Determination of artemether and dihydroartemisinin in human plasma with a new hydrogen peroxide stabilization method

Bioanalysis

Volumn 5, Issue 12, 2013, Pages 1501-1506

  Huang, Liusheng ^a   Olson, Alexander ^a   Gingrich, David ^a   Aweeka, Francesca T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; DIHYDROARTEMISININ; FERROUS ION; HEMOGLOBIN; HYDROGEN PEROXIDE;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG STRUCTURE; HEMOLYSIS; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SOLID PHASE EXTRACTION;

ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN PEROXIDE; ISOTOPE LABELING; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 84879639526     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.91     Document Type: Article

References (13)

1. Peys E Vandenkerckhove J Van Hemel J Sas B. Simultaneous determination of β-artemether and its metabolite dihydroartemisinin in human plasma and urine by a high-performance liquid chromatography-mass spectrometry assay using electrospray ionisation. Chromatographia 61, 637-641 (2005).
2. Shi B YU Y Li Z et al. Quantitative analysis of artemether and its metabolite dihydroartemisinin in human plasma by LC with tandem mass spectrometry. Chromatographia 64, 523-530 (2006).
3. Souppart C Gauducheau N Sandrenan N Richard F. Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 774, 195-203 (2002)
4. Hanpithakpong W Kamanikom B Singhasivanon P White NJ Day NPJ Lindegardh N. A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma. Bioanalysis 1, 37-46 (2009).
5. Huang L Jayewardene AL Li X Marzan F Lizak PS Aweeka FT. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for determination of artemether and its active metabolite dihydroartemisinin in human plasma. J. Pharm. Biomed. Anal. 50, 959-965 (2009).
6. Wiesner L Govender K Meredith SA Norman J Smith PJ. A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples. J. Pharm. Biomed. Anal. 55, 373-8 (2011).
7. Lindegardh N Hanpithakpong W Kamanikom B et al. Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 876, 54-60 (2008).
8. Keiser J Gruyer MS Perrottet N Zanolari B Mercier T Decosterd LA. Pharmacokinetics parameters of artesunate and dihydroartemisinin in rats infected or not by Fasciola hepatica. J. Antimicrob. Chemother. 63, 543-549 (2009).
9. Hodel EM Zanolari B Mercier T et al. A single LC tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 867-886 (2009).
10. AIDS Clinical Trials Group network guidelines for method development and validation based on (and including) FDA guidelines dated by 2001. Version 2 (2005).
11. Colussi D, Parisot C, Legay F, Lefèvre G. Binding of artemether and lumefantrine to plasma proteins and Erythrocytes. Eur. J. Pharm. Sci. 9, 9-16 (1999).
12. Batty KT, Ilett KF, Davis TM. Protein binding and α:β anomer ratio of dihydroartemisinin in vivo. Br. J. Clin. Pharmacol. 57, 529-533 (2004).
13. Blessborn D, Sköld K, Zeeberg D, Kaewkhao K, Sköld O Ahnoff M. Heat stabilization of blood spot samples for determination of metabolically unstable drug compounds. Bioanalysis 5(1), 31-39 (2013).