Ectodysplasin/NF-κB signaling in embryonic mammary gland development

Journal of Mammary Gland Biology and Neoplasia

Volumn 18, Issue 2, 2013, Pages 165-169

  Lindfors, Päivi H ^a   Voutilainen, Maria ^a   Mikkola, Marja L ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Branching; Breast; Duct; Ectodermal dysplasia; HED; Placode

Indexed keywords

ECTODYSPLASIN A; ECTODYSPLASIN RECEPTOR; EDAR ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

BRANCHING MORPHOGENESIS; BREAST DUCT; ECTODERM; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HYPOHIDROTIC ECTODERMAL DYSPLASIA; MAMMARY GLAND; MORPHOGENESIS; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ECTODYSPLASINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84879694644     PISSN: 10833021     EISSN: 15737039     Source Type: Journal    
DOI: 10.1007/s10911-013-9277-5     Document Type: Review

References (34)

1. Mikkola ML. TNF superfamily in skin appendage development. Cytokine Growth Factor Rev. 2008;19(3-4):219-30.
2. Mikkola ML. Molecular aspects of hypohidrotic ectodermal dysplasia. Am J Med Genet A. 2009;149A(9):2031-6.
3. Clarke A, Phillips DI, Brown R, Harper PS. Clinical aspects of X-linked hypohidrotic ectodermal dysplasia. Arch Dis Child. 1987;62(10):989-96.
4. Naito A, Yoshida H, Nishioka E, Satoh M, Azuma S, Yamamoto T, et al. TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A. 2002;99(13):8766-71.
5. Morlon A, Munnich A, Smahi A. TAB2, TRAF6 and TAK1 are involved in NF-κB activation induced by the TNF-receptor, Edar and its adaptator Edaradd. Hum Mol Genet. 2005;14(23):3751-7.
6. Perkins ND. Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol. 2007;8(1):49-62.
7. Schmidt-Ullrich R, Aebischer T, Hülsken J, Birchmeier W, Klemm U, Scheidereit C. Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices. Development. 2001;128(19):3843-53.
8. Pispa J, Mikkola ML, Mustonen T, Thesleff I. Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr Patterns. 2003;3(5):675-9.
9. Häärä O, Fujimori S, Schmidt-Ullrich R, Hartmann C, Thesleff I, Mikkola ML. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development. 2011;138(13):2681-91.
10. Voutilainen M, Lindfors PH, Lefebvre S, Ahtiainen L, Fliniaux I, Rysti E, et al. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB. Proc Natl Acad Sci USA. 2012;109(15):5744-9.
11. Dickson KM, Bhakar AL, Barker PA. TRAF6-dependent NF-κB transcriptional activity during mouse development. Dev Dyn. 2004;231(1):122-7.
12. Pispa J, Pummila M, Barker PA, Thesleff I, Mikkola ML. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet. 2008;17(21):3380-91.
13. Mustonen T, Pispa J, Mikkola ML, Pummila M, Kangas AT, Pakkasjärvi L, et al. Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev Biol. 2003;259(1):123-36.
14. Mustonen T, Ilmonen M, Pummila M, Kangas AT, Laurikkala J, Jaatinen R, et al. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development. 2004;131(20):4907-19.
15. Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, et al. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004;131(19):4819- 29.
16. Ahn Y, Sims C, Logue JM, Weatherbee SD, Krumlauf R. Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013;140(3):583-93.
17. Panchal H, Wansbury O, Parry S, Ashworth A, Howard B. Neuregulin3 alters cell fate in the epidermis and mammary gland. BMC Dev Biol. 2007;7:105.
18. Howard B, Panchal H, McCarthy A, Ashworth A. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005;19(17):2078-90.
19. Demicco EG, Kavanagh KT, Romieu-Mourez R, Wang X, Shin SR, Landesman-Bollag E, et al. RelB/p52 NF-κB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IκB-alpha expression and promote carcinogenesis of the mammary gland. Mol Cell Biol. 2005;25(22):10136-47.
20. Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, et al. Nuclear factor-κB (NF-κB) regulates proliferation and branching in mouse mammary epithelium. Mol Biol Cell. 2001;12(5):1445-55.
21. Chang SH, Jobling S, Brennan K, Headon DJ. Enhanced Edar signalling has pleiotropic effects on craniofacial and cutaneous glands. PLoS One. 2009;4(10):e7591.
22. Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T. A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene. BMC Genet. 2011;12:91.
23. Kamberov YG, Wang S, Tan J, Gerbault P, Wark A, Tan L, et al. Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell. 2013;152(4):691-702.
24. Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol. 2010;2(6):a003251.
25. Kratochwil K. Development and loss of androgen responsiveness in the embryonic rudiment of the mouse mammary gland. Dev Biol. 1977;61(2):358-65.
26. Tsukamoto AS, Grosschedl R, Guzman RC, Parslow T, Varmus HE. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell. 1988;55(4):619-25.
27. Lane TF, Leder P. Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene. 1997;15(18):2133-44.
28. Lefebvre S, Fliniaux I, Schneider P, Mikkola ML. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132(4):1094-102.
29. Boras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis. 2008;4(2):116-22.
30. Häärä O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux I, Åberg T, et al. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling. Development. 2012;139(17):3189-99.
31. Huh SH, Närhi K, Lindfors PH, Häärä O, Yang L, Ornitz DM, et al. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013;27(4):450-8.
32. Mégarbané H, Cluzeau C, Bodemer C, Fraïtag S, Chababi-Atallah M, Mégarbané A, et al. Unusual presentation of a severe autosomal recessive anhydrotic ectodermal dysplasia with a novel mutation in the EDAR gene. Am J Med Genet A. 2008;146A(20):2657-62.
33. Haghighi A, Nikuei P, Haghighi-Kakhki H, Saleh-Gohari NH, Baghestani S, Krawitz PM, et al. Identification of a novel missense mutation in EDAR causing autosomal recessive hypohidrotic ectodermal dysplasia with bilateral amastia and palmoplantar hyperkeratosis. Br J Dermatol. 2012. doi: 10.1111/bjd.12151.
34. Berlin AL, Paller AS, Chan LS. Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology. J Am Acad Dermatol. 2002;47(2):169-87.