SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells

Oncology Reports

Volumn 30, Issue 2, 2013, Pages 801-808

  Son, Mi Kwon ^a   Jung, Kyung Hee ^a   Lee, Hee Seung ^a   Lee, Hyunseung ^a   Kim, Soo Jung ^a   Yan, Hong Hua ^a   Ryu, Ye Lim ^a   Hong, Soon Sun ^a  

^a Inha University School of Medicine   (South Korea)

Author keywords

Angiogenesis; Apoptosis; Pancreatic cancer; Pulsatilla saponin D; SB365

Indexed keywords

CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PLANT EXTRACT; PROTEIN BCL 2; PULSATILLA KOREANA EXTRACT; SAPONIN DERIVATIVE; SB 365; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PLANT ROOT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSATILLA; PULSATILLA KOREANA; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PLANT EXTRACTS; PLANT ROOTS; PROTO-ONCOGENE PROTEINS C-BCL-2; PULSATILLA; SAPONINS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84879677981     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2517     Document Type: Article

References (27)

1. Li D, Xie K, Wolff R and Abbruzzese JL: Pancreatic cancer. Lancet 363: 1049-1057, 2004. (Pubitemid 38410779)
2. Saif MW: Adjuvant therapy of pancreatic cancer: beyond gemcitabine. Highlights from the '2011 ASCO Gastrointestinal Cancers Symposium'. San Francisco, CA, USA. January 20-22, 2011. JOP 12: 106-109, 2011.
3. Theissen G, Pardon B and Wagner R: A quantitative assessment for transcriptional pausing of DNA-dependent RNA polymerases in vitro. Anal Biochem 189: 254-261, 1990. (Pubitemid 20312807)
4. Block G, Patterson B and Subar A: Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18: 1-29, 1992.
5. Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Runia S and Boyle P: Life-time history of smoking and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands. Int J Cancer 49: 816-822, 1991.
6. Cassileth BR: Alternative and complementary medicine. Separating the wheat from the chaff. Cancer 86: 1900-1902, 1999.
7. Bae K (ed). The Medicinal Plants of Korea. Kyu-Hak Press, Seoul, pp139, 1999.
8. Ye WC, Ou BX, Ji NN, Zhao SX, Ye T, McKervey MA and Stevenson P: Patensin, a saponin from Pulsatilla patens var. multifida. Phytochemistry 39: 937-939, 1995.
9. Ye WC, Ji NN, Zhao SX, Liu JH, Ye T, McKervey MA and Stevenson P: Triterpenoids from Pulsatilla chinensis. Phytochemistry 42: 799-802, 1996. (Pubitemid 27096892)
10. Bang SC, Lee JH, Song GY, Kim DH, Yoon MY and Ahn BZ: Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem Pharm Bull 53: 1451-1454, 2005.
11. Kim Y, Bang SC, Lee JH and Ahn BZ: Pulsatilla saponin D: the antitumor principle from Pulsatilla koreana. Arch Pharm Res 27: 915-918, 2004. (Pubitemid 43073686)
12. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ and Wicha MS: In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270, 2003. (Pubitemid 36583168)
13. Smith M and Boon HS: Counseling cancer patients about herbal medicine. Patient Educ Couns 38: 109-120, 1999. (Pubitemid 29430204)
14. Li Y, Ahmed F, Ali S, Philip PA, Kucuk O and Sarkar FH: Inactivation of nuclear factor κB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res 65: 6934-6942, 2005. (Pubitemid 41060733)
15. Li F, Fernandez PP, Rajendran P, Hui KM and Sethi G: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett 292: 197-207, 2010.
16. Peng L, Zhou Y, Kong de Y and Zhang WD: Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother Res 24: 864-868, 2010.
17. Tin MM, Cho CH, Chan K, James AE and Ko JK: Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis 28: 1347-1355, 2007. (Pubitemid 47062696)
18. Chen PS, Shih YW, Huang HC and Cheng HW: Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS One 6: e20164, 2011.
19. Petronilli V, Penzo D, Scorrano L, Bernardi P and Di Lisa F: The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276: 12030-12034, 2001.
20. Armstrong JS: Mitochondria: a target for cancer therapy. Br J Pharmacol 147: 239-248, 2006.
21. Folkman J: Angiogenesis. Annu Rev Med 57: 1-18, 2006.
22. Xia C, Meng Q, Cao Z, Shi X and Jiang BH: Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. J Cell Physiol 209: 56-66, 2006. (Pubitemid 44318667)
23. Jiang BH, Rue E, Wang GL, Roe R and Semenza GL: Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996. (Pubitemid 26250751)
24. Hong SW, Jung KH, Lee HS, Choi MJ, Son MK, Zheng HM and Hong SS: SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway. Cancer Sci 103: 1929-1937, 2012.
25. Indraccolo S, Stievano L, Minuzzo S, Tosello V, Esposito G, Piovan E, Zamarchi R, Chieco-Bianchi L and Amadori A: Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment. Proc Natl Acad Sci USA 103: 4216-4221, 2006.
26. Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT and De Bruijn EA: Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 56: 549-580, 2004. (Pubitemid 39658463)
27. Alitalo A and Detmar M: Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene 31: 4499-4508, 2012.