The development, physicochemical characterisation and in vitro drug release studies of pectinate gel beads containing thai mango seed kernel extract

Molecules

Volumn 18, Issue 6, 2013, Pages 6504-6520

  Nithitanakool, Saruth ^a   Pithayanukul, Pimolpan ^a   Bourgeois, Sandrine ^b   Fessi, Hatem ^b   Bavovada, Rapepol ^c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITÉ LYON 1   (France)

^c CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Calcium pectinate gel beads; Colon targeted delivery; Enteric coated capsule; Ionotropic gelation; Mango seed kernel; Zinc pectinate gel beads

Indexed keywords

CALCIUM; DRUG CARRIER; GEL; MICROCAPSULE; MICROSPHERE; PLANT EXTRACT; ZINC;

CHEMISTRY; DRUG DELIVERY SYSTEM; GEL; MANGIFERA; MICROCAPSULE; PARTICLE SIZE; PLANT SEED; ARTICLE;

CALCIUM; CAPSULES; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GELS; MANGIFERA; MICROSPHERES; PARTICLE SIZE; PLANT EXTRACTS; SEEDS; ZINC;

EID: 84879665086     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18066504     Document Type: Article

References (25)

1. Haslam, E. Natural polyphenols (vegetable tannins) as drugs: Possible modes of action. J. Nat. Prod. 1996, 59, 205-215.
2. Sharma, L.D.; Bahga, H.S.; Srivastava, P.S. In vitro anthelmintic screening of indigenous medicinal plants against Haemonchus contortus (Rudolphi, 1803) Cobbold, 1898 of sheep and goats. Indian J. Anim. Res. 1971, 5, 33-38.
3. Singh, Y.N. Traditional medicine in Fiji. Some herbal folk cures used by Fiji Indians. J. Ethnopharmacol. 1986, 15, 57-88.
4. Coe, F.G.; Anderson, G.J. Screening of medicinal plants used by the Garifuna of eastern Nicaragua for bioactive compounds. J. Ethnopharmacol. 1996, 53, 29-50.
5. John, D. One hundred useful raw drugs of the Kani Tribes of Trivandrum Forest Division, Kerala, India. Pharmaceut. Biol. 1984, 22, 17-39.
6. Das, P.C.; Das, A.; Mandal, S.; Islam, C.N.; Dutta, M.K.; Patra, B.B.; Sikdar, S.; Chakrabarthy, P.K., 1989. Antiinflammatory and antimicrobial activities of the seed kernel of Mangifera indica. Fitoterapia 1989, 60, 235-240.
7. Soong, Y.Y.; Barlow, P.J. Antioxidant activity and phenolic content of selected fruit seeds. Food Chem. 2004, 88, 411-417.
8. Nithitanakool, S.; Pithayanukul, P.; Bavovada, R. Antioxidant and hepatoprotective activities of Thai mango seed kernel extract. Planta Med. 2009, 75, 1118-1123.
9. Nithitanakool, S.; Pithayanukul, P.; Bavovada, R.; Saparpakorn, P. Molecular docking studies and anti-tyrosinase activity of Thai mango seed kernel extract. Molecules 2009, 14, 257-265.
10. Jiamboonsri, P.; Pithayanukul, P.; Bavovada, R.; Chomnawang, M.T. The inhibitory potential of Thai mango seed kernel extract against Methicillin-Resistant Staphylococcus Aureus. Molecules 2011, 16, 6255-6270.
11. Zhang, J.; Li, L.; Kim, S.H.; Hagerman, A.E.; Lü, J. Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose. Pharm. Res. 2009, 26, 2066-2080.
12. Sinha, V.R.; Kumria, R. Polysaccharides in colon-specific drug delivery. Int. J. Pharm. 2001, 224, 19-38.
13. Mathiowitz, E. Oral drug delivery, small intestine and colon. In Encyclopedia of Controlled Drug Delivery 2, Mathiowitz, E., Ed.; John Wiley & Sons, Inc.: New Jersey, NJ, USA, 1999; pp. 717-728.
14. Cummings, J.H.; Southgate, D.A.T.; Branch, W.J.; Wiggins, H.S.; Houston, H.; Jenkins, D.J.A.; Jivraj, T.; Hill, M.J. The digestion of pectin in the human gut and its effect on calcium absorption and large bowel function. Br. J. Nutr. 1979, 41, 477-485.
15. Liu, L.; Fishman, M.L.; Kost, J.; Hicks, K.B. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003, 24, 3333-3343.
16. Aydin, Z.; Akbuǧa, J. Preparation and evaluation of pectin beads. Int. J. Pharm. 1996 137, 133-136.
17. Bourgeois, S.; Gernet, M.; Pradeau, D.; Andremont, A.; Fattal, E. Evaluation of critical formulation parameters influencing the bioactivity of β-lactamases entrapped in pectin beads. Int. J. Pharm. 2006, 324, 2-9.
18. El-Gibaly, I. Oral delayed-release system based on Zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int. J. Pharm. 2002, 232, 199-211.
19. Atyabi, F.; Majzoob, S.; Iman, M.; Salehi, M.; Dorkoosh, F. In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon. Carbohydr. Polym. 2005, 61, 39-51.
20. Chambin, O.; Dupuis, G.; Champion, D.; Voilley, A.; Pourcelot, Y. Colon-specific drug delivery: Influence of solution reticulation properties upon pectin beads performance. Int. J. Pharm. 2006, 321, 86-93.
21. Bajpai, S.K.; Sharma, S. Investigation of swelling/degradation behavior of alginate beads crosslinked with Ca2+ and Ba2+ ions. React. Funct. Polym. 2004, 59, 129-140.
22. Sriamornsak, P.; Kennedy, R.A. Swelling and diffusion studies of calcium polysaccharide gels intended for film coating. Int. J. Pharm. 2008, 358, 205-213.
23. Dronnet, V.M.; Renard, C.M.G.C.; Axelos, M.A.V.; Thibault, J.-F. Characterisation and selectivity of divalent metal ions binding by citrus and sugar-beet pectins. Carbohydrate Polym. 1996, 30, 253-263.
24. Semdé, R.; Amighi, K.; Devleeschouwer, M.J.; Moës, A.J. Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate. Int. J. Pharm. 2000, 197, 169-179.
25. Wong T.W.; Nurjaya S. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave. Eur. J. Pharm. Biopharm. 2008, 69, 176-188.