In vitro assessment of Tinospora cordifolia stem for its antioxidant, free radical scavenging and DNA protective potentials

International Journal of Pharma and Bio Sciences

Volumn 4, Issue 1, 2013, Pages 373-388

  Ghate, Nikhil Baban ^a   Chaudhuri, Dipankar ^a   Mandal, Nripendranath ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Antioxidant; DNA protection; Radical scavenging; Tinospora cordifolia

Indexed keywords

ALKALOID; ASCORBIC ACID; CARBOHYDRATE; FLAVANOID; HYDROGEN PEROXIDE; IRON CHELATING AGENT; NITRIC OXIDE; PHENOL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TANNIN; TINOSPORA CORDIFOLIA EXTRACT;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; IC 50; IN VITRO STUDY; LIPID PEROXIDATION; PHYTOCHEMISTRY; PLANT STEM;

TINOSPORA CORDIFOLIA;

EID: 84879651177     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Aruoma OI, Halliwell B, Hoey BM, Butter J, The antioxidant action of Nacetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Bio Med, 6 (6): 593-597, (1989)
2. Halliwell B, Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med, 91 (3): S14-S22, (1991)
3. Henle ES; Linn S, Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J Biol Chem, 272 (31): 19095-19098, (1997)
4. Marnett LJ, Oxyradicals and DNA damage. Carcinogenesis, 21 (3): 361-370, (2000)
5. Retsky KL, Freeman MW, Frei B, Ascorbic acid oxidation product(s) protect human low-density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem, 268 (2): 1304-1309, (1993)
6. Braca A, Sortino C, Politi M, Morelli I, Mendez J, Antioxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol, 79 (3): 379-381, (2002)
7. Ashokkumar D, Mazumder UK, Gupta M, Senthilkumar GP, Selvan VT, Evaluation of antioxidant and free radical scavenging activities of Oxystelma esculentum in various in vitro models. J Complement Integr Med, 5 (1): Article 9, (2008)
8. Packer L, Ong ASH, Biological oxidants and antioxidants: Molecular mechanisms and health effects. Champaign: AOCS Press, (1998)
9. Hill AF. Economic Botany. A textbook of useful plants and plant products. 2nd edn. McGarw-Hill Book Company Inc, New York (1952)
10. Nadkami KM, Nadkami AK, Indian Meteria Medica, 3rd ed. Mumbai: M/S popular prakashan Pvt. Ltd. (1976)
11. Chopra RN, Nayar SL, Chopra IC, Glossary of Indian medicinal plants, New delhi: CSIR, (1956)
12. Kirtikar KR, Basu BD, Indian Medicinal Plants, Vol. 1. 2nd ed. New Connaught place. Dehradun: M/S Bishen singh, Mahendra pal singh, (1975)
13. Chopra RN, Chora LC, Handa KD, Kapur LD editors. Indigenous drugs of India. 2nd ed. Kolkata. M/S Dhar VN & sons, (1982)
14. Nayampalli S, Ainapure SS, Nadkami PM, Study of antiallergic acid Bronchodilator effect of Tinospora cordifolia. Ind J Pharmacol, 14: 64-66, (1982)
15. Zhao TF, Wang X, Rimando AM, Che C, Folkloric medicinal plant: Tinospora sagittata var. cravaniana and Mohonia bealei. Planta Med, 57 (5): 505, (1991)
16. Prince PSM, Menon VP, Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother res, 17 (4): 410-413, (2003)
17. Sengupta M, Sharma GD, Chakraborty B, Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC Complement Altern Med, 11 (10): 102, (2011)
18. Bishayi B, Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCL4 intoxicated mature albino mice. J Toxicol Sci, 27 (3): 139-146, (2002)
19. Patel MB, Aldose reductase inhibitory activity and anti catraract potential of some traditionally acclaimed antidiabetic medicinal plants. Orient Pharm Exp Med, 9 (3): 245-251, (2009)
20. Patel MB, Mishra S, Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase. Phytother Res, (2012) (In press)
21. Harborne JB, Baxter H. Phytochemical dictionary: a handbook of bioactive compounds from plants. Taylor and Francis Ltd: 4 John St-London, (1995)
22. Kokate CK, Purohit AP, Gokhale SB Test book of Pharmacognosy, 7th Ed. Nirali Prakashan: 105 (2003)
23. Singleton VL, Rossi JA, Colorimetry of total phenolics with phosphomolybdicphosphotungstic acid reagents. Am J Enol Viticult, 16 (58): 144-158, (1965)
24. Zhishen J, Mengcheng T, Jianming W, The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Food Chem, 64 (4): 555-559, (1999)
25. Sadasivam S. "Biochemical Methods" In: A. Manickam, New Age International (P) Limited, New Delhi, 10-197, (1997)
26. Singh DK, Srivastava B, Sahu A, Spectroscopic determination of rauwolfia alkaloids: estimation of reserpine in pharmaceuticals. Anal Sci, 20 (3): 571-573, (2004)
27. Roe JH, Comparative Analysis for Ascorbic Acid by the 2,4-Dinitrophenylhydrazine Method with the Coupling Reaction at Different Temperatures: a Procedure for Determining Specificity. J Biol Chem, 236 (5): 1611-1613, (1961)
28. Robert EB, Method for estimation of tannin in grain sorghum. Agro J, 63: 511, (1971)
29. Hazra B, Biswas S, Mandal N, Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complement Altern Med, 8: 63, (2008)
30. Mahakunakorn P, Antioxidant and free radical scavenging activity of Choto-san and its related constituents. Biol Pharm Bull, 27 (1): 38-46, (2004)
31. Long LH, Evans PJ, Halliwell B, Hydrogen peroxide in human urine: implications for antioxidant defense and redox regulation. Biochem Biophys Res Commun;262 (3): 605-609 (1999)
32. Beckman JS, Chen H, Ischiropulos H, Crow JP, Oxidative chemistry of peroxynitrite. Method Enzymol, 233: 229-240, (1994)
33. Pedraza-Chaverrí J, Barrera D, Maldonado PD, Chirino YI, Macías-Ruvalcaba NA, Medina-Campos ON, Castro L, Salcedo MI, Hernández-Pando R, S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol, 30: 4-5, (2004)
34. Aruoma OI, Halliwell B, Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase. Biochem J;248: 973-6 (1987)
35. Oyaizu M, Studies on products of browning reactions: Antioxidant activities of products of browning reaction prepared from glucose amine. Jap J Nutr, 44: 307-315, (1986)
36. .Kizil G, Kizil M, Yavuz M, Emen S, Hakimoglu F, Antioxidant activities of ethanol extracts of Hypericum triquetrifolium and Hypericum scabroides. Pharm Biol, 46 (4): 231-242, (2008)
37. Hazra B, Sarkar R, Biswas S, Mandal N, The Antioxidant, Iron Chelating and DNA Protective Properties of 70% Methanolic Extract of 'Katha' (Heartwood extract of Acacia catechu). J Comp Integr Med, 7 (1): article 5, (2010)
38. Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB, The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Rad Res, 22 (4): 375-383, (1995)
39. Kessler M, Ubeaud G, Jung L, Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol, 55 (1): 131-142 (2003)
40. Jesus NZT, Falcao HS, Gomes IF, Leite TJA, Lima GRM, Barbosa-Filho JM, Tavares JF, Silva MS, Athayde-Filho PF, Batista LM, Tannins, peptic ulcer and related mechanisms. Int J Mol Sci, 13 (3): 3203-3228 (2012)
41. Weisburger JH, Eat to live, not live to eat. Nutrition, 16, 767-773 (2001)
42. Tylor BS, Kion YM, Wang QI, Sharpio RA, Billiar TR, Geller DA, Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression. Arch. Surg, 132 (11): 1177-1183 (1997)
43. Pacher P, Beckman JS and Liaudet L, Nitric Oxide and Peroxynitrite: in Health and disease. Physiol Rev, 87 (1): 315-424, (2002)
44. Kochevar EI, Redmond WR, Photosensitized production of singlet oxygen. Methods Enzymol, 319: 20-28 (2000)