Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4419-4423

  Waszkielewicz, A M ^a   Gunia, A ^a   Szkaradek, N ^a   Pytka, K ^a   Siwek, A ^a   Satala G ^b   Bojarski, A J ^b   Szneler, E ^c   Marona, H ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

1,4 Piperazine derivatives; 5 HT; Adrenergic receptors; Anticonvulsant activity; Epilepsy; MES; Serotoninergic receptors; Xanthone

Indexed keywords

3 METHOXY 5 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 9H XANTHEN 9 ONE; 6 METHOXY 5 [[4 (BENZYL)PIPERAZIN 1 YL]METHYL] 9H XANTHEN 9 ONE; ALPHA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; PIPERAZINE; SEROTONIN 1A RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7B RECEPTOR; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MOUSE; NONHUMAN; SEIZURE;

ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; HALF-LIFE; KINETICS; PIPERAZINES; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, SEROTONIN; SEIZURES; XANTHONES;

RATTUS;

EID: 84879689703     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.062     Document Type: Article

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