Identification of potent Yes1 kinase inhibitors using a library screening approach

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4398-4403

  Patel, Paresma R ^a,b   Sun, Hongmao ^c   Li, Samuel Q ^d   Shen, Min ^c   Khan, Javed ^d   Thomas, Craig J ^c   Davis, Mindy I ^c  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

HTS; Inhibitor; Kinase; Rhabdomyosarcoma; Screening; Small molecule; Yes1

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AMG TIE 2 1; ANTINEOPLASTIC AGENT; AZ 23; AZ 628; DASATINIB; DOVITINIB; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; REBASTINIB; SARACATINIB; SGI 1776; UNCLASSIFIED DRUG; YES1 KINASE; YES1 KINASE INHIBITOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BREAST METASTASIS; CANCER CELL CULTURE; CELL ASSAY; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; DRUG SCREENING; DRUG STRUCTURE; HIGH THROUGHPUT SCREEN; HUMAN; IC 50; MOLECULAR LIBRARY; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); RHABDOMYOSARCOMA;

BINDING SITES; CELL LINE; CELL SURVIVAL; DRUG DESIGN; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-YES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879693612     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.072     Document Type: Article

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