.
15. Theodore WH, Porter RJ. Removal of sedative-hypnotic antiepileptic drugs from the regimens of patients with intractable epilepsy. Ann Neurol 1983;13:320-324.
16. Leppik IE. Monotherapy and polypharmacy. Neurology 2000;55:S25-S29.
17. Pugh MJ, Cramer J, Knoefel J et al. Potentially inappropriate antiepileptic drugs for elderly patients with epilepsy. J Am Geriatr Soc 2004;52:417-422.
18. Casten R, Lawton MP, Parmelee PA et al. Psychometric characteristics of the Minimum Data Set I. Confirmatory factor analysis. J Am Geriatr Soc 1998;46:726-735.
19. Lawton MP, Casten R, Parmelee PA et al. Psychometric characteristics of the Minimum Data Set II. Validity. J Am Geriatr Soc 1998;46:736-744.
20. Gruber-Baldini AL, Zimmerman SI, Mortimore E et al. The validity of the Minimum Data Set in measuring the cognitive impairment of persons admitted to nursing homes. J Am Geriatr Soc 2000;48:1601-1606.
21. Morris JN, Fries BE, Morris SA. Scaling ADLs within the MDS. J Gerontol A Biol Sci Med Sci 1999;54A:M546-M553.
22. Patsalos PN, Froscher W, Pisani F et al. The importance of drug interactions in epilepsy therapy. Epilepsia 2002;43:365-385.
23. Sabers A, Gram L. Drug treatment of epilepsy in the 1990s. Achievements and new developments. Drugs 1996;52:483-493.
24. Leppik IE, Sherwin AL. Anticonvulsant activity of phenobarbital and phenytoin in combination. J Pharmacol Exp Ther 1977;200:570-575.
25. Weaver LC, Swinyard EA, Woodbury LA et al. Studies on anticonvulsant drug combinations: Phenobarbital and diphenylhydantoin. J Pharmacol Exp Ther 1955;113:359-370.
26. Cohen B, Showstack N, Myerson A. The synergism of phenobarbital, Dilantin sodium, and other drugs. JAMA 1940;114:480-484.
27. Mattson RH, Cramer JA, Collins JF et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985;313:145-151.
28. Smith DB, Mattson RH, Cramer JA et al. Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. Epilepsia 1987;28(Suppl. 3):S50-S58.
29. Karceski S, Morell M, Carpenter D. The expert consensus guideline series. Treatment of epilepsy. Epilepsy Behav 2001;2:A1-A50.
30. Scheuer ML, Cohen J. Seizures and epilepsy in the elderly. Neurol Clin 1993;11:787-804.