Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Journal of Antibiotics

Volumn 66, Issue 6, 2013, Pages 319-325

  Shen, Li ^a   M Maddox, Marcus ^b   Adhikari, Sudip ^c   Bruhn, David F ^b   Kumar, Manish ^c   Lee, Robin E ^b   Hurdle, Julian G ^c   Lee, Richard E ^b   Sun, Dianqing ^a  

^a UNIVERSITY OF HAWAII AT HILO   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

antibacterial; antitubercular; diarylheptanoid; engelhardione; macrocycle; pterocarine

Indexed keywords

ENGELHARDIONE DERIVATIVE; MACROCYCLIC COMPOUND; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; VANCOMYCIN;

ALDOL REACTION; ALKYLATION; AMINATION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HYDROGENATION; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MICROWAVE IRRADIATION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION;

AMINATION; AMINES; ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; CHROMATOGRAPHY; DIARYLHEPTANOIDS; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; HYDROGENATION; ISOMERISM; MACROCYCLIC COMPOUNDS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; OXIMES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; NEGIBACTERIA; POSIBACTERIA;

EID: 84879634938     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2013.21     Document Type: Article

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