Dihydroxyxanthones prenylated derivatives: Synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 18, 2007, Pages 6080-6088

  Castanheiro, Raquel A P ^a   Pinto, Madalena M M ^a   Silva, Artur M S ^b   Cravo, Sara M M ^a   Gales, Luís ^a,c   Damas, Ana M ^a,c   Nazareth, Naïr ^a   Nascimento, Maria S J ^a   Eaton, Graham ^d  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF AVEIRO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Antitumor activity; NMR spectroscopy; Prenylation; X ray crystallography; Xanthones

Indexed keywords

1 HYDROXY 2 METHYL 3 (3 METHYLBUT 2 ENYLOXY)XANTHONE; 1 HYDROXY 3 (3 METHYLBUT 2 ENYLOXY) 2 (1,1 DIMETHYLPROP 2 ENYL)XANTHONE; 1 HYDROXY 6',6' DIMETHYL 4',5' DLHYDROPYRANO[2',3':3,2]XANTHONE; PRENYL BROMIDE; PRENYLAMINE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ALKALINITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; OXIDATION; PRENYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; RING CLOSING METATHESIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; XANTHONES;

EID: 34447630284     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.037     Document Type: Article

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